Matthias Kretzler

Matthias Kretzler

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Matthias Kretzler

Publications by authors named "Matthias Kretzler"

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Molecular Profiling of Cutaneous Lupus Lesions Identifies Subgroups Distinct from Clinical Phenotypes.

J Clin Med 2019 Aug 17;8(8). Epub 2019 Aug 17.

Division of Rheumatology, Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.3390/jcm8081244DOI Listing
August 2019

Correlation Between Baseline GFR and Subsequent Change in GFR in Norwegian Adults Without Diabetes and in Pima Indians.

Am J Kidney Dis 2019 Jun 28;73(6):777-785. Epub 2019 Jan 28.

Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway; Section of Nephrology, University Hospital of North Norway, Tromsø, Norway.

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http://dx.doi.org/10.1053/j.ajkd.2018.11.011DOI Listing
June 2019

Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease.

JCI Insight 2019 Jun 20;4(12). Epub 2019 Jun 20.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1172/jci.insight.128120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629103PMC
June 2019

MultiPLIER: A Transfer Learning Framework for Transcriptomics Reveals Systemic Features of Rare Disease.

Cell Syst 2019 May;8(5):380-394.e4

Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA; Childhood Cancer Data Laboratory, Alex's Lemonade Stand Foundation, Philadelphia, PA, USA; Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA; Institute of Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538307PMC
May 2019

Glomerular podocytes in kidney health and disease.

Lancet 2019 03;393(10174):856-858

Department of Nephrology, Rambam Health Care Campus, Haifa, Israel; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

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http://dx.doi.org/10.1016/S0140-6736(18)33000-9DOI Listing
March 2019

Decoding the genetic determinants of gene regulation in the kidney.

Kidney Int 2019 01;95(1):16-18

Division of Nephrology, University of Michigan, Ann Arbor, Michigan, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183081
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http://dx.doi.org/10.1016/j.kint.2018.11.013DOI Listing
January 2019

Upregulation of Tumor Susceptibility Gene 101 (TSG101) by mechanical stress in podocytes.

Cell Mol Biol (Noisy-le-grand) 2019 Jan 31;65(1):84-88. Epub 2019 Jan 31.

Dept. of Anatomy and Cell Biology, University Medicine Greifswald, D-17487 Greifswald, Germany.

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January 2019

Hydroxypropyl-β-cyclodextrin protects from kidney disease in experimental Alport syndrome and focal segmental glomerulosclerosis.

Kidney Int 2018 12 6;94(6):1151-1159. Epub 2018 Oct 6.

Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA; Peggy and Harold Katz Family Drug Discovery Center, University of Miami Miller School of Medicine, Miami, Florida, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278936PMC
December 2018

Systems biology approaches to identify disease mechanisms and facilitate targeted therapy in the management of glomerular disease.

Curr Opin Nephrol Hypertens 2018 11;27(6):433-439

Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1097/MNH.0000000000000446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568000PMC
November 2018

Tyro3 is a podocyte protective factor in glomerular disease.

JCI Insight 2018 11 15;3(22). Epub 2018 Nov 15.

Department of Medicine/Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1172/jci.insight.123482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302948PMC
November 2018

Renal Pre-Competitive Consortium (RPC): discovering therapeutic targets together.

Drug Discov Today 2018 10 18;23(10):1695-1699. Epub 2018 May 18.

Internal Medicine, University of Michigan, Ann Arbor, MI 48103, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2018.05.021DOI Listing
October 2018

Urinary epidermal growth factor as a prognostic marker for the progression of Alport syndrome in children.

Pediatr Nephrol 2018 10 11;33(10):1731-1739. Epub 2018 Jun 11.

Department of Pediatrics, Peking University First Hospital, No.1 Xi An Men Da Jie, Beijing, 100034, People's Republic of China.

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http://dx.doi.org/10.1007/s00467-018-3988-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132884PMC
October 2018

An integrative systems biology approach for precision medicine in diabetic kidney disease.

Diabetes Obes Metab 2018 10;20 Suppl 3:6-13

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1111/dom.13416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541014PMC
October 2018

Urinary epidermal growth factor predicts renal prognosis in antineutrophil cytoplasmic antibody-associated vasculitis.

