Matthew T V Chan

Matthew T V Chan

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Matthew T V Chan

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One-year Results of a Factorial Randomized Trial of Aspirin versus Placebo and Clonidine versus Placebo in Patients Having Noncardiac Surgery.

Anesthesiology 2020 Apr;132(4):692-701

From the Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio (D.I.S., A.K., A.T.) Population Health Research Institute (D.I.S., D.C., S.Y., Y.L.M., A.L., K.B., S.P., P.J.D.) Department of Medicine (D.C., S.Y., G.G., P.J.D.) Department of Health Research Methods, Evidence, and Impact (D.C., S.Y., G.G., Y.L.M., A.L., P.J.D.) Faculty of Health Sciences, Department of Anesthesia (Y.L.M.) Department of Surgery (R.W., A.L.), McMaster University, Hamilton, Ontario, Canada Department of Anaesthesia and Pain Management, Royal Melbourne Hospital and Centre for Integrated Critical Care, University of Melbourne, Melbourne, Australia (K.L.) Public Health and Clinical Epidemiology-Iberoamerican Cochrane Centre, Barcelona, Spain (E.P.) University of Alberta and Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada (M.G.) Department of Research, Foundation for Pediatric Cardiology, Institute of Cardiology and Faculty of Health Sciences (Departamento de Investigaciones, Fundación Cardioinfantil-Instituto de Cardiología and Facultad de Ciencias de la Salud), Universidad Autónoma de Bucaramanga, Colombia (J.C.V.) University of Western Ontario, London, Ontario, Canada (M.M.) Department of Clinical Research, Narayana Hrudayalaya Limited, Bangalore, India (A.S.) University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (B.M.B.) Department of Anaesthesia and Intensive Care, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark (C.S.M.) Department of Anesthesiology and Perioperative Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Canada (J.L.P., I.G.) St. John's Medical College and Research Institute, Bangalore, Karnataka, India (D.X.) Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong (M.T.V.C.) University of North Carolina School of Medicine, Chapel Hills, North Carolina (P.A.K.) NHS Grampian and the University of Aberdeen, Aberdeen, United Kingdom (P.F.) Knowledge and Evidence Unite (Unidad de Conocimiento y Evidencia), Universidad Peruana Cayetano Heredia, Lima, Peru (G.M.) Department of Anaesthesia, Intensive Care, and Pain Medicine, Medical University of Vienna, Vienna, Austria (E.F.) Shifa International Hospitals, Islamabad, Pakistan (M.A.) University of the Andes and Santa Maria Clinic (Universidad de Los Andes and Clinica Santa María), Santiago, Chile (D.T.) Department of Anesthesiology, University of Malaya, Kuala Lumpur, Malaysia (C.Y.W.) Biomedical Research Institute (IIB - Sant Pau), Barcelona, Spain (P.P.) Hospital Israelita Albert Einstein, São Paulo, Brazil (O.B.) Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada (S.S.) Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute and Vita-Salute University, Milan, Italy (G.L.).

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http://dx.doi.org/10.1097/ALN.0000000000003158DOI Listing
April 2020

Emerging roles of non-coding RNAs in scoliosis.

Cell Prolif 2020 Feb 12;53(2):e12736. Epub 2019 Dec 12.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/cpr.12736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046479PMC
February 2020

Cathelicidin preserves intestinal barrier function in polymicrobial sepsis.

Crit Care 2020 02 10;24(1):47. Epub 2020 Feb 10.

Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.

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http://dx.doi.org/10.1186/s13054-020-2754-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011568PMC
February 2020

Preoperative Vitamin D Concentration and Cardiac, Renal, and Infectious Morbidity after Noncardiac Surgery.

