Matthias Heinig

Matthias Heinig

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Matthias Heinig

Matthias Heinig

Publications by authors named "Matthias Heinig"

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40Publications

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Inferring Interaction Networks From Multi-Omics Data.

Front Genet 2019 12;10:535. Epub 2019 Jun 12.

Institute of Computational Biology, HelmholtzZentrum München, Munich, Germany.

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http://dx.doi.org/10.3389/fgene.2019.00535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582773PMC
June 2019

Association of Human Promoter Variants with the Occurrence of Knee-Osteoarthritis in a Case Control Association Study.

Int J Mol Sci 2019 Mar 19;20(6). Epub 2019 Mar 19.

Experimental Rheumatology Unit, Department of Orthopedics, Jena University Hospital, Waldkrankenhaus 'Rudolf Elle', 07607 Eisenberg, Germany.

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http://dx.doi.org/10.3390/ijms20061382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471183PMC
March 2019

Efficient Parameter Estimation Enables the Prediction of Drug Response Using a Mechanistic Pan-Cancer Pathway Model.

Cell Syst 2018 12 28;7(6):567-579.e6. Epub 2018 Nov 28.

Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg 85764, Germany; Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Technische Universität München, Garching 85748, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.10.013DOI Listing
December 2018

Unilateral temporal interictal epileptiform discharges correctly predict the epileptogenic zone in lesional temporal lobe epilepsy.

Epilepsia 2018 08 15;59(8):1577-1582. Epub 2018 Jul 15.

Epilepsy Center, Department of Neurology, University Hospital, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1111/epi.14514DOI Listing
August 2018

Using Gene Expression to Annotate Cardiovascular GWAS Loci.

Authors:
Matthias Heinig

Front Cardiovasc Med 2018 5;5:59. Epub 2018 Jun 5.

Institute of Computational Biology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.3389/fcvm.2018.00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996083PMC
June 2018

Cadm2 regulates body weight and energy homeostasis in mice.

Mol Metab 2018 02 22;8:180-188. Epub 2017 Nov 22.

Max Delbrück Center for Molecular Medicine, Robert Rössle Strasse 10, 13125 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985021PMC
February 2018

Epigenetics and Control of RNAs.

Methods Mol Biol 2017 ;1488:217-237

Helmholtz Zentrum München, Institute of Computational Biology (ICB), Neuherberg, 85764, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6427-7_9DOI Listing
January 2018

Rapid Genome-wide Recruitment of RNA Polymerase II Drives Transcription, Splicing, and Translation Events during T Cell Responses.

Cell Rep 2017 04;19(3):643-654

Institute for Diabetes and Obesity (IDO), German Center for Environmental Health GmbH, Munich 85748, Germany; German Center for Diabetes Research (DZD), German Center for Environmental Health GmbH, Munich 85764, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.069DOI Listing
April 2017

52 Genetic Loci Influencing Myocardial Mass.

Authors:
Pim van der Harst Jessica van Setten Niek Verweij Georg Vogler Lude Franke Matthew T Maurano Xinchen Wang Irene Mateo Leach Mark Eijgelsheim Nona Sotoodehnia Caroline Hayward Rossella Sorice Osorio Meirelles Leo-Pekka Lyytikäinen Ozren Polašek Toshiko Tanaka Dan E Arking Sheila Ulivi Stella Trompet Martina Müller-Nurasyid Albert V Smith Marcus Dörr Kathleen F Kerr Jared W Magnani Fabiola Del Greco M Weihua Zhang Ilja M Nolte Claudia T Silva Sandosh Padmanabhan Vinicius Tragante Tõnu Esko Gonçalo R Abecasis Michiel E Adriaens Karl Andersen Phil Barnett Joshua C Bis Rolf Bodmer Brendan M Buckley Harry Campbell Megan V Cannon Aravinda Chakravarti Lin Y Chen Alessandro Delitala Richard B Devereux Pieter A Doevendans Anna F Dominiczak Luigi Ferrucci Ian Ford Christian Gieger Tamara B Harris Eric Haugen Matthias Heinig Dena G Hernandez Hans L Hillege Joel N Hirschhorn Albert Hofman Norbert Hubner Shih-Jen Hwang Annamaria Iorio Mika Kähönen Manolis Kellis Ivana Kolcic Ishminder K Kooner Jaspal S Kooner Jan A Kors Edward G Lakatta Kasper Lage Lenore J Launer Daniel Levy Alicia Lundby Peter W Macfarlane Dalit May Thomas Meitinger Andres Metspalu Stefania Nappo Silvia Naitza Shane Neph Alex S Nord Teresa Nutile Peter M Okin Jesper V Olsen Ben A Oostra Josef M Penninger Len A Pennacchio Tune H Pers Siegfried Perz Annette Peters Yigal M Pinto Arne Pfeufer Maria Grazia Pilia Peter P Pramstaller Bram P Prins Olli T Raitakari Soumya Raychaudhuri Ken M Rice Elizabeth J Rossin Jerome I Rotter Sebastian Schafer David Schlessinger Carsten O Schmidt Jobanpreet Sehmi Herman H W Silljé Gianfranco Sinagra Moritz F Sinner Kamil Slowikowski Elsayed Z Soliman Timothy D Spector Wilko Spiering John A Stamatoyannopoulos Ronald P Stolk Konstantin Strauch Sian-Tsung Tan Kirill V Tarasov Bosco Trinh Andre G Uitterlinden Malou van den Boogaard Cornelia M van Duijn Wiek H van Gilst Jorma S Viikari Peter M Visscher Veronique Vitart Uwe Völker Melanie Waldenberger Christian X Weichenberger Harm-Jan Westra Cisca Wijmenga Bruce H Wolffenbuttel Jian Yang Connie R Bezzina Patricia B Munroe Harold Snieder Alan F Wright Igor Rudan Laurie A Boyer Folkert W Asselbergs Dirk J van Veldhuisen Bruno H Stricker Bruce M Psaty Marina Ciullo Serena Sanna Terho Lehtimäki James F Wilson Stefania Bandinelli Alvaro Alonso Paolo Gasparini J Wouter Jukema Stefan Kääb Vilmundur Gudnason Stephan B Felix Susan R Heckbert Rudolf A de Boer Christopher Newton-Cheh Andrew A Hicks John C Chambers Yalda Jamshidi Axel Visel Vincent M Christoffels Aaron Isaacs Nilesh J Samani Paul I W de Bakker

