Matthias Rief

Matthias Rief

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Matthias Rief

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An Active, Ligand-Responsive Pulling Geometry Reports on Internal Signaling between Subdomains of the DnaK Nucleotide-Binding Domain in Single-Molecule Mechanical Experiments.

Biochemistry 2019 Nov 23;58(47):4744-4750. Epub 2019 May 23.

Physik Department E22 , Technische Universität München , 85748 Garching , Germany.

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http://dx.doi.org/10.1021/acs.biochem.9b00155DOI Listing
November 2019

Noise reduction and motion elimination in low-dose 4D myocardial computed tomography perfusion (CTP): preliminary clinical evaluation of the ASTRA4D algorithm.

Eur Radiol 2019 Sep 4;29(9):4572-4582. Epub 2019 Feb 4.

Department of Radiology, Charité Medical School, Charitéplatz 1, 10117, Berlin, Germany.

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http://dx.doi.org/10.1007/s00330-018-5899-8DOI Listing
September 2019

Bioorthogonal protein-DNA conjugation methods for force spectroscopy.

Sci Rep 2019 Sep 25;9(1):13820. Epub 2019 Sep 25.

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, UK.

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http://dx.doi.org/10.1038/s41598-019-49843-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761116PMC
September 2019

The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range.

Nat Commun 2019 08 9;10(1):3626. Epub 2019 Aug 9.

Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, 85748, Garching, Germany.

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http://dx.doi.org/10.1038/s41467-019-11518-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689086PMC
August 2019

Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data.

BMJ 2019 06 12;365:l1945. Epub 2019 Jun 12.

Department of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany

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http://dx.doi.org/10.1136/bmj.l1945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561308PMC
June 2019

Patient Preferences for Coronary CT Angiography with Stress Perfusion, SPECT, or Invasive Coronary Angiography.

Radiology 2019 05 19;291(2):340-348. Epub 2019 Mar 19.

From the Department of Cardiology, Johns Hopkins Hospital and Health System, Baltimore, Md (A.M., A.L.V., M.R.O., M.M., C.C., P.M.); Departments of Radiology (M.D., M.L., M.R., S.F., M.P.) and Anesthesiology (E.S.), Charité-Universitätsmedizin Berlin, Humboldt-Universität and Freie Universität zu Berlin, Schumannstr 20/21, Berlin 10117, Germany; Department of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.T.); Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil (C.E.R.); Department of Medicine, Division of Cardiology, St Luke's International Hospital, Tokyo, Japan (H.N.); Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (K.F.K.); Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands (J.G.); Department of Radiology, Mount Elizabeth Hospital, Singapore (J.H.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); Department of Radiology, Mie University Hospital, Tsu, Japan (K.K.); Department of Radiology, Albert Einstein Hospital, São Paulo, Brazil (C.N.); Department of Radiology, Beth Israel Deaconess Medical Center, Harvard University, Boston, Mass (M.E.C.); Department of Radiology, University of Ottawa Faculty of Medicine, Ottawa, Canada (F.J.R.); Department of Cardiology, National Heart Center Singapore, Singapore (S.Y.T.); and Department of Radiology, Toronto General Hospital, Toronto, Canada (N.P.).

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http://dx.doi.org/10.1148/radiol.2019181409DOI Listing
May 2019

Nucleotide-Dependent Dimer Association and Dissociation of the Chaperone Hsp90.

J Phys Chem B 2018 12 13;122(49):11373-11380. Epub 2018 Sep 13.

Institute of Physical Chemistry , University of Freiburg , Freiburg , Baden-Württemberg 79104 , Germany.

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http://dx.doi.org/10.1021/acs.jpcb.8b07301DOI Listing
December 2018

Single-molecule force spectroscopy reveals folding steps associated with hormone binding and activation of the glucocorticoid receptor.

Proc Natl Acad Sci U S A 2018 11 26;115(46):11688-11693. Epub 2018 Oct 26.