Anesthesiology 2020 Jan;132(1):121-130

From the Department of Outcomes Research (A.T., A.S.A., C.H., P.S., K.M., A.K., K.R., D.I.S.) Department of General Anesthesiology (A.T., K.M., A.K., K.R.) Anesthesiology Institute, and the Department of Quantitative Health Sciences (A.S.A.), Cleveland Clinic, Cleveland, Ohio the Department of Health Research Methods, Evidence, and Impact (P.J.D., E.D.) the Department of Medicine (A.P., M.T.), McMaster University, Hamilton, Canada the Population Health Research Institute, Hamilton, Canada (P.J.D., E.D.) Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom (R.P.) the Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China (M.T.V.C., W.K.K.W.) the Department of Surgery, University of Manitoba, Winnipeg, Canada (S.S.) the Department of Medicine, Western University, London, Canada (A.X.G.) the Department of Cardiology, Leeds General Infirmary, Leeds, United Kingdom (R.S.).

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http://dx.doi.org/10.1097/ALN.0000000000003000DOI Listing
January 2020

Aberrantly expressed long non-coding RNAs in air pollution-induced congenital defects.

J Cell Mol Med 2019 Nov 26;23(11):7717-7725. Epub 2019 Sep 26.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1111/jcmm.14645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815773PMC
November 2019

Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration.

Cell Prolif 2019 Nov 16;52(6):e12704. Epub 2019 Oct 16.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/cpr.12704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869348PMC
November 2019

Differentially expressed circular RNAs in air pollution-exposed rat embryos.

Environ Sci Pollut Res Int 2019 Nov 21;26(33):34421-34429. Epub 2019 Oct 21.

Department of Orthopedic Surgery, The General Hospital of Xingtai Mining Industry Bloc., Orthopaedic Hospital of Xingtai, Xingtai, Hebei, China.

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http://dx.doi.org/10.1007/s11356-019-06489-wDOI Listing
November 2019

Anaesthetic depth and complications after major surgery: an international, randomised controlled trial.

Lancet 2019 11 20;394(10212):1907-1914. Epub 2019 Oct 20.

Monash University, Melbourne, VIC, Australia; Royal Melbourne Hospital and University of Melbourne, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1016/S0140-6736(19)32315-3DOI Listing
November 2019

Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer.

Cancer Prev Res (Phila) 2019 Oct 20;12(10):653-666. Epub 2019 Aug 20.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1158/1940-6207.CAPR-19-0134DOI Listing
October 2019

Autophagy in intracellular bacterial infection.

Semin Cell Dev Biol 2019 Sep 10. Epub 2019 Sep 10.

Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, and Centre for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2019.07.014DOI Listing
September 2019

Unrecognized Obstructive Sleep Apnea in Patients Undergoing Surgery-Reply.

JAMA 2019 09;322(12):1211-1212

Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jama.2019.10994DOI Listing
September 2019

MicroRNA signature of air pollution exposure-induced congenital defects.

J Cell Physiol 2019 Aug 18;234(10):17896-17904. Epub 2019 Mar 18.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1002/jcp.28422DOI Listing
August 2019

Long non-coding RNAs in the spinal cord injury: Novel spotlight.

J Cell Mol Med 2019 Aug 29;23(8):4883-4890. Epub 2019 May 29.

Department of Anaesthesia and Intensive Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14422
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http://dx.doi.org/10.1111/jcmm.14422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653026PMC
August 2019

Relationship between Perioperative Hypotension and Perioperative Cardiovascular Events in Patients with Coronary Artery Disease Undergoing Major Noncardiac Surgery.

Anesthesiology 2019 05;130(5):756-766

From the Lilibeth Caberto London Kidney Clinical Research Unit, London Health Sciences Centre, London, Canada (P.S.R.) the Department of Medicine (P.S.R., T.S., E.D., V.T., P.J.D.) Department of Health Research Methods, Evidence and Impact (P.S.R., E.D., P.J.D.), McMaster University, Hamilton, Canada the Population Health Research Institute, Hamilton, Canada (E.D., P.J.D.) the Division of General Internal Medicine, McGill University Health Center, Montreal, Canada (A.B.) the Department of Anesthesia and Intensive Care, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, China (M.T.V.C.) the Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada (C.B.) the Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada (B.J.W.C.) the Department of Radiology, University of Ottawa, Ottawa, Canada (B.J.W.C.) the Department of Anesthesia, University of Toronto, Toronto, Canada (J.S.K).

