Publications

The 99th percentile and imprecision of point-of-care cardiac troponin I in comparison to central laboratory tests in a large reference population.
Clin Biochem 2017 Dec 10;50(18):1198-1202. Epub 2017 Aug 10.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. Electronic address:



Comparison of traditional diabetes risk scores and HbA1c to predict type 2 diabetes mellitus in a population based cohort study.
J Diabetes Complications 2017 Nov 1;31(11):1602-1607. Epub 2017 Aug 1.
Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.



Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
PLoS Med 2017 Sep 12;14(9):e1002383. Epub 2017 Sep 12.
Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, United States of America.

NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality.
J Am Soc Nephrol 2017 Aug 30;28(8):2311-2321. Epub 2017 Mar 30.
Due to the number of contributing authors, the affiliations are listed in the supplemental material.

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
PLoS Genet 2017 Aug 23;13(8):e1006972. Epub 2017 Aug 23.

Genome-wide association and targeted analysis of copy number variants with psoriatic arthritis in German patients.
BMC Med Genet 2017 Aug 23;18(1):92. Epub 2017 Aug 23.
Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Schwabachanlage 10, 91054, Erlangen, Germany.


Data on subgroup specific baseline characteristics and serum sphingosine-1-phosphate concentrations in the Study of Health in Pomerania.
Data Brief 2017 Jun 11;12:46-50. Epub 2017 Mar 11.
Institute of Pharmacology, Department of General Pharmacology, University Medicine Greifswald, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Germany.


Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania.
Clin Chim Acta 2017 May 31;468:25-31. Epub 2017 Jan 31.
Institute of Pharmacology, Department of General Pharmacology, University Medicine Greifswald, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Germany. Electronic address:

Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes.
Sci Rep 2017 May 22;7(1):2235. Epub 2017 May 22.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.


No mediating effects of glycemic control and inflammation on the association between vitamin D and lung function in the general population.
Respir Med 2017 Apr 20;125:1-7. Epub 2017 Feb 20.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), Greifswald Partner Site, Greifswald, Germany. Electronic address:

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
Nat Commun 2017 Apr 26;8:14977. Epub 2017 Apr 26.
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
PLoS Genet 2017 Apr 27;13(4):e1006528. Epub 2017 Apr 27.
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.
J Am Soc Nephrol 2017 Mar 5;28(3):981-994. Epub 2016 Dec 5.
National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts;

The Influence of Type 1 Diabetes Mellitus on Pulmonary Function and Exercise Capacity - Results from the Study of Health in Pomerania (SHIP).
Exp Clin Endocrinol Diabetes 2017 Jan 4;125(1):64-69. Epub 2016 Oct 4.
Department of Internal Medicine B, Cardiology, Pneumology, Weaning, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Germany.


Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.
BMC Med 2017 Jan 9;15(1). Epub 2017 Jan 9.
Medical Clinic I, University of Lübeck, Experimental and Clinical Endocrinology, Ratzeburger Allee 160, Zentralklinikum (Haus 40), 23538, Lübeck, Germany.

Novel genetic loci associated with hippocampal volume.
Nat Commun 2017 Jan 18;8:13624. Epub 2017 Jan 18.
Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.

