Publications by authors named "Matthias Dobbelstein"

78Publications

Correction: The integrated stress response induces R-loops and hinders replication fork progression.

Cell Death Dis 2020 Jul 31;11(7):608. Epub 2020 Jul 31.

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, 37077, Göttingen, Germany.

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July 2020

The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis.

J Clin Invest 2020 11;130(11):5765-5781

Interfaculty Institute for Biochemistry, University of Tübingen, Tübingen, Germany.

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November 2020

The integrated stress response induces R-loops and hinders replication fork progression.

Cell Death Dis 2020 07 16;11(7):538. Epub 2020 Jul 16.

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, 37077, Göttingen, Germany.

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July 2020

Mdm4 supports DNA replication in a p53-independent fashion.

Oncogene 2020 06 19;39(25):4828-4843. Epub 2020 May 19.

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, D-37077, Göttingen, Germany.

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June 2020

Mdm2: Open questions.

Cancer Sci 2020 Jul 11;111(7):2203-2211. Epub 2020 Jun 11.

Institute for Advanced Study, Princeton, NJ, USA.

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July 2020

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication.

Proc Natl Acad Sci U S A 2018 11 9;115(48):E11311-E11320. Epub 2018 Nov 9.

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences, University Medical Center Göttingen, D-37077 Göttingen, Germany;

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November 2018

CDK4 inhibition diminishes p53 activation by MDM2 antagonists.

Cell Death Dis 2018 09 11;9(9):918. Epub 2018 Sep 11.

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, D-37077, Göttingen, Germany.

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September 2018

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.

Cancer Cell 2018 08;34(2):298-314.e7

Institute of Molecular Oncology, University Medical Center Göttingen, Göttingen 37077, Germany; Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address:

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August 2018

Inhibition of MAPKAPK2/MK2 facilitates DNA replication upon cancer cell treatment with gemcitabine but not cisplatin.

Cancer Lett 2018 08 25;428:45-54. Epub 2018 Apr 25.

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, D-37077, Göttingen, Germany. Electronic address:

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August 2018

Mdm2 as a chromatin modifier.

J Mol Cell Biol 2017 02;9(1):74-80

Institute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, Germany.

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February 2017

Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.

Cell Death Differ 2017 02 11;24(2):300-316. Epub 2016 Nov 11.

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen D-37077, Germany.

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February 2017

p53 Activity Results in DNA Replication Fork Processivity.

Cell Rep 2016 11;17(7):1845-1857

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, 37077 Göttingen, Germany. Electronic address:

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November 2016

Fortifying p53 - beyond Mdm2 inhibitors.

Aging (Albany NY) 2016 09;8(9):1836-1837

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, D-37077 Göttingen, Germany.

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September 2016

Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity.

Oncotarget 2016 May;7(22):31623-38

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen, Germany.

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May 2016

LTR12 promoter activation in a broad range of human tumor cells by HDAC inhibition.

Oncotarget 2016 Jun;7(23):33484-97

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center, University of Göttingen, Göttingen, Germany.

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June 2016

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.

Mol Cell 2016 Jan 31;61(1):68-83. Epub 2015 Dec 31.

Institute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, Germany. Electronic address:

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January 2016