Publications by authors named "Matthias P Ebert"

100Publications

Multi-omics integration identifies a selective vulnerability of colorectal cancer subtypes to YM155.

Int J Cancer 2020 Nov 13. Epub 2020 Nov 13.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg University, Heidelberg, Germany.

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November 2020

Preventive Transhepatic Tract Embolisation after Percutaneous Biliary Interventions: A Systematic Review.

Can J Gastroenterol Hepatol 2020 1;2020:8849284. Epub 2020 Oct 1.

Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

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October 2020

Long, relapsing, and atypical symptomatic course of COVID-19 in a B-cell-depleted patient after rituximab.

Semin Arthritis Rheum 2020 10 30;50(5):1087-1088. Epub 2020 Jun 30.

Department of Medicine II, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany. Electronic address:

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October 2020

Cancer-Associated Mutations in Normal Colorectal Mucosa Adjacent to Sporadic Neoplasia.

Clin Transl Gastroenterol 2020 Jul;11(7):e00212

1Department Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 2German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; 3Central Interdisciplinary Endoscopy (ZIE), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 4Institute of Pathology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 5German Cancer Consortium (DKTK), Heidelberg, Germany.

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July 2020

[Gastrointestinal tumors in older patients].

Z Gastroenterol 2020 Jun 16;58(6):564-576. Epub 2020 Jun 16.

II. Medizinische Klinik, Universitätsmedizin Mannheim, Medizinische Fakultät, Universität Heidelberg.

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June 2020

Review article: bugs, inflammation and mood-a microbiota-based approach to psychiatric symptoms in inflammatory bowel diseases.

Aliment Pharmacol Ther 2020 07 11;52(2):247-266. Epub 2020 Jun 11.

Department of Medicine and Therapeutics, Institute of Digestive Disease, LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong.

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July 2020

Complete Remission of Metastatic HER2+ Oesophagogastric Junctional Adenocarcinoma under long-term Trastuzumab Treatment.

J Gastrointestin Liver Dis 2019 Dec 9;28(4):503-507. Epub 2019 Dec 9.

Department of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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December 2019

The effect of gender-specific invitation letters on utilization of colorectal cancer screening.

Z Gastroenterol 2019 Sep 16;57(9):1051-1058. Epub 2019 Sep 16.

Department of Internal Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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September 2019

Management of immune related adverse events induced by immune checkpoint inhibition.

Cancer Lett 2019 08 30;456:80-87. Epub 2019 Apr 30.

Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1-3, 68167, Mannheim, Germany.

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August 2019

Random gene sets in predicting survival of patients with hepatocellular carcinoma.

J Mol Med (Berl) 2019 06 17;97(6):879-888. Epub 2019 Apr 17.

Division of Hepatology & Division of Clinical Bioinformatics, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

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June 2019

A multicenter open-label phase II trial to evaluate nivolumab and ipilimumab for 2nd line therapy in elderly patients with advanced esophageal squamous cell cancer (RAMONA).

BMC Cancer 2019 Mar 14;19(1):231. Epub 2019 Mar 14.

Department of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

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March 2019

Clinical Course of Chronic Pancreatitis in Elderly Patients.

Digestion 2019 10;100(3):152-159. Epub 2019 Jan 10.

Department of Medicine II, University Medical Center Mannheim, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany,

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February 2020

Spatial Distribution of Endogenous Tissue Protease Activity in Gastric Carcinoma Mapped by MALDI Mass Spectrometry Imaging.

Mol Cell Proteomics 2019 Jan 18;18(1):151-161. Epub 2020 Sep 18.

From the ‡Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163 Mannheim, Germany;; §Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163 Mannheim, Germany;. Electronic address:

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January 2019

Clinical evaluation of the M-ANNHEIM classification: Development of the M-ANNHEIM-Surgery-Score as a new tool to monitor patients with chronic pancreatitis.

Z Gastroenterol 2018 Dec 10;56(12):1481-1490. Epub 2018 Dec 10.

Department of Medicine II, University-Medical-Center Mannheim, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany.

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December 2018

Correction to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.

J Exp Clin Cancer Res 2018 11 2;37(1):267. Epub 2018 Nov 2.

Department of Medicine II, Molecular Hepatology Section, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3 (H42, Floor 4), 68167, Mannheim, Germany.

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November 2018

Spatial Distribution of Endogenous Tissue Protease Activity in Gastric Carcinoma Mapped by MALDI Mass Spectrometry Imaging.

Mol Cell Proteomics 2019 01 7;18(1):151-161. Epub 2018 Oct 7.

From the ‡Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163 Mannheim, Germany;

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January 2019

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.

J Exp Clin Cancer Res 2018 Sep 3;37(1):211. Epub 2018 Sep 3.

Department of Medicine II, Molecular Hepatology Section, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3 (H42, Floor 4), 68167, Mannheim, Germany.