Physik Department E22, Technical University of Munich, 85748 Garching, Germany;

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http://dx.doi.org/10.1073/pnas.1807618115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243279PMC
November 2018

DNA double-strand breaks in blood lymphocytes induced by two-day Tc-MIBI myocardial perfusion scintigraphy.

Eur Radiol 2018 Jul 30;28(7):3075-3081. Epub 2018 Jan 30.

Department of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

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http://link.springer.com/10.1007/s00330-017-5239-4
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http://dx.doi.org/10.1007/s00330-017-5239-4DOI Listing
July 2018

A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy.

Proc Natl Acad Sci U S A 2018 05 18;115(18):4666-4671. Epub 2018 Apr 18.

Physik Department E22, Technische Universität München, 85748 Garching, Germany;

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http://dx.doi.org/10.1073/pnas.1716899115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939067PMC
May 2018

Coronary Artery Disease: Analysis of Diagnostic Performance of CT Perfusion and MR Perfusion Imaging in Comparison with Quantitative Coronary Angiography and SPECT-Multicenter Prospective Trial.

Radiology 2018 02 25;286(2):461-470. Epub 2017 Sep 25.

From the Departments of Radiology (M.R., B.K., E.Z., M.D.), Nuclear Medicine (M.P.), and Cardiology (M.L.), Charité-Universitätsmedizin Berlin, Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Health and Human Services, National Institutes of Health, Bethesda, Md (M.Y.C., W.P.B., A.E.A.); Department of Medicine, Johns Hopkins University, Baltimore, Md (A.L.V., J.M.M., R.T.G., J.L.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (C.C.); Departments of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (M.D.C.); and Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany (P.S.).

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http://dx.doi.org/10.1148/radiol.2017162447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790301PMC
February 2018

Folding and Domain Interactions of Three Orthologs of Hsp90 Studied by Single-Molecule Force Spectroscopy.

Structure 2018 01 21;26(1):96-105.e4. Epub 2017 Dec 21.

Physics Department E22, Technical University of Munich, Garching, Bavaria 85748, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.11.023DOI Listing
January 2018

Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1.

Nat Methods 2017 Nov 18;14(11):1090-1096. Epub 2017 Sep 18.

Group of Molecular Mechanotransduction, Max Planck Institute of Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.1038/nmeth.4431DOI Listing
November 2017

Mechanically switching single-molecule fluorescence of GFP by unfolding and refolding.

Proc Natl Acad Sci U S A 2017 10 3;114(42):11052-11056. Epub 2017 Oct 3.

Physik Department E22, Technische Universität München, 85748 Garching, Germany;

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http://dx.doi.org/10.1073/pnas.1704937114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651744PMC
October 2017

Computed tomography versus invasive coronary angiography: design and methods of the pragmatic randomised multicentre DISCHARGE trial.

Eur Radiol 2017 Jul 18;27(7):2957-2968. Epub 2016 Nov 18.

Department of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

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http://dx.doi.org/10.1007/s00330-016-4620-zDOI Listing
July 2017

Nanomechanics of the substrate binding domain of Hsp70 determine its allosteric ATP-induced conformational change.

Proc Natl Acad Sci U S A 2017 06 22;114(23):6040-6045. Epub 2017 May 22.

Physik Department E22, Technische Universität München, 85748 Garching, Germany;

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http://dx.doi.org/10.1073/pnas.1619843114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468673PMC
June 2017

Analysis and Prediction of Claustrophobia during MR Imaging with the Claustrophobia Questionnaire: An Observational Prospective 18-month Single-Center Study of 6500 Patients.

Radiology 2017 Apr 25;283(1):148-157. Epub 2016 Nov 25.

From the Department of Radiology, Charité Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany.

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http://dx.doi.org/10.1148/radiol.2016160476DOI Listing
April 2017

Special issue: Biomolecular forces.

J Struct Biol 2017 01;197(1):1-2

Eidgenössische Technische Hochschule (ETH) Zürich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.jsb.2016.12.008DOI Listing
January 2017

α-Actinin/titin interaction: A dynamic and mechanically stable cluster of bonds in the muscle Z-disk.

