Matthias Bros

Matthias Bros

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Matthias Bros

Matthias Bros

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The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery.

Front Immunol 2018 2;9:1760. Epub 2018 Aug 2.

Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.01760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082927PMC
October 2019

The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4 T Cells.

J Immunol Res 2019 14;2019:4726532. Epub 2019 Aug 14.

Department of Pharmacology, University Medical Center of Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1155/2019/4726532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714327PMC
August 2019

A general concept for the introduction of hydroxamic acids into polymers.

Chem Sci 2019 Aug 17;10(29):7009-7022. Epub 2019 Jun 17.

Institute of Organic Chemistry , Johannes Gutenberg University , Duesbergweg 10-14 , 55128 Mainz , Germany . Email:

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http://dx.doi.org/10.1039/c9sc02557jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676332PMC
August 2019

RhoA as a Key Regulator of Innate and Adaptive Immunity.

Cells 2019 07 17;8(7). Epub 2019 Jul 17.

University Medical Center Mainz, Department of Dermatology, Langenbeckstraße 1, 55131 Mainz, Germany.

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http://dx.doi.org/10.3390/cells8070733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678964PMC
July 2019

HPMA-Based Nanocarriers for Effective Immune System Stimulation.

Macromol Biosci 2019 06 10;19(6):e1800481. Epub 2019 Apr 10.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, ,55128, Mainz, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.2018004
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http://dx.doi.org/10.1002/mabi.201800481DOI Listing
June 2019

CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis.

Front Immunol 2019 4;10:123. Epub 2019 Feb 4.

Department of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369709PMC
February 2019

Delivering all in one: Antigen-nanocapsule loaded with dual adjuvant yields superadditive effects by DC-directed T cell stimulation.

J Control Release 2018 11 13;289:23-34. Epub 2018 Sep 13.

Dermatology Clinic, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany; Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.09.008DOI Listing
November 2018

DNA Vaccines-How Far From Clinical Use?

Int J Mol Sci 2018 Nov 15;19(11). Epub 2018 Nov 15.

Department of Dermatology, University Medical Center, 55131 Mainz, Germany.

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http://www.mdpi.com/1422-0067/19/11/3605
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http://dx.doi.org/10.3390/ijms19113605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274812PMC
November 2018

Interleukin-1 Beta-A Friend or Foe in Malignancies?

Int J Mol Sci 2018 Jul 24;19(8). Epub 2018 Jul 24.

Department of Dermatology, University Medical Center, 55131 Mainz, Germany.

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http://dx.doi.org/10.3390/ijms19082155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121377PMC
July 2018

BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells.

Oncotarget 2018 Jun 19;9(47):28294-28308. Epub 2018 Jun 19.

Department of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://www.oncotarget.com/fulltext/25511
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http://dx.doi.org/10.18632/oncotarget.25511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033361PMC
June 2018

Inducible knockdown of procollagen I protects mice from liver fibrosis and leads to dysregulated matrix genes and attenuated inflammation.

Matrix Biol 2018 03 6;66:34-49. Epub 2017 Nov 6.

Institute of Translational Immunology, Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2017.11.002DOI Listing
March 2018

Role of Protein Kinase C and Nox2-Derived Reactive Oxygen Species Formation in the Activation and Maturation of Dendritic Cells by Phorbol Ester and Lipopolysaccharide.

Oxid Med Cell Longev 2017 28;2017:4157213. Epub 2017 Mar 28.

Center for Cardiology/Cardiology 1, Laboratory of Molecular Cardiology, Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1155/2017/4157213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387830PMC
February 2018

Surface Modification of Polysaccharide-Based Nanoparticles with PEG and Dextran and the Effects on Immune Cell Binding and Stimulatory Characteristics.

Mol Pharm 2017 12 8;14(12):4403-4416. Epub 2017 Nov 8.

Department of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz , Staudingerweg 5, 55128 Mainz, Germany.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00507DOI Listing
December 2017

PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes.

