Matthew R Sydes

Matthew R Sydes

UNVERIFIED PROFILE

Are you Matthew R Sydes?   Register this Author

Register author
Matthew R Sydes

Matthew R Sydes

Publications by authors named "Matthew R Sydes"

Are you Matthew R Sydes?   Register this Author

99Publications

3533Reads

37Profile Views

A third trial oversight committee: Functions, benefits and issues.

Clin Trials 2019 Oct 30:1740774519881619. Epub 2019 Oct 30.

MRC Clinical Trials Unit at UCL, University College London (UCL), London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1740774519881619DOI Listing
October 2019

Marginal structural models with dose-delay joint-exposure for assessing variations to chemotherapy intensity.

Stat Methods Med Res 2019 Sep 19;28(9):2787-2801. Epub 2018 Jun 19.

1 Mathematical Institute Leiden University, Leiden, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0962280218780619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728750PMC
September 2019

Mind the gap? The platform trial as a working environment.

Trials 2019 May 29;20(1):297. Epub 2019 May 29.

CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-019-3377-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540560PMC
May 2019

Implementing monitoring triggers and matching of triggered and control sites in the TEMPER study: a description and evaluation of a triggered monitoring management system.

Trials 2019 Apr 17;20(1):227. Epub 2019 Apr 17.

MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, 90 High Holborn 2nd Floor, London, WC1V 6LJ, UK.

View Article

Download full-text PDF

Source
https://trialsjournal.biomedcentral.com/articles/10.1186/s13
Publisher Site
http://dx.doi.org/10.1186/s13063-019-3301-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471958PMC
April 2019

Revisiting Intermittent Therapy in Metastatic Prostate Cancer: Can Less Be More in the "New World Order"?

Eur Urol Focus 2019 03 23;5(2):125-133. Epub 2019 Feb 23.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euf.2019.02.006DOI Listing
March 2019

Cross-sectional analysis of UK research studies in 2015: results from a scoping project with the UK Health Research Authority.

BMJ Open 2018 10 17;8(10):e022340. Epub 2018 Oct 17.

MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02234
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-022340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196875PMC
October 2018

Influence of an International Consensus Conference on Practice Patterns in Advanced Prostate Cancer.

Eur Urol 2018 08 3;74(2):239-240. Epub 2018 May 3.

Department of Oncology/Haematology, Kantonsspital St Gallen, St Gallen, Switzerland; Department of Oncology and Haematology, University Hospital Berne, Berne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2018.04.024DOI Listing
August 2018

Two-years Postradiotherapy Biopsies: Lessons from MRC RT01 Trial.

Eur Urol 2018 06 4;73(6):968-976. Epub 2018 Jan 4.

Institute of Cancer Research and Royal Marsden Hospitals, Sutton and London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2017.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954168PMC
June 2018

Salvage Treatment After Radical Prostatectomy.

Eur Urol 2018 02 2;73(2):166-167. Epub 2017 Aug 2.

MRC Clinical Trials Unit at UCL, London, UK.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03022838173065
Publisher Site
http://dx.doi.org/10.1016/j.eururo.2017.07.025DOI Listing
February 2018

A cohort examination to establish reporting of the remit and function of Trial Steering Committees in randomised controlled trials.

Trials 2017 Dec 8;18(1):590. Epub 2017 Dec 8.

MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Block F Waterhouse Building, 1-5 Brownlow Street, Liverpool, L69 3GL, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-017-2300-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723080PMC
December 2017

Abiraterone in Metastatic Prostate Cancer.

N Engl J Med 2017 10;377(17):1696-7

University College London, London, United Kingdom

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMc1711029
Publisher Site
http://dx.doi.org/10.1056/NEJMc1711029DOI Listing
October 2017

Metastasis-Free Survival Is a Strong Surrogate of Overall Survival in Localized Prostate Cancer.

J Clin Oncol 2017 09 10;35(27):3097-3104. Epub 2017 Aug 10.