Proc Natl Acad Sci U S A 2017 01 17;114(5):1015-1020. Epub 2017 Jan 17.

Physik Department E22, Technische Universität München, 85748 Garching, Germany;

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http://dx.doi.org/10.1073/pnas.1612681114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293040PMC
January 2017

Single-molecule dissection of stacking forces in DNA.

Science 2016 09;353(6304)

Labor für Biomolekulare Nanotechnologie, Physik Department and Walter Schottky Institute, Technische Universität München, Am Coulombwall 4a, Garching near Munich, Germany. Munich Center for Integrated Protein Science, 81377 Munich, Germany. Institute for Advanced Study, TUM, Germany.

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http://dx.doi.org/10.1126/science.aaf5508DOI Listing
September 2016

Knotting and unknotting of a protein in single molecule experiments.

Proc Natl Acad Sci U S A 2016 07 23;113(27):7533-8. Epub 2016 Jun 23.

Physik Department E22, Technische Universität München, 85748 Garching, Germany; Munich Center for Integrated Protein Science, 81377 Munich, Germany

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http://dx.doi.org/10.1073/pnas.1600614113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941514PMC
July 2016

Systemic embolization with coronary artery obstruction from a left ventricular thrombus.

Intensive Care Med 2016 Feb 5;42(2):273-4. Epub 2015 Aug 5.

Department of Cardiothoracic Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1007/s00134-015-3984-xDOI Listing
February 2016

Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments.

Proc Natl Acad Sci U S A 2016 Feb 19;113(5):1232-7. Epub 2016 Jan 19.

Physik-Department, Technische Universität München, 85748 Garching, Germany; Munich Center for Integrated Protein Science, 81377 München, Germany;

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http://dx.doi.org/10.1073/pnas.1518827113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747692PMC
February 2016

Subnanometre enzyme mechanics probed by single-molecule force spectroscopy.

Nat Commun 2016 Feb 24;7:10848. Epub 2016 Feb 24.

Physik Department E22, Technische Universität München, James Franck Strasse 1, 85748 Garching, Germany.

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http://dx.doi.org/10.1038/ncomms10848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770092PMC
February 2016

Extracellular rigidity sensing by talin isoform-specific mechanical linkages.

Nat Cell Biol 2015 Dec 2;17(12):1597-606. Epub 2015 Nov 2.

Max Planck Institute of Biochemistry, Group of Molecular Mechanotransduction, Martinsried D-82152, Germany.

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http://dx.doi.org/10.1038/ncb3268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662888PMC
December 2015

Ligand-induced changes of the apparent transition-state position in mechanical protein unfolding.

Biophys J 2015 Jul;109(2):365-72

Physik Department E22, Technische Universität München, Garching, Germany; Munich Center for Integrated Protein Science, München, Germany.

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http://dx.doi.org/10.1016/j.bpj.2015.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621620PMC
July 2015

A compact native 24-residue supersecondary structure derived from the villin headpiece subdomain.

Biophys J 2015 Feb;108(3):678-86

Physik Department E22, Technische Universität München, Garching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.11.3482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317555PMC
February 2015

Computer-aided CT coronary artery stenosis detection: comparison with human reading and quantitative coronary angiography.

Int J Cardiovasc Imaging 2014 Dec 13;30(8):1621-7. Epub 2014 Aug 13.

Department of Radiology, Charité, Medical School, Humboldt-University and Free University, Charitéplatz 1, 10117, Berlin, Germany,

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http://dx.doi.org/10.1007/s10554-014-0513-xDOI Listing
December 2014

Intra-arterial ultra low iodine CT angiography of renal transplant arteries.

Cardiovasc Intervent Radiol 2014 Aug 25;37(4):1062-7. Epub 2014 Jan 25.

Department of Radiology, Charité Medical School, Charitéplatz 1, 10117, Berlin, Germany,

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http://dx.doi.org/10.1007/s00270-014-0838-9DOI Listing
August 2014

Sequence-resolved free energy profiles of stress-bearing vimentin intermediate filaments.

