Matthew Traylor

Matthew Traylor

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Matthew Traylor

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Do Cerebral Small Vessel Disease and Multiple Sclerosis Share Common Mechanisms of White Matter Injury?

Stroke 2019 Aug 21;50(8):1968-1972. Epub 2019 Jun 21.

From the Department of Clinical Neurosciences (R.B.B., M.T., S.S., H.S.M.), University of Cambridge, United Kingdom.

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http://dx.doi.org/10.1161/STROKEAHA.118.023649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661245PMC
August 2019

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2019 Jul;51(7):1192-1193

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-019-0449-0DOI Listing
July 2019

ukbtools: An R package to manage and query UK Biobank data.

PLoS One 2019 31;14(5):e0214311. Epub 2019 May 31.

Department of Medical & Molecular Genetics, King's College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214311PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544205PMC
May 2019

Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.

PLoS One 2018 1;13(11):e0206554. Epub 2018 Nov 1.

University of Maryland School of Medicine, Baltimore, MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206554PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211695PMC
April 2019

Homocysteine and small vessel stroke: A mendelian randomization analysis.

Ann Neurol 2019 Apr 11;85(4):495-501. Epub 2019 Mar 11.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/ana.25440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594149PMC
April 2019

Encephalopathy in a Large Cohort of British Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Patients.

Stroke 2019 Feb;50(2):283-290

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (A.M.D., R.Y.Y.T., J.T., M.T., H.S.M.).

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http://dx.doi.org/10.1161/STROKEAHA.118.023661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358181PMC
February 2019

Genetic variation in is associated with white matter hyperintensities (n = 11,226).

Neurology 2019 02 18;92(8):e749-e757. Epub 2019 Jan 18.

From the Department of Clinical Neurosciences, Stroke Research Group (M.T., D.J.T., I.D.C., D.M.L.F., A.O.O., L.R.-J., H.S.M.), University of Cambridge, UK; Department of Cerebrovascular Diseases (G.B.), Fondazione IRCCS Istituto Neurologico "Carlo Besta," Milan, Italy; Institute for Stroke and Dementia Research (M.D.), Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich; German Center for Neurodegenerative Diseases (DZNE) and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany; Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND) (R.L.), KU Leuven-University of Leuven; Department of Neurology (R.L.), University Hospitals Leuven; Laboratory of Neurobiology (R.L.), VIB Center for Brain and Disease Research, Leuven, Belgium; Center for Human Genetic Research (J.R.) and Division of Neurocritical Care and Emergency Neurology (J.R.) and J. Philip Kistler Stroke Research Center (J.R., N.S.R.), Department of Neurology, Massachusetts General Hospital, Boston; Nuffield Department of Clinical Neurosciences (Clinical Neurology), Stroke Prevention Research Unit (P.M.R.), University of Oxford; Centre for Clinical Brain Sciences and Institute for Genetics and Molecular Medicine (C.L.M.S.), University of Edinburgh, UK; Stroke Division, Florey Institute of Neuroscience and Mental Health (V.T.), University of Melbourne; and Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396967PMC
February 2019

Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.

Neurology 2019 Feb 25;92(9):e944-e950. Epub 2019 Jan 25.

From the Unit of Cardiovascular and Nutritional Epidemiology (S.C.L.), Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Stroke Research Group, Department of Clinical Neurosciences (M.T., H.S.M.), MRC Biostatistics Unit (S.B.), and Department of Public Health and Primary Care (S.B.), University of Cambridge, UK; Department of Cerebrovascular Diseases (G.B.B.), Fondazione IRCCS-Istituto Neurologico Carlo Besta, Milano, Italy; Department of Clinical Pathology and Genetics (C.J.), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg; and Department of Surgical Sciences (K.M.), Uppsala University, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000007001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404465PMC
February 2019

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke.

Circulation 2019 Jan;139(2):256-268

Institute for Stroke and Dementia Research, University Hospital of Ludwig-Maximilians-University, Munich, Germany (M.K.G., J.B., R.M., M.D.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035905DOI Listing
January 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

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http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Genome-wide meta-analysis identifies 3 novel loci associated with stroke.

Ann Neurol 2018 12 30;84(6):934-939. Epub 2018 Nov 30.

Institute for Stroke and Dementia Research, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

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http://doi.wiley.com/10.1002/ana.25369
Publisher Site
http://dx.doi.org/10.1002/ana.25369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644297PMC
December 2018

