Publications by authors named "Matthias Rath"

93Publications

Vitamin C inhibits the calcification process in human vascular smooth muscle cells.

Am J Cardiovasc Dis 2020 15;10(2):108-116. Epub 2020 Jun 15.

Department of Cardiovascular Diseases, Dr. Rath Research Institute 5941 Optical Court, San Jose, CA 95138, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364280PMC
June 2020

Identification and characterization of a GLMN splice site variant in a family with glomuvenous malformations.

Eur J Dermatol 2020 Apr;30(2):179-181

Department of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Fleischmannstraße 43, 17475 Greifswald, Germany.

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http://dx.doi.org/10.1684/ejd.2020.3716DOI Listing
April 2020

CRISPR/Cas9-mediated Generation of Human Endothelial Cell Knockout Models of CCM Disease.

Methods Mol Biol 2020 ;2152:169-177

Department of Human Genetics, University Medicine Greifswald and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1007/978-1-0716-0640-7_13DOI Listing
January 2020

Fibronectin rescues aberrant phenotype of endothelial cells lacking either CCM1, CCM2 or CCM3.

FASEB J 2020 Jul 9;34(7):9018-9033. Epub 2020 Jun 9.

Department of Human Genetics, University Medicine Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1096/fj.201902888RDOI Listing
July 2020

First interchromosomal insertion in a patient with cerebral and spinal cavernous malformations.

Sci Rep 2020 04 14;10(1):6306. Epub 2020 Apr 14.

Department of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1038/s41598-020-63337-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156631PMC
April 2020

Novel Pathogenic Variants in a Cassette Exon of in Patients With Cerebral Cavernous Malformations.

Front Neurol 2019 20;10:1219. Epub 2019 Nov 20.

Department of Human Genetics, University Medicine Greifswald and Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.3389/fneur.2019.01219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879547PMC
November 2019

Postzygotic mosaicism in cerebral cavernous malformation.

J Med Genet 2020 03 24;57(3):212-216. Epub 2019 Aug 24.

Department of Human Genetics, University Medicine Greifswald, Greifswald, Germany

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http://dx.doi.org/10.1136/jmedgenet-2019-106182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042965PMC
March 2020

Precise CCM1 gene correction and inactivation in patient-derived endothelial cells: Modeling Knudson's two-hit hypothesis in vitro.

Mol Genet Genomic Med 2019 07 23;7(7):e00755. Epub 2019 May 23.

Department of Human Genetics, University Medicine Greifswald and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1002/mgg3.755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625102PMC
July 2019

Exome sequencing identifies a recurrent SOX2 deletion in a patient with gait ataxia and dystonia lacking major ocular malformations.

J Neurol Sci 2019 Jun 8;401:34-36. Epub 2019 Apr 8.

Department of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Fleischmannstraße 43, 17475 Greifswald, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2019.04.007DOI Listing
June 2019

10-undecynoic acid is a new anti-adherent agent killing biofilm of oral Streptococcus spp.

PLoS One 2019 18;14(4):e0214763. Epub 2019 Apr 18.

Department of Infectious Diseases, Dr. Rath Research Institute BV, Santa Clara, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214763PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472753PMC
December 2019

Anti-borreliae efficacy of selected organic oils and fatty acids.

BMC Complement Altern Med 2019 Feb 4;19(1):40. Epub 2019 Feb 4.

Department of Infectious Diseases, Dr. Rath Research Institute, 1260 Memorex Dr., Santa Clara, CA, 95050, USA.

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http://dx.doi.org/10.1186/s12906-019-2450-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360722PMC
February 2019

Identification of pathogenic YY1AP1 splice variants in siblings with Grange syndrome by whole exome sequencing.

Am J Med Genet A 2019 02 17;179(2):295-299. Epub 2018 Dec 17.

Department of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1002/ajmg.a.60700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590215PMC
February 2019

Biallelic CCM3 mutations cause a clonogenic survival advantage and endothelial cell stiffening.

J Cell Mol Med 2019 03 13;23(3):1771-1783. Epub 2018 Dec 13.

Department of Human Genetics, University Medicine Greifswald and Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1111/jcmm.14075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378188PMC
March 2019

Diagnostic Single Gene Analyses Beyond Sanger.

Hamostaseologie 2018 Aug 27;38(3):158-165. Epub 2018 Sep 27.

Department of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.5482/HAMO-17-01-0008DOI Listing
August 2018

Cerebral Cavernous Malformations: An Update on Prevalence, Molecular Genetic Analyses, and Genetic Counselling.