Proc Natl Acad Sci U S A 2014 Aug 21;111(31):11359-64. Epub 2014 Jul 21.

Physik Department E22, Technische Universität München, 85748 Garching, Germany;Nanosystems Initiative Munich, 80799 Munich, Germany

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http://dx.doi.org/10.1073/pnas.1403122111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128112PMC
August 2014

Forced protein unfolding leads to highly elastic and tough protein hydrogels.

Nat Commun 2013 ;4:2974

1] Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1 [2] State Key Laboratory of Precision Measurements Technology and Instruments, School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 30072, China.

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http://dx.doi.org/10.1038/ncomms3974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983047PMC
July 2014

Contrast agent bolus tracking with a fixed threshold or a manual fast start for coronary CT angiography.

Eur Radiol 2014 Jun 26;24(6):1229-38. Epub 2014 Mar 26.

Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany.

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http://dx.doi.org/10.1007/s00330-014-3148-3DOI Listing
June 2014

Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin.

Proc Natl Acad Sci U S A 2014 Apr 2;111(15):5568-73. Epub 2014 Apr 2.

Physik Department E22, Technische Universität München, 85748 Garching, Germany.

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http://dx.doi.org/10.1073/pnas.1319448111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992639PMC
April 2014

Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy.

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):18156-61. Epub 2013 Oct 21.

Physik Department E22, Technische Universität München, 85748 Garching, Germany.

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http://dx.doi.org/10.1073/pnas.1311495110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831443PMC
November 2013

Mechanical stability of the antibody domain CH3 homodimer in different oxidation states.

J Am Chem Soc 2013 Oct 26;135(40):15085-91. Epub 2013 Sep 26.

Physik Department E22, Technische Universität München , James-Franck-Straße 1, 85748 Garching, Germany.

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http://dx.doi.org/10.1021/ja405076jDOI Listing
October 2013

Rigid DNA beams for high-resolution single-molecule mechanics.

Angew Chem Int Ed Engl 2013 Jul 21;52(30):7766-71. Epub 2013 Jun 21.

Physik Department, Walter Schottky Institute, Technische Universität München, Am Coulombwall 4a, 85748 Garching near Munich, Germany.

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http://dx.doi.org/10.1002/anie.201302727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749440PMC
July 2013

Time efficiency and diagnostic accuracy of new automated myocardial perfusion analysis software in 320-row CT cardiac imaging.

Korean J Radiol 2013 Jan-Feb;14(1):21-9. Epub 2012 Dec 28.

Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin 10117, Germany.

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http://dx.doi.org/10.3348/kjr.2013.14.1.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542299PMC
June 2013

From mechanical folding trajectories to intrinsic energy landscapes of biopolymers.

Proc Natl Acad Sci U S A 2013 Mar 4;110(12):4500-5. Epub 2013 Mar 4.

Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742, USA.

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http://dx.doi.org/10.1073/pnas.1214051110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606983PMC
March 2013

Force as a single molecule probe of multidimensional protein energy landscapes.

Curr Opin Struct Biol 2013 Feb 30;23(1):48-57. Epub 2012 Dec 30.

Physik Department E22, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.

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http://dx.doi.org/10.1016/j.sbi.2012.11.007DOI Listing
February 2013

Dynamic force sensing of filamin revealed in single-molecule experiments.

Proc Natl Acad Sci U S A 2012 Nov 13;109(48):19679-84. Epub 2012 Nov 13.

Physik Department E22, Technische Universität München, 85748 Garching, Germany.

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http://dx.doi.org/10.1073/pnas.1211274109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511698PMC
November 2012

Calcium-dependent folding of single calmodulin molecules.

Proc Natl Acad Sci U S A 2012 Oct 2;109(44):17814-9. Epub 2012 Jul 2.

Physik Department E22, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.