Macromol Biosci 2017 10 31;17(10). Epub 2017 Jul 31.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.

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http://dx.doi.org/10.1002/mabi.201700061DOI Listing
October 2017

Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines.

J Control Release 2017 07 10;258:146-160. Epub 2017 May 10.

Institute of Organic Chemistry, Johannes Gutenberg University, Duesbergweg 10-14, 55099 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.05.012DOI Listing
July 2017

Inactivation of the KSRP gene modifies collagen antibody induced arthritis.

Mol Immunol 2017 07 13;87:207-216. Epub 2017 May 13.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01615890173011
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http://dx.doi.org/10.1016/j.molimm.2017.05.003DOI Listing
July 2017

The Influence of Block Ionomer Microstructure on Polyplex Properties: Can Simulations Help to Understand Differences in Transfection Efficiency?

Small 2017 05 24;13(17). Epub 2017 Feb 24.

Institute of Organic Chemistry, Johannes Gutenberg University, Duesbergweg 10-14, 55099, Mainz, Germany.

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http://doi.wiley.com/10.1002/smll.201603694
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http://dx.doi.org/10.1002/smll.201603694DOI Listing
May 2017

Tumor-derived immuno-modulators induce overlapping pro-tolerogenic gene expression signatures in human dendritic cells.

Hum Immunol 2016 Dec 2;77(12):1223-1231. Epub 2016 Sep 2.

Department of Dermatology, Johannes Gutenberg-University, Mainz, Obere Zahlbacher Str. 63, D-55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2016.08.014DOI Listing
December 2016

No role of IFITM3 in brain tumor formation in vivo.

Oncotarget 2016 12;7(52):86388-86405

Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University, School of Medicine, Mainz, Germany.

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http://dx.doi.org/10.18632/oncotarget.13199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349921PMC
December 2016

Targeting cells of the immune system: mannosylated HPMA-LMA block-copolymer micelles for targeting of dendritic cells.

Nanomedicine (Lond) 2016 Oct 15;11(20):2679-2697. Epub 2016 Sep 15.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany.

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http://dx.doi.org/10.2217/nnm-2016-0167DOI Listing
October 2016

Functionalization of Active Ester-Based Polymersomes for Enhanced Cell Uptake and Stimuli-Responsive Cargo Release.

Biomacromolecules 2016 10 27;17(10):3305-3317. Epub 2016 Sep 27.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz , Duesbergweg 10-14, 55128 Mainz, Germany.

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http://dx.doi.org/10.1021/acs.biomac.6b01049DOI Listing
October 2016

Oxidation-Responsive and "Clickable" Poly(ethylene glycol) via Copolymerization of 2-(Methylthio)ethyl Glycidyl Ether.

J Am Chem Soc 2016 07 19;138(29):9212-23. Epub 2016 Jul 19.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz , Duesbergweg 10-14, 55128 Mainz, Germany.

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http://dx.doi.org/10.1021/jacs.6b04548DOI Listing
July 2016

The phosphodiesterase 4 inhibitor roflumilast augments the Th17-promoting capability of dendritic cells by enhancing IL-23 production, and impairs their T cell stimulatory activity due to elevated IL-10.

Int Immunopharmacol 2016 Jun 16;35:174-184. Epub 2016 Apr 16.

Department of Dermatology, Johannes Gutenberg-University, Mainz, Obere Zahlbacher Str. 63, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1016/j.intimp.2016.03.025DOI Listing
June 2016

Inhibitors of β-catenin affect the immuno-phenotype and functions of dendritic cells in an inhibitor-specific manner.

Int Immunopharmacol 2016 Mar 26;32:118-124. Epub 2016 Jan 26.

University Medical Center Mainz, Department of Dermatology, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2016.01.018DOI Listing
March 2016

Bioreducible Poly-L-Lysine-Poly[HPMA] Block Copolymers Obtained by RAFT-Polymerization as Efficient Polyplex-Transfection Reagents.