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September 2018

A multicenter phase 4 geriatric assessment directed trial to evaluate gemcitabine +/- nab-paclitaxel in elderly pancreatic cancer patients (GrantPax).

BMC Cancer 2018 Jul 18;18(1):747. Epub 2018 Jul 18.

Department of Medicine II, Medical Faculty Mannheim, University Hospital Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

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July 2018

Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab.

J Clin Oncol 2018 07 24;36(20):2052-2060. Epub 2018 May 24.

Erik van Dijk, Hedde D. Biesma, Martijn Cordes, Maarten Neerincx, Paul P. Eijk, Henk M.W. Verheul, Nicole C.T. van Grieken, and Bauke Ylstra, Vrije Universiteit Medical Center; Gerrit A. Meijer, Netherlands Cancer Institute; Cornelis J.A. Punt, Academic Medical Center, Amsterdam; Miriam Koopman, University Medical Center Utrecht, Utrecht, the Netherlands; Dominiek Smeets and Diether Lambrechts, KU Leuven, Leuven, Belgium; Sudipto Das, Orna Bacon, Jochen H.M. Prehn, Bryan T. Hennessey, Darran P. O'Connor, and Annette T. Byrne, Royal College of Surgeons in Ireland; Verena Murphy, Cancer Trials Ireland; Anna Barat, Deborah A. McNamara, and Elaine W. Kay, Beaumont Hospital; Bozena Fender and William M. Gallagher, OncoMark Ltd; Rut Klinger and William M. Gallagher, University College Dublin, Dublin, United Kingdom; Johannes Betge, Timo Gaiser, and Matthias P.A. Ebert, University Hospital Mannheim, Mannheim, Germany; and Fotios Loupakis, Veneto Institute of Oncology IOV-IRCCS Padua, Italy.

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July 2018

Prevalence of inflammatory bowel disease in alcoholic, non-alcoholic and autoimmune pancreatitis.

Z Gastroenterol 2018 05 7;56(5):469-478. Epub 2018 May 7.

Department of Medicine II, University Medical Center Mannheim, Medical Faculty of the University of Heidelberg, Mannheim, Germany.

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May 2018

Checkpoints and beyond - Immunotherapy in colorectal cancer.

Semin Cancer Biol 2019 04 30;55:78-89. Epub 2018 Apr 30.

Department of Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, University Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Electronic address:

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April 2019

CRISPR/Cas9 for cancer research and therapy.

Semin Cancer Biol 2019 04 16;55:106-119. Epub 2018 Apr 16.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, and Heidelberg University, Department Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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April 2019

Invitation letters increase participation in colorectal cancer screening - results from an observational study.

Z Gastroenterol 2017 Dec 6;55(12):1307-1312. Epub 2017 Dec 6.

Department of Internal Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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December 2017

Monitoring and predicting disease activity in autoimmune pancreatitis with the M-ANNHEIM-AiP-Activity-Score.

Pancreatology 2018 Jan 25;18(1):29-38. Epub 2017 Oct 25.

Department of Medicine II, University Medical Center Mannheim, Medical Faculty at Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Electronic address:

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January 2018

Prevalence and Incidence of Autoimmune Pancreatitis in the Population Living in the Southwest of Germany.

Digestion 2017 11 29;96(4):187-198. Epub 2017 Sep 29.

Department of Medicine II, University Medical Centre Mannheim, Medical Faculty of the University of Heidelberg, Mannheim, Germany.

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November 2017

Intrinsic neural network dysfunction in quiescent Crohn's Disease.

Sci Rep 2017 09 14;7(1):11579. Epub 2017 Sep 14.

Department of General Psychiatry, Heidelberg University Hospital, 69115, Heidelberg, Germany.

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September 2017

Diagnosing autoimmune pancreatitis with the Unifying-Autoimmune-Pancreatitis-Criteria.

Pancreatology 2017 May - Jun;17(3):381-394. Epub 2017 Mar 18.

Department of Medicine II, University Medical Centre Mannheim, University of Heidelberg, Germany; Department of Clinical Science, Intervention & Technology, Karolinska Institute, Stockholm, Sweden.

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March 2018

Risk of Cancer in Patients with Autoimmune Pancreatitis: A Single-Center Experience from Germany.

Digestion 2017 23;95(2):172-180. Epub 2017 Feb 23.

Department of Medicine II, University Medical Centre Mannheim, Medical Faculty of the University of Heidelberg, Mannheim, Germany.

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June 2017

Lymph node retrieval in colorectal cancer: determining factors and prognostic significance.

Int J Colorectal Dis 2017 Jul 16;32(7):991-998. Epub 2017 Feb 16.

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria.

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July 2017

Multiple behavioral factors are associated with occurrence of large, flat colorectal polyps.