Mol Syndromol 2018 Feb 25;9(2):60-69. Epub 2018 Jan 25.

Department of Human Genetics, University Medicine Greifswald and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald.

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http://dx.doi.org/10.1159/000486292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836221PMC
February 2018

First large genomic inversion in familial cerebral cavernous malformation identified by whole genome sequencing.

Neurogenetics 2018 01 2;19(1):55-59. Epub 2017 Dec 2.

Department of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Fleischmannstraße 43, D-17475, Greifswald, Germany.

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http://dx.doi.org/10.1007/s10048-017-0531-7DOI Listing
January 2018

Exome sequencing results in identification and treatment of brain dopamine-serotonin vesicular transport disease.

J Neurol Sci 2017 08 22;379:296-297. Epub 2017 Jun 22.

Department of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2017.06.034DOI Listing
August 2017

High-throughput sequencing of the entire genomic regions of CCM1/KRIT1, CCM2 and CCM3/PDCD10 to search for pathogenic deep-intronic splice mutations in cerebral cavernous malformations.

Eur J Med Genet 2017 Sep 20;60(9):479-484. Epub 2017 Jun 20.

Department of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmg.2017.06.007DOI Listing
September 2017

Modulation of MMP-2 and -9 secretion by cytokines, inducers and inhibitors in human melanoma A-2058 cells.

Oncol Rep 2017 Jun 24;37(6):3681-3687. Epub 2017 Apr 24.

Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3892/or.2017.5597DOI Listing
June 2017

Constitutional de novo and postzygotic mutations in isolated cases of cerebral cavernous malformations.

Mol Genet Genomic Med 2017 Jan 20;5(1):21-27. Epub 2016 Dec 20.

Department of Human Genetics University Medicine Greifswald and Interfaculty Institute of Genetics and Functional Genomics University of Greifswald Greifswald Germany.

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http://dx.doi.org/10.1002/mgg3.256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241208PMC
January 2017

Modulation of MMP-2 and MMP-9 secretion by cytokines, inducers and inhibitors in human glioblastoma T-98G cells.

Oncol Rep 2017 Mar 19;37(3):1907-1913. Epub 2017 Jan 19.

Dr. Rath Research Institute, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3892/or.2017.5391DOI Listing
March 2017

Myocardial energetics and the role of micronutrients in heart failure: a critical review.

Am J Cardiovasc Dis 2016 15;6(3):81-92. Epub 2016 Sep 15.

Dr. Rath Research Institute Santa Clara, CA 95050, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030388PMC
September 2016

Anticancer Efficacy of Polyphenols and Their Combinations.

Nutrients 2016 Sep 9;8(9). Epub 2016 Sep 9.

Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3390/nu8090552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037537PMC
September 2016

FAM222B Is Not a Likely Novel Candidate Gene for Cerebral Cavernous Malformations.

Mol Syndromol 2016 Jul 18;7(3):144-52. Epub 2016 Jun 18.

Department of Human Genetics, University Medicine Greifswald and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1159/000446884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988258PMC
July 2016

Lipoprotein(a) and vitamin C impair development of breast cancer tumors in Lp(a)+; Gulo-/- mice.

Int J Oncol 2016 Sep 1;49(3):895-902. Epub 2016 Jul 1.

Dr. Rath Research Institute, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3892/ijo.2016.3597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948959PMC
September 2016

Cooperation of Doxycycline with Phytochemicals and Micronutrients Against Active and Persistent Forms of Borrelia sp.

Int J Biol Sci 2016 22;12(9):1093-103. Epub 2016 Jul 22.

Dr. Rath Research Institute BV, Santa Clara, California 95050, USA.

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http://dx.doi.org/10.7150/ijbs.16060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997053PMC
November 2017

The anti-borreliae efficacy of phytochemicals and micronutrients: an update.

Ther Adv Infect Dis 2016 Jun 4;3(3-4):75-82. Epub 2016 Jul 4.

Dr. Rath Research Institute, Santa Clara, CA, USA.

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http://dx.doi.org/10.1177/2049936116655502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971593PMC
June 2016

Efficacy of nutritional treatment in patients with psoriasis: A case report.

Exp Ther Med 2015 Sep 8;10(3):1071-1073. Epub 2015 Jul 8.

Dr. Rath Research Institute, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3892/etm.2015.2631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533159PMC
September 2015

Hypoascorbemia induces atherosclerosis and vascular deposition of lipoprotein(a) in transgenic mice.

Am J Cardiovasc Dis 2015 20;5(1):53-62. Epub 2015 Mar 20.

