Matthew S Lebo

Matthew S Lebo

UNVERIFIED PROFILE

Are you Matthew S Lebo?   Register this Author

Register author
Matthew S Lebo

Matthew S Lebo

Publications by authors named "Matthew S Lebo"

Are you Matthew S Lebo?   Register this Author

35Publications

1306Reads

13Profile Views

Considerations for clinical curation, classification, and reporting of low-penetrance and low effect size variants associated with disease risk.

Genet Med 2019 12 31;21(12):2765-2773. Epub 2019 May 31.

Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine, Cambridge, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41436-019-0560-8DOI Listing
December 2019

Variant classification changes over time in BRCA1 and BRCA2.

Genet Med 2019 10 11;21(10):2248-2254. Epub 2019 Apr 11.

Department of Pathology and Laboratory Medicine, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41436-019-0493-2DOI Listing
October 2019

Correction: Variant classification changes over time in BRCA1 and BRCA2.

Genet Med 2019 Oct;21(10):2406-2407

Department of Pathology and Laboratory Medicine, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41436-019-0526-xDOI Listing
October 2019

A Rigorous Interlaboratory Examination of the Need to Confirm Next-Generation Sequencing-Detected Variants with an Orthogonal Method in Clinical Genetic Testing.

J Mol Diagn 2019 Mar 3;21(2):318-329. Epub 2019 Jan 3.

Laboratory for Molecular Medicine, Partners HealthCare, Cambridge, Massachusetts; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2018.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629256PMC
March 2019

Interpretation of Genomic Sequencing Results in Healthy and Ill Newborns: Results from the BabySeq Project.

Am J Hum Genet 2019 01;104(1):76-93

Harvard Medical School, Boston, MA 02115, USA; Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2018.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323417PMC
January 2019

Automated typing of red blood cell and platelet antigens: a whole-genome sequencing study.

Lancet Haematol 2018 Jun 17;5(6):e241-e251. Epub 2018 May 17.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Partners Personalized Medicine, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2352-3026(18)30053-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438177PMC
June 2018

A curated gene list for reporting results of newborn genomic sequencing.

Genet Med 2017 07 12;19(7):809-818. Epub 2017 Jan 12.

Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/gim.2016.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507765PMC
July 2017

VisCap: inference and visualization of germ-line copy-number variants from targeted clinical sequencing data.

Genet Med 2016 07 17;18(7):712-9. Epub 2015 Dec 17.

Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/gim.2015.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940431PMC
July 2016

"Big Data" Gets Personal.

Sci Transl Med 2016 Jan;8(322):322fs3-3fs3

Harvard Medical School, Boston, MA 02115, U.S.A. Partners HealthCare Personalized Medicine, Boston, MA 02115, U.S.A. Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, U.S.A. Broad Institute of MIT and Harvard, Boston, MA 02115, U.S.A.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aad9460DOI Listing
January 2016

Canadian Open Genetics Repository (COGR): a unified clinical genomics database as a community resource for standardising and sharing genetic interpretations.

J Med Genet 2015 Jul 22;52(7):438-45. Epub 2015 Apr 22.

Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine, Cambridge, Massachusetts, USA Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jmedgenet-2014-102933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501169PMC
July 2015

Designing algorithms for determining significance of DNA missense changes.

Methods Mol Biol 2014 ;1168:251-62

Novartis Institutes for Biomedical Research, 500 Technology Square, 840-14, Cambridge, MA, 02139, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-0847-9_14DOI Listing
January 2015

New molecular genetic tests in the diagnosis of heart disease.

Clin Lab Med 2014 Mar 14;34(1):137-56, vii-viii. Epub 2014 Jan 14.

Partners HealthCare Center for Personalized Genetic Medicine, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cll.2013.11.011DOI Listing
March 2014