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http://dx.doi.org/10.1097/ALN.0000000000002654DOI Listing
May 2019

Translational genomics in pancreatic ductal adenocarcinoma: A review with re-analysis of TCGA dataset.

Semin Cancer Biol 2019 04 26;55:70-77. Epub 2018 Apr 26.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2018.04.004DOI Listing
April 2019

Melatonin protected against the detrimental effects of microRNA-363 in a rat model of vitamin A-associated congenital spinal deformities: Involvement of Notch signaling.

J Pineal Res 2019 Apr 14;66(3):e12558. Epub 2019 Feb 14.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1111/jpi.12558DOI Listing
April 2019

Exhaled air dispersion during high-flow nasal cannula therapy CPAP different masks.

Eur Respir J 2019 Apr 11;53(4). Epub 2019 Apr 11.

Dept of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

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http://dx.doi.org/10.1183/13993003.02339-2018DOI Listing
April 2019

Effect of cultural background and healthcare environment on postoperative opioid requirement.

Can J Anaesth 2019 03 10;66(3):309-317. Epub 2018 Dec 10.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s12630-018-01267-7DOI Listing
March 2019

Effect of methylprednisolone on acute kidney injury in patients undergoing cardiac surgery with a cardiopulmonary bypass pump: a randomized controlled trial.

CMAJ 2019 03;191(9):E247-E256

Division of Nephrology (Garg, Cuerden, Sontrop), Department of Medicine, London Health Sciences Centre, London, Ont.; Department of Anaesthesia and Intensive Care (Chan), The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Departments of Health Research Methods, Evidence, and Impact, and Medicine (Devereaux, Walsh), McMaster University, Hamilton, Ont.; Tehran Heart Center (Abbasi), Tehran University of Medical Sciences, Tehran, Iran; Division of Nephrology (Hildebrand), Department of Medicine, University of Alberta, Edmonton, Alta.; Département de médecine (Lamontagne), Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Que.; Department of Surgery (Lamy) McMaster University, Hamilton, Ont.; Department of Cardiac Surgery (Noiseux), Université de Montréal, Montréal, Que.; Division of Nephrology, Johns Hopkins School of Medicine (Parikh), Baltimore, Md.; The George Institute for Global Health (Perkovic), Sydney, Australia; Division of Cardiac Surgery (Quantz), London Health Sciences Centre, University Hospital, London, Ont.; Montreal Heart Institute (Rochon), Université de Montréal, Montréal, Que.; Department of Surgery (Royse), University of Melbourne, Melbourne, Australia; Department of Outcomes Research (Sessler), Cleveland Clinic, Cleveland, Ohio; Department of Cardiac Surgery (Shah), Princess Alexandra Hospital, Brisbane, Australia; Department of Cardiovascular and Thoracic Surgery (Tagarakis), Aristotle University of Thessaloniki, Thessaloniki, Greece; Division of Cardiac Surgery (Teoh), Southlake Regional Health Centre, Newmarket, Ont.; Population Health Research Institute (Vincent, Whitlock), Hamilton, Ont.; Department of Cardiothoracic Anesthesiology (Yared), Cleveland Clinic, Cleveland, Ohio; Division of Cardiology (Yusuf), Department of Medicine, McMaster University, Hamilton, Ont.

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http://www.cmaj.ca/lookup/doi/10.1503/cmaj.181644
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http://dx.doi.org/10.1503/cmaj.181644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400656PMC
March 2019

Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features.

Theranostics 2018 12;8(6):1740-1751. Epub 2018 Feb 12.