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Authors:
Nora Franceschini Claudia Giambartolomei Paul S de Vries Chris Finan Joshua C Bis Rachael P Huntley Ruth C Lovering Salman M Tajuddin Thomas W Winkler Misa Graff Maryam Kavousi Caroline Dale Albert V Smith Edith Hofer Elisabeth M van Leeuwen Ilja M Nolte Lingyi Lu Markus Scholz Muralidharan Sargurupremraj Niina Pitkänen Oscar Franzén Peter K Joshi Raymond Noordam Riccardo E Marioni Shih-Jen Hwang Solomon K Musani Ulf Schminke Walter Palmas Aaron Isaacs Adolfo Correa Alan B Zonderman Albert Hofman Alexander Teumer Amanda J Cox André G Uitterlinden Andrew Wong Andries J Smit Anne B Newman Annie Britton Arno Ruusalepp Bengt Sennblad Bo Hedblad Bogdan Pasaniuc Brenda W Penninx Carl D Langefeld Christina L Wassel Christophe Tzourio Cristiano Fava Damiano Baldassarre Daniel H O'Leary Daniel Teupser Diana Kuh Elena Tremoli Elmo Mannarino Enzo Grossi Eric Boerwinkle Eric E Schadt Erik Ingelsson Fabrizio Veglia Fernando Rivadeneira Frank Beutner Ganesh Chauhan Gerardo Heiss Harold Snieder Harry Campbell Henry Völzke Hugh S Markus Ian J Deary J Wouter Jukema Jacqueline de Graaf Jacqueline Price Janne Pott Jemma C Hopewell Jingjing Liang Joachim Thiery Jorgen Engmann Karl Gertow Kenneth Rice Kent D Taylor Klodian Dhana Lambertus A L M Kiemeney Lars Lind Laura M Raffield Lenore J Launer Lesca M Holdt Marcus Dörr Martin Dichgans Matthew Traylor Matthias Sitzer Meena Kumari Mika Kivimaki Mike A Nalls Olle Melander Olli Raitakari Oscar H Franco Oscar L Rueda-Ochoa Panos Roussos Peter H Whincup Philippe Amouyel Philippe Giral Pramod Anugu Quenna Wong Rainer Malik Rainer Rauramaa Ralph Burkhardt Rebecca Hardy Reinhold Schmidt Renée de Mutsert Richard W Morris Rona J Strawbridge S Goya Wannamethee Sara Hägg Sonia Shah Stela McLachlan Stella Trompet Sudha Seshadri Sudhir Kurl Susan R Heckbert Susan Ring Tamara B Harris Terho Lehtimäki Tessel E Galesloot Tina Shah Ulf de Faire Vincent Plagnol Wayne D Rosamond Wendy Post Xiaofeng Zhu Xiaoling Zhang Xiuqing Guo Yasaman Saba Abbas Dehghan Adrie Seldenrijk Alanna C Morrison Anders Hamsten Bruce M Psaty Cornelia M van Duijn Deborah A Lawlor Dennis O Mook-Kanamori Donald W Bowden Helena Schmidt James F Wilson James G Wilson Jerome I Rotter Joanna M Wardlaw John Deanfield Julian Halcox Leo-Pekka Lyytikäinen Markus Loeffler Michele K Evans Stéphanie Debette Steve E Humphries Uwe Völker Vilmundur Gudnason Aroon D Hingorani Johan L M Björkegren Juan P Casas Christopher J O'Donnell

Nat Commun 2018 12 3;9(1):5141. Epub 2018 Dec 3.

Intramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-07340-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277418PMC
December 2018

Serum 25-Hydroxyvitamin D Concentrations and Ischemic Stroke and Its Subtypes.

Stroke 2018 Oct;49(10):2508-2511

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., H.S.M.).

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http://dx.doi.org/10.1161/STROKEAHA.118.022242DOI Listing
October 2018

Circulating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.

Nutrients 2018 Oct 25;10(11). Epub 2018 Oct 25.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB20QQ, UK.

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http://www.mdpi.com/2072-6643/10/11/1575
Publisher Site
http://dx.doi.org/10.3390/nu10111575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266991PMC
October 2018

Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer's Disease: A Mendelian Randomization Study.

Nutrients 2018 Sep 6;10(9). Epub 2018 Sep 6.

Department of Surgical Sciences, Uppsala University, 75105 Uppsala, Sweden.

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http://dx.doi.org/10.3390/nu10091243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165184PMC
September 2018

Protein Engineering on Human Recombinant Follistatin: Enhancing Pharmacokinetic Characteristics for Therapeutic Application.

J Pharmacol Exp Ther 2018 08 11;366(2):291-302. Epub 2018 May 11.

Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.118.24
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http://dx.doi.org/10.1124/jpet.118.248195DOI Listing
August 2018

Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease: A Mendelian Randomization Analysis.

Stroke 2018 06 23;49(6):1325-1331. Epub 2018 Apr 23.

Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom (J.L., L.R.-J., H.S.M., M.T.)

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.117.020536
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.117.020536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976219PMC
June 2018

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.

Stroke 2018 06 11;49(6):1340-1347. Epub 2018 May 11.

From the Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom (L.C.A.R.-J., D.J.T., H.S.M., M.T.)

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http://dx.doi.org/10.1161/STROKEAHA.118.020811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976227PMC
June 2018

Should Family Be Permitted in a Trauma Bay?

Authors:
Matthew Traylor

AMA J Ethics 2018 May 1;20(5):455-463. Epub 2018 May 1.

