Matthias Lienhard

Matthias Lienhard

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Matthias Lienhard

Matthias Lienhard

Publications by authors named "Matthias Lienhard"

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14Publications

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Combined Targeted Resequencing of Cytosine DNA Methylation and Mutations of DNA Repair Genes with Potential Use for Poly(ADP-Ribose) Polymerase 1 Inhibitor Sensitivity Testing.

J Mol Diagn 2019 Mar 19;21(2):198-213. Epub 2018 Dec 19.

Department of Translational Epigenetics and Tumor Genetics, University Hospital Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University Hospital Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2018.10.007DOI Listing
March 2019

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

Quantitative Comparison of Large-Scale DNA Enrichment Sequencing Data.

Methods Mol Biol 2016 ;1418:191-208

German Cancer Research Center, In Neuenheimer Feld 580, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-3578-9_10DOI Listing
December 2016

Analyzing and interpreting genome data at the network level with ConsensusPathDB.

Nat Protoc 2016 10 8;11(10):1889-907. Epub 2016 Sep 8.

Department of Pathology and Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2016.117DOI Listing
October 2016

Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis.

Proc Natl Acad Sci U S A 2015 Aug 21;112(31):E4236-45. Epub 2015 Jul 21.

Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, CA 92037; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093; Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037

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http://dx.doi.org/10.1073/pnas.1510510112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534209PMC
August 2015

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.

Nat Cell Biol 2015 May 27;17(5):545-57. Epub 2015 Apr 27.

1] The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA [2] The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/ncb3147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593707PMC
May 2015

ARH-seq: identification of differential splicing in RNA-seq data.

Nucleic Acids Res 2014 Aug 11;42(14):e110. Epub 2014 Jun 11.

Max-Planck-Institute for Molecular Genetics, Department of Vertebrate Genomics, Ihnestrasse 63-73, 14195 Berlin, Germany

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http://dx.doi.org/10.1093/nar/gku495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132698PMC
August 2014

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility.

Nat Immunol 2014 Aug 6;15(8):777-88. Epub 2014 Jul 6.

1] La Jolla Institute for Allergy & Immunology, La Jolla, California, USA. [2] Clinical and Experimental Sciences, Southampton National Institute for Health Research Respiratory Biomedical Research Unit, University of Southampton, Faculty of Medicine, Southampton, UK. [3] University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/ni.2937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140783PMC
August 2014

MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments.

Bioinformatics 2014 Jan 13;30(2):284-6. Epub 2013 Nov 13.

Departments of Vertebrate Genomics and Developmental Biology, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany, Department of Rheumatology and Clinical Immunology, Institute of Pathology, Laboratory of Molecular Tumour Pathology, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany and Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892689PMC
January 2014

RNA-Seq provides new insights in the transcriptome responses induced by the carcinogen benzo[a]pyrene.

Toxicol Sci 2012 Dec 13;130(2):427-39. Epub 2012 Aug 13.

Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/toxsci/kfs250DOI Listing
December 2012