Publications by authors named "Matthias Geyer"

100Publications

Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly.

FEBS Lett 2020 Jun 16. Epub 2020 Jun 16.

Institute of Structural Biology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/1873-3468.13865DOI Listing
June 2020

Effective Hamiltonian model for helically constrained quantum systems within adiabatic perturbation theory: Application to the chirality-induced spin selectivity (CISS) effect.

J Chem Phys 2020 Jun;152(21):214105

Institute for Materials Science and Max Bergmann Center of Biomaterials, TU Dresden, 01062 Dresden, Germany.

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http://dx.doi.org/10.1063/5.0005181DOI Listing
June 2020

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.

Cell Rep 2020 03;30(11):3743-3754.e6

Department of Neurodegenerative Disease and Gerontopsychiatry/Neurology, University of Bonn Medical Center, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.02.025DOI Listing
March 2020

The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21.

Nucleic Acids Res 2019 12;47(22):11861-11879

Molecular Immunology and Cell Biology, Life & Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.

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http://dx.doi.org/10.1093/nar/gkz1057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145526PMC
December 2019

The formin Drosophila homologue of Diaphanous2 (Diaph2) controls microtubule dynamics in colorectal cancer cells independent of its FH2-domain.

Sci Rep 2019 03 29;9(1):5352. Epub 2019 Mar 29.

Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf Martinistrasse 52, D-20246, Hamburg, Germany.

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http://dx.doi.org/10.1038/s41598-019-41731-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441084PMC
March 2019

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.

Cell Chem Biol 2019 06 21;26(6):792-803.e10. Epub 2019 Mar 21.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biology Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588464PMC
June 2019

Sensitizing HR-proficient cancers to PARP inhibitors.

Mol Cell Oncol 2017 3;4(6):e1299272. Epub 2017 Mar 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1080/23723556.2017.1299272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706951PMC
March 2017

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.

Nat Commun 2017 09 5;8(1):442. Epub 2017 Sep 5.

Institute of Innate Immunity, Department of Structural Immunology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.

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http://dx.doi.org/10.1038/s41467-017-00481-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585231PMC
September 2017

Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice.

J Mol Biol 2018 01 19;430(2):142-152. Epub 2017 Jul 19.

Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.

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http://dx.doi.org/10.1016/j.jmb.2017.07.012DOI Listing
January 2018

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain.

J Exp Med 2017 06 2;214(6):1725-1736. Epub 2017 May 2.

Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany

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http://dx.doi.org/10.1084/jem.20160933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460996PMC
June 2017

D186/D190 is an allele-dependent determinant of HIV-1 Nef function.

Virology 2016 11 24;498:44-56. Epub 2016 Aug 24.

Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00426822163021
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http://dx.doi.org/10.1016/j.virol.2016.08.012DOI Listing
November 2016

Structural and Functional Analysis of the Cdk13/Cyclin K Complex.

Cell Rep 2016 Jan 31;14(2):320-31. Epub 2015 Dec 31.

Institute of Innate Immunity, Department of Structural Immunology, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany; Center of Advanced European Studies and Research, Group Physical Biochemistry, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany; Max Planck Institute of Molecular Physiology, Department of Physical Biochemistry, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany. Electronic address:

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http://www.cell.com/cms/attachment/2046215624/2057236642/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221112471501438
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http://dx.doi.org/10.1016/j.celrep.2015.12.025DOI Listing
January 2016

Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.

Mol Cell 2016 Jan 10;61(1):54-67. Epub 2015 Dec 10.

Comprehensive Cancer Center Mainfranken, Versbacher Straße 5, 97078 Würzburg, Germany; Department of Radiation Oncology, University Hospital Würzburg, Josef-Schneider-Straße 11, 97080 Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.11.007DOI Listing
January 2016

The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation.

Nat Commun 2015 May 12;6:7088. Epub 2015 May 12.

1] Center of Advanced European Studies and Research, Group Physical Biochemistry, Ludwig-Erhard-Allee 2, Bonn 53175, Germany [2] Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany [3] Institute of Innate Immunity, Department of Structural Immunology, Sigmund-Freud-Str. 25, Bonn 53127, Germany.

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http://dx.doi.org/10.1038/ncomms8088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432619PMC
May 2015

Synergistic activation of Toll-like receptor 8 by two RNA degradation products.

Nat Struct Mol Biol 2015 Feb;22(2):99-101

1] Institute of Innate Immunity, University Clinics Bonn, University of Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA, the German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, and the Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1038/nsmb.2967DOI Listing
February 2015

Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres.

Eur J Cell Biol 2015 Feb 12;94(2):101-13. Epub 2014 Dec 12.

Department of Anatomy and Molecular Embryology, Ruhr-University, Bochum, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejcb.2014.11.003DOI Listing
February 2015

Formins as effector proteins of Rho GTPases.

