Matthew Scharff

Matthew Scharff

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Matthew Scharff

Matthew Scharff

Publications by authors named "Matthew Scharff"

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AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes.

Front Immunol 2020 30;11:788. Epub 2020 Apr 30.

Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, United States.

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http://dx.doi.org/10.3389/fimmu.2020.00788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204545PMC
April 2020

Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells.

mBio 2018 04 17;9(2). Epub 2018 Apr 17.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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http://dx.doi.org/10.1128/mBio.02315-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904410PMC
April 2018

Overlapping hotspots in CDRs are critical sites for V region diversification.

Proc Natl Acad Sci U S A 2015 Feb 2;112(7):E728-37. Epub 2015 Feb 2.

Department of Applied Mathematics and Statistics, State University of New York, Stony Brook, NY 11794

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http://dx.doi.org/10.1073/pnas.1500788112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343087PMC
February 2015

Detection and measurement of staphylococcal enterotoxin-like K (SEl-K) secretion by Staphylococcus aureus clinical isolates.

J Clin Microbiol 2014 Jul 7;52(7):2536-43. Epub 2014 May 7.

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

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http://dx.doi.org/10.1128/JCM.00387-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097694PMC
July 2014

A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation.

Nat Commun 2014 Jun 13;5:4137. Epub 2014 Jun 13.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx New York 10461, USA.

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http://dx.doi.org/10.1038/ncomms5137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154566PMC
June 2014

AID and Apobec3G haphazard deamination and mutational diversity.

Cell Mol Life Sci 2013 Sep 22;70(17):3089-108. Epub 2012 Nov 22.

Departments of Biological Sciences and Chemistry, Molecular and Computational Biology Section, University of Southern California, Los Angeles, CA 90089-2910, USA.

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http://dx.doi.org/10.1007/s00018-012-1212-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600397PMC
September 2013

HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.

Proc Natl Acad Sci U S A 2013 Jun 28;110(24):9879-84. Epub 2013 May 28.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.1303524110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683785PMC
June 2013

AIDing antibody diversity by error-prone mismatch repair.

Semin Immunol 2012 Aug 14;24(4):293-300. Epub 2012 Jun 14.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.smim.2012.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422444PMC
August 2012

Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells.

mBio 2011 11;2(5). Epub 2011 Oct 11.

Departments of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.1128/mBio.00186-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190358PMC
January 2012

The use of Bcl-2 over-expression to stabilize hybridomas specific to the HERG potassium channel.

J Immunol Methods 2012 Jan 15;375(1-2):215-22. Epub 2011 Nov 15.

Department of Molecular Pharmacology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY 10461, United States.

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http://dx.doi.org/10.1016/j.jim.2011.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253882PMC
January 2012

Mismatch-mediated error prone repair at the immunoglobulin genes.

Biomed Pharmacother 2011 Dec 24;65(8):529-36. Epub 2011 Oct 24.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave-Chanin 404, Bronx, NY 10461, United States.

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http://dx.doi.org/10.1016/j.biopha.2011.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235044PMC
December 2011

Msh6 protects mature B cells from lymphoma by preserving genomic stability.

Am J Pathol 2010 Nov 7;177(5):2597-608. Epub 2010 Oct 7.

Cell Biology Department, Chanin 403, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.

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http://dx.doi.org/10.2353/ajpath.2010.100234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966815PMC
November 2010

A requirement for FcγR in antibody-mediated bacterial toxin neutralization.

J Exp Med 2010 Oct 4;207(11):2395-405. Epub 2010 Oct 4.

Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1084/jem.20100995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964574PMC
October 2010

PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.

Proc Natl Acad Sci U S A 2010 Jul 12;107(30):13384-9. Epub 2010 Jul 12.

Department of Cell Biology, and Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.1008589107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922181PMC
July 2010

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.

Proc Natl Acad Sci U S A 2010 Jan 22;107(2):809-14. Epub 2009 Dec 22.

Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1073/pnas.0913790107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818930PMC
January 2010

Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro.

J Immunol Methods 2009 Oct 17;350(1-2):71-8. Epub 2009 Jul 17.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002217590900200
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http://dx.doi.org/10.1016/j.jim.2009.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762006PMC
October 2009

V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment.

Proc Natl Acad Sci U S A 2009 May 14;106(21):8629-34. Epub 2009 May 14.

Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.0903803106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682541PMC
May 2009

H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination.

Proc Natl Acad Sci U S A 2009 Mar 10;106(13):5288-93. Epub 2009 Mar 10.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.0901368106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654022PMC
March 2009

SHMTool: a webserver for comparative analysis of somatic hypermutation datasets.

DNA Repair (Amst) 2009 Jan 8;8(1):137-41. Epub 2008 Nov 8.

Dept of Systems and Computational Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.dnarep.2008.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659805PMC
January 2009

Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.

Proc Natl Acad Sci U S A 2008 Oct 14;105(42):16248-53. Epub 2008 Oct 14.

Departments of Cell Biology and Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.0808182105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571010PMC
October 2008

The biochemistry of somatic hypermutation.

Annu Rev Immunol 2008 ;26:481-511

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1146/annurev.immunol.26.021607.090236DOI Listing
June 2008

Does antisense make sense of AID targeting?

Proc Natl Acad Sci U S A 2008 Mar 5;105(10):3661-2. Epub 2008 Mar 5.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.0800935105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268770PMC
March 2008

Human recombinant Fab fragments with sub-nanomolar affinities for acetylated histones.

