Publications by authors named "Matthias P Wymann"

65Publications

PI3K Regulatory Protein p84 Determines Mast Cell Sensitivity to Ras Inhibition-Moving Towards Cell Specific PI3K Targeting?

Authors:
Julie R Jin Elena Gogvadze Ana R Xavier Thomas Bohnacker Jan Voelzmann Matthias P Wymann

Front Immunol 2020 28;11:585070. Epub 2020 Oct 28.

Department of Biomedicine, University of Basel, Basel, Switzerland.

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October 2020

4-(Difluoromethyl)-5-(4-((3,5)-3,5-dimethylmorpholino)-6-(()-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders.

Authors:
Chiara Borsari Erhan Keles Denise Rageot Andrea Treyer Thomas Bohnacker Lukas Bissegger Martina De Pascale Anna Melone Rohitha Sriramaratnam Florent Beaufils Matthias Hamburger Paul Hebeisen Wolfgang Löscher Doriano Fabbro Petra Hillmann Matthias P Wymann

J Med Chem 2020 11 9;63(22):13595-13617. Epub 2020 Nov 9.

Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

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November 2020

Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex.

Authors:
Wiebke Theilmann Birthe Gericke Alina Schidlitzki Syed Muhammad Muneeb Anjum Saskia Borsdorf Timon Harries Steven L Roberds Dean J Aguiar Daniela Brunner Steven C Leiser Dekun Song Doriano Fabbro Petra Hillmann Matthias P Wymann Wolfgang Löscher

Neuropharmacology 2020 12 3;180:108297. Epub 2020 Sep 3.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address:

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December 2020

Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD.

Authors:
Elisabeth Singer Carolin Walter Doriano Fabbro Denise Rageot Florent Beaufils Matthias P Wymann Nadine Rischert Olaf Riess Petra Hillmann Huu Phuc Nguyen

Neuropharmacology 2020 01 14;162:107812. Epub 2019 Oct 14.

Department of Human Genetics, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany. Electronic address:

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January 2020

Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl-Pyrimidine Moiety.

Authors:
Chiara Borsari Denise Rageot Florent Beaufils Thomas Bohnacker Erhan Keles Ivan Buslov Anna Melone Alexander M Sele Paul Hebeisen Doriano Fabbro Petra Hillmann Matthias P Wymann

ACS Med Chem Lett 2019 Oct 3;10(10):1473-1479. Epub 2019 Sep 3.

Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

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October 2019

Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.

Authors:
Andrew J Takeda Timothy J Maher Yu Zhang Stephen M Lanahan Molly L Bucklin Susan R Compton Paul M Tyler William A Comrie Makoto Matsuda Kenneth N Olivier Stefania Pittaluga Joshua J McElwee Debra A Long Priel Douglas B Kuhns Roger L Williams Peter J Mustillo Matthias P Wymann V Koneti Rao Carrie L Lucas

Nat Commun 2019 09 25;10(1):4364. Epub 2019 Sep 25.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

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September 2019

A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor.

Authors:
Chiara Borsari Denise Rageot Alix Dall'Asen Thomas Bohnacker Anna Melone Alexander M Sele Eileen Jackson Jean-Baptiste Langlois Florent Beaufils Paul Hebeisen Doriano Fabbro Petra Hillmann Matthias P Wymann

J Med Chem 2019 09 11;62(18):8609-8630. Epub 2019 Sep 11.

Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.

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September 2019

()-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.

Authors:
Denise Rageot Thomas Bohnacker Erhan Keles Jacob A McPhail Reece M Hoffmann Anna Melone Chiara Borsari Rohitha Sriramaratnam Alexander M Sele Florent Beaufils Paul Hebeisen Doriano Fabbro Petra Hillmann John E Burke Matthias P Wymann

J Med Chem 2019 07 20;62(13):6241-6261. Epub 2019 Jun 20.

Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.

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July 2019

The Novel TORC1/2 Kinase Inhibitor PQR620 Has Anti-Tumor Activity in Lymphomas as a Single Agent and in Combination with Venetoclax.