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http://dx.doi.org/10.1001/journalofethics.2018.20.5.ecas5-1805DOI Listing
May 2018

Genetically-Predicted Adult Height and Alzheimer's Disease.

J Alzheimers Dis 2017 ;60(2):691-698

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.3233/JAD-170528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037293PMC
April 2018

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2018 04 12;50(4):524-537. Epub 2018 Mar 12.

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-018-0058-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968830PMC
April 2018

Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study.

Stroke 2018 04 13;49(4):820-827. Epub 2018 Mar 13.

From the Department of Clinical Sciences, Lund University, Malmö, Sweden (G.H., G.E., O.M., M.O.-M.); Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (G.H.); Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.C.L.); and Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., H.S.M.).

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http://dx.doi.org/10.1161/STROKEAHA.117.019653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895121PMC
April 2018

Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis.

BMJ 2017 12 6;359:j5375. Epub 2017 Dec 6.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717765PMC
http://dx.doi.org/10.1136/bmj.j5375DOI Listing
December 2017

Recombinant expression and characterization of Lucilia cuprina CYP6G3: Activity and binding properties toward multiple pesticides.

Insect Biochem Mol Biol 2017 11 14;90:14-22. Epub 2017 Sep 14.

School of Chemistry and Molecular Biology, University of Queensland, St. Lucia 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ibmb.2017.09.004DOI Listing
November 2017

is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.

Neurology 2017 Oct 27;89(17):1829-1839. Epub 2017 Sep 27.

From the Centre for Clinical Brain Sciences (K.R., C.L.M.S.), College of Medicine and Veterinary Medicine (V.S., H.M.), and Institute for Genetics and Molecular Medicine (C.L.M.S.), University of Edinburgh, UK; Institute for Stroke and Dementia Research (R.M., M.D.), Klinikum der Universität München, Munich, Germany; Center for Human Genetic Research (C.D.A., F.R., J.R.) and J. Philip Kistler Stroke Research Center (C.D.A., F.R., N.S.R., J.R.) and Division of Neurocritical Care and Emergency Neurology (C.D.A., F.R., J.R.), Department of Neurology, Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (C.D.A., F.R., J.R.), Broad Institute, Cambridge, MA; Population Health Research Institute (M.C., M.O., G.P.), McMaster University, Hamilton Health Sciences Centre, Ontario, Canada; Department of Medicine (T.D., B.D.M.), University of Maryland School of Medicine, Baltimore; Division of Neurocritical Care and Emergency Neurology (G.J.F.), Department of Neurology, Yale University School of Medicine, New Haven, CT; Stroke Pharmacogenomics and Genetics (I.F.-C.), Fundació Docència i Recerca Mutua Terrassa, Mutua de Terrassa Hospital; Neurovascular Research Unit (J.J.-C.), Department of Neurology, and Program in Inflammation and Cardiovascular Disorders (J.J.-C.), Institut Municipal d'Investigacio´Medica-Hospital del Mar, Universitat Autonoma de Barcelona, Spain; Department of Clinical Sciences Lund (A.L.), Neurology, Lund University; Department of Neurology and Rehabilitation Medicine (A.L., M.S.), Neurology, Skåne University Hospital, Lund, Sweden; Neurovascular Research Laboratory and Neurovascular Unit (J.M.), Institut de Recerca, Hospital Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; HRB Clinical Research Facility (M.O.), NUI Galway, and University Hospital Galway, Ireland; Department of Neurology (A.S.), Jagiellonian University Medical College, Krakow, Poland; Cardiovascular Epidemiology Research Group (M.S.), Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Clinical Neurosciences (M.T., H.S.M.), University of Cambridge, UK; Department of Neurology (S.L.P.), Brain Centre Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Boston University Schools of Medicine and Public Health (S.S.); Framingham Heart Study (S.S.), Framingham, MA; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville; Department of Neurology (D.W.), University of Cincinnati College of Medicine, OH; Geriatrics Research and Education Clinical Center (B.D.M.), Baltimore Veterans Administration Medical Center, MD; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

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http://dx.doi.org/10.1212/WNL.0000000000004560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664302PMC
October 2017

Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study.

Neurology 2017 Aug 30;89(5):454-460. Epub 2017 Jun 30.

From the Stroke Research Group (S.L.C., M.T., H.S.M.), Department of Clinical Neurosciences, and MRC Epidemiology Unit (R.A.S., C.C.L., N.J.W.), University of Cambridge, UK; Unit of Nutritional Epidemiology (S.C.L.), Institute of Environmental Medicine, Karolinska Institutet, Stockholm; Department of Clinical Sciences (G.H., O.M., M.O.-M.), Lund University, Malmö, Sweden; and Boston University School of Medicine (S.S.), MA.

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http://dx.doi.org/10.1212/WNL.0000000000004173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539736PMC
August 2017

Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms.

Stroke 2017 06 3;48(6):1451-1456. Epub 2017 May 3.