Wanling Xie, Meredith M. Regan, and Christopher J. Sweeney, Dana-Farber Cancer Institute, Boston, MA; Marc Buyse, International Drug Development Institute; Bertrand Tombal, Université Catholique de Louvain, Louvain-la-Neuve; Laurence Collette, European Organisation for Research and Treatment of Cancer, Brussels, Belgium; Susan Halabi, Duke University Medical Center, Durham, NC; Philip W. Kantoff, Memorial Sloan Kettering Cancer Center, New York, NY; Oliver Sartor, Tulane Medical School, New Orleans, LA; Howard Soule, Prostate Cancer Foundation, Santa Monica; Howard M. Sandler, Cedars-Sinai Medical Center, Los Angeles, CA; Noel W. Clarke, The Christie NHS Foundation Trust, Manchester; Matthew R. Sydes, University College London, London, United Kingdom; James J. Dignam, University of Chicago, Chicago, IL; Karim Fizazi, Institut Gustave-Roussy, Villejuif, France; Wendy R. Paruleker, Canadian Cancer Trials Group, Kingston, Ontario, Canada; and Scott G. Williams, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2017.73.9987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652387PMC
September 2017

Reply to Che-Kai Tsao, Matthew D. Galsky, and William K. Oh's Platinum Opinion. Docetaxel for Metastatic Hormone-Sensitive Prostate Cancer: Urgent Need To Minimize The Risk Of Neutropenic Fever. Eur Urol 2016;70:707-708.

Eur Urol 2017 07 6;72(1):e17. Epub 2016 Oct 6.

University Hospitals Birmingham NHS Foundation Trust, The Medical School, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2016.09.036DOI Listing
July 2017

Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy.

N Engl J Med 2017 07 3;377(4):338-351. Epub 2017 Jun 3.

From the Institute of Cancer and Genomic Sciences, University of Birmingham (N.D.J.), and University Hospital Birmingham (A.Z.), Birmingham, the Institute of Cancer Research (J.S.B., D.P.D., G.A.), Medical Research Council Clinical Trials Unit at University College London (M.R. Spears, C.L.A., C.G., C.B., M.K.B.P., M.R. Sydes), King's College London and Guy's and St. Thomas' NHS Foundation Trust (S.C.), and Royal Marsden NHS Foundation Trust (C.C.P.), London, Salford Royal NHS Foundation Trust, Salford (N.W.C.), Cardiff University School of Medicine (M.D.M.) and Velindre Cancer Centre (J.F.L.), Cardiff, Gloucestershire Royal Hospital (A.W.S.R.) and Gloucestershire Hospitals NHS Foundation Trust (J.B.), Gloucester, University of Glasgow, Glasgow (R.J.J., J.M.R.), St. James's University Hospital, Leeds (W.R.C.), University Hospital of North-Midlands, Stoke-on-Trent (F.A.), Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter (S.A.), Rosemere Cancer Centre, Royal Preston Hospital, Preston (A.J.B.), Dorset Cancer Centre, Poole Hospital, Poole (S.B.), Royal Derby Hospital, Derby (P.C.), Weston Park Hospital, Sheffield (C.F.), Portsmouth Oncology Centre, Queen Alexandra Hospital, Portsmouth (J.G.), Musgrove Park Hospital, Taunton (E.G.), Hull and East Yorkshire Hospitals NHS Trust, Hull (M.H.), Mount Vernon Cancer Centre, Northwood (P.J.H.), Clatterbridge Cancer Centre, Wirral (Z.I.M.), Brighton and Sussex University Hospitals NHS Trust (F.M.) and Sussex Cancer Centre, Royal Sussex County Hospital (A.R.), Brighton, NHS Highland, Inverness (N.M.), Royal Surrey County Hospital, Guildford (J.M.-K.), Northern Ireland Cancer and Queens University, Belfast (J.O.), Lancashire Teaching Hospitals NHS Trust, Preston (O.P.), Churchill Hospital, Oxford (A.P.), Shrewsbury and Telford Hospitals NHS Trust, Shrewsbury (N.N.S.), East Kent Hospitals NHS Trust, Canterbury (C.T.), Swansea University College of Medicine, Swansea (J. Wagstaff), and Christie NHS Foundation Trust, Manchester (J. Wylie) - all in the United Kingdom; and the Department of Medical Oncology, Kantonsspital St. Gallen, St. Gallen (S.G.), and University Hospital of Lausanne, Lausanne (D.R.B.) - both in Switzerland. Two of the authors (D.M., R.M.) were unaffiliated lay members of the STAMPEDE investigators.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1702900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533216PMC
July 2017

Data Authorship as an Incentive to Data Sharing.