Small GTPases 2014 10;5:e29513. Epub 2014 Jun 10.

Center of Advanced European Studies and Research (caesar); Group Physical Biochemistry; Bonn, Germany.

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http://dx.doi.org/10.4161/sgtp.29513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111664PMC
February 2015

Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation.

Nucleic Acids Res 2014 Jul 23;42(12):7577-90. Epub 2014 May 23.

Max Planck Institute of Molecular Physiology, Department of Physical Biochemistry, 44227 Dortmund, Germany Center of Advanced European Studies and Research (caesar), Group Physical Biochemistry, 53175 Bonn, Germany

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http://dx.doi.org/10.1093/nar/gku449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081074PMC
July 2014

The structure and substrate specificity of human Cdk12/Cyclin K.

Nat Commun 2014 Mar 24;5:3505. Epub 2014 Mar 24.

1] Group Physical Biochemistry, Center of Advanced European Studies and Research, Ludwig-Erhard-Allee 2, Bonn 53175, Germany [2] Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany.

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http://dx.doi.org/10.1038/ncomms4505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973122PMC
March 2014

FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers.

J Cell Sci 2014 Apr 30;127(Pt 7):1379-93. Epub 2014 Jan 30.

Department of Molecular Cell Biology, Center for Medical Biotechnology, University of Duisburg-Essen, 45141 Essen, Germany.

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http://dx.doi.org/10.1242/jcs.134627DOI Listing
April 2014

Link between primate lentiviral coreceptor usage and Nef function.

Cell Rep 2013 Nov 21;5(4):997-1009. Epub 2013 Nov 21.

Institute of Molecular Virology, University of Ulm, 89069 Ulm, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247130061
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http://dx.doi.org/10.1016/j.celrep.2013.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133736PMC
November 2013

The RNA polymerase II carboxy-terminal domain (CTD) code.

Chem Rev 2013 Nov 16;113(11):8456-90. Epub 2013 Aug 16.

Department of Molecular Epigenetics, Helmholtz Center Munich and Center for Integrated Protein Science Munich (CIPSM) , Marchioninistrasse 25, 81377 Munich, Germany.

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http://dx.doi.org/10.1021/cr400071fDOI Listing
November 2013

FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers.

J Cell Sci 2013 Apr 26;126(Pt 8):1891-901. Epub 2013 Feb 26.

Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1242/jcs.126706DOI Listing
April 2013

Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition.

Nat Commun 2012 May 15;3:842. Epub 2012 May 15.

Max-Planck-Institut für molekulare Physiologie, Abt. Physikalische Biochemie, Otto-Hahn-Straße 11, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1038/ncomms1846DOI Listing
May 2012

Exogenous nef induces proinflammatory signaling events in murine macrophages.

Viral Immunol 2012 Apr 13;25(2):117-30. Epub 2012 Mar 13.

Department of Biology, University Roma Tre, Rome, Italy.

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http://dx.doi.org/10.1089/vim.2011.0082DOI Listing
April 2012

Positional screening and NMR structure determination of side-chain-to-side-chain cyclized β3-peptides.

Org Biomol Chem 2012 Feb 20;10(7):1365-73. Epub 2011 Dec 20.

Max Planck Institute of Molecular Physiology, Otto-Hahn Strasse 11, 44227, Dortmund, Germany.

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http://dx.doi.org/10.1039/c1ob06422cDOI Listing
February 2012

Nef surfaces: where to interfere with function.

Curr HIV Res 2011 Oct;9(7):543-51

Max Planck Institute of Molecular Physiology, Department of Physical Biochemistry, Germany.

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http://dx.doi.org/10.2174/157016211798842053DOI Listing
October 2011

The control of HIV transcription: keeping RNA polymerase II on track.

Cell Host Microbe 2011 Nov;10(5):426-35

Gladstone Institutes of Virology and Immunology, University of California, San Francisco, 94158, USA.

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http://dx.doi.org/10.1016/j.chom.2011.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478145PMC
November 2011

Structure and dynamics of a stabilized coiled-coil domain in the P-TEFb regulator Hexim1.

J Mol Biol 2011 Dec 18;414(5):639-53. Epub 2011 Oct 18.

Max-Planck-Institut für molekulare Physiologie, Abteilung Physikalische Biochemie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00222836110114
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http://dx.doi.org/10.1016/j.jmb.2011.10.022DOI Listing
December 2011

Mechanistic insights into the translocation of full length HIV-1 Tat across lipid membranes.

Biochim Biophys Acta 2011 Nov 27;1808(11):2685-93. Epub 2011 Jul 27.

Institute of Organic and Biomolecular Chemistry, Tammannstr. 2, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.bbamem.2011.07.030DOI Listing
November 2011

Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly.