Dr. Rath Research Institute Santa Clara, CA, USA.

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http://www.ajcd.us/files/ajcd0007056.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447075PMC
June 2015

Modulation of uPA, MMPs and their inhibitors by a novel nutrient mixture in human colorectal, pancreatic and hepatic carcinoma cell lines.

Int J Oncol 2015 Jul 18;47(1):370-6. Epub 2015 May 18.

Dr. Rath Research Institute, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3892/ijo.2015.3008DOI Listing
July 2015

Modulation of uPA, MMPs and their inhibitors by a novel nutrient mixture in human glioblastoma cell lines.

Int J Oncol 2014 Aug 26;45(2):887-94. Epub 2014 May 26.

Dr Rath Research Institute, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3892/ijo.2014.2465DOI Listing
August 2014

Birth defects after incestuous mating: calculating the probability of causality and reflecting on the desirability of genetic testing.

Eur J Med Genet 2013 May 5;56(5):243-4. Epub 2013 Mar 5.

Department of Clinical Genetics and Institute of Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ejmg.2013.02.007DOI Listing
May 2013

Inhibition of the SK-N-MC human neuroblastoma cell line in vivo and in vitro by a novel nutrient mixture.

Oncol Rep 2013 May 27;29(5):1714-20. Epub 2013 Feb 27.

Dr Rath Research Institute, Oncology Division, Santa Clara, CA, USA.

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http://dx.doi.org/10.3892/or.2013.2307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658814PMC
May 2013

Suppression of metastasis of intratesticular inoculation of B16FO melanoma cells by a novel nutrient mixture in male athymic nude mice.

Exp Ther Med 2012 Nov 31;4(5):775-780. Epub 2012 Aug 31.

Dr Rath Research Institute, Oncology Division, 1260 Memorex Drive, Santa Clara, CA, USA.

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http://dx.doi.org/10.3892/etm.2012.689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493699PMC
November 2012

Antineoplastic activity of a nutrient mixture in Y-79 malignant retinoblastoma cells.

Oncol Rep 2013 Jan 29;29(1):29-33. Epub 2012 Oct 29.

Dr Rath Research Institute, Cancer Division, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3892/or.2012.2110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583477PMC
January 2013

Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in human female cancer cell lines.

Oncol Rep 2012 Sep 20;28(3):768-76. Epub 2012 Jun 20.

Department of Oncology, Dr. Rath Research Institute, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3892/or.2012.1879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583510PMC
September 2012

Micronutrient Synergy in the Fight against Hepatocellular Carcinoma.

Cancers (Basel) 2012 Mar 23;4(2):323-39. Epub 2012 Mar 23.

Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3390/cancers4020323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712691PMC
March 2012

Evolution of angiotensin II-mediated atherosclerosis in ApoE KO mice.

Mol Med Rep 2010 Jul-Aug;3(4):565-70

Dr Rath Research Institute, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3892/mmr_00000298DOI Listing
October 2012

Nutrient supplementation modulates angiotensin II-mediated atherosclerosis in ApoE KO mice.

Mol Med Rep 2010 May-Jun;3(3):417-25

Dr. Rath Research Institute, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.3892/mmr_00000274DOI Listing
October 2012

Standardisation of a new model of H9N2/Escherichia coli challenge in broilers in the Lebanon.

Vet Ital 2009 Apr-Jun;45(2):317-22

Department of Animal and Veterinary Sciences, Faculty of Agricultural and Food Sciences (FAFS), American University of Beirut (AUB), Beirut, Lebanon.

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October 2012

Chemopreventive effect of a novel nutrient mixture on lung tumorigenesis induced by urethane in male A/J mice.

Tumori 2009 Jul-Aug;95(4):508-13

Dr Rath Research Institute, Oncology Division, Santa Clara, CA 95050, USA.

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November 2009

Suppression of growth and hepatic metastasis of murine B16FO melanoma cells by a novel nutrient mixture.

Oncol Rep 2008 Oct;20(4):809-17

Oncology Division, Dr Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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October 2008

Inhibition of glioma cell line A-172 MMP activity and cell invasion in vitro by a nutrient mixture.

Med Oncol 2007 ;24(2):231-8

Oncology Division, Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA, 95050, USA.

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http://dx.doi.org/10.1007/BF02698045DOI Listing
December 2007

Inhibitory effects of a nutrient mixture on human testicular cancer cell line NT 2/DT matrigel invasion and MMP activity.

Med Oncol 2007 ;24(2):183-8

Cancer Division, Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA, 95050, USA.