Ann Rheum Dis 2018 09 3;77(9):1339-1344. Epub 2018 May 3.

Department of Medicine, Renal Division, Peking University First Hospital, Beijing, China.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2017-21257
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http://dx.doi.org/10.1136/annrheumdis-2017-212578DOI Listing
September 2018

Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome.

Exp Mol Pathol 2018 08 6;105(1):120-129. Epub 2018 Jul 6.

Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1016/j.yexmp.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167754PMC
August 2018

Single-Cell Sequencing the Glomerulus, Unraveling the Molecular Programs of Glomerular Filtration, One Cell at a Time.

J Am Soc Nephrol 2018 Aug 12;29(8):2036-2038. Epub 2018 Jul 12.

Department of Computational Medicine and Bioinformatics, University of Michigan Medical Center, Ann Arbor, Michigan.

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http://dx.doi.org/10.1681/ASN.2018060626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065087PMC
August 2018

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping.

Cell Stem Cell 2018 Jun 17;22(6):929-940.e4. Epub 2018 May 17.

Department of Medicine, Division of Nephrology, University of Washington School of Medicine, Seattle, WA 98109, USA; Kidney Research Institute, University of Washington School of Medicine, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine and Quellos High Throughput Screening Core, University of Washington School of Medicine, Seattle, WA 98109, USA; Department of Pathology, University of Washington School of Medicine, Seattle, WA 98109, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183021
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http://dx.doi.org/10.1016/j.stem.2018.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984728PMC
June 2018

A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome.

Kidney Int 2018 02 18;93(2):439-449. Epub 2017 Oct 18.

Division of Nephrology, University of Michigan, Ann Arbor, Michigan, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794609PMC
February 2018

Novel avenues for drug discovery in diabetic kidney disease.

Expert Opin Drug Discov 2018 01 16;13(1):65-74. Epub 2017 Nov 16.

b Division of Nephrology, Department of Internal Medicine , University of Michigan , Ann Arbor , MI , USA.

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http://dx.doi.org/10.1080/17460441.2018.1398731DOI Listing
January 2018

A systems approach to renal inflammation in SLE.

Clin Immunol 2017 12 14;185:109-118. Epub 2016 Aug 14.

Feinstein Institute, Center for Autoimmunity and Musculoskeletal Diseases, Manhasset, NY, USA 11030. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309209PMC
December 2017

Defining Renal Neoplastic Disease, One Cell at a Time: Mass Cytometry, a New Tool for the Study of Kidney Biology and Disease.

Am J Kidney Dis 2017 12 12;70(6):758-761. Epub 2017 Oct 12.

University of Michigan, Ann Arbor, Michigan.

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https://linkinghub.elsevier.com/retrieve/pii/S02726386173090
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http://dx.doi.org/10.1053/j.ajkd.2017.08.009DOI Listing
December 2017

Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients.

EBioMedicine 2017 Dec 31;26:68-77. Epub 2017 Oct 31.

Kidney Research Institute, University of Washington, Seattle, WA, United States; Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA, United States.

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http://dx.doi.org/10.1016/j.ebiom.2017.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832558PMC
December 2017

Podocyte-specific JAK2 overexpression worsens diabetic kidney disease in mice.

Kidney Int 2017 10 26;92(4):909-921. Epub 2017 May 26.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610635PMC
October 2017

Genetic and environmental risk factors for chronic kidney disease.

Kidney Int Suppl (2011) 2017 Oct 20;7(2):88-106. Epub 2017 Sep 20.

Institute of Genetic Epidemiology, Medical Center and Faculty of Medicine-University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1016/j.kisu.2017.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341015PMC
October 2017

Blood Pressure and Visit-to-Visit Blood Pressure Variability Among Individuals With Primary Proteinuric Glomerulopathies.

Hypertension 2017 08 26;70(2):315-323. Epub 2017 Jun 26.

From the Cohen Children's Medical Center of New York (C.B.S.); The Children's Hospital of Philadelphia, PA (K.E.C.M.); University of Michigan, Ann Arbor (L.H.M., M.K.); Arbor Research, MI (L.H.M.); Johns Hopkins School of Medicine, Baltimore, MD (K.J.P., T.M.B.); Temple University, Philadelphia, PA (C.A.G.); University of North Carolina, Chapel Hill (K.L.G.); and Children's Mercy Hospital, Kansas City, MO (T.S.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518633PMC
August 2017

Renal biopsy-driven molecular target identification in glomerular disease.