Authors:
Chiara Tarantelli Eugenio Gaudio Petra Hillmann Filippo Spriano Giulio Sartori Luca Aresu Luciano Cascione Denise Rageot Ivo Kwee Florent Beaufils Emanuele Zucca Anastasios Stathis Matthias P Wymann Vladimir Cmiljanovic Doriano Fabbro Francesco Bertoni

Cancers (Basel) 2019 Jun 4;11(6). Epub 2019 Jun 4.

Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.

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June 2019

A class of highly selective inhibitors bind to an active state of PI3Kγ.

Authors:
Gangadhara Gangadhara Göran Dahl Thomas Bohnacker Rebecca Rae Jenny Gunnarsson Stefan Blaho Linda Öster Helena Lindmark Kostas Karabelas Nils Pemberton Christian Tyrchan Mickael Mogemark Matthias P Wymann Roger L Williams Matthew W D Perry Tineke Papavoine Jens Petersen

Nat Chem Biol 2019 04 4;15(4):348-357. Epub 2019 Feb 4.

Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

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April 2019

New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease.

Authors:
Luca Aresu Serena Ferraresso Laura Marconato Luciano Cascione Sara Napoli Eugenio Gaudio Ivo Kwee Chiara Tarantelli Andrea Testa Chiara Maniaci Alessio Ciulli Petra Hillmann Thomas Bohnacker Matthias P Wymann Stefano Comazzi Massimo Milan Fulvio Riondato Giulia Dalla Rovere Mery Giantin Diana Giannuzzi Francesco Bertoni

Haematologica 2019 06 13;104(6):e256-e259. Epub 2018 Dec 13.

Università della Svizzera Italiana, Institute of Oncology Research, Bellinzona, Switzerland

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June 2019

Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders.

Authors:
Denise Rageot Thomas Bohnacker Anna Melone Jean-Baptiste Langlois Chiara Borsari Petra Hillmann Alexander M Sele Florent Beaufils Marketa Zvelebil Paul Hebeisen Wolfgang Löscher John Burke Doriano Fabbro Matthias P Wymann

J Med Chem 2018 11 14;61(22):10084-10105. Epub 2018 Nov 14.

Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.

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November 2018

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy.

Authors:
Claudia Brandt Petra Hillmann Andreas Noack Kerstin Römermann Leon A Öhler Denise Rageot Florent Beaufils Anna Melone Alexander M Sele Matthias P Wymann Doriano Fabbro Wolfgang Löscher

Neuropharmacology 2018 09 3;140:107-120. Epub 2018 Aug 3.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address:

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September 2018

PQR309 Is a Novel Dual PI3K/mTOR Inhibitor with Preclinical Antitumor Activity in Lymphomas as a Single Agent and in Combination Therapy.

Authors:
Chiara Tarantelli Eugenio Gaudio Alberto J Arribas Ivo Kwee Petra Hillmann Andrea Rinaldi Luciano Cascione Filippo Spriano Elena Bernasconi Francesca Guidetti Laura Carrassa Roberta Bordone Pittau Florent Beaufils Reto Ritschard Denise Rageot Alexander Sele Barbara Dossena Francesca Maria Rossi Antonella Zucchetto Monica Taborelli Valter Gattei Davide Rossi Anastasios Stathis Georg Stussi Massimo Broggini Matthias P Wymann Andreas Wicki Emanuele Zucca Vladimir Cmiljanovic Doriano Fabbro Francesco Bertoni

Clin Cancer Res 2018 01 24;24(1):120-129. Epub 2017 Oct 24.

Università della Svizzera Italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.

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January 2018

5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.

Authors:
Florent Beaufils Natasa Cmiljanovic Vladimir Cmiljanovic Thomas Bohnacker Anna Melone Romina Marone Eileen Jackson Xuxiao Zhang Alexander Sele Chiara Borsari Jürgen Mestan Paul Hebeisen Petra Hillmann Bernd Giese Marketa Zvelebil Doriano Fabbro Roger L Williams Denise Rageot Matthias P Wymann

J Med Chem 2017 09 1;60(17):7524-7538. Epub 2017 Sep 1.

Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.

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September 2017

PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity.