Institute of Digestive Diseases and Department of Medicine & Therapeutics, State Key Laboratory of Digestive Diseases, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.7150/thno.22010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858179PMC
January 2019

Emerging roles of long non-coding RNAs in neuropathic pain.

Cell Prolif 2019 Jan 25;52(1):e12528. Epub 2018 Oct 25.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, Hong Kong.

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http://doi.wiley.com/10.1111/cpr.12528
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http://dx.doi.org/10.1111/cpr.12528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430490PMC
January 2019

Autophagy, NAFLD and NAFLD-Related HCC.

Adv Exp Med Biol 2018;1061:127-138

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1007/978-981-10-8684-7_10DOI Listing
November 2018

Long non-coding RNAs in nucleus pulposus cell function and intervertebral disc degeneration.

Cell Prolif 2018 Oct 24;51(5):e12483. Epub 2018 Jul 24.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/cpr.12483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528936PMC
October 2018

The long non-coding RNA SPRY4-IT1: An emerging player in tumorigenesis and osteosarcoma.

Cell Prolif 2018 Aug 27;51(4):e12446. Epub 2018 Feb 27.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/cpr.12446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528852PMC
August 2018

Association Between Bacteremia From Specific Microbes and Subsequent Diagnosis of Colorectal Cancer.

Gastroenterology 2018 08 3;155(2):383-390.e8. Epub 2018 May 3.

State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, and CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.04.028DOI Listing
August 2018

Immune consequences induced by photodynamic therapy in non-melanoma skin cancers: a review.

Environ Sci Pollut Res Int 2018 Jul 12;25(21):20569-20574. Epub 2018 Jun 12.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1007/s11356-018-2426-zDOI Listing
July 2018

Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery.

N Engl J Med 2018 Jun 9;378(24):2263-2274. Epub 2018 May 9.

From Alfred Hospital (P.S.M., J.S., S.W.), Monash University (P.S.M., R.B., T.C., A.F., K.L., J.S., S.W.), and the University of Melbourne (R.B., P.P., D.S., C.C., K.L.), Melbourne, VIC, Austin Hospital, Heidelberg, VIC (R.B., P.P., D.S., C.C.), Royal Perth Hospital and the University of Western Australia, Perth (T.C.), Royal Melbourne Hospital, Parkville, VIC (K.L.), and Royal Adelaide Hospital and Discipline of Acute Care Medicine, University of Adelaide, Adelaide, SA (T.P.) - all in Australia; Auckland City Hospital, Auckland, and the Medical Research Institute of New Zealand, Wellington - both in New Zealand (S. McGuinness, R.P.); the Chinese University of Hong Kong, Hong Kong (M.T.V.C.); University Health Network, Toronto (S. McCluskey); and Derriford Hospital, Plymouth, United Kingdom (G.M.).

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http://dx.doi.org/10.1056/NEJMoa1801601DOI Listing
June 2018

Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost-consequence analysis.

