Matthias Hebrok

Matthias Hebrok

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Matthias Hebrok

Publications by authors named "Matthias Hebrok"

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Pancreatic pericytes originate from the embryonic pancreatic mesenchyme.

Dev Biol 2019 May 13;449(1):14-20. Epub 2019 Feb 13.

Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.01.020DOI Listing
May 2019

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.

Cell Stem Cell 2018 Jun;22(6):810-823

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007036PMC
June 2018

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca Sensitivity of Insulin Secretion Vesicles.

Dev Cell 2018 05 12;45(3):347-361.e5. Epub 2018 Apr 12.

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; The Program of Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962294PMC
May 2018

Atypical flat lesions derive from pancreatic acinar cells.

Pancreatology 2017 May - Jun;17(3):350-353. Epub 2017 Apr 25.

Institute of Pathology, University Clinic Duesseldorf, Heinrich-Heine University, Duesseldorf, Germany.

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http://dx.doi.org/10.1016/j.pan.2017.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770228PMC
March 2018

Replication confers β cell immaturity.

Nat Commun 2018 02 2;9(1):485. Epub 2018 Feb 2.

Diabetes Center, Department of Medicine, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41467-018-02939-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797102PMC
February 2018

Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.

Stem Cell Reports 2017 09 10;9(3):807-819. Epub 2017 Aug 10.

Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA; UCSF Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599226PMC
September 2017

Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy.

ACS Nano 2017 08 7;11(8):7747-7757. Epub 2017 Aug 7.

UCSF-UC Berkeley Joint PhD Program in Bioengineering , San Francisco, California 94143, United States.

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http://dx.doi.org/10.1021/acsnano.7b01239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667644PMC
August 2017

Designing β Cells.

Authors:
Matthias Hebrok

Cell Metab 2017 02;25(2):223-224

Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.01.018DOI Listing
February 2017

All mixed up: defining roles for β-cell subtypes in mature islets.

Genes Dev 2017 02;31(3):228-240

Diabetes Center, Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1101/gad.294389.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358720PMC
February 2017

Life and death of β cells in Type 1 diabetes: A comprehensive review.

J Autoimmun 2016 07 24;71:51-8. Epub 2016 Mar 24.

Department of Immunobiology, Yale University, New Haven, CT, USA; Department of Internal Medicine, Yale University, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903951PMC
July 2016

Human islets contain four distinct subtypes of β cells.

Nat Commun 2016 07 11;7:11756. Epub 2016 Jul 11.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1038/ncomms11756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942571PMC
July 2016

p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia.

Cancer Res 2016 06 31;76(11):3351-63. Epub 2016 Mar 31.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. The McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891257PMC
June 2016

Human pancreatic beta-like cells converted from fibroblasts.

Nat Commun 2016 Jan 6;7:10080. Epub 2016 Jan 6.

Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1038/ncomms10080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729817PMC
January 2016

Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.

Development 2015 Dec 19;142(23):4010-25. Epub 2015 Oct 19.

Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA Division of Maternal Fetal Medicine, University of California San Francisco, San Francisco, CA 94143, USA Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA The Eli & Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA Human Embryonic Stem Cell Program, University of California San Francisco, San Francisco, CA 94143, USA Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA

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http://dx.doi.org/10.1242/dev.122846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712832PMC
December 2015

β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.

Cell 2015 Dec 25;163(6):1457-67. Epub 2015 Nov 25.

Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674150147
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http://dx.doi.org/10.1016/j.cell.2015.10.076DOI Listing
December 2015

Regulation of Cellular Identity in Cancer.

Dev Cell 2015 Dec;35(6):674-84

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692359PMC
December 2015

Aberrant innate immune activation following tissue injury impairs pancreatic regeneration.

PLoS One 2014 10;9(7):e102125. Epub 2014 Jul 10.

Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102125PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092101PMC
November 2015

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells.

Curr Opin Genet Dev 2015 Jun 21;32:171-80. Epub 2015 Apr 21.

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523641PMC
June 2015

CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.

Stem Cell Reports 2015 Mar 26;4(3):374-89. Epub 2015 Feb 26.

Department of Cell and Tissue Biology and Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375943PMC
March 2015

Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice.

PLoS One 2013 20;8(8):e72213. Epub 2013 Aug 20.

Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072213PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748057PMC
January 2015

Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease.

Cell Stem Cell 2015 Jan 20;16(1):18-31. Epub 2014 Nov 20.

Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289422PMC
January 2015

Dicer regulates differentiation and viability during mouse pancreatic cancer initiation.

PLoS One 2014 1;9(5):e95486. Epub 2014 May 1.

Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095486PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006805PMC
December 2014

Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors.

EMBO J 2014 Oct 25;33(19):2135-6. Epub 2014 Aug 25.

Diabetes Center, University of California-San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.15252/embj.201489751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282500PMC
October 2014

Diabetes. Solving human β-cell development--what does the mouse say?

Nat Rev Endocrinol 2014 May 25;10(5):253-5. Epub 2014 Feb 25.

Diabetes Center, Department of Medicine, University of California-San Francisco, 513 Parnassus Avenue, HSW 1116, Box 0540, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1038/nrendo.2014.18DOI Listing
May 2014

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation.

Gut 2014 Apr 3;63(4):656-64. Epub 2013 May 3.

Department of Medicine, Diabetes Center, University of California-San Francisco, , San Francisco, California, USA.

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http://dx.doi.org/10.1136/gutjnl-2012-304287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883808PMC
April 2014

Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages.

Cell Stem Cell 2014 Feb;14(2):228-36

Gladstone Institute of Cardiovascular Disease and Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909140000
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http://dx.doi.org/10.1016/j.stem.2014.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747235PMC
February 2014

VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus.

Genes Dev 2013 Dec;27(23):2563-75

Diabetes Center, Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA;

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http://dx.doi.org/10.1101/gad.227785.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861670PMC
December 2013

Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia.

Gastroenterology 2013 Nov 25;145(5):1088-1097.e8. Epub 2013 Jul 25.

Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1053/j.gastro.2013.07.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805717PMC
November 2013

Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development.

Cell Stem Cell 2013 Aug 16;13(2):219-29. Epub 2013 May 16.

Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143-0540, USA.

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http://dx.doi.org/10.1016/j.stem.2013.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869399PMC
August 2013

Canonical wnt signaling is required for pancreatic carcinogenesis.

Cancer Res 2013 Aug 12;73(15):4909-22. Epub 2013 Jun 12.

Department of Surgery, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763696PMC
August 2013

Control of cell identity in pancreas development and regeneration.

Gastroenterology 2013 Jun;144(6):1170-9

Division of Gastroenterology, Department of Medicine, Department of Cell and Developmental Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1053/j.gastro.2013.01.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639438PMC
June 2013

Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs.

Diabetes 2013 May 10;62(5):1581-92. Epub 2013 Jan 10.

Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.2337/db12-0167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636645PMC
May 2013

Bmi1 is required for regeneration of the exocrine pancreas in mice.

Gastroenterology 2012 Sep 17;143(3):821-831.e2. Epub 2012 May 17.

Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2012.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485080PMC
September 2012

Diabetic β Cells: To Be or Not To Be?

Cell 2012 Sep;150(6):1103-4

Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.cell.2012.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692270PMC
September 2012

Generating β cells from stem cells-the story so far.

Authors:
Matthias Hebrok

Cold Spring Harb Perspect Med 2012 Jun;2(6):a007674

Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1101/cshperspect.a007674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367541PMC
June 2012

Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming.

Hum Mol Genet 2012 May 27;21(9):2054-67. Epub 2012 Jan 27.

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Diabetes Center, South San Francisco, CA, USA.

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http://dx.doi.org/10.1093/hmg/dds023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315209PMC
May 2012

Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice.

Proc Natl Acad Sci U S A 2011 Oct 3;108(41):17010-5. Epub 2011 Oct 3.

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.1105404108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193206PMC
October 2011

Pancreatic mesenchyme regulates epithelial organogenesis throughout development.

PLoS Biol 2011 Sep 6;9(9):e1001143. Epub 2011 Sep 6.

Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167782PMC
September 2011

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.

Nat Cell Biol 2011 May 17;13(5):541-9. Epub 2011 Apr 17.

Department of Ob/Gyn and Center for Reproductive Sciences, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA.

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http://www.nature.com/articles/ncb2239
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http://dx.doi.org/10.1038/ncb2239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987913PMC
May 2011

Pancreatic mesenchyme regulates epithelial organogenesis throughout development.