Authors:
Ludovic Breasson Barbara Becattini Claudia Sardi Angela Molinaro Fabio Zani Romina Marone Fabrizio Botindari Mélanie Bousquenaud Curzio Ruegg Matthias P Wymann Giovanni Solinas

Sci Signal 2017 Jul 18;10(488). Epub 2017 Jul 18.

Department of Medicine/Physiology, University of Fribourg, 1700 Fribourg, Switzerland.

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July 2017

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.

Authors:
Thomas Bohnacker Andrea E Prota Florent Beaufils John E Burke Anna Melone Alison J Inglis Denise Rageot Alexander M Sele Vladimir Cmiljanovic Natasa Cmiljanovic Katja Bargsten Amol Aher Anna Akhmanova J Fernando Díaz Doriano Fabbro Marketa Zvelebil Roger L Williams Michel O Steinmetz Matthias P Wymann

Nat Commun 2017 03 9;8:14683. Epub 2017 Mar 9.

Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.

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March 2017

Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.

Authors:
Natalia F Smirnova Stéphanie Gayral Christophe Pedros Gervaise Loirand Nathalie Vaillant Nicole Malet Sahar Kassem Denis Calise Dominique Goudounèche Matthias P Wymann Emilio Hirsch Alain-Pierre Gadeau Laurent O Martinez Abdelhadi Saoudi Muriel Laffargue

J Exp Med 2014 Aug 29;211(9):1779-92. Epub 2014 Jul 29.

INSERM, UMR1048, F-31300 Toulouse, France Université Toulouse III, Institut de Maladies Métaboliques et Cardiovasculaires, F-31300 Toulouse, France

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August 2014

Cell-permeant and photocleavable chemical inducer of dimerization.

Authors:
Mirjam Zimmermann Ruben Cal Elia Janett Viktor Hoffmann Christian G Bochet Edwin Constable Florent Beaufils Matthias P Wymann

Angew Chem Int Ed Engl 2014 Apr 26;53(18):4717-20. Epub 2014 Mar 26.

University of Basel, Department of Biomedicine, Mattenstrasse 28, Basel (Switzerland).

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April 2014

Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway.

Authors:
Stephanie Gayral Roselyne Garnotel Audrey Castaing-Berthou Sebastien Blaise Anne Fougerat Elodie Berge Aurelie Montheil Nicole Malet Matthias P Wymann Pascal Maurice Laurent Debelle Laurent Martiny Laurent O Martinez Alexey V Pshezhetsky Laurent Duca Muriel Laffargue

Cardiovasc Res 2014 Apr 19;102(1):118-27. Epub 2013 Dec 19.

INSERM UMR 1048, I2MC, Bât. L3, 1 av Jean-Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.

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April 2014

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.

Authors:
Romy Walser John E Burke Elena Gogvadze Thomas Bohnacker Xuxiao Zhang Daniel Hess Peter Küenzi Michael Leitges Emilio Hirsch Roger L Williams Muriel Laffargue Matthias P Wymann

PLoS Biol 2013 25;11(6):e1001587. Epub 2013 Jun 25.

Department of Biomedicine, University of Basel, Basel, Switzerland.

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January 2014

Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy.

Authors:
Emilie Collmann Thomas Bohnacker Romina Marone Janet Dawson Markus Rehberg Rowan Stringer Fritz Krombach Christoph Burkhart Emilio Hirsch Gregory J Hollingworth Matthew Thomas Matthias P Wymann

J Allergy Clin Immunol 2013 Oct 14;132(4):959-68. Epub 2013 May 14.

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.

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October 2013

Membrane dynamics in physiology and disease.

Authors:
Matthias P Wymann Kai Simons

FEBS J 2013 Jun 3;280(12):2729. Epub 2013 Jun 3.

Department of Biomedicine, University of Basel, Switzerland.

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June 2013

Chemical development of intracellular protein heterodimerizers.

Authors:
Dominik Erhart Mirjam Zimmermann Olivier Jacques Matthias B Wittwer Beat Ernst Edwin Constable Marketa Zvelebil Florent Beaufils Matthias P Wymann

Chem Biol 2013 Apr;20(4):549-57

Department of Biomedicine, University of Basel, 4003 Basel, Switzerland.

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April 2013

Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors.