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http://dx.doi.org/10.1073/pnas.1201801109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497792PMC
October 2012

A new manganese-based oral contrast agent (CMC-001) for liver MRI: pharmacological and pharmaceutical aspects.

Acta Radiol 2012 Sep 20;53(7):707-13. Epub 2012 Jul 20.

Research and Development, CMC Contrast AB, Scion DTU, Lyngby, Denmark.

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http://dx.doi.org/10.1258/ar.2012.120034DOI Listing
September 2012

Auto- and cross-power spectral analysis of dual trap optical tweezer experiments using Bayesian inference.

Rev Sci Instrum 2012 Sep;83(9):095116

Department of Physics, Freie Universität Berlin, 14195 Berlin, Germany.

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http://aip.scitation.org/doi/10.1063/1.4753917
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http://dx.doi.org/10.1063/1.4753917DOI Listing
September 2012

Torque generation of kinesin motors is governed by the stability of the neck domain.

Mol Cell 2012 Apr;46(2):147-58

Physik Department E22, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.

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http://dx.doi.org/10.1016/j.molcel.2012.04.005DOI Listing
April 2012

Hidden Markov analysis of trajectories in single-molecule experiments and the effects of missed events.

Chemphyschem 2012 Mar 5;13(4):1079-86. Epub 2012 Mar 5.

Physik Department E22, Technische Universität München, James-Franck-Str, 85748 Garching, Germany.

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http://doi.wiley.com/10.1002/cphc.201100814
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http://dx.doi.org/10.1002/cphc.201100814DOI Listing
March 2012

Single-molecule protein unfolding and refolding using atomic force microscopy.

Methods Mol Biol 2011 ;783:233-50

Department of Physics, TU Munich, Garching, Germany.

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http://dx.doi.org/10.1007/978-1-61779-282-3_13DOI Listing
January 2012

The complex folding network of single calmodulin molecules.

Science 2011 Oct;334(6055):512-6

Physik Department E22, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.

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http://dx.doi.org/10.1126/science.1207598DOI Listing
October 2011

Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin.

Proc Natl Acad Sci U S A 2011 Aug 8;108(34):14139-44. Epub 2011 Aug 8.

Physik Department E22, Technische Universität München, James-Franck-Straße, 85748 Garching, Germany.

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http://dx.doi.org/10.1073/pnas.1105734108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161521PMC
August 2011

Complex unfolding kinetics of single-domain proteins in the presence of force.

Biophys J 2010 Sep;99(5):1620-7

Loomis Laboratory, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.

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http://dx.doi.org/10.1016/j.bpj.2010.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931718PMC
September 2010

Structural and mechanical hierarchies in the alpha-crystallin domain dimer of the hyperthermophilic small heat shock protein Hsp16.5.

J Mol Biol 2010 Jul 2;400(5):1046-56. Epub 2010 Jun 2.

Center for Integrated Protein Science (CIPSM) Munich, Physik Department E22, Technische Universität München, James-Franck-Strasse 1, 85748 Garching, Germany.

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http://dx.doi.org/10.1016/j.jmb.2010.05.065DOI Listing
July 2010

Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner.

Proc Natl Acad Sci U S A 2010 Jun 24;107(23):10460-5. Epub 2010 May 24.

Physik Department E22, Technische Universität München, James-Franck-Strasse, D-85748 Garching, Germany.

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http://dx.doi.org/10.1073/pnas.1005177107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890855PMC
June 2010

Evidence for a broad transition-state ensemble in calmodulin folding from single-molecule force spectroscopy.

Angew Chem Int Ed Engl 2010 Apr;49(19):3306-9

Physik-Department E22, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.

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http://doi.wiley.com/10.1002/anie.200905747
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http://dx.doi.org/10.1002/anie.200905747DOI Listing
April 2010

Direct evidence of the multidimensionality of the free-energy landscapes of proteins revealed by mechanical probes.

Phys Rev E Stat Nonlin Soft Matter Phys 2010 Mar 30;81(3 Pt 1):031923. Epub 2010 Mar 30.