PLoS Biol 2011 Sep 6;9(9):e1001143. Epub 2011 Sep 6.

Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167782PMC
September 2011

KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.

Nat Rev Cancer 2010 Oct 3;10(10):683-95. Epub 2010 Sep 3.

Diabetes Center, University of California, San Francisco, 513 Parnassus Ave, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nrc2899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085546PMC
October 2010

Primary cilia regulate Gli/Hedgehog activation in pancreas.

Proc Natl Acad Sci U S A 2010 Jun 17;107(22):10109-14. Epub 2010 May 17.

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.0909900107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890485PMC
June 2010

Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.

PLoS Genet 2010 Jun 17;6(6):e1000990. Epub 2010 Jun 17.

Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1000990
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http://dx.doi.org/10.1371/journal.pgen.1000990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887466PMC
June 2010

Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function.

Diabetes 2010 May 25;59(5):1211-21. Epub 2010 Feb 25.

Diabetes Center, University of California, San Francisco, San Francisco, California, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db09-09
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http://dx.doi.org/10.2337/db09-0914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857901PMC
May 2010

Cellular plasticity within the pancreas--lessons learned from development.

Dev Cell 2010 Mar;18(3):342-56

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.devcel.2010.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085547PMC
March 2010

Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.

J Clin Invest 2010 Feb 11;120(2):508-20. Epub 2010 Jan 11.

Diabetes Center, Department of Medicine, UCSF, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1172/JCI40045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810083PMC
February 2010

Dicer is required for proper liver zonation.

J Pathol 2009 Nov;219(3):365-72

Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1002/path.2606DOI Listing
November 2009

It's a free for all--insulin-positive cells join the group of potential progenitors for pancreatic ductal adenocarcinoma.

Cancer Cell 2009 Nov;16(5):359-61

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.10.006DOI Listing
November 2009

Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis.

Gastroenterology 2009 Jun 6;136(7):2304-2315.e1-4. Epub 2009 Mar 6.

Pathology Division, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.1053/j.gastro.2009.02.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167383PMC
June 2009

Stem cells to pancreatic beta-cells: new sources for diabetes cell therapy.

Endocr Rev 2009 May 23;30(3):214-27. Epub 2009 Apr 23.

Department of Medicine, Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA.

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https://academic.oup.com/edrv/article-lookup/doi/10.1210/er.
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http://dx.doi.org/10.1210/er.2009-0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726841PMC
May 2009

A role for von Hippel-Lindau protein in pancreatic beta-cell function.

Diabetes 2009 Feb 25;58(2):433-41. Epub 2008 Nov 25.

Diabetes Center, Department of Medicine, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.2337/db08-0749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628617PMC
February 2009

Wnt5a is essential for intestinal elongation in mice.

Dev Biol 2009 Feb 7;326(2):285-94. Epub 2008 Dec 7.

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.ydbio.2008.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654720PMC
February 2009

Stabilization of beta-catenin induces pancreas tumor formation.

Gastroenterology 2008 Oct 9;135(4):1288-300. Epub 2008 Jul 9.

Diabetes Center, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.06.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613004PMC
October 2008

Hedgehog spikes pancreas regeneration.

Gastroenterology 2008 Aug 11;135(2):347-51. Epub 2008 Jul 11.

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http://linkinghub.elsevier.com/retrieve/pii/S001650850801184
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http://dx.doi.org/10.1053/j.gastro.2008.06.063DOI Listing
August 2008

Regulated beta-cell regeneration in the adult mouse pancreas.

Diabetes 2008 Apr 14;57(4):958-66. Epub 2007 Dec 14.

Diabetes Center, University of California San Francisco, California, USA.

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http://dx.doi.org/10.2337/db07-0913DOI Listing
April 2008

Safer, longer-lasting regulatory T cells with beta-catenin.

Nat Med 2008 Feb;14(2):118-9

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http://dx.doi.org/10.1038/nm0208-118DOI Listing
February 2008

Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.

J Clin Invest 2007 Dec;117(12):4034-43

Cardiovascular Research Institute, Diabetes Center, Department of Cellular and Molecular Pharmacology, UCSF School of Medicine, San Francisco, California 94143-2240, USA.

