Matthew L Freedman

Matthew L Freedman

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Matthew L Freedman

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Sex specific associations in genome wide association analysis of renal cell carcinoma.

Authors:
Ruhina S Laskar David C Muller Peng Li Mitchell J Machiela Yuanqing Ye Valerie Gaborieau Matthieu Foll Jonathan N Hofmann Leandro Colli Joshua N Sampson Zhaoming Wang Delphine Bacq-Daian Anne Boland Behnoush Abedi-Ardekani Geoffroy Durand Florence Le Calvez-Kelm Nivonirina Robinot Helene Blanche Egor Prokhortchouk Konstantin G Skryabin Laurie Burdett Meredith Yeager Sanja Radojevic-Skodric Slavisa Savic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Stefan Rascu Anush Mukeria David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Beata Świątkowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Antonia Trichopoulou Elio Riboli Kim Overvad Salvatore Panico Borje Ljungberg Raviprakash T Sitaram Graham G Giles Roger L Milne Gianluca Severi Fiona Bruinsma Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard D Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Wong-Ho Chow Lee E Moore Toni K Choueiri Christopher Wood Mattias Johansson James D McKay Kevin M Brown Nathaniel Rothman Mark G Lathrop Jean-Francois Deleuze Xifeng Wu Paul Brennan Stephen J Chanock Mark P Purdue Ghislaine Scelo

Eur J Hum Genet 2019 Jun 23. Epub 2019 Jun 23.

International Agency for Research on Cancer (IARC), Lyon, France.

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http://dx.doi.org/10.1038/s41431-019-0455-9DOI Listing
June 2019

Super-Enhancer-Associated LncRNA UCA1 Interacts Directly with AMOT to Activate YAP Target Genes in Epithelial Ovarian Cancer.

iScience 2019 Jun 20;17:242-255. Epub 2019 Jun 20.

Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Center for Bioinformatics and Functional Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.06.025DOI Listing
June 2019

The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study.

Authors:
Mattias Johansson Robert Carreras-Torres Ghislaine Scelo Mark P Purdue Daniela Mariosa David C Muller Nicolas J Timpson Philip C Haycock Kevin M Brown Zhaoming Wang Yuanqing Ye Jonathan N Hofmann Matthieu Foll Valerie Gaborieau Mitchell J Machiela Leandro M Colli Peng Li Jean-Guillaume Garnier Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Sanja Radojevic-Skodric Simona Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Elisabete Weiderpass Börje Ljungberg Raviprakash Tumkur Sitaram Christel Häggström Fiona Bruinsma Susan J Jordan Gianluca Severi Ingrid Winship Kristian Hveem Lars J Vatten Tony Fletcher Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Gabriella Andreotti Laura E Beane Freeman Stella Koutros Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Kathryn M Wilson J Michael Gaziano Howard D Sesso Neal D Freedman Alexander S Parker Jeanette E Eckel-Passow Wen-Yi Huang Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Timothy Eisen Marc Henrion James Larkin Poulami Barman Bradley C Leibovich Toni K Choueiri G Mark Lathrop Jean-Francois Deleuze Marc Gunter James D McKay Xifeng Wu Richard S Houlston Stephen J Chanock Caroline Relton J Brent Richards Richard M Martin George Davey Smith Paul Brennan

PLoS Med 2019 01 3;16(1):e1002724. Epub 2019 Jan 3.

International Agency for Research on Cancer (IARC), Lyon, France.

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http://dx.doi.org/10.1371/journal.pmed.1002724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317776PMC
January 2019

Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia.

Cancer Cell 2018 12 29;34(6):982-995.e7. Epub 2018 Nov 29.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA; Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183048
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http://dx.doi.org/10.1016/j.ccell.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298230PMC
December 2018

Corrigendum re "Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma" [Eur Urol 2017;72:747-54].

Authors:
Mitchell J Machiela Jonathan N Hofmann Robert Carreras-Torres Kevin M Brown Mattias Johansson Zhaoming Wang Matthieu Foll Peng Li Nathaniel Rothman Sharon A Savage Valerie Gaborieau James D McKay Yuanqing Ye Marc Henrion Fiona Bruinsma Susan Jordan Gianluca Severi Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Mannisto Stephanie Weinstein Peter E Clark Todd E Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard S Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Leandro M Colli Joshua N Sampson Celine Besse Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Mirjana Mijuskovic Miodrag Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot H B As Bueno-de-Mesquita Federico Canzian Eric J Duell Börje Ljungberg Raviprakash T Sitaram Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen James Larkin Toni K Choueiri G Mark Lathrop Bin Tean Teh Jean-Francois Deleuze Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock Ghislaine Scelo Mark P Purdue

Eur Urol 2018 09 28;74(3):e85-e86. Epub 2018 May 28.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183036
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http://dx.doi.org/10.1016/j.eururo.2018.05.017DOI Listing
September 2018

A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer.

