Publications

VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface.
Dev Cell 2014 Jun 22;29(5):591-606. Epub 2014 May 22.
Cambridge Institute for Medical Research and Department of Clinical Biochemistry, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK. Electronic address:

Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.
Nat Commun 2014 May 13;5:3828. Epub 2014 May 13.
Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer.
Biol Cell 2013 May 7;105(5):191-207. Epub 2013 Mar 7.
Centre de Recherche de Gif, Laboratoire d'Enzymologie et Biochimie Structurales, CNRS UPR3082, Avenue de la Terrasse, Gif-sur-Yvette Cedex 91198, France.

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.
J Cell Sci 2010 Nov 5;123(Pt 21):3703-17. Epub 2010 Oct 5.
Department of Clinical Biochemistry, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrookes Hospital, Cambridge CB2 0XY, UK.

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.
J Cell Sci 2009 Jul 16;122(Pt 14):2371-82. Epub 2009 Jun 16.
University of Cambridge, Cambridge Institute for Medical Research, Department of Clinical Biochemistry, Wellcome Trust/MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK.

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