Can J Surg 2018 06;61(3):185-194

From the University Hospital of Düsseldorf, Düsseldorf, Germany (Lurati Buse); the University Hospital of Basel, Basel, Switzerland (Lurati Buse); the University of Calgary, Calgary, Alta. (Manns); McMaster University, Hamilton, Ont. (Lamy, Guyatt, Tiboni, Devereaux); the Hospital de Clínicas de Porto Alegre, Universidade Federal de Rio Grande do Sul, Brazil (Polanczyk); the Chinese University of Hong Kong, Sha Tin, NT, Hong Kong (Chan); the University of Malaya, Kuala Lampur, Malaysia (Wang); the Fundación Cardioinfantil - Instituto de Cardiología, Bogotá and Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia (Villar); St. John's Medical College and Research Institute, Bangalore, India (Sigamani); the Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio (Sessler); the HCor Research Institute (Hospital do CoraÇão), São Paulo, Brazil (Berwanger); the Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa (Biccard); Barts and The London School of Medicine and Dentistry, London, UK (Pearse); the Hospital de Sant Pau, Barcelona, Spain (Urrútia); the Jagiellonian University Medical College, Krakow, Poland (Szczeklik); the Hospital General Universitario Gregorio Marañón, Madrid, Spain (Garutti); the University of Manitoba, Winnipeg, Man. (Srinathan); the Universidad Peruana Cayetano Heredia, Lima, Peru (Malaga); the Christian Medical College, Ludhiana, India (Abraham); the George Institute for Global Health, University of Sydney, Sydney, Australia (Chow); the University of Alberta Hospital, Edmonton, Alta. (Jacka); the University College London, London, UK (Ackland); the London Health Sciences Centre, London, Ont. (Macneil); the University of Leeds, Leeds, UK (Sapsford); the Royal Liverpool Broadgreen University Hospital Trust, Liverpool, UK (Leuwer); and the HÔpital Pitié-Salpêtrière, Paris, France (Le Manach).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973906PMC
http://dx.doi.org/10.1503/cjs.010217DOI Listing
June 2018

NOVA1 acts as an oncogene in melanoma via regulating FOXO3a expression.

J Cell Mol Med 2018 05 2;22(5):2622-2630. Epub 2018 Mar 2.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong City, Hong Kong.

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http://dx.doi.org/10.1111/jcmm.13527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908123PMC
May 2018

A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese population.

J Cell Mol Med 2018 04 14;22(4):2368-2377. Epub 2018 Feb 14.

State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine & Therapeutics, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/jcmm.13530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867068PMC
April 2018

Systematic review of prediction models for delirium in the older adult inpatient.

BMJ Open 2018 04 28;8(4):e019223. Epub 2018 Apr 28.

Department of Anesthesiology, University of Wisconsin Madison School of Medicine and Public Health, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1136/bmjopen-2017-019223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931306PMC
April 2018

Targeted Genotyping Identifies Susceptibility Locus in Brain-derived Neurotrophic Factor Gene for Chronic Postsurgical Pain.

Anesthesiology 2018 03;128(3):587-597

From the Department of Anaesthesia and Intensive Care (Y.T., X.L., Z.M., S.K., I.H.T.H., B.J., S.T., T.G., W.K.K.W., M.T.V.C.), Li Ka Shing Institute of Health Sciences (Y.T., X.L., S.K., I.H.T.H., B.J., S.T., S.H.W., J.Y., W.K.K.W., M.T.V.C.), School of Biomedical Sciences (Y.S., C.H.K.C.), and Department of Medicine and Therapeutics (S.H.W., J.Y., W.K.K.W.), Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, China; the Shandong Provincial Key Laboratory of Mental Disorders, Department of Neurobiology, School of Medicine, Shandong University, Jinan, Shandong, China (M.J., H.Y., Z.C.); the Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany (P.L); and the Department of Anaesthesia and Intensive Care, Tuen Mun Hospital, Hong Kong Special Administrative Region, China (B.C.P.C., C.K.M.L.).

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http://dx.doi.org/10.1097/ALN.0000000000001977DOI Listing
March 2018

Long non-coding RNAs in rheumatoid arthritis.

Cell Prolif 2018 Feb 7;51(1). Epub 2017 Nov 7.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/cpr.12404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620844PMC
February 2018

Emerging roles of MicroRNAs in osteonecrosis of the femoral head.

Cell Prolif 2018 Feb 12;51(1). Epub 2017 Nov 12.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/cpr.12405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620832PMC
February 2018

Circulating microRNA signature of steroid-induced osteonecrosis of the femoral head.

Cell Prolif 2018 Feb 4;51(1). Epub 2017 Dec 4.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1111/cpr.12418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528947PMC
February 2018

Common Deregulation of Seven Biological Processes by MicroRNAs in Gastrointestinal Cancers.

Sci Rep 2018 02 19;8(1):3287. Epub 2018 Feb 19.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1038/s41598-018-21573-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818544PMC
February 2018

Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis.