N Engl J Med 2017 07;377(4):402

Imperial College London, London, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1707245DOI Listing
July 2017

Adding Celecoxib With or Without Zoledronic Acid for Hormone-Naïve Prostate Cancer: Long-Term Survival Results From an Adaptive, Multiarm, Multistage, Platform, Randomized Controlled Trial.

J Clin Oncol 2017 May 13;35(14):1530-1541. Epub 2017 Mar 13.

Malcolm D. Mason, Cardiff University School of Medicine, Velindre Hospital; Jim Barber, Velindre Cancer Centre, Cardiff; Noel W. Clarke, The Christie and Salford Royal NHS Foundation Trusts; John Logue, Christie Hospital, Manchester; Nicholas D. James, Institute of Cancer and Genomic Sciences; Emilio Porfiri, The Medical School, University of Birmingham; Nicholas D. James, Queen Elizabeth Hospital; Emilio Porfiri, University Hospitals Birmingham NHS Foundation Trust, Birmingham; David P. Dearnaley, Gerhardt Attard, and Christopher C. Parker, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust; Melissa R. Spears, Alastair W.S. Ritchie, Francesca Schiavone, David Matheson, Robin Millman, Clare Gilson, Mahesh K.B. Parmar, and Matthew R. Sydes, MRC Clinical Trials Unit at UCL, London; William Cross, Leeds Teaching Hospitals NHS Trust, Leeds; Rob J. Jones and J. Martin Russell, University of Glasgow; Rob J. Jones and Jan Wallace, Beatson West of Scotland Cancer Centre, Glasgow; Azman Ibrahim, The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, Wirral; Anna Lydon, Torbay District Hospital, Torquay; Ashok D. Nikapota, Sussex Cancer Centre, Brighton; Ashok D. Nikapota, Worthing Hospital, Worthing; Joe M. O'Sullivan, Centre for Cancer Research and Cell Biology, Queen's University, Belfast; Andrew Protheroe, Churchill Hospital, Oxford; Narayanan Nair Srihari, Shrewsbury and Telford Hospitals NHS Trust, Shrewsbury; David Tsang, Southend Hospital, Southend-on-Sea; David Tsang, Basildon Hospital, Basildon; John Wagstaff, The South West Wales Cancer Institute; John Wagstaff, Swansea University College of Medicine, Swansea; Catherine Walmsley, Royal Preston Hospital, Preston, United Kingdom; George N. Thalmann, University Hospital; Estelle Cassoly, SAKK Coordinating Center, Berne; and Cyrill A. Rentsch, University Hospital Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2016.69.0677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455701PMC
May 2017

Repurposing Metformin as Therapy for Prostate Cancer within the STAMPEDE Trial Platform.

Eur Urol 2016 12 19;70(6):906-908. Epub 2016 Jul 19.

Department of Urology, The Christie and Salford Royal NHS Foundation Trusts, Manchester, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2016.07.015DOI Listing
December 2016

How do you design randomised trials for smaller populations? A framework.

BMC Med 2016 Nov 25;14(1):183. Epub 2016 Nov 25.

London Hub for Trials Methodology Research, MRC Clinical Trials Unit at UCL, Aviation House, 125 Kingsway, London, WC2B 6NH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12916-016-0722-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123370PMC
November 2016

Will chemotherapy change the management of prostate cancer?

BJU Int 2016 08 22;118(2):190-2. Epub 2016 Jan 22.

Department of Medical Oncology, Guy's Hospital, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bju.13400DOI Listing
August 2016

What are the roles and valued attributes of a Trial Steering Committee? Ethnographic study of eight clinical trials facing challenges.