Institute of Molecular and Cell Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1103/PhysRevE.81.031923DOI Listing
March 2010

Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex.

Proc Natl Acad Sci U S A 2010 Feb 1;107(7):2908-13. Epub 2010 Feb 1.

King's College London BHF Research Excellence Centre, Randall Division for Cell and Molecular Biophysics and Cardiovascular Division, New Hunt's House, Guy's Campus, London SE1 1UL, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0913736107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814874PMC
February 2010

Full distance-resolved folding energy landscape of one single protein molecule.

Proc Natl Acad Sci U S A 2010 Feb 19;107(5):2013-8. Epub 2010 Jan 19.

Physik Department E22, Technische Universität München, James Franck Strasse, 85748 Garching, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0909854107
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http://dx.doi.org/10.1073/pnas.0909854107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836620PMC
February 2010

The lever arm effects a mechanical asymmetry of the myosin-V-actin bond.

Biophys J 2010 Jan;98(2):277-81

Physik-Department E22, Technische Universität München, Garching, Germany.

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http://dx.doi.org/10.1016/j.bpj.2009.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808492PMC
January 2010

Detection of focal liver lesions in unenhanced and ferucarbotran-enhanced magnetic resonance imaging: a comparison of T2-weighted breath-hold and respiratory-triggered sequences.

Magn Reson Imaging 2009 Nov 10;27(9):1223-9. Epub 2009 Jun 10.

Department of Radiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Campus Mitte, 10117 Berlin, Germany.

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http://dx.doi.org/10.1016/j.mri.2009.05.001DOI Listing
November 2009

Ligand binding mechanics of maltose binding protein.

J Mol Biol 2009 Nov 3;393(5):1097-105. Epub 2009 Sep 3.

Physik Department E22, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360901092
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http://dx.doi.org/10.1016/j.jmb.2009.08.066DOI Listing
November 2009

Designing the folding mechanics of coiled coils.

Chemphyschem 2009 Nov;10(16):2800-4

Physik Department E22, Technische Universität München, James Franck Strasse, 85748 Garching, Germany.

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http://dx.doi.org/10.1002/cphc.200900575DOI Listing
November 2009

The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk.

Proc Natl Acad Sci U S A 2009 Aug 21;106(32):13307-133310. Epub 2009 Jul 21.

Physik Department E22, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.

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http://dx.doi.org/10.1073/pnas.0902312106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726412PMC
August 2009

Single-molecule force spectroscopy distinguishes target binding modes of calmodulin.

Proc Natl Acad Sci U S A 2009 Aug 10;106(34):14361-6. Epub 2009 Aug 10.

Physik-Department E22, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0904654106
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732892PMC
August 2009

Biochemistry. Force signaling in biology.

Science 2009 Jun;324(5932):1278-80

Physik Department E22, Technische Universität München, James-Franck-Strasse, 85748 München, Germany.

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http://dx.doi.org/10.1126/science.1175874DOI Listing
June 2009

Dissection of kinesin's processivity.

PLoS One 2009 26;4(2):e4612. Epub 2009 Feb 26.

Physics Department E22, Technical University Munich, Garching, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004612PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644789PMC
April 2009

Single molecule mechanics of the kinesin neck.

Proc Natl Acad Sci U S A 2009 Apr 14;106(17):6992-7. Epub 2009 Apr 14.

Physics Department E22, Technische Universität München, James Franck Strasse, 85748 Garching, Germany.

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http://dx.doi.org/10.1073/pnas.0812620106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678465PMC
April 2009

Tightening the knot in phytochrome by single-molecule atomic force microscopy.

Biophys J 2009 Feb;96(4):1508-14

Department of Physics, Technische Universität München, D-85748 Garching, Germany.

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http://dx.doi.org/10.1016/j.bpj.2008.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717258PMC
February 2009

Surprising simplicity in the single-molecule folding mechanics of proteins.

Angew Chem Int Ed Engl 2009 ;48(4):820-2

Physikdepartment E22, TU München, James-Franck-Strasse, 85748 Garching, Germany.