Metabolic Fingerprints of Circulating IGF-1 and the IGF-1/IGFBP-3 Ratio: A Multifluid Metabolomics Study.
J Clin Endocrinol Metab 2016 Dec 6;101(12):4730-4742. Epub 2016 Oct 6.
Institute of Clinical Chemistry and Laboratory Medicine (H.K., M.P., H.W., M.N., N.F.) and Institute for Community Medicine (H.V.), University Medicine Greifswald, Interfaculty Institute for Genetics and Functional Genomics (U.V.), University Medicine and Ernst-Moritz Arndt-University Greifswald, and German Center for Cardiovascular Research (M.N., N.F.), partner site Greifswald, 17475 Greifswald, Germany; Institute of Computational Biology (K.T.D., J.K., K.S.), Helmholtz-Zentrum München, and German Center for Diabetes Research (J.K.), and Institute of Bioinformatics and Systems Biology (W.R.-M., G.K.), Helmholtz Zentrum München, German Research Center for Environmental Health, and Institute of Experimental Genetics (A.A., J.A.), Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany, and German Center for Diabetes Research (J.A.), 85764 München-Neuherberg, Germany; Schwerpunktpraxis für Diabetes und Hormonerkrankungen (H.W.), 99094 Erfurt, Germany; Weill Cornell Medical College in Qatar (K.S.), Education City, Qatar Foundation, Doha, Qatar; Lehrstuhl für Experimentelle Genetik (J.A.), Technische Universität München, 85350 Freising-Weihenstephan, Germany; Research Centre for Prevention and Health (N.F.), Capital Region of Denmark, 2600 Glostrup, Denmark.

Novel genetic loci underlying human intracranial volume identified through genome-wide association.
Nat Neurosci 2016 Dec 3;19(12):1569-1582. Epub 2016 Oct 3.
Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.


Sex Hormones and Sleep in Men and Women From the General Population: A Cross-Sectional Observational Study.
J Clin Endocrinol Metab 2016 Nov 12;101(11):3968-3977. Epub 2016 Jul 12.
Institute of Clinical Chemistry and Laboratory Medicine (H.K., H.W., M.N., R.H.), Departments of Internal Medicine B (R.E., A.O., B.S.) and Cardiology (S.G., M.D.), and Institute for Community Medicine (H.V.), University Medicine Greifswald, D-17475 Greifswald, Germany; Interdisciplinary Sleep Center (I.F., T.P.), Charité, University Medicine, 10117 Berlin, Germany; German Centre for Cardiovascular Research (S.G., H.V., M.D., M.N.) and German Centre for Diabetes Research (H.V.), partner site Greifswald, 13092 Greifswald, Germany; and Faculty of Applied Public Health (R.H.), European University of Applied Sciences, 18051 Rostock, Germany.

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.
Aging Cell 2016 Oct 21;15(5):811-24. Epub 2016 Jun 21.
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.

A reference panel of 64,976 haplotypes for genotype imputation.
Nat Genet 2016 Oct 22;48(10):1279-83. Epub 2016 Aug 22.
Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.




Plasma Fibroblast Growth Factor 23: Clinical Correlates and Association With Cardiovascular Disease and Mortality in the Framingham Heart Study.
J Am Heart Assoc 2016 Jul 6;5(7). Epub 2016 Jul 6.
Preventive Medicine and Epidemiology Section, Boston University School of Medicine, Boston, MA Cardiology Section, Evans Department of Medicine, Boston University School of Medicine, Boston, MA Department of Epidemiology, Boston University School of Public Health, Boston, MA National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA.


Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.
Behav Genet 2016 Mar 11;46(2):170-82. Epub 2015 Sep 11.
Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.


Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Diabetes 2016 Mar 2;65(3):803-17. Epub 2015 Dec 2.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Renal Division, Medical Center, University of Freiburg, Freiburg, Germany

Quality assurance in the pre-analytical phase of human urine samples by (1)H NMR spectroscopy.
Arch Biochem Biophys 2016 Jan 8;589:10-7. Epub 2015 Aug 8.
Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Ferdinand-Sauerbruch-Straße NK, 17475 Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), Greifswald Partner Site, Greifswald, Germany. Electronic address:

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
Nat Commun 2016 Jan 21;7:10023. Epub 2016 Jan 21.
NHLBI's Framingham Heart Study and the Center for Population Studies, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.

