Publications by authors named "Matthias P Wymann"

65Publications

Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD.

Neuropharmacology 2020 01 14;162:107812. Epub 2019 Oct 14.

Department of Human Genetics, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany. Electronic address:

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January 2020

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy.

Neuropharmacology 2018 09 3;140:107-120. Epub 2018 Aug 3.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address:

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September 2018

Cell-permeant and photocleavable chemical inducer of dimerization.

Angew Chem Int Ed Engl 2014 Apr 26;53(18):4717-20. Epub 2014 Mar 26.

University of Basel, Department of Biomedicine, Mattenstrasse 28, Basel (Switzerland).

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April 2014

Membrane dynamics in physiology and disease.

FEBS J 2013 Jun 3;280(12):2729. Epub 2013 Jun 3.

Department of Biomedicine, University of Basel, Switzerland.

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June 2013

Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors.

Ann N Y Acad Sci 2013 Mar;1280:44-7

Department of Biomedicine, University of Basel, Basel, Switzerland.

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March 2013

Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation.

PLoS One 2013 11;8(3):e58054. Epub 2013 Mar 11.

Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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December 2013

The chemical biology of phosphoinositide 3-kinases.

Chembiochem 2012 Sep 10;13(14):2022-35. Epub 2012 Sep 10.

Institute of Biochemistry & Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

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September 2012

C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms.

Blood 2012 Jul 6;120(4):880-90. Epub 2012 Jun 6.

Klinikum der Universität München, Walter Brendel Centre of Experimental Medicine, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistrasse 15, Munich, Germany.

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July 2012

Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL.

J Lipid Res 2012 Jan 4;53(1):34-42. Epub 2011 Nov 4.

Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

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January 2012

PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.

Proc Natl Acad Sci U S A 2011 Oct 26;108(42):E854-63. Epub 2011 Sep 26.

Laboratory of Metabolic Stress Biology, Division of Physiology, Department of Medicine, University of Fribourg, CH-1700 Fribourg, Switzerland.

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October 2011

Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.

PLoS One 2011 Feb 22;6(2):e17229. Epub 2011 Feb 22.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

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February 2011

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma.

Proc Natl Acad Sci U S A 2009 Dec 11;106(48):20312-7. Epub 2009 Nov 11.

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Center of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany.

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December 2009

Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.

EMBO J 2009 Jul 2;28(14):2018-27. Epub 2009 Jul 2.

Center for Pediatrics and Adolescent Medicine and Centre of Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg 79106, Germany.

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July 2009

PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.

Sci Signal 2009 Jun 9;2(74):ra27. Epub 2009 Jun 9.

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel, Switzerland.

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June 2009

The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression.

Mol Cell Biol 2008 Oct 21;28(19):5886-98. Epub 2008 Jul 21.

Cancer Research-UK Laboratories, Department of Oncology, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.

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October 2008

Lipid signalling in disease.

Nat Rev Mol Cell Biol 2008 Feb;9(2):162-76

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.

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February 2008

Targeting phosphoinositide 3-kinase: moving towards therapy.

Biochim Biophys Acta 2008 Jan 12;1784(1):159-85. Epub 2007 Oct 12.

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058, Basel, Switzerland.

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January 2008

Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.

J Immunol 2005 Sep;175(5):2783-7

Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge, United Kingdom.

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September 2005

Susi, a negative regulator of Drosophila PI3-kinase.

Dev Cell 2005 Jun;8(6):817-27

Zoologisches Institut, Universität Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland.

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June 2005

Phosphoinositide 3-kinase in disease: timing, location, and scaffolding.

Curr Opin Cell Biol 2005 Apr;17(2):141-9

Inst. Biochemistry and Genetics, Dept. Clinical and Biological Sciences, Centre of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058, Basel.

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April 2005

Phosphoinositide 3-kinase gamma mediates Jun kinase activation via its lipid-kinase activity.

Adv Enzyme Regul 2004 ;44:299-308

Institute for Molecular Cell Biology, University of Jena, Drackendorfer Strasse 1, D-07747 Jena, Germany.

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March 2005

Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1.

Exp Cell Res 2003 Oct;290(1):120-31

Randall Centre, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK.

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October 2003

Phosphoinositide 3-kinase signalling--which way to target?

Trends Pharmacol Sci 2003 Jul;24(7):366-76

Department of Medicine, Division of Biochemistry, University of Fribourg, Rue du Musée 5, CH-1700 Fribourg, Switzerland.

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July 2003

Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons.

Neuron 2003 May;38(4):611-24

Brain and Behavior Program and Department of Pathology, Research Institute of the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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May 2003

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function.

Immunity 2002 Mar;16(3):441-51

Institute of Biochemistry, Department of Medicine, University of Fribourg, Rue du Musée 5, CH-1700 Fribourg, Switzerland.

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March 2002

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

Science 2002 Mar 28;295(5562):2088-91. Epub 2002 Feb 28.

Zoologisches Institut der Universität Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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March 2002