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http://dx.doi.org/10.1007/BF02698038DOI Listing
December 2007

Anti-tumor effect of ascorbic acid, lysine, proline, arginine, and epigallocatechin gallate on prostate cancer cell lines PC-3, LNCaP, and DU145.

Res Commun Mol Pathol Pharmacol 2004 ;115-116:251-64

Matthias Rath Research, Cancer Division, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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July 2007

Holistic efficacy of specific nutrient synergy against avian flu virus: pathology and immunomodulation.

Vet Ital 2007 Jan-Mar;43(1):43-54

Department of Animal Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, P.O. Box 11-0236, Beirut, Lebanon.

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May 2010

In vivo and in vitro antitumor effect of a unique nutrient mixture on lung cancer cell line A-549.

Exp Lung Res 2006 Oct;32(9):441-53

Dr. Rath Research Institute, Cancer Division, Santa Clara, California 95050, USA.

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http://dx.doi.org/10.1080/01902140601047658DOI Listing
October 2006

Anticancer effect of lysine, proline, arginine, ascorbic acid and green tea extract on human renal adenocarcinoma line 786-0.

Oncol Rep 2006 Nov;16(5):943-7

Matthias Rath Research Institute, Cancer Division, Santa Clara, CA 95050, USA.

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November 2006

Inhibition of malignant mesothelioma cell matrix metalloproteinase production and invasion by a novel nutrient mixture.

Exp Lung Res 2006 Mar-Apr;32(3-4):69-79

Dr. Rath Research Institute, Cancer Division, Santa Clara, California, USA.

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http://dx.doi.org/10.1080/01902140600710488DOI Listing
August 2006

Antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on bladder cancer cell line T-24.

Int J Urol 2006 Apr;13(4):415-9

Matthias Rath Research Institute, Cancer Division, Santa Clara, California, USA.

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http://dx.doi.org/10.1111/j.1442-2042.2006.01309.xDOI Listing
April 2006

Modulation of human renal cell carcinoma 786-0 MMP-2 and MMP-9 activity by inhibitors and inducers in vitro.

Med Oncol 2006 ;23(2):245-50

Matthias Rath Research Institute, Cancer Division, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.1385/mo:23:2:245DOI Listing
October 2006

In vivo and in vitro antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on human fibrosarcoma cells HT-1080.

Med Oncol 2006 ;23(1):105-11

Matthias Rath Research Institute, Cancer Division, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.1385/mo:23:1:105DOI Listing
June 2006

Natural nutrient mixture effectively reduces collagen matrix contraction driven by human uterine smooth muscle cells.

J Obstet Gynaecol Res 2006 Feb;32(1):23-31

Matthias Rath Research Institute, Santa Clara, California, USA.

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http://dx.doi.org/10.1111/j.1447-0756.2006.00367.xDOI Listing
February 2006

In vivo and in vitro antitumor effect of ascorbic acid, lysine, proline and green tea extract on human melanoma cell line A2058.

In Vivo 2006 Jan-Feb;20(1):25-32

Dr. Rath Research Institute, Cancer Division, Santa Clara, CA 95050, USA.

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April 2006

Anti-angiogenic effects of a nutrient mixture on human umbilical vein endothelial cells.

Oncol Rep 2005 Dec;14(6):1399-404

Matthias Rath Research Institute, Cancer Division, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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December 2005

Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis.

Oncol Rep 2005 Oct;14(4):807-15

Matthias Rath Research Institute, Cancer Division, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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October 2005

In vitro and in vivo antitumorigenic activity of a mixture of lysine, proline, ascorbic acid, and green tea extract on human breast cancer lines MDA-MB-231 and MCF-7.

Med Oncol 2005 ;22(2):129-38

Matthias Rath Research, Cancer Research Division, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.1385/MO:22:2:129DOI Listing
November 2005

Antitumor effect of a combination of lysine, proline, arginine, ascorbic acid, and green tea extract on pancreatic cancer cell line MIA PaCa-2.

Int J Gastrointest Cancer 2005 ;35(2):97-102

MRI, Cancer Research Division, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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http://dx.doi.org/10.1385/IJGC:35:2:097DOI Listing
September 2005

Antitumor effect of nutrient synergy on human osteosarcoma cells U-2OS, MNNG-HOS and Ewing's sarcoma SK-ES.1.

Oncol Rep 2005 Feb;13(2):253-7

Matthias Rath Research, Cancer Division, 1260 Memorex Drive, Santa Clara, CA 95050, USA.

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February 2005