Association of sex hormones with incident 10-year cardiovascular disease and mortality in women.
Maturitas 2015 Dec 28;82(4):424-30. Epub 2015 Aug 28.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine Greifswald, Greifswald, Germany; European University of Applied Sciences, Faculty of Applied Public Health, Rostock, Germany. Electronic address:

Endogenous Androgens and Sex Hormone-Binding Globulin in Women and Risk of Metabolic Syndrome and Type 2 Diabetes.
J Clin Endocrinol Metab 2015 Dec 7;100(12):4595-603. Epub 2015 Oct 7.
Institute of Clinical Chemistry and Laboratory Medicine (B.F., H.K. H.W., M.N., R.H.), DZHK (German Centre for Cardiovascular Research) (S.G., H.W., H.V., M.D., M.N., R.H.), Greifswald, Germany 17475, Institute for Community Medicine (H.V.), Department of Cardiology (S.G., M.D.), University Medicine Greifswald, Germany 17475; Department of Clinical Chemistry (B.G.K.), University Hospital, South Manchester, United Kingdom M23 9LT; Department of Internal Medicine I (G.B.), University Lübeck, Germany 23562; and European University of Applied Sciences (R.H.), Faculty of Applied Public Health, Rostock, Germany 18057.

Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples.
Neuroimage 2015 Nov 6;122:149-57. Epub 2015 Aug 6.
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Germany; German Center for Neurodegenerative Diseases DZNE, Site Rostock/Greifswald, Germany; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS Hospital Stralsund, Germany.

Longitudinal effects of systemic inflammation markers on periodontitis.
J Clin Periodontol 2015 Nov 14;42(11):988-97. Epub 2015 Nov 14.
Unit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Pedodontics and Primary Prevention, University Medicine Greifswald, Greifswald, Germany.


Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality.
PLoS Genet 2015 Sep 9;11(9):e1005487. Epub 2015 Sep 9.
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Doha, Qatar.

Discrepant post filter ionized calcium concentrations by common blood gas analyzers in CRRT using regional citrate anticoagulation.
Crit Care 2015 Sep 8;19:321. Epub 2015 Sep 8.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Strasse, 17475, Greifswald, Germany.

Gender-specific pathway differences in the human serum metabolome.
Metabolomics 2015;11(6):1815-1833. Epub 2015 Aug 4.
German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany ; Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany.

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.
JAMA Psychiatry 2015 Jul;72(7):642-50
Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.

A genetic risk score for thyroid peroxidase antibodies associates with clinical thyroid disease in community-based populations.
J Clin Endocrinol Metab 2015 May 26;100(5):E799-807. Epub 2015 Feb 26.
Renal Division (U.T.S., Y.L., A.K.), Department of Medicine IV, Medical Center, University of Freiburg, 79106 Freiburg, Germany; Department of Internal Medicine and Rotterdam Thyroid Center (M.M., L.C., A.G.U., R.P.P.) and Department of Epidemiology (L.C., A.H.), Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands; Institute for Community Medicine (A.T., H.V.), Interfaculty Institute for Genetics and Functional Genomics (G.H.), and Institute of Clinical Chemistry and Laboratory Medicine (M.N.), University Medicine Greifswald, 17475 Greifswald, Germany; and Department of Epidemiology (N.D., E.S., A.K.), Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205.

Genome-wide association study for endothelial growth factors.
Circ Cardiovasc Genet 2015 Apr 31;8(2):389-97. Epub 2014 Dec 31.
From the Framingham Heart Study, MA (W.L., M.-H.C., M.G.L., H.L., R.S.V.); Christian-Albrechts-University Kiel, Institute of Epidemiology, Kiel, Germany (W.L., M.K.); Department of Neurology (M.-H.C.), Division of Graduate Medical Sciences (R.S.), Department of Medicine (H.L.), Section of Epidemiology and Prevention, School of Medicine (R.S.V.), Department of Mathematics (M.G.L.), and Department of Epidemiology, School of Public Health (R.S.V.), Boston University, MA; Interfaculty Institute for Genetics and Functional Genomics (A.T., U.V.), Section Study of Health in Pomerania - Clinical-Epidemiological Research, Institute for Community Medicine (A.T., S.E.B., R.L., H.V.), and Institute for Clinical Chemistry and Laboratory Medicine (M.N., H.W.), University Medicine, Greifswald, Germany; Cardiovascular Division, Vanderbilt University, Nashville, TN (H.M.S., D.B.S.); and German Center of Cardiovascular Research, Partner Site Greifswald, Germany (U.V., M.N., H.V., H.W.).