Authors:
Matthias P Wymann Giovanni Solinas

Ann N Y Acad Sci 2013 Mar;1280:44-7

Department of Biomedicine, University of Basel, Basel, Switzerland.

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March 2013

Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation.

Authors:
Manoj K Barthwal Joshua J Anzinger Qing Xu Thomas Bohnacker Matthias P Wymann Howard S Kruth

PLoS One 2013 11;8(3):e58054. Epub 2013 Mar 11.

Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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December 2013

The chemical biology of phosphoinositide 3-kinases.

Authors:
Matthias P Wymann Carsten Schultz

Chembiochem 2012 Sep 10;13(14):2022-35. Epub 2012 Sep 10.

Institute of Biochemistry & Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

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September 2012

Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels.

Authors:
Stephanie J Harris Loredana Ciuclan Peter M Finan Matthias P Wymann Christoph Walker John Westwick Stephen G Ward Matthew J Thomas

Eur J Immunol 2012 Dec 1;42(12):3394-404. Epub 2012 Oct 1.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.

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December 2012

C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms.

Authors:
Christoph A Reichel Daniel Puhr-Westerheide Gabriele Zuchtriegel Bernd Uhl Nina Berberich Stefan Zahler Matthias P Wymann Bruno Luckow Fritz Krombach

Blood 2012 Jul 6;120(4):880-90. Epub 2012 Jun 6.

Klinikum der Universität München, Walter Brendel Centre of Experimental Medicine, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistrasse 15, Munich, Germany.

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July 2012

Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL.

Authors:
Joshua J Anzinger Janet Chang Qing Xu Manoj K Barthwal Thomas Bohnacker Matthias P Wymann Howard S Kruth

J Lipid Res 2012 Jan 4;53(1):34-42. Epub 2011 Nov 4.

Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

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January 2012

PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.

Authors:
Barbara Becattini Romina Marone Fabio Zani Denis Arsenijevic Josiane Seydoux Jean-Pierre Montani Abdul G Dulloo Bernard Thorens Frédéric Preitner Matthias P Wymann Giovanni Solinas

Proc Natl Acad Sci U S A 2011 Oct 26;108(42):E854-63. Epub 2011 Sep 26.

Laboratory of Metabolic Stress Biology, Division of Physiology, Department of Medicine, University of Fribourg, CH-1700 Fribourg, Switzerland.

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October 2011

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

Authors:
Alessia Perino Alessandra Ghigo Enrico Ferrero Fulvio Morello Gaetano Santulli George S Baillie Federico Damilano Allan J Dunlop Catherine Pawson Romy Walser Renzo Levi Fiorella Altruda Lorenzo Silengo Lorene K Langeberg Gitte Neubauer Stephane Heymans Giuseppe Lembo Matthias P Wymann Reinhard Wetzker Miles D Houslay Guido Iaccarino John D Scott Emilio Hirsch

Mol Cell 2011 Apr;42(1):84-95

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino 10126, Italy.

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April 2011

Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.

Authors:
Christoph A Reichel Max Lerchenberger Bernd Uhl Markus Rehberg Nina Berberich Stefan Zahler Matthias P Wymann Fritz Krombach

PLoS One 2011 Feb 22;6(2):e17229. Epub 2011 Feb 22.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

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February 2011

Neutral not a loss: phosphoinositides beyond the head group.

Authors:
Matthias P Wymann Markus R Wenk

Nat Methods 2011 Mar;8(3):219-20

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March 2011

Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.

Authors:
Elisa Ciraolo Fulvio Morello Robin M Hobbs Frieder Wolf Romina Marone Manuela Iezzi Xiaoyun Lu Giulio Mengozzi Fiorella Altruda Giovanni Sorba Kaomei Guan Pier Paolo Pandolfi Matthias P Wymann Emilio Hirsch

Mol Biol Cell 2010 Mar 6;21(5):704-11. Epub 2010 Jan 6.

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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March 2010

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma.

Authors:
Barbara Kurig Aliaksei Shymanets Thomas Bohnacker Prajwal Carsten Brock Mohammad Reza Ahmadian Michael Schaefer Antje Gohla Christian Harteneck Matthias P Wymann Elisabeth Jeanclos Bernd Nürnberg

Proc Natl Acad Sci U S A 2009 Dec 11;106(48):20312-7. Epub 2009 Nov 11.