From the Stroke Research Center (C.D.A., J.R.), Center for Human Genetic Research (C.D.A., J.R.), and Cardiovascular Research Center (S.A.L., L.-C.W., P.T.E.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics, The Broad Insitute of Harvard and MIT, Cambridge, MA (S.A.L., L.-C.W., C.D.A., J.R., P.T.E.); Autism Research Centre (O.E.P.) and Department of Clinical Neurosciences (H.S.M., M.T.), University of Cambridge, United Kingdom; Boston University and National Heart, Lung and Blood Institute's Framingham Heart Study, MA (E.J.B.); Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (E.J.B.); Department of Epidemiology, Boston University School of Public Health, MA (E.J.B.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians Universität, Germany (R.M., M.D.); Munich Cluster of Systems Neurology (SyNergy), Germany (M.D.); Division of Clinical Neurosciences, Neuroimaging Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom (C.L.S.); and Stroke Prevention Research Unit, Nuffield Department of Neuroscience, University of Oxford, United Kingdom (P.M.R.).

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http://dx.doi.org/10.1161/STROKEAHA.116.016198DOI Listing
June 2017

Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe.

BMC Med Genomics 2017 06 19;10(1):47. Epub 2017 Jun 19.

Department of Medical and Molecular Genetics, King's College London, 8th Floor Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.

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http://dx.doi.org/10.1186/s12920-017-0283-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477417PMC
June 2017

New insights into mechanisms of small vessel disease stroke from genetics.

Clin Sci (Lond) 2017 Apr;131(7):515-531

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Box 83, R3 Neurosciences, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, U.K.

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http://dx.doi.org/10.1042/CS20160825DOI Listing
April 2017

Genetics of stroke in a UK African ancestry case-control study: South London Ethnicity and Stroke Study.

Neurol Genet 2017 Apr 15;3(2):e142. Epub 2017 Mar 15.

Department of Medical and Molecular Genetics (M.T., C.M.L.), King's College London, Guy's Hospital; Stroke Research Group (M.T., L.R.-J., H.S.M.), Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus; and SGDP Centre (C.C., H.P., G.B., S.N., C.M.L.), Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

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http://dx.doi.org/10.1212/NXG.0000000000000142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354108PMC
April 2017

An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis.

Biol Psychiatry 2017 03 6;81(6):470-477. Epub 2016 Aug 6.

Medical Research Council, Social, Genetic & Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Mental Health Biomedical Research Centre, South London and Maudsley National Health Service Foundation Trust and King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2016.06.028DOI Listing
March 2017

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

Authors:
Praveen Surendran Fotios Drenos Robin Young Helen Warren James P Cook Alisa K Manning Niels Grarup Xueling Sim Daniel R Barnes Kate Witkowska James R Staley Vinicius Tragante Taru Tukiainen Hanieh Yaghootkar Nicholas Masca Daniel F Freitag Teresa Ferreira Olga Giannakopoulou Andrew Tinker Magdalena Harakalova Evelin Mihailov Chunyu Liu Aldi T Kraja Sune Fallgaard Nielsen Asif Rasheed Maria Samuel Wei Zhao Lori L Bonnycastle Anne U Jackson Narisu Narisu Amy J Swift Lorraine Southam Jonathan Marten Jeroen R Huyghe Alena Stančáková Cristiano Fava Therese Ohlsson Angela Matchan Kathleen E Stirrups Jette Bork-Jensen Anette P Gjesing Jukka Kontto Markus Perola Susan Shaw-Hawkins Aki S Havulinna He Zhang Louise A Donnelly Christopher J Groves N William Rayner Matt J Neville Neil R Robertson Andrianos M Yiorkas Karl-Heinz Herzig Eero Kajantie Weihua Zhang Sara M Willems Lars Lannfelt Giovanni Malerba Nicole Soranzo Elisabetta Trabetti Niek Verweij Evangelos Evangelou Alireza Moayyeri Anne-Claire Vergnaud Christopher P Nelson Alaitz Poveda Tibor V Varga Muriel Caslake Anton Jm de Craen Stella Trompet Jian'an Luan Robert A Scott Sarah E Harris David Cm Liewald Riccardo Marioni Cristina Menni Aliki-Eleni Farmaki Göran Hallmans Frida Renström Jennifer E Huffman Maija Hassinen Stephen Burgess Ramachandran S Vasan Janine F Felix Maria Uria-Nickelsen Anders Malarstig Dermot F Reily Maarten Hoek Thomas Vogt Honghuang Lin Wolfgang Lieb Matthew Traylor Hugh F Markus Heather M Highland Anne E Justice Eirini Marouli Jaana Lindström Matti Uusitupa Pirjo Komulainen Timo A Lakka Rainer Rauramaa Ozren Polasek Igor Rudan Olov Rolandsson Paul W Franks George Dedoussis Timothy D Spector Pekka Jousilahti Satu Männistö Ian J Deary John M Starr Claudia Langenberg Nick J Wareham Morris J Brown Anna F Dominiczak John M Connell J Wouter Jukema Naveed Sattar Ian Ford Chris J Packard Tõnu Esko Reedik Mägi Andres Metspalu Rudolf A de Boer Peter van der Meer Pim van der Harst Giovanni Gambaro Erik Ingelsson Lars Lind Paul Iw de Bakker Mattijs E Numans Ivan Brandslund Cramer Christensen Eva Rb Petersen Eeva Korpi-Hyövälti Heikki Oksa John C Chambers Jaspal S Kooner Alexandra If Blakemore Steve Franks Marjo-Riitta Jarvelin Lise L Husemoen Allan Linneberg Tea Skaaby Betina Thuesen Fredrik Karpe Jaakko Tuomilehto Alex Sf Doney Andrew D Morris Colin Na Palmer Oddgeir Lingaas Holmen Kristian Hveem Cristen J Willer Tiinamaija Tuomi Leif Groop AnneMari Käräjämäki Aarno Palotie Samuli Ripatti Veikko Salomaa Dewan S Alam Abdulla Al Shafi Majumder Emanuele Di Angelantonio Rajiv Chowdhury Mark I McCarthy Neil Poulter Alice V Stanton Peter Sever Philippe Amouyel Dominique Arveiler Stefan Blankenberg Jean Ferrières Frank Kee Kari Kuulasmaa Martina Müller-Nurasyid Giovanni Veronesi Jarmo Virtamo Panos Deloukas Paul Elliott Eleftheria Zeggini Sekar Kathiresan Olle Melander Johanna Kuusisto Markku Laakso Sandosh Padmanabhan David Porteous Caroline Hayward Generation Scotland Francis S Collins Karen L Mohlke Torben Hansen Oluf Pedersen Michael Boehnke Heather M Stringham Philippe Frossard Christopher Newton-Cheh Martin D Tobin Børge Grønne Nordestgaard Mark J Caulfield Anubha Mahajan Andrew P Morris Maciej Tomaszewski Nilesh J Samani Danish Saleheen Folkert W Asselbergs Cecilia M Lindgren John Danesh Louise V Wain Adam S Butterworth Joanna Mm Howson Patricia B Munroe