Macromol Biosci 2016 Jan 29;16(1):106-20. Epub 2015 Jul 29.

Institute of Organic Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55128, Mainz, Germany.

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http://dx.doi.org/10.1002/mabi.201500212DOI Listing
January 2016

Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and on a promoter-independent mechanism.

Virology 2015 Nov 9;485:481-91. Epub 2015 Sep 9.

Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.08.025DOI Listing
November 2015

Cationic Copolymerization of 3,3-Bis(hydroxymethyl)oxetane and Glycidol: Biocompatible Hyperbranched Polyether Polyols with High Content of Primary Hydroxyl Groups.

Biomacromolecules 2015 Oct 23;16(10):3297-307. Epub 2015 Sep 23.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz , Duesbergweg 10-14, D-55128 Mainz, Germany.

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http://pubs.acs.org/doi/10.1021/acs.biomac.5b00951
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http://dx.doi.org/10.1021/acs.biomac.5b00951DOI Listing
October 2015

Poly-L-Lysine-Poly[HPMA] Block Copolymers Obtained by RAFT Polymerization as Polyplex-Transfection Reagents with Minimal Toxicity.

Macromol Biosci 2015 Aug 13;15(8):1159-73. Epub 2015 May 13.

Institute of Organic Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55128 Mainz, Germany.

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http://dx.doi.org/10.1002/mabi.201500022DOI Listing
August 2015

Directed interactions of block copolypept(o)ides with mannose-binding receptors: PeptoMicelles targeted to cells of the innate immune system.

Macromol Biosci 2015 Jan 5;15(1):63-73. Epub 2015 Jan 5.

Institute of Organic Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55099, Mainz, Germany.

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http://dx.doi.org/10.1002/mabi.201400417DOI Listing
January 2015

Introducing PeptoPlexes: polylysine-block-polysarcosine based polyplexes for transfection of HEK 293T cells.

Macromol Biosci 2014 Oct 18;14(10):1380-95. Epub 2014 Jun 18.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, D-55128, Mainz, Germany.

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http://dx.doi.org/10.1002/mabi.201400167DOI Listing
October 2014

Toward anticancer immunotherapeutics: well-defined polymer-antibody conjugates for selective dendritic cell targeting.

Macromol Biosci 2014 Oct 30;14(10):1444-57. Epub 2014 Jun 30.

Institute of Organic Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55128, Mainz, Germany.

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http://dx.doi.org/10.1002/mabi.201400190DOI Listing
October 2014

Selective uptake of cylindrical poly(2-oxazoline) brush-antiDEC205 antibody-OVA antigen conjugates into DEC-positive dendritic cells and subsequent T-cell activation.

Chemistry 2014 Sep 8;20(39):12405-10. Epub 2014 Aug 8.

Institute for Physical Chemistry, University of Mainz, Jakob-Welder Weg 11, 55099 Mainz (Germany); Graduate School Materials Science, Staudinger Weg 9, 55128 Mainz (Germany).

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http://dx.doi.org/10.1002/chem.201403942DOI Listing
September 2014

The Wnt/β-catenin pathway attenuates experimental allergic airway disease.

J Immunol 2014 Jul 13;193(2):485-95. Epub 2014 Jun 13.

Department of Pulmonology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

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http://dx.doi.org/10.4049/jimmunol.1400013DOI Listing
July 2014

Dendritic cell motility and T cell activation requires regulation of Rho-cofilin signaling by the Rho-GTPase activating protein myosin IXb.

J Immunol 2014 Apr 19;192(8):3559-68. Epub 2014 Mar 19.

Institute of Molecular Cell Biology, Westfalian Wilhelms University-Münster, Münster 48149, Germany.

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http://dx.doi.org/10.4049/jimmunol.1300695DOI Listing
April 2014

Polypeptoid-block-polypeptide copolymers: synthesis, characterization, and application of amphiphilic block Copolypept(o)ides in drug formulations and miniemulsion techniques.