J Am Coll Cardiol 2016 09;68(13):1435-1448

Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2016.07.729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478167PMC
September 2016

Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events.

Genomics Proteomics Bioinformatics 2016 08 17;14(4):235-43. Epub 2016 May 17.

Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, 20246 Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Hamburg/Kiel/Luebeck, Germany.

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http://dx.doi.org/10.1016/j.gpb.2016.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996851PMC
August 2016

Principles of microRNA Regulation Revealed Through Modeling microRNA Expression Quantitative Trait Loci.

Genetics 2016 08 3;203(4):1629-40. Epub 2016 Jun 3.

RNA Bioinformatics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany High Throughput Genomics, Department of Mathematics and Computer Science, Freie Universität Berlin, 14195 Berlin, Germany.

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http://dx.doi.org/10.1534/genetics.116.187153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981266PMC
August 2016

Meta-analysis identifies seven susceptibility loci involved in the atopic march.

Nat Commun 2015 Nov 6;6:8804. Epub 2015 Nov 6.

Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1038/ncomms9804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667629PMC
November 2015

Alternative Splicing Signatures in RNA-seq Data: Percent Spliced in (PSI).

Curr Protoc Hum Genet 2015 Oct 6;87:11.16.1-14. Epub 2015 Oct 6.

Cardiovascular and Metabolic Sciences, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1002/0471142905.hg1116s87DOI Listing
October 2015

Quantitative interaction proteomics of neurodegenerative disease proteins.

Cell Rep 2015 May 7;11(7):1134-46. Epub 2015 May 7.

Max Delbrück Center for Molecular Medicine, Robert-Rössle-Straße 10, 13092 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.04.030DOI Listing
May 2015

Translational regulation shapes the molecular landscape of complex disease phenotypes.

Nat Commun 2015 May 26;6:7200. Epub 2015 May 26.

Cardiovascular and Metabolic Sciences, Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Robert-Rossle-Strasse 10, 13125 Berlin, Germany.

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http://www.nature.com/articles/ncomms8200
Publisher Site
http://dx.doi.org/10.1038/ncomms8200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455061PMC
May 2015

histoneHMM: Differential analysis of histone modifications with broad genomic footprints.

BMC Bioinformatics 2015 Feb 22;16:60. Epub 2015 Feb 22.

Groningen Bioinformatics Center, University of Groningen, Nijenborgh 7, AG, Groningen, 9747, The Netherlands.

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http://dx.doi.org/10.1186/s12859-015-0491-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347972PMC
February 2015

Natural variation of histone modification and its impact on gene expression in the rat genome.

Genome Res 2014 Jun 2;24(6):942-53. Epub 2014 May 2.

Max-Delbrück-Center for Molecular Medicine (MDC), 13125 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner site Berlin, 13125 Berlin, Germany.

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http://dx.doi.org/10.1101/gr.169029.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032858PMC
June 2014

Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.

Physiol Genomics 2011 Nov 16;43(21):1207-18. Epub 2011 Aug 16.

Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College, London, United Kingdom.

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http://physiolgenomics.physiology.org/content/physiolgenomic
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http://physiolgenomics.physiology.org/cgi/doi/10.1152/physio
Publisher Site
http://dx.doi.org/10.1152/physiolgenomics.00210.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217321PMC
November 2011

Transcription factor binding predictions using TRAP for the analysis of ChIP-seq data and regulatory SNPs.

Nat Protoc 2011 Nov 3;6(12):1860-9. Epub 2011 Nov 3.

Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1038/nprot.2011.409DOI Listing
November 2011

Quantifying the effect of sequence variation on regulatory interactions.

Hum Mutat 2010 Apr;31(4):477-83

Max Planck Institute for Molecular Genetics, Computational Biology, Ihnestrasse 73, Berlin, Germany.

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http://dx.doi.org/10.1002/humu.21209DOI Listing
April 2010

New insights into the genetic control of gene expression using a Bayesian multi-tissue approach.

PLoS Comput Biol 2010 Apr 8;6(4):e1000737. Epub 2010 Apr 8.

Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1000737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851562PMC
April 2010

MACAT--microarray chromosome analysis tool.

Bioinformatics 2005 May 30;21(9):2112-3. Epub 2004 Nov 30.

Freie Universitaet Berlin, Bioinformatics programme and Max Planck Institute for Molecular Genetics, Germany.

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http://dx.doi.org/10.1093/bioinformatics/bti183DOI Listing
May 2005

STRIDE: a web server for secondary structure assignment from known atomic coordinates of proteins.

Nucleic Acids Res 2004 Jul;32(Web Server issue):W500-2

Department of Genome Oriented Bioinformatics, Technical University of Munich, Wissenschaftszentrum Weihenstephan, 85354 Freising, Germany.

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http://dx.doi.org/10.1093/nar/gkh429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC441567PMC
July 2004