Int J Colorectal Dis 2017 Apr 28;32(4):575-582. Epub 2016 Nov 28.

Department of Internal Medicine II, Medical Faculty Mannheim, Heidelberg University, Universitätsmedizin Mannheim, Theodor-Kutzer Ufer 1-3, D-68167, Mannheim, Germany.

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April 2017

Inhibition of Rho-Associated Kinase 1/2 Attenuates Tumor Growth in Murine Gastric Cancer.

Neoplasia 2016 08;18(8):500-11

Dept. of Internal Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany. Electronic address:

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August 2016

Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer.

EBioMedicine 2016 Jun 5;8:159-172. Epub 2016 May 5.

Dept. of Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:

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June 2016

Risk Factors for Local Recurrence of Large, Flat Colorectal Polyps after Endoscopic Mucosal Resection.

Digestion 2016 7;93(4):311-7. Epub 2016 Jun 7.

Divisions of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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March 2017

Frequent co-occurrence of high-grade dysplasia in large flat colonic polyps (>20 mm) and synchronous polyps.

BMC Gastroenterol 2015 Jul 10;15:82. Epub 2015 Jul 10.

Department of Internal Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer Ufer 1-3, D-68167, Mannheim, Germany.

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July 2015

Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

PLoS One 2015 26;10(5):e0127146. Epub 2015 May 26.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.

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April 2016

Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer.

Clin Transl Gastroenterol 2015 Apr 30;6:e85. Epub 2015 Apr 30.

1] Sanford-Burnham Medical Research Institute (SBMRI), La Jolla, California, USA [2] Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Campus Can Ruti, Badalona, Barcelona, Spain [3] Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

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April 2015

Gastric Cancer: New Drugs - New Strategies.

Gastrointest Tumors 2014 May 27;1(4):180-94. Epub 2015 Mar 27.

Department of Medicine II, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany.

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May 2014

Label-free in situ monitoring of histone deacetylase drug target engagement by matrix-assisted laser desorption ionization-mass spectrometry biotyping and imaging.

Anal Chem 2014 May 11;86(10):4642-7. Epub 2014 Mar 11.

Institute of Medical Technology, University of Heidelberg and Mannheim University of Applied Sciences , ‡Center for Applied Research in Biomedical Mass Spectrometry (ABIMAS), and §Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences , Paul-Wittsack-Strasse 10, 68163, Mannheim, Germany.

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May 2014

Deficiency of caveolin-1 in Apc(min/+) mice promotes colorectal tumorigenesis.

Carcinogenesis 2013 Sep 2;34(9):2109-18. Epub 2013 May 2.

Department of Internal Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, D-68167 Mannheim, Germany.

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September 2013

Caveolin-1 protects B6129 mice against Helicobacter pylori gastritis.

PLoS Pathog 2013 11;9(4):e1003251. Epub 2013 Apr 11.

Department of Medicine II, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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January 2014

Phase I study of imatinib, cisplatin and 5-fluoruracil or capecitabine in advanced esophageal and gastric adenocarcinoma.

BMC Cancer 2012 Dec 10;12:587. Epub 2012 Dec 10.

Department of Internal Medicine II, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

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December 2012

Direct molecular tissue analysis by MALDI imaging mass spectrometry in the field of gastrointestinal disease.

Gastroenterology 2012 Sep 20;143(3):544-549.e2. Epub 2012 Jul 20.

Institute of Pathology, Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Electronic address:

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September 2012

The role of vascular CXCR4 expression in colorectal carcinoma.

Histopathology 2009 Nov;55(5):576-86

Institute of Pathology Campus Mitte, Charité University Hospital, Berlin, Germany.

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November 2009

Comparison of different tissue sampling methods for protein extraction from formalin-fixed and paraffin-embedded tissue specimens.

Exp Mol Pathol 2010 Feb 24;88(1):190-6. Epub 2009 Sep 24.

Department of Pathology, Charité University Hospital, Charitéplatz 1, 10117 Berlin, Germany.

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February 2010

Potential germline epimutations in Lynch syndrome: more evidence for genetics superseding epigenetics in inactivation of DNA mismatch repair genes in hereditary colorectal cancer.

Gastroenterology 2009 Oct 28;137(4):1524-7. Epub 2009 Aug 28.

Medizinische Klinik, Klinikum Rechts der Isar, Technische Universität München, München, Germany.

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October 2009

Proteomic and metabolic prediction of response to therapy in gastrointestinal cancers.

Nat Clin Pract Gastroenterol Hepatol 2009 Mar;6(3):170-83

Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, München, Germany.

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March 2009

Gene polymorphisms of the NOD-2/CARD-15 gene and the risk of gastric cancer in Germany.

Anticancer Res 2008 Mar-Apr;28(2A):757-62

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, D-39120 Magdeburg, Germany.

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June 2008