J Immunol Methods 2008 Jan 11;329(1-2):1-10. Epub 2007 Oct 11.

Institute of Biology and Immunology, Bulgarian Academy of Sciences, Sofia, Bulgaria.

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http://dx.doi.org/10.1016/j.jim.2007.08.019DOI Listing
January 2008

AID-initiated purposeful mutations in immunoglobulin genes.

Adv Immunol 2007 ;94:127-55

Department of Biological Sciences, University of Southern California, Los Angeles, California, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S006527760694005
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http://dx.doi.org/10.1016/S0065-2776(06)94005-XDOI Listing
September 2007

Targeting AID to the Ig genes.

Adv Exp Med Biol 2007 ;596:93-109

Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA.

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http://dx.doi.org/10.1007/0-387-46530-8_9DOI Listing
April 2007

Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.

J Exp Med 2007 Jan 16;204(1):181-90. Epub 2007 Jan 16.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1084/jem.20062032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118410PMC
January 2007

Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells.

J Immunol Methods 2006 Oct 5;316(1-2):59-66. Epub 2006 Sep 5.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.jim.2006.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677521PMC
October 2006

A role for Mlh3 in somatic hypermutation.

DNA Repair (Amst) 2006 Jun 27;5(6):675-82. Epub 2006 Mar 27.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.

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http://meiosis.cornell.edu/pubs/li2006.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S156878640600053
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http://dx.doi.org/10.1016/j.dnarep.2006.02.003DOI Listing
June 2006

The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus.

Immunity 2006 Apr;24(4):393-403

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1016/j.immuni.2006.02.011DOI Listing
April 2006

Tumor necrosis factor-alpha and CD40L modulate cell surface morphology and induce aggregation in Ramos Burkitt's lymphoma cells.

Leuk Lymphoma 2006 Mar;47(3):507-19

Department of Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1080/10428190500221454DOI Listing
March 2006

Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells.

Proc Natl Acad Sci U S A 2005 Aug 8;102(33):11829-34. Epub 2005 Aug 8.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0505449102
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http://dx.doi.org/10.1073/pnas.0505449102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188009PMC
August 2005

Methylation protects cytidines from AID-mediated deamination.

Mol Immunol 2005 Mar;42(5):599-604

Department of Immunology, University of Toronto, Medical Sciences Bldg. 5265, Toronto, Canada, M5S 1A8.

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http://dx.doi.org/10.1016/j.molimm.2004.09.007DOI Listing
March 2005

Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype.

J Immunol 2005 Feb;174(4):2132-42

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.4049/jimmunol.174.4.2132DOI Listing
February 2005

Identifying protein-protein interactions in somatic hypermutation.

J Exp Med 2005 Feb 14;201(4):493-6. Epub 2005 Feb 14.

University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1084/jem.20050161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213056PMC
February 2005

The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies.

J Allergy Clin Immunol 2004 Oct;114(4):726-35; quiz 736

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.jaci.2004.07.049DOI Listing
October 2004

Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching.

Proc Natl Acad Sci U S A 2004 Oct 14;101(43):15428-33. Epub 2004 Oct 14.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.0406827101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524454PMC
October 2004

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice.

Nat Immunol 2004 Feb 11;5(2):224-9. Epub 2004 Jan 11.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://www.nature.com/articles/ni1031
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http://dx.doi.org/10.1038/ni1031DOI Listing
February 2004

The generation of antibody diversity through somatic hypermutation and class switch recombination.

Genes Dev 2004 Jan;18(1):1-11

Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1161904
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http://dx.doi.org/10.1101/gad.1161904DOI Listing
January 2004

Mutations in AID and UNG extend the function of AID.

Nat Immunol 2003 Oct;4(10):945-6

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http://dx.doi.org/10.1038/ni1003-945DOI Listing
October 2003

Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin.

Immunity 2003 Oct;19(4):479-89

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin 403, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/s1074-7613(03)00261-9DOI Listing
October 2003

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase.

Proc Natl Acad Sci U S A 2003 Apr 21;100(7):4102-7. Epub 2003 Mar 21.

Department of Biological Sciences, Hedco Molecular Biology Laboratories, University of Southern California, University Park, Los Angeles, CA 90089-1340, USA.

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http://dx.doi.org/10.1073/pnas.0730835100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153055PMC
April 2003

Cutting edge: the G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination.

J Immunol 2003 Feb;170(4):1620-4

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin 403, Bronx, NY 10461, USA.

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http://dx.doi.org/10.4049/jimmunol.170.4.1620DOI Listing
February 2003

High affinity mimotope of the polysaccharide capsule of Cryptococcus neoformans identified from an evolutionary phage peptide library.

J Immunol 2002 Dec;169(12):6992-9

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.4049/jimmunol.169.12.6992DOI Listing
December 2002

Somatic hypermutation of the AID transgene in B and non-B cells.

Proc Natl Acad Sci U S A 2002 Sep 29;99(19):12304-8. Epub 2002 Aug 29.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin 403, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.192442899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129440PMC
September 2002

Mutation detection of immunoglobulin V-regions by DHPLC.

J Immunol Methods 2002 Aug;266(1-2):165-73

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/s0022-1759(02)00147-3DOI Listing
August 2002

AID and mismatch repair in antibody diversification.

Nat Rev Immunol 2002 Aug;2(8):605-14

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin 403, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1038/nri858DOI Listing
August 2002

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas.

Nature 2002 Feb 30;415(6873):802-6. Epub 2002 Jan 30.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue Chanin 403, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1038/nature714DOI Listing
February 2002