Matthias E Lauer

Evaluation of bovine milk extracellular vesicles for the delivery of locked nucleic acid antisense oligonucleotides.

Eur J Pharm Biopharm 2021 Jan 26;158:198-210. Epub 2020 Nov 26.

Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland. Electronic address:

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January 2021

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody.

Nat Commun 2020 06 24;11(1):3196. Epub 2020 Jun 24.

Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Wagistrasse 10, 8952, Schlieren, Switzerland.

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June 2020

The Contorsbody, an antibody format for agonism: Design, structure, and function.

Authors:

Guy J Georges Stefan Dengl Alexander Bujotzek Friederike Hesse Jens A A Fischer Achim Gärtner Jörg Benz Matthias E Lauer Philippe Ringler Henning Stahlberg Friederike Plath Ulrich Brinkmann Sabine Imhof-Jung

Comput Struct Biotechnol J 2020 14;18:1210-1220. Epub 2020 May 14.

Roche Pharmaceutical Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Nonnenwald 2, 82377 Penzberg, Germany.

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May 2020

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.

Authors:

Ricardo Guerrero-Ferreira Nicholas Mi Taylor Ana-Andreea Arteni Pratibha Kumari Daniel Mona Philippe Ringler Markus Britschgi Matthias E Lauer Ali Makky Joeri Verasdonck Roland Riek Ronald Melki Beat H Meier Anja Böckmann Luc Bousset Henning Stahlberg

Elife 2019 12 9;8. Epub 2019 Dec 9.

Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of Basel, Basel, Switzerland.

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December 2019

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity.

MAbs 2019 Nov-Dec;11(8):1402-1414. Epub 2019 Sep 17.

Roche Pharma Research and Early Development (pRED), Discovery Oncology, Roche Innovation Center Zurich , Schlieren , Switzerland.

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June 2020

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.

Nat Neurosci 2019 07 24;22(7):1099-1109. Epub 2019 Jun 24.

Roche Pharma Research and Early Development, Lead Discovery, Roche Innovation Center Basel, Basel, Switzerland.

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July 2019

Highly flexible, IgG-shaped, trivalent antibodies effectively target tumor cells and induce T cell-mediated killing.

Authors:

Steffen Dickopf Matthias E Lauer Philippe Ringler Christian Spick Peter Kern Ulrich Brinkmann

Biol Chem 2019 02;400(3):343-350

Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Nonnenwald 2, D-82377 Penzberg, Germany.

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February 2019

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles.

Authors:

Paula P Navarro Christel Genoud Daniel Castaño-Díez Alexandra Graff-Meyer Amanda J Lewis Yvonne de Gier Matthias E Lauer Markus Britschgi Bernd Bohrmann Stephan Frank Jürgen Hench Gabriel Schweighauser Annemieke J M Rozemuller Wilma D J van de Berg Henning Stahlberg Sarah H Shahmoradian

Sci Rep 2018 12 21;8(1):18046. Epub 2018 Dec 21.

Department of Biology and Chemistry, Paul Scherrer Institute, Villigen, Switzerland.

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December 2018

Cryo-EM structure of alpha-synuclein fibrils.

Authors:

Ricardo Guerrero-Ferreira Nicholas Mi Taylor Daniel Mona Philippe Ringler Matthias E Lauer Roland Riek Markus Britschgi Henning Stahlberg

Elife 2018 07 3;7. Epub 2018 Jul 3.

Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, Basel, Switzerland.

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July 2018

A Miniaturized Extruder to Prototype Amorphous Solid Dispersions: Selection of Plasticizers for Hot Melt Extrusion.

Authors:

Matthias E Lauer Reto Maurer Anne T De Paepe Cordula Stillhart Laurence Jacob Rajesh James Yuki Kojima Rene Rietmann Tom Kissling Joost A van den Ende Sabine Schwarz Olaf Grassmann Susanne Page

Pharmaceutics 2018 May 19;10(2). Epub 2018 May 19.

Pharmaceutical Research and Development, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.

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May 2018

Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs.

Authors:

Friederike Plath Philippe Ringler Alexandra Graff-Meyer Henning Stahlberg Matthias E Lauer Arne C Rufer Melissa A Graewert Dmitri Svergun Gerald Gellermann Christof Finkler Jan O Stracke Atanas Koulov Volker Schnaible

MAbs 2016 07 31;8(5):928-40. Epub 2016 Mar 31.

a Analytical Development and Quality Control, Pharmaceutical Technical Development Europe, F. Hoffmann-La Roche Ltd. , Basel , Switzerland.

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July 2016

Cholesteryl ester transfer between lipoproteins does not require a ternary tunnel complex with CETP.

Authors:

Matthias E Lauer Alexandra Graff-Meyer Arne C Rufer Cyrille Maugeais Elisabeth von der Mark Hugues Matile Brigitte D'Arcy Christine Magg Philippe Ringler Shirley A Müller Sebastian Scherer Gregor Dernick Ralf Thoma Michael Hennig Eric J Niesor Henning Stahlberg

J Struct Biol 2016 May 12;194(2):191-8. Epub 2016 Feb 12.

Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of Basel, Mattenstrasse 26, CH-4058 Basel, Switzerland. Electronic address:

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May 2016