Nat Genet 2016 10 12;48(10):1151-1161. Epub 2016 Sep 12.

Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/ng.3654DOI Listing
October 2016

Genetic discovery in multi-ethnic populations.

Eur J Hum Genet 2016 08 4;24(8):1097-8. Epub 2016 May 4.

SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1038/ejhg.2016.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970698PMC
August 2016

Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease.

Ann Neurol 2016 05 23;79(5):739-747. Epub 2016 Feb 23.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/ana.24621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864940PMC
May 2016

Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke.

Stroke 2016 05 12;47(5):1174-9. Epub 2016 Apr 12.

From the Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (M.T., L.C.A.R.-J., H.S.M.); Department of Medical and Molecular Genetics, King's College London, London, United Kingdom (M.T.); Laboratory of Neurobiology, Vesalius Research Center, VIB, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease, University of Leuven, Leuven, Belgium (V.T.); Department of Neurology, Austin Health and Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia (V.T.); School of Medicine and Public Health (E.G.H.) and Centre for Clinical Epidemiology and Biostatistics, Hunter Medical Research Institute and School of Medicine and Public Health (C.L.), University of Newcastle, Newcastle, NSW, Australia; Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia (E.G.H.); School of Life Science, University of Lincoln, Lincoln, United Kingdom (S.B.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany (R.M., M.D.); Department of Cerebrovascular Disease, IRCCS Istituto Neurologico Carlo Besta, Milan, Italy (G.B.); Division of Clinical Neurosciences, Neuroimaging Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom (C.S.); Stroke Prevention Research Unit, Nuffield Department of Neuroscience, University of Oxford, Oxford, United Kingdom (P.M.R.); and Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.).

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http://dx.doi.org/10.1161/STROKEAHA.115.011625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839546PMC
May 2016

No Additional Prognostic Value of Genetic Information in the Prediction of Vascular Events after Cerebral Ischemia of Arterial Origin: The PROMISe Study.

PLoS One 2015 23;10(4):e0119203. Epub 2015 Apr 23.

Department of Neurology and Neurosurgery, Utrecht Stroke Center, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119203PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408031PMC
April 2016

Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype.

Stroke 2016 Mar 2;47(3):646-51. Epub 2016 Feb 2.

From the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (L.C.A.R.-J., M.T., H.S.M.); Department of Medical & Molecular Genetics, King's College London, London, UK (M.T.); Stroke and Dementia Research Centre, Department of Clinical Neuroscience, St George's University of London, London, UK (P.A.-S.); KULeuven Department of Experimental Neurology and Leuven Research Institute for Neuroscience and Disease, University of Leuven, and Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium and Department of Neurology, Austin Health and Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia (V.T.); Division of Clinical Neurosciences, Neuroimaging Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Neuroscience, University of Oxford, UK (P.M.R.); Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milano, Italy (G.B.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University Munich and Munich Cluster of Systems Neurology, SyNergy, Munich, Germany (M.D.); Department of Neurology, Mayo Clinic, Jacksonville (J.M.); School of Nursing and Midwifery (J.M.) and Hunter Medical Research Institute (J.M., C.L.), University of Newcastle, NSW, Australia; Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Boston (N.S.R., J.R.); Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK (A.H.); and School of Life Science, University of Lincoln, Lincoln, UK (S.B.).