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Center of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany.

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December 2009

Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.

Authors:
Sandra Santos-Sierra Sachin D Deshmukh Julia Kalnitski Peter Küenzi Matthias P Wymann Douglas T Golenbock Philipp Henneke

EMBO J 2009 Jul 2;28(14):2018-27. Epub 2009 Jul 2.

Center for Pediatrics and Adolescent Medicine and Centre of Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg 79106, Germany.

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July 2009

PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.

Authors:
Thomas Bohnacker Romina Marone Emilie Collmann Ronan Calvez Emilio Hirsch Matthias P Wymann

Sci Signal 2009 Jun 9;2(74):ra27. Epub 2009 Jun 9.

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel, Switzerland.

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June 2009

Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.

Authors:
Romina Marone Dominik Erhart Ann C Mertz Thomas Bohnacker Christian Schnell Vladimir Cmiljanovic Frédéric Stauffer Carlos Garcia-Echeverria Bernd Giese Sauveur-Michel Maira Matthias P Wymann

Mol Cancer Res 2009 Apr;7(4):601-13

Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.

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April 2009

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.

Authors:
Elisa Ciraolo Manuela Iezzi Romina Marone Stefano Marengo Claudia Curcio Carlotta Costa Ornella Azzolino Cristiano Gonella Cristina Rubinetto Haiyan Wu Walter Dastrù Erica L Martin Lorenzo Silengo Fiorella Altruda Emilia Turco Letizia Lanzetti Piero Musiani Thomas Rückle Christian Rommel Jonathan M Backer Guido Forni Matthias P Wymann Emilio Hirsch

Sci Signal 2008 Sep 9;1(36):ra3. Epub 2008 Sep 9.

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

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September 2008

Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation.

Authors:
Matthew Thomas Matthew J Edwards Elzbieta Sawicka Nicholas Duggan Emilio Hirsch Matthias P Wymann Charles Owen Alexandre Trifilieff Christoph Walker John Westwick Peter Finan

Immunology 2009 Mar 27;126(3):413-22. Epub 2008 Aug 27.

Novartis Institutes for BioMedical Research, Horsham, West Sussex, United Kingdom.

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March 2009

The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression.

Authors:
Rosaline C-Y Hui Ana R Gomes Demetra Constantinidou Joana R Costa Christina T Karadedou Silvia Fernandez de Mattos Matthias P Wymann Jan J Brosens Almut Schulze Eric W-F Lam

Mol Cell Biol 2008 Oct 21;28(19):5886-98. Epub 2008 Jul 21.

Cancer Research-UK Laboratories, Department of Oncology, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.

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October 2008

Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.

Authors:
Anne Fougerat Stéphanie Gayral Pierre Gourdy Alexia Schambourg Thomas Rückle Matthias K Schwarz Christian Rommel Emilio Hirsch Jean-François Arnal Jean-Pierre Salles Bertrand Perret Monique Breton-Douillon Matthias P Wymann Muriel Laffargue

Circulation 2008 Mar 11;117(10):1310-7. Epub 2008 Feb 11.

INSERM U563, Département Lipoprotéines et Médiateurs Lipidiques, Toulouse-Purpan, BP 3028, 31024 Toulouse Cedex 3, France.

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March 2008

Lipid signalling in disease.

Authors:
Matthias P Wymann Roger Schneiter

Nat Rev Mol Cell Biol 2008 Feb;9(2):162-76

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.

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February 2008

Targeting phosphoinositide 3-kinase: moving towards therapy.

Authors:
Romina Marone Vladimir Cmiljanovic Bernd Giese Matthias P Wymann

Biochim Biophys Acta 2008 Jan 12;1784(1):159-85. Epub 2007 Oct 12.

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058, Basel, Switzerland.

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January 2008

Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

Authors:
Hong Ji Felix Rintelen Caroline Waltzinger Dominique Bertschy Meier Antonio Bilancio Wayne Pearce Emilio Hirsch Matthias P Wymann Thomas Rückle Montserrat Camps Bart Vanhaesebroeck Klaus Okkenhaug Christian Rommel

Blood 2007 Oct 12;110(8):2940-7. Epub 2007 Jul 12.