Biomacromolecules 2014 Feb 3;15(2):548-57. Epub 2014 Jan 3.

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz , Duesbergweg 10-14, 55128 Mainz, Germany.

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http://dx.doi.org/10.1021/bm401542zDOI Listing
February 2014

Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB.

J Exp Clin Cancer Res 2014 Feb 13;33:16. Epub 2014 Feb 13.

Department of Dermatology, Medical Center of the Johannes Gutenberg-University, Mainz, Germany.

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http://dx.doi.org/10.1186/1756-9966-33-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926270PMC
February 2014

The chemotherapeutic agent topotecan differentially modulates the phenotype and function of dendritic cells.

Cancer Immunol Immunother 2013 Aug 11;62(8):1315-26. Epub 2013 May 11.

Department of Dermatology, Clinical Research Unit Allergology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacher-Str. 63, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00262-013-1431-9DOI Listing
August 2013

Differential gene expression analysis identifies murine Cacnb3 as strongly upregulated in distinct dendritic cell populations upon stimulation.

Gene 2011 Feb 30;472(1-2):18-27. Epub 2010 Oct 30.

Department of Dermatology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.gene.2010.10.013DOI Listing
February 2011

Mutated cylindromatosis gene affects the functional state of dendritic cells.

Eur J Immunol 2010 Oct;40(10):2848-57

Clinical Research Unit Allergology, Department of Dermatology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.

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http://dx.doi.org/10.1002/eji.200939285DOI Listing
October 2010

The RNA binding protein tristetraprolin influences the activation state of murine dendritic cells.

Mol Immunol 2010 Feb 28;47(5):1161-70. Epub 2009 Nov 28.

Department of Dermatology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.molimm.2009.11.002DOI Listing
February 2010

A novel plasmid DNA electroporation method allows transfection of murine DC.

J Immunol Methods 2009 Mar 30;343(1):13-20. Epub 2009 Jan 30.

Clinical Research Unit Allergology, Department of Dermatology, Johannes Gutenberg-University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.jim.2009.01.006DOI Listing
March 2009

The untranslated region of exon 2 of the human neuronal nitric oxide synthase (NOS1) gene exerts regulatory activity.

Gene 2007 Dec 5;405(1-2):36-46. Epub 2007 Sep 5.

Department of Dermatology, Johannes Gutenberg University, Mainz, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S037811190700459
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http://dx.doi.org/10.1016/j.gene.2007.08.018DOI Listing
December 2007

Formalin-fixed Staphylococcus aureus particles prevent allergic sensitization in a murine model of type I allergy.

Int Arch Allergy Immunol 2007 15;144(3):183-96. Epub 2007 Jun 15.

Clinical Research Unit Allergology, Department of Dermatology, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1159/000103991DOI Listing
November 2007

A newly established murine immature dendritic cell line can be differentiated into a mature state, but exerts tolerogenic function upon maturation in the presence of glucocorticoid.

Blood 2007 May 5;109(9):3820-9. Epub 2007 Jan 5.

Clinical Research Unit Allergology, Department of Dermatology, Johannes Gutenberg-University, Obere Zahlbacher Strasse 63, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1182/blood-2006-07-035576DOI Listing
May 2007

Induction of regulatory T cells by leflunomide in a murine model of contact allergen sensitivity.

J Invest Dermatol 2006 Jul 16;126(7):1524-33. Epub 2006 Mar 16.

Clinical Research Unit Allergology, Department of Dermatology, Johannes Gutenberg-University, Mainz, Germany.

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http://dx.doi.org/10.1038/sj.jid.5700228DOI Listing
July 2006

The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer.

J Immunol 2003 Aug;171(4):1825-34

Clinical Research Unit Allergology, Department of Dermatology, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.4049/jimmunol.171.4.1825DOI Listing
August 2003