Trials 2016 07 1;17(1):307. Epub 2016 Jul 1.

MRC ConDuCT Hub for Trials Methodology Research, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2PS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-016-1425-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930562PMC
July 2016

Best practice for analysis of shared clinical trial data.

BMC Med Res Methodol 2016 Jul 8;16 Suppl 1:76. Epub 2016 Jul 8.

Research and Development Statistics, Bayer Pharma AG, 13353, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12874-016-0170-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943488PMC
July 2016

Data sharing and the evolving role of statisticians.

BMC Med Res Methodol 2016 Jul 8;16 Suppl 1:75. Epub 2016 Jul 8.

Hoffman-La Roche, Grenzacherstrasse 124, Basel, 4070, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12874-016-0172-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943485PMC
July 2016

STAMPEDE trial and patients with non-metastatic prostate cancer - Authors' reply.

Lancet 2016 Jul;388(10041):235-6

Medical Research Council, Clinical Trials Unit, University College London, London WC2B 6NH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(16)31041-8DOI Listing
July 2016

Systemic therapy for vulval Erosive Lichen Planus (the 'hELP' trial): study protocol for a randomised controlled trial.

Trials 2016 Jan 4;17. Epub 2016 Jan 4.

Centre of Evidence Based Dermatology, University of Nottingham, King's Meadow Campus, Lenton Lane, NG7 2NR, Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-015-1133-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698814PMC
January 2016

Comments on 'A modest proposal for dropping poor arms in clinical trials' by Proschan and Dodd.

Stat Med 2015 Aug;34(18):2678-9

MRC Clinical Trials Unit at UCL, 125 Kingsway, London, WC2B 6NH, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/sim.6337DOI Listing
August 2015

Final Report of the Intergroup Randomized Study of Combined Androgen-Deprivation Therapy Plus Radiotherapy Versus Androgen-Deprivation Therapy Alone in Locally Advanced Prostate Cancer.

J Clin Oncol 2015 Jul 17;33(19):2143-50. Epub 2015 Feb 17.

Malcolm D. Mason, Cardiff University School of Medicine, Velindre Hospital; James B.P. Barber, Velindre Hospital, Cardiff; Matthew R. Sydes, Mahesh K.B. Parmar, Gordana Jovic, Medical Research Council Clinical Trials Unit at University College London, London; Peter Kirkbride, The Clatterbridge Cancer Centre National Health Service Foundation Trust, Wirral; Richard Cowan, Christie Hospital, University of Manchester, Manchester; John Anderson, Sheffield Teaching Hospitals, National Health Service Foundation Trust, Sheffield; John Hetherington, Castle Hill Hospital, Hull; Salah El-Sharkawi, South West Wales Cancer Centre, Swansea; P.D. John Hardman, The James Cook University Hospital, Middlesbrough, United Kingdom; Wendy R. Parulekar, Andrea Hiltz, and Bingshu E. Chen, NCIC Clinical Trials Group, Queen's University; Michael Brundage, Cancer Centre of Southeastern Ontario, Kingston; Mary Gospodarowicz and Padraig Warde, University of Toronto, Princess Margaret Cancer Centre; Charles Hayter, University of Toronto, Carlo Fidani Peel Regional Cancer Center, Toronto, Ontario; Edmund C. Kostashuk, Fraser Valley Cancer Centre, Surrey; Michael McKenzie, Vancouver Cancer Centre, Vancouver, British Columbia; Jinka Sathya, Memorial University of Newfoundland, St Johns, Newfoundland and Labrador, Canada; Luis Souhami, McGill University, Montreal, Quebec, Canada; and Gregory Swanson, University of Texas Health Science Center, San Antonio, TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2014.57.7510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477786PMC
July 2015

Impact of Radiotherapy When Added to Androgen-Deprivation Therapy for Locally Advanced Prostate Cancer: Long-Term Quality-of-Life Outcomes From the NCIC CTG PR3/MRC PR07 Randomized Trial.

J Clin Oncol 2015 Jul 26;33(19):2151-7. Epub 2015 May 26.