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http://dx.doi.org/10.1161/STROKEAHA.115.011545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760380PMC
March 2016

Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.

Stroke 2016 Feb 5;47(2):307-16. Epub 2016 Jan 5.

From the Veterans Affairs Maryland Health Care System, Baltimore, MD (Y.-C.C., S.J.K., J.W.C., B.D.M.); University of Maryland School of Medicine, Baltimore (Y.-C.C., H.X., S.J.K., J.W.C., J.R.O., B.D.M.); The University of Gothenburg, Gothenburg, Sweden (T.M.S., C.J.); University of Rostock, Rostock, Germany (A.-K.G., A. Rolfs); University of Nottingham Malaysia Campus, Selangor Darul Ehsa, Malaysia (W.K.H.); University of Cambridge, Cambridge, UK (M.T., J.D., S.B., H.S.M., S.D., D.S.); Institut Pasteur de Lille, F-59000 Lille, France (P.A.); University of Newcastle, Australia (E.G.H.); Ludwig-Maximilians-Universität, Munich, Germany (R.M., K.S., M.D.); Wellcome Trust Sanger Institute, Cambridge, UK (J.D.); Center for Non-Communicable Diseases, Karachi, Pakistan (A. Rasheed, D.S.); University of Pennsylvania (W.Z., D.S.); Basel University Hospital, Switzerland (S.E.); Heidelberg University Hospital, Germany (C.G.-G.); Centre d'Étude du Polymorphisme Humain, Paris, France (Y.K.); RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (Y.K.); National Genotyping Center, Evry, France (M.L.); Genome Quebec, McGill University, Montreal, Canada (M.L.); Lille University Hospital, France (D.L., S.D.); KU Leuven - University of Leuven, Leuven, Belgium (V.T.); Vesalius Research Center, VIB, Leuven, Belgium (V.T.); University Hospitals Leuven, Leuven, Belgium (V.T.); Helsinki University Central Hospital, Helsinki, Finland (T.M.M., T.T.); Università degli Studi di Brescia, Brescia, Italy (A. Pezzini); Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy (E.A.P., G.B.B.); University of Lund, Sweden (B.N.); University of Oxford, John Radcliffe Hospital (P.M.R.); University of Edinburgh, Edinburgh, UK (C.S.); Jagiellonian University Medical College, Krakow, Poland (A.S.); Lund University, Lund, Sweden (A.L.); Skåne University Hospital, Lund, Sweden (A.L.); University of Glasgow, Glasgow, UK (M.R.W.); University of Adelaide, Australia (J.J.); Mount Sinai Hos

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http://dx.doi.org/10.1161/STROKEAHA.115.011328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729659PMC
February 2016

Oxidative phosphorylation and lacunar stroke: Genome-wide enrichment analysis of common variants.

Neurology 2016 Jan 16;86(2):141-5. Epub 2015 Dec 16.

From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK; School of Life Science (S.B.), University of Lincoln, UK; and the Center for Human Genetic Research (C.D.A.), Department of Neurology, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000002260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731691PMC
January 2016

Differences in Common Genetic Predisposition to Ischemic Stroke by Age and Sex.

Stroke 2015 Nov 6;46(11):3042-7. Epub 2015 Oct 6.

From the Stroke Research Group, Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (M.T., L.C.A.R.-J., S.B., H.S.M.); School of Medicine and Public Health (E.G.H.) School of Nursing and Midwifery (J.M.M.), University of Newcastle, Callaghan, Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, New Lambton Heights, Newcastle, Australia (E.G.H., C.L.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Centre for Clinical Brain Sciences and Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, United Kingdom (P.M.R.); Hunter Medical Research Institute, New Lambton Heights, Newcastle, Australia (J.M.M.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Adelaide, South Australia, Australia (S.A.K.); Department of Cerebrovascular Disease, IRCCS Istituto Neurologico Carlo Besta, Milan, Italy (G.B.); Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.); Department of Neurology, John Hunter Hospital, New Lambton Heights, Newcastle, Australia (C.L.); Department of Medical and Molecular Genetics, King's College London, London, United Kingdom (C.M.L.); and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom (C.M.L.).

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http://dx.doi.org/10.1161/STROKEAHA.115.009816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617282PMC
November 2015

Genetic Architecture of Lacunar Stroke.

Stroke 2015 Sep 4;46(9):2407-12. Epub 2015 Aug 4.