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

Authors:
Catherine A Brownstein Alan H Beggs Nils Homer Barry Merriman Timothy W Yu Katherine C Flannery Elizabeth T DeChene Meghan C Towne Sarah K Savage Emily N Price Ingrid A Holm Lovelace J Luquette Elaine Lyon Joseph Majzoub Peter Neupert David McCallie Peter Szolovits Huntington F Willard Nancy J Mendelsohn Renee Temme Richard S Finkel Sabrina W Yum Livija Medne Shamil R Sunyaev Ivan Adzhubey Christopher A Cassa Paul I W de Bakker Hatice Duzkale Piotr Dworzyński William Fairbrother Laurent Francioli Birgit H Funke Monica A Giovanni Robert E Handsaker Kasper Lage Matthew S Lebo Monkol Lek Ignaty Leshchiner Daniel G MacArthur Heather M McLaughlin Michael F Murray Tune H Pers Paz P Polak Soumya Raychaudhuri Heidi L Rehm Rachel Soemedi Nathan O Stitziel Sara Vestecka Jochen Supper Claudia Gugenmus Bernward Klocke Alexander Hahn Max Schubach Mortiz Menzel Saskia Biskup Peter Freisinger Mario Deng Martin Braun Sven Perner Richard J H Smith Janeen L Andorf Jian Huang Kelli Ryckman Val C Sheffield Edwin M Stone Thomas Bair E Ann Black-Ziegelbein Terry A Braun Benjamin Darbro Adam P DeLuca Diana L Kolbe Todd E Scheetz Aiden E Shearer Rama Sompallae Kai Wang Alexander G Bassuk Erik Edens Katherine Mathews Steven A Moore Oleg A Shchelochkov Pamela Trapane Aaron Bossler Colleen A Campbell Jonathan W Heusel Anne Kwitek Tara Maga Karin Panzer Thomas Wassink Douglas Van Daele Hela Azaiez Kevin Booth Nic Meyer Michael M Segal Marc S Williams Gerard Tromp Peter White Donald Corsmeier Sara Fitzgerald-Butt Gail Herman Devon Lamb-Thrush Kim L McBride David Newsom Christopher R Pierson Alexander T Rakowsky Aleš Maver Luca Lovrečić Anja Palandačić Borut Peterlin Ali Torkamani Anna Wedell Mikael Huss Andrey Alexeyenko Jessica M Lindvall Måns Magnusson Daniel Nilsson Henrik Stranneheim Fulya Taylan Christian Gilissen Alexander Hoischen Bregje van Bon Helger Yntema Marcel Nelen Weidong Zhang Jason Sager Lu Zhang Kathryn Blair Deniz Kural Michael Cariaso Greg G Lennon Asif Javed Saloni Agrawal Pauline C Ng Komal S Sandhu Shuba Krishna Vamsi Veeramachaneni Ofer Isakov Eran Halperin Eitan Friedman Noam Shomron Gustavo Glusman Jared C Roach Juan Caballero Hannah C Cox Denise Mauldin Seth A Ament Lee Rowen Daniel R Richards F Anthony San Lucas Manuel L Gonzalez-Garay C Thomas Caskey Yu Bai Ying Huang Fang Fang Yan Zhang Zhengyuan Wang Jorge Barrera Juan M Garcia-Lobo Domingo González-Lamuño Javier Llorca Maria C Rodriguez Ignacio Varela Martin G Reese Francisco M De La Vega Edward Kiruluta Michele Cargill Reece K Hart Jon M Sorenson Gholson J Lyon David A Stevenson Bruce E Bray Barry M Moore Karen Eilbeck Mark Yandell Hongyu Zhao Lin Hou Xiaowei Chen Xiting Yan Mengjie Chen Cong Li Can Yang Murat Gunel Peining Li Yong Kong Austin C Alexander Zayed I Albertyn Kym M Boycott Dennis E Bulman Paul M K Gordon A Micheil Innes Bartha M Knoppers Jacek Majewski Christian R Marshall Jillian S Parboosingh Sarah L Sawyer Mark E Samuels Jeremy Schwartzentruber Isaac S Kohane David M Margulies

Genome Biol 2014 Mar 25;15(3):R53. Epub 2014 Mar 25.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/gb-2014-15-3-r53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073084PMC
March 2014

A GC-wave correction algorithm that improves the analytical performance of aCGH.

J Mol Diagn 2012 Nov 23;14(6):550-9. Epub 2012 Aug 23.

Research and Development, Esoterix Genetic Laboratories LLC, Westborough, Massachusetts 01581, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2012.06.002DOI Listing
November 2012

Dynamic, mating-induced gene expression changes in female head and brain tissues of Drosophila melanogaster.

BMC Genomics 2010 Oct 6;11:541. Epub 2010 Oct 6.

Section of Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-11-541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091690PMC
October 2010

Ecdysone receptor acts in fruitless- expressing neurons to mediate drosophila courtship behaviors.

Curr Biol 2009 Sep 30;19(17):1447-52. Epub 2009 Jul 30.

Section of Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2009.06.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763606PMC
September 2009

Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis.

BMC Genomics 2009 Feb 13;10:80. Epub 2009 Feb 13.

Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-10-80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656526PMC
February 2009