Michael Brundage, Queen's Cancer Research Institute and Cancer Centre of Southeastern Ontario; Wendy R. Parulekar and Bingshu E. Chen, NCIC Clinical Trials Group, Queen's University, Kingston; Padraig Warde and Andrea Bezjak, Princess Margaret Cancer Center, Toronto, Ontario; Matthew Parliament, Cross Cancer Institute, Edmonton, Alberta; Jean-Paul Bahary, Centre Hospitalier de l'Université de Montréal-Hôpital Notre-Dame, Montreal, Quebec, Canada; Matthew R. Sydes, Mahesh K.B. Parmar, and Karen Sanders, Medical Research Council Clinical Trials Unit, University College London, London; Richard Cowan, Christie Hospital and University of Manchester, Manchester; Peter Kirkbride, Clatterbridge Cancer Centre, National Health Service Foundation Trust, Wirral; Clare Moynihan, Institute of Cancer Research, Sutton; and Malcolm D. Mason, Cardiff University School of Medicine, Velindre Hospital, Cardiff, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2014.57.8724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477787PMC
July 2015

Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial.

J Clin Oncol 2015 Jul 1;33(20):2279-87. Epub 2015 Jun 1.

Stefan S. Bielack, Klinikum Stuttgart-Olgahospital, Stuttgart; Mathias Werner, Helios Klinikum Emil von Behring; Per-Ulf Tunn, Helios Klinikum Berlin-Buch, Berlin; Knut Helmke, Altonaer Kinderkrankenhaus, Hamburg; Heribert Jürgens, Gabriele Calaminus, Joachim Gerss, and Trude Butterfass-Bahloul, Universitätsklinikum Münster, Münster; Peter Reichardt, Klinik für Interdisziplinäre Onkologie, Bad Saarow, Germany; Sigbjørn Smeland and Kirsten Sundby Hall, Oslo University Hospital; Kirsten Sundby Hall, Norwegian Radium Hospital, Oslo, Norway; Jeremy S. Whelan, University College London Hospitals; Gordana Jovic, Jane M. Hook, and Matthew R. Sydes, University College London; Beatrice Seddon and Maria Michelagnoli, University College Hospital, London; Bernadette Brennan, Christie Hospital and Royal Manchester Children's Hospital, Manchester; Susan Picton, Leeds University Hospital, Leeds, United Kingdom; Neyssa Marina, Stanford University Medical Center; Claudia Deffenbaugh, Lucille Salter Packard Children's Hospital, Palo Alto; Mark D. Krailo, Children's Oncology Group, Arcadia, CA; Mark Gebhardt and Allen Goorin, Dana-Farber Cancer Institute; Mark Gebhardt and Lisa A. Teot, Children's Hospital Boston, Boston, MA; Zsuzsanna Pápai, National Medical Center, Budapest, Hungary; James Meyer, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA; Helen Nadel, British Columbia Children's Hospital and University of British Columbia, Vancouver, British Columbia; Mark Bernstein, Dalhousie University, Halifax, Nova Scotia, Canada; R. Lor Randall, University of Utah, Salt Lake City, UT; Rajaram Nagarajan, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; G. Douglas Letson, H. Lee Moffit Cancer Center and Research Institute, Tampa, FL; Daniel Baumhoer, Universitätsspital Basel; Thomas Kühne, University Children's Hospital Basel, Basel, Switzerland; Leo Kager, St Anna's Children Hospital; Reinhard Windhager, Medica

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2014.60.0734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486345PMC
July 2015

Sharing data from clinical trials: the rationale for a controlled access approach.

Trials 2015 Mar 23;16:104. Epub 2015 Mar 23.

Medical Research Council Clinical Trials Unit at UCL, Aviation House, 125 Kingsway, London, WC2B 6NH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-015-0604-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369803PMC
March 2015

Outcomes and endpoints in cancer trials: bridging the divide.

Lancet Oncol 2015 Jan 29;16(1):e43-52. Epub 2014 Dec 29.

University of Toronto Princess Margaret Cancer Centre, Toronto, ON, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(14)70380-8DOI Listing
January 2015

A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1.