Merck Serono S. A., Geneva Research Center, Geneva, Switzerland.

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October 2007

A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress.

Authors:
César Nombela-Arrieta Thorsten R Mempel Silvia F Soriano Irina Mazo Matthias P Wymann Emilio Hirsch Carlos Martínez-A Yoshinori Fukui Ulrich H von Andrian Jens V Stein

J Exp Med 2007 Mar 26;204(3):497-510. Epub 2007 Feb 26.

Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland.

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March 2007

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

Authors:
Montserrat Camps Thomas Rückle Hong Ji Vittoria Ardissone Felix Rintelen Jeffrey Shaw Chiara Ferrandi Christian Chabert Corine Gillieron Bernard Françon Thierry Martin Denise Gretener Dominique Perrin Didier Leroy Pierre-Alain Vitte Emilio Hirsch Matthias P Wymann Rocco Cirillo Matthias K Schwarz Christian Rommel

Nat Med 2005 Sep 28;11(9):936-43. Epub 2005 Aug 28.

Serono Pharmaceutical Research Institute, Serono International S.A., 14, Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.

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September 2005

Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.

Authors:
Louise M C Webb Elena Vigorito Matthias P Wymann Emilio Hirsch Martin Turner

J Immunol 2005 Sep;175(5):2783-7

Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge, United Kingdom.

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September 2005

Susi, a negative regulator of Drosophila PI3-kinase.

Authors:
Franz Wittwer Malika Jaquenoud Walter Brogiolo Marcel Zarske Philipp Wüstemann Rafael Fernandez Hugo Stocker Matthias P Wymann Ernst Hafen

Dev Cell 2005 Jun;8(6):817-27

Zoologisches Institut, Universität Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland.

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June 2005

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.

Authors:
Alison M Condliffe Keith Davidson Karen E Anderson Chris D Ellson Tom Crabbe Klaus Okkenhaug Bart Vanhaesebroeck Martin Turner Louise Webb Matthias P Wymann Emilio Hirsch Thomas Ruckle Montserrat Camps Christian Rommel Shaun P Jackson Edwin R Chilvers Len R Stephens Phillip T Hawkins

Blood 2005 Aug 5;106(4):1432-40. Epub 2005 May 5.

The Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK.

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August 2005

Phosphoinositide 3-kinase in disease: timing, location, and scaffolding.

Authors:
Matthias P Wymann Romina Marone

Curr Opin Cell Biol 2005 Apr;17(2):141-9

Inst. Biochemistry and Genetics, Dept. Clinical and Biological Sciences, Centre of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058, Basel.

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April 2005

Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases.

Authors:
Matthew J Thomas Alexandra Smith Denise H Head Laura Milne Andrew Nicholls Wayne Pearce Bart Vanhaesebroeck Matthias P Wymann Emilio Hirsch Alexandre Trifilieff Christoph Walker Peter Finan John Westwick

Eur J Immunol 2005 Apr;35(4):1283-91

Novartis Institutes for BioMedical Research, Horsham, UK.

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April 2005

Phosphoinositide 3-kinase gamma mediates Jun kinase activation via its lipid-kinase activity.

Authors:
Regina Pietrucha Ignacio Rubio Matthias P Wymann Reinhard Wetzker

Adv Enzyme Regul 2004 ;44:299-308

Institute for Molecular Cell Biology, University of Jena, Drackendorfer Strasse 1, D-07747 Jena, Germany.

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March 2005

Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis.

Authors:
Enrico Lupia Alberto Goffi Paolo De Giuli Ornella Azzolino Ornella Bosco Enrico Patrucco Maria Cristina Vivaldo Marco Ricca Matthias P Wymann Emilio Hirsch Giuseppe Montrucchio Giorgio Emanuelli

Am J Pathol 2004 Dec;165(6):2003-11

Dipartimento di Fisiopatologia Clinica, Università di Torino, Via Genova 3, 10126 Torino, Italy.

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December 2004

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation.

