Matthew R Nelson

Matthew R Nelson

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Matthew R Nelson

Matthew R Nelson

Publications by authors named "Matthew R Nelson"

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Predicting clinically promising therapeutic hypotheses using tensor factorization.

BMC Bioinformatics 2019 Feb 8;20(1):69. Epub 2019 Feb 8.

Computational Biology, GSK R&D, 1250 S. Collegeville Road, UP12-200, Collegeville, PA, USA.

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http://dx.doi.org/10.1186/s12859-019-2664-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368709PMC
February 2019

STOPGAP: a database for systematic target opportunity assessment by genetic association predictions.

Bioinformatics 2017 Sep;33(17):2784-2786

Target Sciences, GSK, King of Prussia, Philadelphia, PA 27513, USA.

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http://dx.doi.org/10.1093/bioinformatics/btx274DOI Listing
September 2017

Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenet Genomics 2017 03;27(3):89-100

aGlaxoSmithKline Research and Development, Durham, North Carolina bGlaxoSmithKline Research and Development, King of Prussia, Pennsylvania cDepartment of Biostatistics and/or Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA dGlaxoSmithKline Research and Development, Sydney, New South Wales, Australia eSeoul National University fDNA Link Inc., Seoul, Korea gKyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1097/FPC.0000000000000260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287433PMC
March 2017

Trial watch: Impact of genetically supported target selection on R&D productivity.

Nat Rev Drug Discov 2016 Aug;15(9):596-597

GlaxoSmithKline, 709 Swedeland Rd, UW2230, King of Prussia, Pennsylvania 19406, USA.

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http://dx.doi.org/10.1038/nrd.2016.164DOI Listing
August 2016

HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury.

Pharmacogenet Genomics 2016 May;26(5):218-24

Departments of aSystems Biology bBiomedical Informatics cThe Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York dUNC Eshelman School of Pharmacy, Chapel Hill, North Carolina eTarget Sciences, GSK, King of Prussia, Pennsylvania, USA fInstitute for Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel gDrug Commission of the German Medical Association (DCGMA), Berlin, Germany hInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne iNational Institute for Health Research (NIHR), Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospital NHS Trust and University of Nottingham, Nottingham, UK jDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The National University Hospital of Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1097/FPC.0000000000000209DOI Listing
May 2016

The genetics of drug efficacy: opportunities and challenges.

Nat Rev Genet 2016 Apr 14;17(4):197-206. Epub 2016 Mar 14.

Target Sciences, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA.

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http://dx.doi.org/10.1038/nrg.2016.12DOI Listing
April 2016

GWASdb v2: an update database for human genetic variants identified by genome-wide association studies.

Nucleic Acids Res 2016 Jan 28;44(D1):D869-76. Epub 2015 Nov 28.

Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

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http://dx.doi.org/10.1093/nar/gkv1317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702921PMC
January 2016

Improved genome inference in the MHC using a population reference graph.

Nat Genet 2015 Jun 27;47(6):682-8. Epub 2015 Apr 27.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449272PMC
June 2015

Comparing variant calling algorithms for target-exon sequencing in a large sample.

BMC Bioinformatics 2015 Mar 7;16:75. Epub 2015 Mar 7.

Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1186/s12859-015-0489-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359451PMC
March 2015

The international serious adverse events consortium.

Nat Rev Drug Discov 2014 Nov;13(11):795-6

iSAEC Scientific Management Committee and at GlaxoSmithKline, Research Triangle Park, North Carolina 27709-3398, USA.

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http://dx.doi.org/10.1038/nrd4441DOI Listing
November 2014

Analysis of rare variant population structure in Europeans explains differential stratification of gene-based tests.

Eur J Hum Genet 2014 Sep 8;22(9):1137-44. Epub 2014 Jan 8.

1] Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA [2] Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/ejhg.2013.297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135410PMC
September 2014

Multi-population classical HLA type imputation.

PLoS Comput Biol 2013 14;9(2):e1002877. Epub 2013 Feb 14.

Department of Statistics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1371/journal.pcbi.1002877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572961PMC
October 2013

Novel ECG criteria for right ventricular systolic dysfunction in patients with right bundle branch block.

Int J Cardiol 2013 Aug 25;167(4):1385-9. Epub 2012 Apr 25.

Division of Cardiovascular Diseases, Mayo Clinic, Phoenix, Arizona 85054, USA.

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http://dx.doi.org/10.1016/j.ijcard.2012.04.025DOI Listing
August 2013

Comparison of statistical tests for association between rare variants and binary traits.

PLoS One 2012 9;7(8):e42530. Epub 2012 Aug 9.

Quantitative Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042530PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415421PMC
April 2013

Echocardiographic measures of myocardial deformation by speckle-tracking technologies: the need for standardization?

J Am Soc Echocardiogr 2012 Nov 12;25(11):1189-94. Epub 2012 Sep 12.

Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona, USA.

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http://dx.doi.org/10.1016/j.echo.2012.08.006DOI Listing
November 2012

Histologic remission of cardiac amyloidosis: a case report.

Amyloid 2012 Jun 7;19(2):106-9. Epub 2012 Mar 7.

Division of Cardiovascular Diseases, Mayo Clinic Scottsdale, Arizona, USA.

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http://dx.doi.org/10.3109/13506129.2012.660892DOI Listing
June 2012

Carotid intimal-medial thickness in active professional American football players aged 23 to 35 years.