From the Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (M.T., S.B., H.S.M.); Department of Neurology, Université Paris Descartes Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, Institut National de la Santé et de la Recherche Médicale S894, Centre Hospitalier Sainte-Anne, Paris, France (J.-C.B.); Department of Neurology, Leeds General Infirmary, Leeds, United Kingdom (A.H.); Department of Medical and Molecular Genetics, King's College London, London, United Kingdom (C.M.L.); and MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom (C.M.L.).

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http://dx.doi.org/10.1161/STROKEAHA.115.009485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542563PMC
September 2015

Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke.

Stroke 2015 Aug 9;46(8):2069-74. Epub 2015 Jul 9.

From the Department of Medical & Molecular Genetics (K.B.H., C.M.L.), Department of Twin Research and Genetic Epidemiology (P.G.H., F.M.K.W.), and MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience (C.M.L.), King's College London, London, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institut für Schlaganfallund Demenzforschung, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 17, Munich, Germany (M.D.); Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford (P.M.R.); Center for Public Health Genomics, and Cardiovascular Research Center, University of Virginia, Charlottesville, VA (B.B.W); Department of Biostatistics, Boston University School of Public Health, Boston, MA (B.B.W); Department of Neurology, Boston University School of Medicine, Boston, MA (S.S.); and Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.).

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http://dx.doi.org/10.1161/STROKEAHA.115.009387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512747PMC
August 2015

Homogeneous case subgroups increase power in genetic association studies.

Eur J Hum Genet 2015 Jun 1;23(6):863-9. Epub 2014 Oct 1.

1] Department of Medical and Molecular Genetics, King's College London, London, UK [2] Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.

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http://dx.doi.org/10.1038/ejhg.2014.194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795054PMC
June 2015

Common NOTCH3 Variants and Cerebral Small-Vessel Disease.

Stroke 2015 Jun 7;46(6):1482-7. Epub 2015 May 7.

From the Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (L.C.A.R.-J., M.T., S.B., H.S.M.); Stroke and Dementia Research Center, Department of Clinical Neuroscience, St George's University of London, London, United Kingdom (P.A.-S.); Department of Experimental Neurology, KULeuven and Leuven Research Institute for Neuroscience and Disease, University of Leuven, Leuven, Belgium (V.T.); Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium (V.T.); Division of Clinical Neurosciences, Neuroimaging Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom (C.S.); Stroke Prevention Research Unit, Nuffield Department of Neuroscience, University of Oxford, Oxford, United Kingdom (P.M.R.); Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milano, Italy (G.B.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University Munich, Munich, Germany (M.D.); Department of Neurology, Mayo Clinic, Jacksonville, FL (J.M.); Center for Clinical Epidemiology and Biostatistics, Department of Neurology, Hunter Medical Research Institute and School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia (C.L.); Department of Neurology, Center for Human Genetic Research and Massachusetts General Hospital, Boston (N.S.R., J.R.); and Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom (A.H.).

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http://dx.doi.org/10.1161/STROKEAHA.114.008540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442025PMC
June 2015

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.

Authors:
Benjamin F J Verhaaren Stéphanie Debette Joshua C Bis Jennifer A Smith M Kamran Ikram Hieab H Adams Ashley H Beecham Kumar B Rajan Lorna M Lopez Sandra Barral Mark A van Buchem Jeroen van der Grond Albert V Smith Katrin Hegenscheid Neelum T Aggarwal Mariza de Andrade Elizabeth J Atkinson Marian Beekman Alexa S Beiser Susan H Blanton Eric Boerwinkle Adam M Brickman R Nick Bryan Ganesh Chauhan Christopher P L H Chen Vincent Chouraki Anton J M de Craen Fabrice Crivello Ian J Deary Joris Deelen Philip L De Jager Carole Dufouil Mitchell S V Elkind Denis A Evans Paul Freudenberger Rebecca F Gottesman Vilmundur Guðnason Mohamad Habes Susan R Heckbert Gerardo Heiss Saima Hilal Edith Hofer Albert Hofman Carla A Ibrahim-Verbaas David S Knopman Cora E Lewis Jiemin Liao David C M Liewald Michelle Luciano Aad van der Lugt Oliver O Martinez Richard Mayeux Bernard Mazoyer Mike Nalls Matthias Nauck Wiro J Niessen Ben A Oostra Bruce M Psaty Kenneth M Rice Jerome I Rotter Bettina von Sarnowski Helena Schmidt Pamela J Schreiner Maaike Schuur Stephen S Sidney Sigurdur Sigurdsson P Eline Slagboom David J M Stott John C van Swieten Alexander Teumer Anna Maria Töglhofer Matthew Traylor Stella Trompet Stephen T Turner Christophe Tzourio Hae-Won Uh André G Uitterlinden Meike W Vernooij Jing J Wang Tien Y Wong Joanna M Wardlaw B Gwen Windham Katharina Wittfeld Christiane Wolf Clinton B Wright Qiong Yang Wei Zhao Alex Zijdenbos J Wouter Jukema Ralph L Sacco Sharon L R Kardia Philippe Amouyel Thomas H Mosley W T Longstreth Charles C DeCarli Cornelia M van Duijn Reinhold Schmidt Lenore J Launer Hans J Grabe Sudha S Seshadri M Arfan Ikram Myriam Fornage

Circ Cardiovasc Genet 2015 Apr 7;8(2):398-409. Epub 2015 Feb 7.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427240PMC
April 2015

Genetic overlap between diagnostic subtypes of ischemic stroke.

