Matthew W State

Matthew W State

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Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity.

Neuron 2018 11 11;100(4):831-845.e7. Epub 2018 Oct 11.

Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273183082
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http://dx.doi.org/10.1016/j.neuron.2018.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250594PMC
November 2018

Lost in Translation: Traversing the Complex Path from Genomics to Therapeutics in Autism Spectrum Disorder.

Neuron 2018 10;100(2):406-423

Department of Psychiatry, Langley Porter Psychiatric Institute, Quantitative Biosciences Institute, Institute for Human Genetics, and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273183090
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http://dx.doi.org/10.1016/j.neuron.2018.10.015DOI Listing
October 2018

Tourette disorder and other tic disorders.

Handb Clin Neurol 2018 ;147:343-354

Child Study Center, Yale School of Medicine, New Haven, CT, United States; Department of Psychiatry, Yale University, New Haven, CT, United States. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-63233-3.00023-3DOI Listing
July 2018

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Cell 2018 07;174(3):505-520

Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247911PMC
July 2018

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

Authors:
Sébastien Küry Geeske M van Woerden Thomas Besnard Martina Proietti Onori Xénia Latypova Meghan C Towne Megan T Cho Trine E Prescott Melissa A Ploeg Stephan Sanders Holly A F Stessman Aurora Pujol Ben Distel Laurie A Robak Jonathan A Bernstein Anne-Sophie Denommé-Pichon Gaëtan Lesca Elizabeth A Sellars Jonathan Berg Wilfrid Carré Øyvind Løvold Busk Bregje W M van Bon Jeff L Waugh Matthew Deardorff George E Hoganson Katherine B Bosanko Diana S Johnson Tabib Dabir Øystein Lunde Holla Ajoy Sarkar Kristian Tveten Julitta de Bellescize Geir J Braathen Paulien A Terhal Dorothy K Grange Arie van Haeringen Christina Lam Ghayda Mirzaa Jennifer Burton Elizabeth J Bhoj Jessica Douglas Avni B Santani Addie I Nesbitt Katherine L Helbig Marisa V Andrews Amber Begtrup Sha Tang Koen L I van Gassen Jane Juusola Kimberly Foss Gregory M Enns Ute Moog Katrin Hinderhofer Nagarajan Paramasivam Sharyn Lincoln Brandon H Kusako Pierre Lindenbaum Eric Charpentier Catherine B Nowak Elouan Cherot Thomas Simonet Claudia A L Ruivenkamp Sihoun Hahn Catherine A Brownstein Fan Xia Sébastien Schmitt Wallid Deb Dominique Bonneau Mathilde Nizon Delphine Quinquis Jamel Chelly Gabrielle Rudolf Damien Sanlaville Philippe Parent Brigitte Gilbert-Dussardier Annick Toutain Vernon R Sutton Jenny Thies Lisenka E L M Peart-Vissers Pierre Boisseau Marie Vincent Andreas M Grabrucker Christèle Dubourg Wen-Hann Tan Nienke E Verbeek Martin Granzow Gijs W E Santen Jay Shendure Bertrand Isidor Laurent Pasquier Richard Redon Yaping Yang Matthew W State Tjitske Kleefstra Benjamin Cogné Slavé Petrovski Kyle Retterer Evan E Eichler Jill A Rosenfeld Pankaj B Agrawal Stéphane Bézieau Sylvie Odent Ype Elgersma Sandra Mercier

Am J Hum Genet 2017 Nov;101(5):768-788

CHU Nantes, Service de Génétique Médicale, 9 quai Moncousu, 44093 Nantes Cedex 1, France.

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http://dx.doi.org/10.1016/j.ajhg.2017.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673671PMC
November 2017

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Biol Psychiatry 2016 07;80(2):84-86

Department of Psychiatry, University Neuropsychiatric Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.biopsych.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150945PMC
July 2016

The PsychENCODE project.

Nat Neurosci 2015 Dec;18(12):1707-12

Yale University, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nn.4156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675669PMC
December 2015

Gene hunting in autism spectrum disorder: on the path to precision medicine.

Lancet Neurol 2015 Nov 16;14(11):1109-20. Epub 2015 Apr 16.

Department of Psychiatry, Langley Porter Psychiatric Institute, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/S1474-4422(15)00044-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694565PMC
November 2015

Loss of δ-catenin function in severe autism.

Nature 2015 Apr 25;520(7545):51-6. Epub 2015 Mar 25.