Am J Cardiol 2012 Mar 22;109(6):897-900. Epub 2011 Dec 22.

Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona, USA.

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http://dx.doi.org/10.1016/j.amjcard.2011.10.052DOI Listing
March 2012

Comparison of methods and sampling designs to test for association between rare variants and quantitative traits.

Genet Epidemiol 2011 May;35(4):226-35

GlaxoSmithKline, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1002/gepi.20570DOI Listing
May 2011

Carotid ultrasound identifies high risk subclinical atherosclerosis in adults with low framingham risk scores.

J Am Soc Echocardiogr 2010 Aug 29;23(8):802-8. Epub 2010 Jun 29.

Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.1016/j.echo.2010.06.003DOI Listing
August 2010

Assessing individual cardiac risk using extra-cardiac arterial imaging.

Expert Rev Cardiovasc Ther 2010 Apr;8(4):529-43

Division of Cardiovascular Diseases, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.1586/erc.10.16DOI Listing
April 2010

Quantitative DNA methylation predicts survival in adult acute myeloid leukemia.

Blood 2010 Jan 10;115(3):636-42. Epub 2009 Nov 10.

Department of Internal Medicine III, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1182/blood-2009-03-211003DOI Listing
January 2010

Genome-wide patterns of population structure and admixture in West Africans and African Americans.

Proc Natl Acad Sci U S A 2010 Jan 22;107(2):786-91. Epub 2009 Dec 22.

Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1073/pnas.0909559107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818934PMC
January 2010

Copy number variation in African Americans.

BMC Genet 2009 Mar 24;10:15. Epub 2009 Mar 24.

Department of Neurology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1186/1471-2156-10-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674062PMC
March 2009

Comparison of association methods for dense marker data.

Genet Epidemiol 2008 Dec;32(8):791-9

GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1002/gepi.20347DOI Listing
December 2008

Genes mirror geography within Europe.

Nature 2008 Nov 31;456(7218):98-101. Epub 2008 Aug 31.

Department of Ecology and Evolutionary Biology, Interdepartmental Program in Bioinformatics, University of California-Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/nature07331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735096PMC
November 2008

New method for removal of spectral interferences for beryllium assay using inductively coupled plasma atomic emission spectrometry.

Talanta 2008 Jul 28;76(2):432-40. Epub 2008 Mar 28.

Washington Savannah River Company, Analytical Labs, Building 735-B, Aiken, SC 29808, USA.

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http://dx.doi.org/10.1016/j.talanta.2008.03.032DOI Listing
July 2008

Maldi-TOF mass spectrometry for trisomy detection.

Methods Mol Biol 2008 ;444:123-32

Laboratory of Prenatal Medicine, University Women's Hospital/Department of Research, Basel, Switzerland.

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http://dx.doi.org/10.1007/978-1-59745-066-9_9DOI Listing
June 2008

Analysis of flavin-containing monooxygenase 3 genotype data in populations administered the anti-schizophrenia agent olanzapine.

Drug Metab Lett 2008 Apr;2(2):100-14

Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA.

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http://dx.doi.org/10.2174/187231208784040942DOI Listing
April 2008

Associations between electrocardiographic interval durations and coronary artery calcium scores: the Diabetes Heart Study.

Pacing Clin Electrophysiol 2008 Mar;31(3):314-21

Department of Medicine-Cardiology Section, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1111/j.1540-8159.2008.00991.xDOI Listing
March 2008

Reliable detection of trisomy 21 using MALDI-TOF mass spectrometry.

Genet Med 2006 Nov;8(11):728-34

Laboratory for Prenatal Medicine University Women's Hospital, Department of Research Spitalstrasse 21, CH4031 Basel, Switzerland.

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http://dx.doi.org/10.1097/01.gim.0000245573.42908.34DOI Listing
November 2006

Association of the PDCD5 locus with lung cancer risk and prognosis in smokers.

J Clin Oncol 2006 Apr 20;24(11):1672-8. Epub 2006 Mar 20.

Department of Experimental Oncology and Laboratories, Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy.

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http://dx.doi.org/10.1200/JCO.2005.04.4339DOI Listing
April 2006

Genome-wide SNP association: identification of susceptibility alleles for osteoarthritis.

Autoimmun Rev 2006 Apr 8;5(4):258-63. Epub 2005 Aug 8.

SEQUENOM, Inc., 3595 John Hopkins Court, San Diego, CA, USA 92121.

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http://dx.doi.org/10.1016/j.autrev.2005.07.005DOI Listing
April 2006

Guidelines for conducting and reporting whole genome/large-scale association studies.

Hum Mol Genet 2005 Sep 21;14(17):2485-8. Epub 2005 Jul 21.

Design and Standards, GlaxoSmithKline, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1093/hmg/ddi252DOI Listing
September 2005

Haplotyping in biomedicine-practical challenges.

Nat Biotechnol 2005 Jan;23(1):21-2

Institut des Hautes Etudes Scientifiques, Bures-sur-Yvette, France.

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http://dx.doi.org/10.1038/nbt0105-21DOI Listing
January 2005

Inadequate carbohydrate intake following prolonged exercise does not increase muscle soreness after 15 minutes of downhill running.

Int J Sport Nutr Exerc Metab 2004 Apr;14(2):171-84

Human Performance Research Center at Brigham Young University, Provo, UT 84602, USA.

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http://dx.doi.org/10.1123/ijsnem.14.2.171DOI Listing
April 2004