Pflugers Arch 2017 Aug 29;469(7-8):1021-1028. Epub 2017 Jun 29.

Department of Medicine, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1007/s00424-017-2006-yDOI Listing
August 2017

Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease.

Kidney Int 2017 03 22;91(3):711-719. Epub 2016 Dec 22.

Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313324PMC
March 2017

The relatively poor correlation between random and 24-hour urine protein excretion in patients with biopsy-proven glomerular diseases.

Kidney Int 2016 11 12;90(5):1080-1089. Epub 2016 Aug 12.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065749PMC
http://dx.doi.org/10.1016/j.kint.2016.06.020DOI Listing
November 2016

Defining Glomerular Disease in Mechanistic Terms: Implementing an Integrative Biology Approach in Nephrology.

Clin J Am Soc Nephrol 2016 11 14;11(11):2054-2060. Epub 2016 Sep 14.

Division of Nephrology, University of Michigan Medical Center, Ann Arbor, Michigan; and

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.13651215
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http://dx.doi.org/10.2215/CJN.13651215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108211PMC
November 2016

A reference panel of 64,976 haplotypes for genotype imputation.

Authors:
Shane McCarthy Sayantan Das Warren Kretzschmar Olivier Delaneau Andrew R Wood Alexander Teumer Hyun Min Kang Christian Fuchsberger Petr Danecek Kevin Sharp Yang Luo Carlo Sidore Alan Kwong Nicholas Timpson Seppo Koskinen Scott Vrieze Laura J Scott He Zhang Anubha Mahajan Jan Veldink Ulrike Peters Carlos Pato Cornelia M van Duijn Christopher E Gillies Ilaria Gandin Massimo Mezzavilla Arthur Gilly Massimiliano Cocca Michela Traglia Andrea Angius Jeffrey C Barrett Dorrett Boomsma Kari Branham Gerome Breen Chad M Brummett Fabio Busonero Harry Campbell Andrew Chan Sai Chen Emily Chew Francis S Collins Laura J Corbin George Davey Smith George Dedoussis Marcus Dorr Aliki-Eleni Farmaki Luigi Ferrucci Lukas Forer Ross M Fraser Stacey Gabriel Shawn Levy Leif Groop Tabitha Harrison Andrew Hattersley Oddgeir L Holmen Kristian Hveem Matthias Kretzler James C Lee Matt McGue Thomas Meitinger David Melzer Josine L Min Karen L Mohlke John B Vincent Matthias Nauck Deborah Nickerson Aarno Palotie Michele Pato Nicola Pirastu Melvin McInnis J Brent Richards Cinzia Sala Veikko Salomaa David Schlessinger Sebastian Schoenherr P Eline Slagboom Kerrin Small Timothy Spector Dwight Stambolian Marcus Tuke Jaakko Tuomilehto Leonard H Van den Berg Wouter Van Rheenen Uwe Volker Cisca Wijmenga Daniela Toniolo Eleftheria Zeggini Paolo Gasparini Matthew G Sampson James F Wilson Timothy Frayling Paul I W de Bakker Morris A Swertz Steven McCarroll Charles Kooperberg Annelot Dekker David Altshuler Cristen Willer William Iacono Samuli Ripatti Nicole Soranzo Klaudia Walter Anand Swaroop Francesco Cucca Carl A Anderson Richard M Myers Michael Boehnke Mark I McCarthy Richard Durbin

Nat Genet 2016 10 22;48(10):1279-83. Epub 2016 Aug 22.

Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388176PMC
October 2016

JAK inhibition in the treatment of diabetic kidney disease.

Diabetologia 2016 08 22;59(8):1624-7. Epub 2016 Jun 22.

Department of Internal Medicine, University of Michigan Medical School, 5520 MSRB1, 1150 W. Medical Center Dr., Ann Arbor, MI, 48109-5680, USA.