1] Center for Complex Disease Genomics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] National Institute of Mental Health (NIMH) Autism Centers of Excellence (ACE) Genetics Consortium at the University of California, Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/nature14186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383723PMC
April 2015

The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment.

Nat Commun 2015 Mar 10;6:6404. Epub 2015 Mar 10.

1] Department of Genetics, Yale School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA [2] Kavli Institute for Neuroscience, Yale School of Medicine, PO Box 208001, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1038/ncomms7404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355952PMC
March 2015

The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods.

Eur Child Adolesc Psychiatry 2015 Feb 26;24(2):141-51. Epub 2014 Apr 26.

Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1007/s00787-014-0543-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209328PMC
February 2015

Autism spectrum disorders: from genes to neurobiology.

Curr Opin Neurobiol 2015 Feb 28;30:92-9. Epub 2014 Nov 28.

Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158, United States; Institute for Human Genetics, University of California, San Francisco, San Francisco, California 94143, United States. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2014.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586254PMC
February 2015

Leveraging genetics and genomics to define the causes of mental illness.

Biol Psychiatry 2015 Jan;77(1):3-5

UCLA Center for Autism Research and Treatment, University of California, Los Angeles, Los Angeles, California.. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2014.11.003DOI Listing
January 2015

No evidence for association of autism with rare heterozygous point mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Proteins or Contactins.

PLoS Genet 2015 Jan 26;11(1):e1004852. Epub 2015 Jan 26.

Yale University Department of Genetics, New Haven, Connecticut, United States of America; Yale University Child Study Center, New Haven, Connecticut, United States of America; University of California, San Francisco, Department of Psychiatry, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306541PMC
January 2015

Synaptic, transcriptional and chromatin genes disrupted in autism.

The Inheritance of Tourette Disorder: A review.

J Obsessive Compuls Relat Disord 2014 Oct;3(4):380-385

Department of Psychiatry, Harvard Medical School, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114 ; Department of Neurology, Harvard Medical School, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114.

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http://dx.doi.org/10.1016/j.jocrd.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260404PMC
October 2014

The developmental transcriptome of the human brain: implications for neurodevelopmental disorders.

Curr Opin Neurol 2014 Apr;27(2):149-56

aDepartment of Neurobiology and Kavli Institute for Neuroscience bDepartment of Genetics, Yale School of Medicine, New Haven, Connecticut, cDepartment of Psychiatry, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1097/WCO.0000000000000069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038354PMC
April 2014

Recent challenges to the psychiatric diagnostic nosology: a focus on the genetics and genomics of neurodevelopmental disorders.

Int J Epidemiol 2014 Apr 11;43(2):465-75. Epub 2014 Mar 11.

Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA, Department of Psychiatry, Yonsei University College of Medicine, Seoul, South Korea and Department of Psychiatry, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1093/ije/dyu037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047292PMC
April 2014

Psychiatric disorders: diagnosis to therapy.

Cell 2014 Mar;157(1):201-14

Department of Psychiatry and Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.02.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104191PMC
March 2014

Intellectual disability is associated with increased runs of homozygosity in simplex autism.

Am J Hum Genet 2013 Jul 3;93(1):103-9. Epub 2013 Jul 3.

Laboratory for Molecular Medicine, Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, 70 Ship Street, Providence, RI 02912, USA.

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http://dx.doi.org/10.1016/j.ajhg.2013.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710760PMC
July 2013

Recent developments in the genetics of autism spectrum disorders.

Curr Opin Genet Dev 2013 Jun 25;23(3):310-5. Epub 2013 Mar 25.

Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, United States.

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http://dx.doi.org/10.1016/j.gde.2013.02.003DOI Listing
June 2013

The autism sequencing consortium: large-scale, high-throughput sequencing in autism spectrum disorders.

Neuron 2012 Dec;76(6):1052-6

Seaver Autism Center, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences, and the Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863639PMC
December 2012

Neuroscience. The emerging biology of autism spectrum disorders.

Science 2012 Sep;337(6100):1301-3

Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1126/science.1224989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657753PMC
September 2012

A complex chromosomal rearrangement involving chromosomes 2, 5, and X in autism spectrum disorder.

Am J Med Genet B Neuropsychiatr Genet 2012 Jul 16;159B(5):529-36. Epub 2012 May 16.

Departamento de Genética e Biologia Evolutiva, Centro de Estudos do Genoma Humano, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1002/ajmg.b.32059DOI Listing
July 2012

The conundrums of understanding genetic risks for autism spectrum disorders.