Traffic 2011 Jul 5;12(7):867-77. Epub 2011 May 5.

Abteilung Physikalische Biochemie, Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1111/j.1600-0854.2011.01205.xDOI Listing
July 2011

Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis.

J Biol Chem 2010 Dec 11;285(51):39768-78. Epub 2010 Oct 11.

Universität Regensburg, Institut für Biophysik und Physikalische Biochemie, Universitätsstrasse 31, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1074/jbc.M110.145235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000958PMC
December 2010

1H, 15N, and 13C assignments of the N-terminal activation domain of Dictyostelium discoideum Formin C.

Biomol NMR Assign 2011 Apr 7;5(1):47-9. Epub 2010 Oct 7.

Department of Chemistry, Biomolecular NMR Spectroscopy, Technische Universität München, Garching, Germany.

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http://link.springer.com/10.1007/s12104-010-9264-3
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http://dx.doi.org/10.1007/s12104-010-9264-3DOI Listing
April 2011

Endogenous regeneration after collagenase-induced knee joint damage in the adult newt Notophthalmus viridescens.

Ann Rheum Dis 2011 Jan 31;70(1):214-20. Epub 2010 Aug 31.

Department of Rheumatology and Clinical Immunology, Justus-Liebig-University of Gießen, Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany.

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http://dx.doi.org/10.1136/ard.2009.126136DOI Listing
January 2011

Rationale of using different biological therapies in rheumatoid arthritis.

Arthritis Res Ther 2010 24;12(4):214. Epub 2010 Aug 24.

Justus-Liebig-University of Giessen, Department of Rheumatology and Clinical Immunology, Kerckhoff-Klinik, Benekestr, Bad Nauheim, Germany.

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http://dx.doi.org/10.1186/ar3102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945050PMC
January 2011

Interaction of propionylated and butyrylated histone H3 lysine marks with Brd4 bromodomains.

Angew Chem Int Ed Engl 2010 Sep;49(38):6768-72

Abteilung Physikalische Biochemie, Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1002/anie.201002724DOI Listing
September 2010

Migratory potential of rheumatoid arthritis synovial fibroblasts: additional perspectives.

Cell Cycle 2010 Jun 15;9(12):2286-91. Epub 2010 Jun 15.

Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik; Bad Nauheim, Germany.

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http://dx.doi.org/10.4161/cc.9.12.11907DOI Listing
June 2010

Formation of Tat-TAR containing ribonucleoprotein complexes for biochemical and structural analyses.

Methods 2011 Jan 10;53(1):78-84. Epub 2010 Apr 10.

Max-Planck-Institut für molekulare Physiologie, Abteilung Physikalische Biochemie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1016/j.ymeth.2010.04.001DOI Listing
January 2011

Complex formation and light activation in membrane-embedded sensory rhodopsin II as seen by solid-state NMR spectroscopy.

Structure 2010 Mar;18(3):293-300

Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.str.2010.01.011DOI Listing
March 2010

A flexible bipartite coiled coil structure is required for the interaction of Hexim1 with the P-TEFB subunit cyclin T1.

Biochemistry 2010 Apr;49(14):3083-91

Max-Planck-Institut für molekulare Physiologie, Abteilung Physikalische Biochemie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1021/bi902072fDOI Listing
April 2010

Actual status of antiinterleukin-1 therapies in rheumatic diseases.

Curr Opin Rheumatol 2010 May;22(3):246-51

Department of Rheumatology and Clinical Immunology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany.

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http://dx.doi.org/10.1097/BOR.0b013e3283373fa0DOI Listing
May 2010

Fifteen formins for an actin filament: a molecular view on the regulation of human formins.

Biochim Biophys Acta 2010 Feb 25;1803(2):152-63. Epub 2010 Jan 25.

Max-Planck-Institut für Molekulare Physiologie, Abteilung Physikalische Biochemie, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2010.01.014DOI Listing
February 2010

The pathogenesis of systemic sclerosis revisited.

Clin Rev Allergy Immunol 2011 Apr;40(2):92-103

Department of Rheumatology and Clinical Immunology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany.

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http://dx.doi.org/10.1007/s12016-009-8193-3DOI Listing
April 2011

HIV-1 Nef membrane association depends on charge, curvature, composition and sequence.

Nat Chem Biol 2010 Jan 22;6(1):46-53. Epub 2009 Nov 22.

Max-Planck-Institut für molekulare Physiologie, Abteilung Physikalische Biochemie, Dortmund, Germany.

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http://dx.doi.org/10.1038/nchembio.268DOI Listing
January 2010

Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.

J Mol Biol 2010 Jan 31;395(1):28-41. Epub 2009 Oct 31.

Abteilung Physikalische Biochemie, Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, D-44227 Dortmund, Germany.