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http://doi.wiley.com/10.1002/anie.200804723
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January 2009

Ligand-dependent equilibrium fluctuations of single calmodulin molecules.

Science 2009 Jan;323(5914):633-7

Physik Department E22, Technische Universität München, James-Franck-Strasse, 85748 München, Germany.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1166191
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January 2009

Navigating the folding energy landscape of green fluorescent protein.

Angew Chem Int Ed Engl 2008 ;47(43):8192-5

Physikdepartment E22, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.

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http://doi.wiley.com/10.1002/anie.200802987
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December 2008

Mechanical unfoldons as building blocks of maltose-binding protein.

J Mol Biol 2008 Apr 21;378(2):447-58. Epub 2008 Feb 21.

Physik Department E22, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.

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http://dx.doi.org/10.1016/j.jmb.2008.02.025DOI Listing
April 2008

Elastic bond network model for protein unfolding mechanics.

Phys Rev Lett 2008 Mar 4;100(9):098101. Epub 2008 Mar 4.

Dana-Farber Cancer Institute and BCMP, Harvard Medical School, Boston, MA 02115, USA.

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https://link.aps.org/doi/10.1103/PhysRevLett.100.098101
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March 2008

Single-molecule dynamics of mechanical coiled-coil unzipping.

Langmuir 2008 Feb 1;24(4):1338-42. Epub 2007 Nov 1.

Physik Department E22, Technische Universität München, James-Franck-Strasse, Munich, Germany.

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http://dx.doi.org/10.1021/la7023567DOI Listing
February 2008

Direct observation of active protein folding using lock-in force spectroscopy.

Biophys J 2007 Dec 17;93(11):3989-98. Epub 2007 Aug 17.

Physik Department E22, Technische Universität München, München, Germany.

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http://dx.doi.org/10.1529/biophysj.107.114397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2084248PMC
December 2007

Revealing the bifurcation in the unfolding pathways of GFP by using single-molecule experiments and simulations.

Proc Natl Acad Sci U S A 2007 Dec 13;104(51):20268-73. Epub 2007 Dec 13.

Physik Department E22, Technische Universität München, James-Franck-Strasse, D-85748 Garching, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0705458104
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154420PMC
December 2007

Myosin V stepping mechanism.

Proc Natl Acad Sci U S A 2007 Sep 18;104(39):15328-33. Epub 2007 Sep 18.

Institut Curie, Centre National de la Recherche Scientifique Unité Mixte de Recherche 168, 75231 Paris, France.

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http://dx.doi.org/10.1073/pnas.0706653104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000544PMC
September 2007

Cysteine engineering of polyproteins for single-molecule force spectroscopy.

Nat Protoc 2006 ;1(1):80-4

Physik Department, Technische Universität München, James-Franck-Strasse, D-85748 Garching bei München, Germany.

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http://dx.doi.org/10.1038/nprot.2006.12DOI Listing
June 2007

Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium.

J Biol Chem 2007 Jan 22;282(3):1948-55. Epub 2006 Nov 22.

Institut für Biochemie I, Zentrum Molekulare Medizin Köln, Medizinische Fakultät, Universität zu Köln, 50931 Köln, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M610262200
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January 2007

Anisotropic deformation response of single protein molecules.

Proc Natl Acad Sci U S A 2006 Aug 14;103(34):12724-8. Epub 2006 Aug 14.

Physik Department E22, Technische Universität München, James-Franck-Strasse, D-85748 Garching, Germany.

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http://dx.doi.org/10.1073/pnas.0602995103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568916PMC
August 2006

Myosin-V is a mechanical ratchet.

Proc Natl Acad Sci U S A 2006 Jun 26;103(23):8680-5. Epub 2006 May 26.

Physics Department E22, Technical University of Munich, James-Franck-Strasse, D-85748 Garching, Germany.

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http://dx.doi.org/10.1073/pnas.0510191103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482639PMC
June 2006