Nat Neurosci 2011 Oct 30;14(12):1499-506. Epub 2011 Oct 30.

Program on Neurogenetics, Departments of Child Psychiatry, Psychiatry and Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nn.2924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940335PMC
October 2011

The genetics of Tourette disorder.

Authors:
Matthew W State

Curr Opin Genet Dev 2011 Jun 27;21(3):302-9. Epub 2011 Jan 27.

Department of Child Psychiatry, Yale University School of Medicine, New Haven, CT 06520, United States.

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http://dx.doi.org/10.1016/j.gde.2011.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102152PMC
June 2011

Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.

Neuron 2011 Jun;70(5):863-85

Program on Neurogenetics, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939065PMC
June 2011

High levels of histidine decarboxylase in the striatum of mice and rats.

Neurosci Lett 2011 May 1;495(2):110-4. Epub 2011 Apr 1.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.neulet.2011.03.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081964PMC
May 2011

The erosion of phenotypic specificity in psychiatric genetics: emerging lessons from CNTNAP2.

Authors:
Matthew W State

Biol Psychiatry 2011 May;69(9):816-7

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1016/j.biopsych.2011.03.021DOI Listing
May 2011

The genetics of child psychiatric disorders: focus on autism and Tourette syndrome.

Authors:
Matthew W State

Neuron 2010 Oct;68(2):254-69

Department of Child Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089662731000828
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http://dx.doi.org/10.1016/j.neuron.2010.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292208PMC
October 2010

Progress in cytogenetics: implications for child psychopathology.

J Am Acad Child Adolesc Psychiatry 2010 Aug 26;49(8):736-51; quiz 856-7. Epub 2010 May 26.

Program on Neurogenetics, Child Study Center, and Yale University School of Medicine, New Haven, CT 06520-7900, USA.

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http://dx.doi.org/10.1016/j.jaac.2010.03.016DOI Listing
August 2010

Novel VLDLR microdeletion identified in two Turkish siblings with pachygyria and pontocerebellar atrophy.

Neurogenetics 2010 Jul 15;11(3):319-25. Epub 2010 Jan 15.

Department of Neurosurgery, Neurobiology, Program on Neurogenetics Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1007/s10048-009-0232-yDOI Listing
July 2010

Another piece of the autism puzzle.

Authors:
Matthew W State

Nat Genet 2010 Jun;42(6):478-9

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http://dx.doi.org/10.1038/ng0610-478DOI Listing
June 2010

The genetics of autism: key issues, recent findings, and clinical implications.

Psychiatr Clin North Am 2010 Mar;33(1):83-105

Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1016/j.psc.2009.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841771PMC
March 2010

Haplotype evolution of SLITRK1, a candidate gene for Gilles de la Tourette syndrome.

Am J Med Genet B Neuropsychiatr Genet 2008 Jun;147B(4):463-6

Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA.

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http://dx.doi.org/10.1002/ajmg.b.30641DOI Listing
June 2008

Autism genetics: strategies, challenges, and opportunities.

Autism Res 2008 Feb;1(1):4-17

Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1002/aur.3DOI Listing
February 2008

Recent advances in the genetics of autism.

Biol Psychiatry 2007 Feb 25;61(4):429-37. Epub 2006 Sep 25.

Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1016/j.biopsych.2006.06.020DOI Listing
February 2007

A surprising METamorphosis: autism genetics finds a common functional variant.

Authors:
Matthew W State

Proc Natl Acad Sci U S A 2006 Nov 30;103(45):16621-2. Epub 2006 Oct 30.

Program on Neurogenetics, Departments of Child Psychiatry and Genetics, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1073/pnas.0608027103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636504PMC
November 2006

[Autism: genetics].

Braz J Psychiatry 2006 May 12;28 Suppl 1:S29-38. Epub 2006 Jun 12.

Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org//S1516-44462006000500005DOI Listing
May 2006

A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y.

J Clin Invest 2006 Feb;116(2):430-5

Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1172/JCI25618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1359045PMC
February 2006

Syndromic patent ductus arteriosus: evidence for haploinsufficient TFAP2B mutations and identification of a linked sleep disorder.

Proc Natl Acad Sci U S A 2005 Feb 31;102(8):2975-9. Epub 2005 Jan 31.

Department of Medicine, Howard Hughes Medical Institute and Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1073/pnas.0409852102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549488PMC
February 2005

Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22.

Am J Med Genet A 2004 Sep;130A(1):37-9

Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/ajmg.a.30066DOI Listing
September 2004