FASEB J 2018 01 25;32(1):37-51. Epub 2017 Aug 25.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China;

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http://www.fasebj.org/doi/10.1096/fj.201601393R
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http://dx.doi.org/10.1096/fj.201601393RDOI Listing
January 2018

Exhaled air dispersion during bag-mask ventilation and sputum suctioning - Implications for infection control.

Sci Rep 2018 01 9;8(1):198. Epub 2018 Jan 9.

Stanley Ho Center for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1038/s41598-017-18614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760517PMC
January 2018

Inattentional blindness in anesthesiology: A simulation study.

J Clin Anesth 2017 Nov 9;42:36-39. Epub 2017 Aug 9.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR.

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http://dx.doi.org/10.1016/j.jclinane.2017.07.015DOI Listing
November 2017

Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway.

J Pineal Res 2017 Oct 16;63(3). Epub 2017 Aug 16.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://doi.wiley.com/10.1111/jpi.12435
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http://dx.doi.org/10.1111/jpi.12435DOI Listing
October 2017

Warning criteria for intraoperative neurophysiologic monitoring.

Curr Opin Anaesthesiol 2017 Oct;30(5):557-562

aDepartment of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region bShandong Provincial Hospital cDepartment of Neurology, Qilu Hospital, Shandong University dBinzhou People's Hospital, Shandong eDepartment of Anaesthesia and Intensive Care, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences fDepartment of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.

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http://dx.doi.org/10.1097/ACO.0000000000000505DOI Listing
October 2017

Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis.

Sci Rep 2017 10 18;7(1):13451. Epub 2017 Oct 18.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.

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http://dx.doi.org/10.1038/s41598-017-13745-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647332PMC
October 2017

Melatonin antagonizes interleukin-18-mediated inhibition on neural stem cell proliferation and differentiation.

J Cell Mol Med 2017 09 21;21(9):2163-2171. Epub 2017 Apr 21.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://doi.wiley.com/10.1111/jcmm.13140
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http://dx.doi.org/10.1111/jcmm.13140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571550PMC
September 2017

High-Sensitivity Troponin Levels, Ischemia, and Mortality-Reply.

JAMA 2017 09;318(9):865

Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.

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http://dx.doi.org/10.1001/jama.2017.9198DOI Listing
September 2017

Neuro-oncological ventral antigen 1 (NOVA1): Implications in neurological diseases and cancers.

Cell Prolif 2017 Aug 10;50(4). Epub 2017 Apr 10.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/cpr.12348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529068PMC
August 2017

Germline-specific dgcr8 knockout in zebrafish using a BACK approach.

Cell Mol Life Sci 2017 07 21;74(13):2503-2511. Epub 2017 Feb 21.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1007/s00018-017-2471-7DOI Listing
July 2017

Pathological Role and Diagnostic Value of Endogenous Host Defense Peptides in Adult and Neonatal Sepsis: A Systematic Review.

Shock 2017 06;47(6):673-679

*Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong †State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong ‡Department of Medicine §The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong ||Department of Rehabilitation, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.

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http://dx.doi.org/10.1097/SHK.0000000000000815DOI Listing
June 2017

CCAT2: A novel oncogenic long non-coding RNA in human cancers.

Cell Prolif 2017 Jun 28;50(3). Epub 2017 Feb 28.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/cpr.12342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529071PMC
June 2017

Deep anesthesia: too much of a good thing?

Can J Anaesth 2017 Jun 31;64(6):574-580. Epub 2017 Mar 31.

Department of Anaesthesia and Intensive Care, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s12630-017-0871-7DOI Listing
June 2017

Protective roles of melatonin in central nervous system diseases by regulation of neural stem cells.

Cell Prolif 2017 Apr 12;50(2). Epub 2016 Dec 12.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/cpr.12323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529065PMC
April 2017

Oncogenes without a Neighboring Tumor-Suppressor Gene Are More Prone to Amplification.