Common genetic variants influence human subcortical brain structures.
Nature 2015 Apr 21;520(7546):224-9. Epub 2015 Jan 21.
QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.
Circ Cardiovasc Genet 2015 Apr 7;8(2):398-409. Epub 2015 Feb 7.

Association of circulating irisin and cardiopulmonary exercise capacity in healthy volunteers: results of the Study of Health in Pomerania.
BMC Pulm Med 2015 Apr 22;15:41. Epub 2015 Apr 22.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany.

Shift of the TSH reference range with improved iodine supply in Northeast Germany.
Eur J Endocrinol 2015 Mar 1;172(3):261-7. Epub 2014 Dec 1.
Institute for Community MedicineErnst Moritz Arndt University, University of Greifswald, Walther-Rathenau Straße 48, D-17475 Greifswald, GermanyInstitute of Clinical Chemistry and Laboratory MedicineUniversity of Greifswald, Greifswald, GermanyDZHK (German Center for Cardiovascular Research)Partner Site Greifswald, University of Greifswald, Greifswald, GermanyDepartamento de Ciências FarmacêuticasUniversidade Regional de Blumenau, Blumenau, Brazil Institute for Community MedicineErnst Moritz Arndt University, University of Greifswald, Walther-Rathenau Straße 48, D-17475 Greifswald, GermanyInstitute of Clinical Chemistry and Laboratory MedicineUniversity of Greifswald, Greifswald, GermanyDZHK (German Center for Cardiovascular Research)Partner Site Greifswald, University of Greifswald, Greifswald, GermanyDepartamento de Ciências FarmacêuticasUniversidade Regional de Blumenau, Blumenau, Brazil.



Function-impairing polymorphisms of the hepatic uptake transporter SLCO1B1 modify the therapeutic efficacy of statins in a population-based cohort.
Pharmacogenet Genomics 2015 Jan;25(1):8-18
aBiopharmacy Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland bInstitute of Pharmacology cInstitute of Community Medicine dInstitute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany.

Regional differences of undiagnosed type 2 diabetes and prediabetes prevalence are not explained by known risk factors.
PLoS One 2014 17;9(11):e113154. Epub 2014 Nov 17.
Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University, Düsseldorf, Germany; Competence Network Diabetes mellitus (Federal Ministry of Education and Research, Germany), Sites Düsseldorf, Munich and Greifswald, Germany.

Higher serum concentrations of N-terminal pro-B-type natriuretic peptide associate with prevalent hypertension whereas lower associate with incident hypertension.
PLoS One 2015 6;10(2):e0117864. Epub 2015 Feb 6.
Department of Internal Medicine, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Modulation of genetic associations with serum urate levels by body-mass-index in humans.
PLoS One 2015 26;10(3):e0119752. Epub 2015 Mar 26.
Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.


Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population.
PLoS One 2015 22;10(5):e0127466. Epub 2015 May 22.
Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.

L-Arginine and SDMA Serum Concentrations Are Associated with Subclinical Atherosclerosis in the Study of Health in Pomerania (SHIP).
PLoS One 2015 22;10(6):e0131293. Epub 2015 Jun 22.
University Medicine Greifswald, Department of Internal Medicine B, Greifswald, Germany; DZHK-German Centre for Cardiovascular Research, partner site Greifswald, Greifswald, Germany.


Rare and low-frequency coding variants alter human adult height.
Nature 2017 02 1;542(7640):186-190. Epub 2017 Feb 1.
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.

Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers.
PLoS One 2017 19;12(4):e0175909. Epub 2017 Apr 19.
Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany.


1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
Sci Rep 2017 04 28;7:45040. Epub 2017 Apr 28.
Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.

Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
Sci Rep 2017 05 26;7:46835. Epub 2017 May 26.

OF