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http://dx.doi.org/10.1007/s00125-016-4021-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942738PMC
August 2016

Using Population Genetics to Interrogate the Monogenic Nephrotic Syndrome Diagnosis in a Case Cohort.

J Am Soc Nephrol 2016 07 3;27(7):1970-83. Epub 2015 Nov 3.

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan.

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http://dx.doi.org/10.1681/ASN.2015050504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926977PMC
July 2016

Glomerular disease: Personalized immunomonitoring in lupus and lupus nephritis.

Nat Rev Nephrol 2016 06 9;12(6):320-1. Epub 2016 May 9.

University of Michigan, 1560 MSRB II, 1150 W. Medical Center Dr.-SPC5676, Ann Arbor, MI 48109-5676, USA.

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http://dx.doi.org/10.1038/nrneph.2016.69DOI Listing
June 2016

Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects.

J Am Soc Nephrol 2016 Mar 6;27(3):814-23. Epub 2015 Jul 6.

Division of Nephrology, Department of Internal Medicine and Department of Physiology and Biophysics, Case Western Reserve University and Rammelkamp Center for Education and Research, MetroHealth System, Cleveland, Ohio;

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http://dx.doi.org/10.1681/ASN.2014111131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769193PMC
March 2016

Molecular studies of lupus nephritis kidneys.

Immunol Res 2015 Dec;63(1-3):187-96

Department of Internal Medicine, Nephrology, University of Michigan, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1007/s12026-015-8693-6DOI Listing
December 2015

Integrative Biology of Diabetic Kidney Disease.

Kidney Dis (Basel) 2015 Dec 23;1(3):194-203. Epub 2015 Sep 23.

Department of Internal Medicine, the Division of Nephrology, University of Michigan, Ann Arbor, Michigan ; Department of Bioinformatics and Computational Medicine, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1159/000439196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768943PMC
December 2015

A Transcriptional Map of the Renal Tubule: Linking Structure to Function.

J Am Soc Nephrol 2015 Nov 27;26(11):2603-5. Epub 2015 Mar 27.

Department of Internal Medicine, Division of Nephrology, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2015030242
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http://dx.doi.org/10.1681/ASN.2015030242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625684PMC
November 2015

The role of renin-angiotensin-aldosterone system genes in the progression of chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study.

Nephrol Dial Transplant 2015 Oct 23;30(10):1711-8. Epub 2015 Apr 23.

School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA Tulane University School of Medicine, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1093/ndt/gfv125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838004PMC
October 2015

Targeted Lipidomic and Transcriptomic Analysis Identifies Dysregulated Renal Ceramide Metabolism in a Mouse Model of Diabetic Kidney Disease.

J Proteomics Bioinform 2015 Oct 18;Suppl 14. Epub 2015 May 18.

Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.4172/jpb.S14-002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712744PMC
October 2015

Opponent's comments.

Nephrol Dial Transplant 2015 Jun;30(6):891

Department of Internal Medicine/Nephrology, University of Michigan, Ann Arbor, MI, USA Arbor Research Collaborative for Health, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1093/ndt/gfv107aDOI Listing
June 2015

Pro: 'The usefulness of biomarkers in glomerular diseases'. The problem: moving from syndrome to mechanism--individual patient variability in disease presentation, course and response to therapy.

Nephrol Dial Transplant 2015 Jun;30(6):892-8

Department of Internal Medicine/Nephrology, University of Michigan, Ann Arbor, MI, USA Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1093/ndt/gfv108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542809PMC
June 2015

Introduction: Precision Medicine for Glomerular Disease: The Road Forward.

Semin Nephrol 2015 May;35(3):209-11

Departments of Medicine and Physiology and Biophysics Case Western Reserve University Rammelkamp Center for Research and Education The MetroHealth System Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.semnephrol.2015.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902811PMC
May 2015

MicroRNA-21 in glomerular injury.

J Am Soc Nephrol 2015 Apr 21;26(4):805-16. Epub 2014 Aug 21.

Internal Medicine, University of Michigan, Ann Arbor, Michigan; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York;

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http://dx.doi.org/10.1681/ASN.2013121274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378097PMC
April 2015

A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease.

Kidney Int 2015 Mar 29;87(3):564-74. Epub 2014 Oct 29.

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ki.2014.346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344842PMC
March 2015