Mol Biol Evol 2017 04;34(4):903-907

Institute of Digestive Diseases and Department of Medicine & Therapeutics, State Key Laboratory of Digestive Diseases, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

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https://academic.oup.com/mbe/article-lookup/doi/10.1093/molb
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http://dx.doi.org/10.1093/molbev/msw295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400371PMC
April 2017

NEAT1: A novel cancer-related long non-coding RNA.

Cell Prolif 2017 Apr 19;50(2). Epub 2017 Jan 19.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/cpr.12329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529067PMC
April 2017

HULC: an oncogenic long non-coding RNA in human cancer.

J Cell Mol Med 2017 02 25;21(2):410-417. Epub 2016 Oct 25.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/jcmm.12956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264137PMC
February 2017

MicroRNA-379 suppresses osteosarcoma progression by targeting PDK1.

J Cell Mol Med 2017 02 25;21(2):315-323. Epub 2016 Oct 25.

Department of Anaesthesia and Intensive Care, State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/jcmm.12966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264134PMC
February 2017

The role of microRNAs in intrahepatic cholangiocarcinoma.

J Cell Mol Med 2017 01 13;21(1):177-184. Epub 2016 Sep 13.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/jcmm.12951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192883PMC
January 2017

Perioperative nocturnal hypoxemia matters in surgical patients with obstructive sleep apnea.

Can J Anaesth 2017 Jan 20;64(1):109-110. Epub 2016 Oct 20.

Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s12630-016-0755-2DOI Listing
January 2017

Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.

N Engl J Med 2017 01 23;376(2):136-148. Epub 2016 Oct 23.

From the Alfred Hospital (P.S.M., D.J.C., S. Marasco, S.W.) and Monash University (P.S.M., J.A.S., A.F., D.J.C., S. Marasco, J.M., S.W.), Melbourne, VIC, St. Vincent's Hospital, Fitzroy, VIC (B.S.), and the Royal Adelaide Hospital, Adelaide, SA (T.P.) - all in Australia; South West Cardiac Centre, Derriford Hospital, Plymouth, United Kingdom (M.J.); Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada (J.S.B.); Auckland City Hospital, Auckland (S. McGuinness), and Waikato Hospital, Hamilton (K.B.) - both in New Zealand; the Chinese University of Hong Kong, Hong Kong (M.T.V.C.); and Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele and Vita-Salute San Raffaele University, Milan (G.L.).

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http://dx.doi.org/10.1056/NEJMoa1606424DOI Listing
January 2017

The involvement of regulatory non-coding RNAs in sepsis: a systematic review.

Crit Care 2016 Nov 28;20(1):383. Epub 2016 Nov 28.

Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong, Hong Kong, Special Administrative Region of China.

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http://dx.doi.org/10.1186/s13054-016-1555-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125038PMC
November 2016

Lentiviral Delivery of Small Hairpin RNA Targeting Connective Tissue Growth Factor Blocks Profibrotic Signaling in Tenon's Capsule Fibroblasts.

Invest Ophthalmol Vis Sci 2016 Oct;57(13):5171-5180

Department of Ophthalmology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.

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http://dx.doi.org/10.1167/iovs.16-19480DOI Listing
October 2016

TUG1: a pivotal oncogenic long non-coding RNA of human cancers.

Cell Prolif 2016 Aug 23;49(4):471-5. Epub 2016 Jun 23.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/cpr.12269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496395PMC
August 2016

Autophagy in sepsis: Degradation into exhaustion?

Autophagy 2016 07 12;12(7):1073-82. Epub 2016 May 12.

a Department of Anesthesia and Intensive Care , The Chinese University of Hong Kong, Hong Kong Special Administrative Region , China.

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http://dx.doi.org/10.1080/15548627.2016.1179410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990998PMC
July 2016

Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis Through Transcriptional Repression of Interleukin-10.