Nat Genet 2014 Aug 29;46(8):891-4. Epub 2014 Jun 29.

1] Fundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde (SERGAS), Santiago de Compostela, Spain. [2] Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3020DOI Listing
August 2014

More multiarm randomised trials of superiority are needed.

Lancet 2014 Jul;384(9940):283-4

MRC Clinical Trials Unit, University College London, London WC2B 6NH, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(14)61122-3DOI Listing
July 2014

Postoperative radiotherapy after radical prostatectomy: let's work together to tackle the known unknowns.

Eur Urol 2014 Jun 27;65(6):1044-5. Epub 2013 Sep 27.

MRC Clinical Trials Unit at UCL, London, UK; Institute of Cancer Research/Royal Marsden Hospital, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2013.09.035DOI Listing
June 2014

The dose-response of the anal sphincter region--an analysis of data from the MRC RT01 trial.

Radiother Oncol 2012 Jun 18;103(3):347-52. Epub 2012 Apr 18.

Joint Department of Physics, Institute of Cancer Research, Surrey, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2012.03.002DOI Listing
June 2012

Parameters for the Lyman Kutcher Burman (LKB) model of Normal Tissue Complication Probability (NTCP) for specific rectal complications observed in clinical practise.

Radiother Oncol 2012 Mar 25;102(3):347-51. Epub 2011 Nov 25.

Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2011.10.022DOI Listing
March 2012

Consolidation radiotherapy in patients with advanced Hodgkin's lymphoma: survival data from the UKLG LY09 randomized controlled trial (ISRCTN97144519).

J Clin Oncol 2010 Jul 24;28(20):3352-9. Epub 2010 May 24.

University of Southampton, Medical Research Council (MRC) Clinical Trials Unit, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2009.26.0323DOI Listing
July 2010

Potential pitfalls in the design and reporting of clinical trials.

Lancet Oncol 2010 Jul 25;11(7):694-700. Epub 2010 May 25.

Cancer Group, Medical Research Council Clinical Trials Unit, London, UK.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S147020451070041
Publisher Site
http://dx.doi.org/10.1016/S1470-2045(10)70041-3DOI Listing
July 2010

Dose-volume constraints to reduce rectal side effects from prostate radiotherapy: evidence from MRC RT01 Trial ISRCTN 47772397.

Int J Radiat Oncol Biol Phys 2010 Mar 18;76(3):747-54. Epub 2009 Jun 18.

Joint Department of Physics, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2009.02.025DOI Listing
March 2010

A comparison of dose-volume constraints derived using peak and longitudinal definitions of late rectal toxicity.

Radiother Oncol 2010 Feb 22;94(2):241-7. Epub 2010 Jan 22.

Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2009.12.019DOI Listing
February 2010

Early salvage radiotherapy after radical prostatectomy.

J Clin Oncol 2010 Jan 14;28(3):e45; author reply e46. Epub 2009 Dec 14.

View Article

Download full-text PDF

Source
http://ascopubs.org/doi/10.1200/JCO.2009.24.2396
Publisher Site
http://dx.doi.org/10.1200/JCO.2009.24.2396DOI Listing
January 2010

Assessing correlations between the spatial distribution of the dose to the rectal wall and late rectal toxicity after prostate radiotherapy: an analysis of data from the MRC RT01 trial (ISRCTN 47772397).

Phys Med Biol 2009 Nov 14;54(21):6535-48. Epub 2009 Oct 14.

Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/0031-9155/54/21/006DOI Listing
November 2009

Interim monitoring of efficacy data is important and appropriate.

J Clin Epidemiol 2008 Mar;61(3):203-4

MRC Clinical Trials Unit, Cancer Group, 222 Euston Road, London NWI 2DA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jclinepi.2007.08.002DOI Listing
March 2008

Using implicit information to identify smoking status in smoke-blind medical discharge summaries.

J Am Med Inform Assoc 2008 Jan-Feb;15(1):29-31. Epub 2007 Oct 18.

Swarthmore College, Computer Science Department, 500 College Avenue, Swarthmore, PA 19081, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1197/jamia.M2440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2274867PMC
February 2008