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http://dx.doi.org/10.1016/j.jmb.2009.10.055DOI Listing
January 2010

Structures of the dual bromodomains of the P-TEFb-activating protein Brd4 at atomic resolution.

J Biol Chem 2009 Dec 13;284(52):36547-56. Epub 2009 Oct 13.

Abteilung Physikalische Biochemie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Strasse 11, D-44227 Dortmund, Germany.

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http://dx.doi.org/10.1074/jbc.M109.033712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794770PMC
December 2009

DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain.

Mol Biol Cell 2009 Oct 26;20(20):4400-11. Epub 2009 Aug 26.

Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany.

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http://dx.doi.org/10.1091/mbc.e09-03-0247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762136PMC
October 2009

NMR spectroscopic investigation of early events in IAPP amyloid fibril formation.

Chembiochem 2009 Jul;10(11):1769-72

Faculty of Chemistry, Physical Chemistry I-Biophysical Chemistry, Dortmund University of Technology, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1002/cbic.200900237DOI Listing
July 2009

HIV-1 Nef perturbs artificial membranes: investigation of the contribution of the myristoyl anchor.

Biophys J 2009 Apr;96(8):3242-50

Institute of Organic and Biomolecular Chemistry, Georg-August University, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.bpj.2008.12.3947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718304PMC
April 2009

Structural insights into the cyclin T1-Tat-TAR RNA transcription activation complex from EIAV.

Nat Struct Mol Biol 2008 Dec 23;15(12):1287-92. Epub 2008 Nov 23.

Max-Planck-Institut für molekulare Physiologie, Abteilung Physikalische Biochemie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1038/nsmb.1513DOI Listing
December 2008

Biophysical analysis of the interaction of Rab6a GTPase with its effector domains.

J Biol Chem 2009 Jan 19;284(5):2628-35. Epub 2008 Nov 19.

Department of Physical Biochemistry, Max Planck Institute for Molecular Physiology, Dortmund, Germany.

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http://dx.doi.org/10.1074/jbc.M806003200DOI Listing
January 2009

The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.

Structure 2008 Sep;16(9):1313-23

Abteilung Physikalische Biochemie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S096921260800257
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http://dx.doi.org/10.1016/j.str.2008.06.008DOI Listing
September 2008

Comparison of design strategies for promotion of beta-peptide 14-helix stability in water.

Chembiochem 2008 Sep;9(14):2254-9

Max Planck Institute of Molecular Physiology, Otto-Hahn Strasse 11, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1002/cbic.200800355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551619PMC
September 2008

The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.

J Biol Chem 2008 Oct 11;283(41):27891-903. Epub 2008 Aug 11.

Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M801800200DOI Listing
October 2008

Dominant negative mutant cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat.

Retrovirology 2008 Jul 11;5:63. Epub 2008 Jul 11.

Division of Infectious Diseases, Department of Medicine, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1186/1742-4690-5-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492875PMC
July 2008

Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding.

J Mol Biol 2008 Apr 13;377(5):1334-45. Epub 2008 Feb 13.

Abteilung Physikalische Biochemie, Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360800178
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http://dx.doi.org/10.1016/j.jmb.2008.01.099DOI Listing
April 2008

Purification, crystallization and preliminary structural characterization of the N-terminal region of the human formin-homology protein FHOD1.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Oct 19;63(Pt 10):878-81. Epub 2007 Sep 19.

Max-Planck-Institut für Molekulare Physiologie, Abteilung Physikalische Biochemie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1107/S1744309107043400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2339718PMC
October 2007

Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb.

Proc Natl Acad Sci U S A 2007 Sep 27;104(36):14312-7. Epub 2007 Aug 27.

Department of Structural Biology, Biozentrum Basel, University of Basel, 4003 Basel, Switzerland.

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http://dx.doi.org/10.1073/pnas.0701848104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955226PMC
September 2007

Cyclin box structure of the P-TEFb subunit cyclin T1 derived from a fusion complex with EIAV tat.

J Mol Biol 2007 Jul 10;370(5):826-36. Epub 2007 May 10.

EMBL Heidelberg, Structural and Computational Biology & Developmental Biology Unit, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jmb.2007.04.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1987359PMC
July 2007

Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription.

Nucleic Acids Res 2007 6;35(6):2003-12. Epub 2007 Mar 6.

Department of Medicine, Rosalind Russell Medical Research Center, University of California at San Francisco, San Francisco, CA 94143-0703, USA.

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http://nar.oxfordjournals.org/content/35/6/2003.full-text-lo
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkm063
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http://dx.doi.org/10.1093/nar/gkm063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874611PMC
May 2007

Extracellular HIV-1 Nef increases migration of monocytes.

Exp Cell Res 2006 Nov 16;312(18):3659-68. Epub 2006 Aug 16.

Institute of Molecular Virology, GSF-National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.yexcr.2006.08.008DOI Listing
November 2006