J Crohns Colitis 2016 Jun 22;10(6):726-34. Epub 2016 Jan 22.

Institute of Digestive Disease and State Key Laboratory of Digestive Disease, Chinese University of Hong Kong, Hong Kong SAR Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong SAR.

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http://dx.doi.org/10.1093/ecco-jcc/jjw020DOI Listing
June 2016

CCAT1: a pivotal oncogenic long non-coding RNA in human cancers.

Cell Prolif 2016 Jun 1;49(3):255-60. Epub 2016 May 1.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, 999077, China.

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http://dx.doi.org/10.1111/cpr.12252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496795PMC
June 2016

Severe Nausea and Vomiting in the Evaluation of Nitrous Oxide in the Gas Mixture for Anesthesia II Trial.

Anesthesiology 2016 May;124(5):1032-40

From the Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Monash University, Melbourne, Victoria, Australia (P.S.M.); Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People's Republic of China (M.T.V.C.); Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia (J.K., A.F.); Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, Perth, Australia (M.J.P.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (M.J.P.); Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia (K.L.); Anaesthesia, Perioperative and Pain Medicine Unit, University of Melbourne, Melbourne, Victoria, Australia (K.L.); Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Victoria, Australia (K.L.); Department of Surgery, Austin Hospital, University of Melbourne, Melbourne, Australia (P.J.P.); Institute for Breathing and Sleep, Victoria, Australia (P.J.P.); Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio (D.I.S.); Department of Anaesthesia, Intensive Care and Pharmacology, Geneva University Hospitals, University of Geneva, Switzerland (G.H.); Department of Anesthesia and Pain Management, University Health Network, Toronto, Ontario, Canada (W.S.B.); Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada (W.S.B.); Department of Anesthesia, Perioperative and Acute Pain Management, Barwon Health, Geelong, Victoria, Australia (C.O.); and Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, United Kingdom (J.R.S.).

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http://dx.doi.org/10.1097/ALN.0000000000001057DOI Listing
May 2016

Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability.

Cancer Res 2016 04 8;76(7):1724-32. Epub 2016 Feb 8.

Institute of Digestive Disease and Department of Medicine & Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

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http://cancerres.aacrjournals.org/content/early/2016/02/06/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-15-2443DOI Listing
April 2016

Role of microRNAs in primary central nervous system lymphomas.

Cell Prolif 2016 Apr 16;49(2):147-53. Epub 2016 Mar 16.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, 999077, China.

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http://dx.doi.org/10.1111/cpr.12243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495944PMC
April 2016

The Role of MicroRNAS in Ankylosing Spondylitis.

Medicine (Baltimore) 2016 Apr;95(14):e3325

From the Department of Orthopedics Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (ZL, JS); State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences and Department of Medicine & Therapeutics (SHW, WKKW); and Department of Anaesthesia and Intensive Care (MTVC), The Chinese University of Hong Kong, Hong Kong, China.

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http://pdfs.journals.lww.com/md-journal/2016/04050/The_Role_
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MD.0000000000003325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998826PMC
April 2016

Stratification of Digestive Cancers with Different Pathological Features and Survival Outcomes by MicroRNA Expression.

Sci Rep 2016 Apr 15;6:24466. Epub 2016 Apr 15.

Institute of Digestive Disease and Department of Medicine &Therapeutics, State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1038/srep24466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832245PMC
April 2016

Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells.

Oncotarget 2016 Mar;7(12):14693-707

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.18632/oncotarget.7492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924745PMC
March 2016

The roles of microRNAs in Wilms' tumors.

Tumour Biol 2016 Feb 3;37(2):1445-50. Epub 2015 Dec 3.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1007/s13277-015-4514-8DOI Listing
February 2016

Circulating epigenetic biomarkers in melanoma.

Tumour Biol 2016 Feb 11;37(2):1487-92. Epub 2015 Dec 11.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1007/s13277-015-4599-0DOI Listing
February 2016