Authors:
Giovanni Solinas Serge Summermatter Davide Mainieri Marcel Gubler Luciano Pirola Matthias P Wymann Sandro Rusconi Jean-Pierre Montani Josiane Seydoux Abdul G Dulloo

FEBS Lett 2004 Nov;577(3):539-44

Department of Medicine, Division of Physiology, University of Fribourg, Switzerland.

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November 2004

Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice.

Authors:
Annalisa Del Prete William Vermi Erica Dander Karel Otero Laura Barberis Walter Luini Sergio Bernasconi Marina Sironi Amerigo Santoro Cecilia Garlanda Fabio Facchetti Matthias P Wymann Annunciata Vecchi Emilio Hirsch Alberto Mantovani Silvano Sozzani

EMBO J 2004 Sep 19;23(17):3505-15. Epub 2004 Aug 19.

Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy.

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September 2004

PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.

Authors:
Enrico Patrucco Antonella Notte Laura Barberis Giulio Selvetella Angelo Maffei Mara Brancaccio Stefano Marengo Giovanni Russo Ornella Azzolino Sergei D Rybalkin Lorenzo Silengo Fiorella Altruda Reinhard Wetzker Matthias P Wymann Giuseppe Lembo Emilio Hirsch

Cell 2004 Aug;118(3):375-87

Department of Genetics, Biology, and Biochemistry, University of Torino, Via Santena 5bis, Italy.

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August 2004

Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1.

Authors:
Gareth E Jones Elena Prigmore Ronan Calvez Catherine Hogan Graham A Dunn Emilio Hirsch Matthias P Wymann Anne J Ridley

Exp Cell Res 2003 Oct;290(1):120-31

Randall Centre, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK.

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October 2003

Phosphoinositide 3-kinase signalling--which way to target?

Authors:
Matthias P Wymann Marketa Zvelebil Muriel Laffargue

Trends Pharmacol Sci 2003 Jul;24(7):366-76

Department of Medicine, Division of Biochemistry, University of Fribourg, Rue du Musée 5, CH-1700 Fribourg, Switzerland.

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July 2003

Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons.

Authors:
Heng-Ye Man Qinhua Wang Wei-Yang Lu William Ju Gholamreza Ahmadian Lidong Liu Sandra D'Souza T P Wong C Taghibiglou Jie Lu Larry E Becker Lin Pei Fang Liu Matthias P Wymann John F MacDonald Yu Tian Wang

Neuron 2003 May;38(4):611-24

Brain and Behavior Program and Department of Pathology, Research Institute of the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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May 2003

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.

Authors:
Michael A Crackower Gavin Y Oudit Ivona Kozieradzki Renu Sarao Hui Sun Takehiko Sasaki Emilio Hirsch Akira Suzuki Tetsuo Shioi Junko Irie-Sasaki Rajan Sah Hai-Ying M Cheng Vitalyi O Rybin Giuseppe Lembo Luigi Fratta Antonio J Oliveira-dos-Santos Jeffery L Benovic C Ronald Kahn Seigo Izumo Susan F Steinberg Matthias P Wymann Peter H Backx Josef M Penninger

Cell 2002 Sep;110(6):737-49

IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, c/o Dr. Bohr Gasse 7, A-1030, Vienna, Austria.

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September 2002

Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane.

Authors:
Lorenz Roggo Vincent Bernard Attila L Kovacs Ann M Rose Fabienne Savoy Monique Zetka Matthias P Wymann Fritz Müller

EMBO J 2002 Apr;21(7):1673-83

Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland.

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April 2002

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function.

Authors:
Muriel Laffargue Ronan Calvez Peter Finan Alexandre Trifilieff Maryse Barbier Fiorella Altruda Emilio Hirsch Matthias P Wymann

Immunity 2002 Mar;16(3):441-51

Institute of Biochemistry, Department of Medicine, University of Fribourg, Rue du Musée 5, CH-1700 Fribourg, Switzerland.

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March 2002

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

Authors:
Hugo Stocker Mirjana Andjelkovic Sean Oldham Muriel Laffargue Matthias P Wymann Brian A Hemmings Ernst Hafen

Science 2002 Mar 28;295(5562):2088-91. Epub 2002 Feb 28.

Zoologisches Institut der Universität Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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March 2002