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http://dx.doi.org/10.1172/JCI32994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2066199PMC
December 2007

Dynamics of embryonic pancreas development using real-time imaging.

Dev Biol 2007 Jun 12;306(1):82-93. Epub 2007 Mar 12.

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.ydbio.2007.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1988845PMC
June 2007

Hedgehogs: la dolce vita. Workshop on Hedgehog-Gli Signaling in Cancer and Stem Cells.

EMBO Rep 2007 May 13;8(5):451-5. Epub 2007 Apr 13.

Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1038/sj.embor.7400959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866211PMC
May 2007

Wnt signaling regulates pancreatic beta cell proliferation.

Proc Natl Acad Sci U S A 2007 Apr 2;104(15):6247-52. Epub 2007 Apr 2.

Department of Developmental Biology, Oncology Division, Stanford University, Stanford, CA 94305-5329, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0701509104
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http://dx.doi.org/10.1073/pnas.0701509104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847455PMC
April 2007

Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.

Proc Natl Acad Sci U S A 2007 Mar 19;104(12):5103-8. Epub 2007 Mar 19.

Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1073/pnas.0701158104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828712PMC
March 2007

Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy.

Hepatology 2007 Feb;45(2):361-8

Diabetes Center, Department of Medicine, Division of Transplantation, University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1002/hep.21523DOI Listing
February 2007

Pancreatic development and disease.

Gastroenterology 2007 Feb;132(2):745-62

Diabetes Center, Department of Medicine, University of California San Francisco, 94143, USA.

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http://dx.doi.org/10.1053/j.gastro.2006.12.054DOI Listing
February 2007

Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis.

Gastroenterology 2006 Dec 26;131(6):1856-69. Epub 2006 Oct 26.

Diabetes Center, Department of Medicine, University of California San Francisco, California 94143, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001650850602284
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http://dx.doi.org/10.1053/j.gastro.2006.10.050DOI Listing
December 2006

Hedgehog/Ras interactions regulate early stages of pancreatic cancer.

Genes Dev 2006 Nov;20(22):3161-73

Diabetes Center, Department of Medicine, University of California, San Francisco, California 94143, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1470806
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http://dx.doi.org/10.1101/gad.1470806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635150PMC
November 2006

Stabilization of beta-catenin impacts pancreas growth.

Development 2006 May 12;133(10):2023-32. Epub 2006 Apr 12.

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1242/dev.02366DOI Listing
May 2006

Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice.

Hepatology 2006 Apr;43(4):817-25

Department of Medicine, Diabetes Center, University of California--San Francisco, San Francisco, CA 94143-0573, USA.

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http://dx.doi.org/10.1002/hep.21131DOI Listing
April 2006

Hedgehog signaling regulates expansion of pancreatic epithelial cells.

Dev Biol 2005 Apr;280(1):111-21

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.ydbio.2005.01.008DOI Listing
April 2005

Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.

Diabetes 2005 Mar;54(3):694-701

Diabetes Center, Department of Medicine, University of California, San Francisco, California, 94143-0573, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771170PMC
http://dx.doi.org/10.2337/diabetes.54.3.694DOI Listing
March 2005

Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization.

Development 2004 Jul;131(14):3457-67

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1242/dev.01189DOI Listing
July 2004

Brain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration.

Trends Cell Biol 2004 Apr;14(4):153-5

Diabetes Center and Department of Medicine, University of California, San Francisco, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744962PMC
April 2004

Development and cancer: lessons learned in the pancreas.

Cell Cycle 2004 Mar 1;3(3):270-2. Epub 2004 Mar 1.

Diabetes Center, Department of Medicine, University of California, San Francisco, California 94143, USA.

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March 2004

Hedgehog signalling in cancer formation and maintenance.

Nat Rev Cancer 2003 Dec;3(12):903-11

Diabetes Center, Department of Medicine, University of California-San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1038/nrc1229DOI Listing
December 2003

Combined activities of hedgehog signaling inhibitors regulate pancreas development.

Development 2003 Oct 13;130(20):4871-9. Epub 2003 Aug 13.

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1242/dev.00653DOI Listing
October 2003

Hedgehog signaling in pancreas development.

Authors:
Matthias Hebrok

Mech Dev 2003 Jan;120(1):45-57

Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143-0540, USA.

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January 2003