Stroke 2015 Mar 22;46(3):615-9. Epub 2015 Jan 22.

From the School of Medicine and Public Health (E.G.H., J.A.), School of Biomedical Sciences and Pharmacy (L.F.L., R.J.S.), and School of Nursing and Midwifery (J.M.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit, Public Health Research Program, Hunter Medical Research Institute, Newcastle, Australia (E.G.H., C.O., J.A.); Department of Clinical Neurosciences, University of Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität Mün-chen, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA (G.F., J.R.); Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (G.F., J.R.); Clinical Trial Service Unit and Epidemiological Studies Unit (J.C.H., R.C.) and Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience (P.M.R.), University of Oxford, UK; Department of Medicine (Y.-C.C., B.D.M.) and Department of Neurology (J.W.C., S.J.K.), University of Maryland School of Medicine, Baltimore, MD; Imperial College Cerebrovascular Research Unit (ICCRU), Imperial College, London, UK (I.C.); Cardiovascular Health Research Unit, Department of Medicine (J.C.B., B.M.P., K.L.W.) and Department of Epidemiology (B.M.P.), University of Washington, Seattle, WA; Institute of Molecular Medicine and Human Genetics Center, the University of Texas Health Science Center at Houston, TX (E.B., M.F.); Department of Cerebrovascular Disease, IRCCS Istituto Neurologico Carlo Besta, Milan, Italy (G.B.B., E.A.P.); Department of Neurology, Veterans Affairs Medical Center, Baltimore, MD (J.W.C., S.J.K.); Department of Neurology, Rhode Island Hospital, Providence, RI (K.L.F.); Departments of Epidemiology, Neurology, and Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands (M.A.I.); School of Medicine, University of Adelaide, Australia (J.J.); H

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http://dx.doi.org/10.1161/STROKEAHA.114.007930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342266PMC
March 2015

Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke.

Stroke 2015 Feb 30;46(2):348-53. Epub 2014 Dec 30.

From the Neuroscience Research Centre, Cardiovascular & Cell Sciences, St. George's University of London, London, United Kingdom (P.A.-S., S.L.); Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Boston (W.D., C.R.Z., L.C., G.J.F., F.R., K.F., A.K., J.R., N.S.R.); Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (M.T., S.B., H.S.M.); Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (F.R., J.R.); Stroke Prevention Research Unit, Nuffield Department of Neuroscience, University of Oxford, Oxford, United Kingdom (P.M.R.); Division of Clinical Neurosciences, Neuroimaging Sciences, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom (C.S.); Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy (G.B.B.); Department of Neurology, Mayo Clinic, Jacksonville, FL (J.F.M.); Centre for Clinical Epidemiology and Biostatistics, Hunter Medical Research Institute and School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia (C.L.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University Munich, Munich, Germany (M.D.); and Munich Cluster for Systems Neurology (SyNergy), Center for Stroke and Dementia Research, Munich, Germany (M.D.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306538PMC
February 2015

Polygenic overlap between kidney function and large artery atherosclerotic stroke.

Stroke 2014 Dec 28;45(12):3508-13. Epub 2014 Oct 28.

From the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245455PMC
December 2014

Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes.

Genet Epidemiol 2013 Jul 14;37(5):495-503. Epub 2013 May 14.

Stroke & Dementia Research Centre, St. George's University of London, London, UK.

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July 2013

Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations.

Stroke 2012 Dec 4;43(12):3161-7. Epub 2012 Oct 4.

Stroke and Dementia Research Group, St Georges, University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK.

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December 2012

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.

Lancet Neurol 2012 Nov 5;11(11):951-62. Epub 2012 Oct 5.

Stroke and Dementia Research Centre, St George's University of London, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(12)70234-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490334PMC
November 2012

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.

Nat Genet 2012 Feb 5;44(3):328-33. Epub 2012 Feb 5.

Wellcome Trust Centre for Human Genetics, University of Oxford, UK.

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February 2012

Rapid and quantitative measurement of metabolic stability without chromatography or mass spectrometry.

J Am Chem Soc 2011 Sep 27;133(37):14476-9. Epub 2011 Jul 27.

Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179854PMC
September 2011

Simultaneous measurement of CYP1A2 activity, regioselectivity, and coupling: Implications for environmental sensitivity of enzyme-substrate binding.

Arch Biochem Biophys 2011 Jan 8;505(2):186-93. Epub 2010 Oct 8.

Department of Chemical and Biomolecular Engineering, University of California, Berkeley, 94720, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179853PMC
January 2011