Cell 2018 07 14;174(2):422-432.e13. Epub 2018 Jun 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183064
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http://dx.doi.org/10.1016/j.cell.2018.05.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046260PMC
July 2018

Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017.

J Clin Oncol 2018 02 13;36(4):414-424. Epub 2017 Dec 13.

Veda N. Giri, Karen E. Knudsen, William K. Kelly, Robert B. Den, Adam P. Dicker, Jean Hoffman-Censits, Mark D. Hurwitz, Colette Hyatt, Grace Lu-Yao, Mark J. Mann, James R. Mark, Peter A. McCue, Ronald E. Myers, Stephen C. Peiper, Edouard J. Trabulsi, and Leonard G. Gomella, Jefferson Sidney Kimmel Cancer Center; Justin E. Bekelman, University of Pennsylvania Perelman School of Medicine; S. Bruce Malkowicz, University of Pennsylvania; Elias Obeid and Robert Uzzo, Fox Chase Cancer Center; Gordon F. Schwartz, Foundation for Breast and Prostate Health, Philadelphia; Mark S. Shahin, Hanjani Institute for Gynecologic Oncology, Abington Hospital-Jefferson Health, Abington, PA; Wassim Abida, Philip Kantoff, and Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mitchell C. Benson, Columbia University, New York, NY; Gerald L. Andriole, Washington University School of Medicine, St Louis, MO; Chris H. Bangma, Erasmus Medical Center, Rotterdam, the Netherlands; Amie Blanco, and Matthew Cooperberg, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco; Christopher J. Kane, University of California San Diego, San Diego; Howard Sandler, Cedars-Sinai Medical Center, Los Angeles; Howard R. Soule, Prostate Cancer Foundation, Santa Monica, CA; Arthur Burnett, William B. Isaacs, Christian P. Pavlovich, and Patrick C. Walsh, Johns Hopkins Medical Institutions, Baltimore; Peter A. Pinto and Carol J. Weil, National Cancer Institute, Bethesda, MD; William J. Catalona and Edward Schaeffer, Northwestern University Feinberg School of Medicine; Scott Eggener, Sarah M. Nielsen, and Donald J. Vander Griend, University of Chicago, Chicago, IL; Kathleen A. Cooney, University of Utah School of Medicine, Salt Lake City, UT; David E. Crawford, University of Colorado, Aurora; Lawrence I. Karsh, The Urology Center of Colorado, Denver; Wendy Poage, Prostate Conditions Education Council, Elizabeth, CO; Neil Fleshner, University of Toronto Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Matthew L. Freedman, Kevin R. Loughlin, and Timothy R. Rebbeck, Dana Farber Cancer Institute, and Harvard TH Chan School of Public Health, Boston, MA; Freddie C. Hamdy, University of Oxford, Oxford, England; R. Jeffrey Karnes, Mayo Clinic, Rochester, MN; Eric A. Klein, Cleveland Clinic, Cleveland; Robert Pilarski, The Ohio State University, Columbus, OH; Daniel W. Lin, University of Washington, Seattle, WA; Martin M. Miner, Brown University, Providence, RI; Todd Morgan and Scott A. Tomlins, University of Michigan, Ann Arbor; Matt T. Rosenberg, Mid-Michigan Health Center, Jackson, MI; Judd W. Moul, Duke University, Duke Cancer Institute, Durham, NC; David F. Penson, Vanderbilt University Medical Center, Nashville, TN; Daniel Petrylak and Brian Shuch, Yale University, New Haven, CT; Curtis A. Pettaway, The University of Texas MD Anderson Cancer Center, Houston; Ganesh V. Raj, University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Oliver Sartor, Tulane University Medical School, New Orleans, LA; Neal D. Shore, Atlantic Urology Clinics/Carolina Urologic Research Center, Myrtle Beach, SC; and Richard Wender, American Cancer Society, Atlanta, GA.

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http://dx.doi.org/10.1200/JCO.2017.74.1173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075860PMC
February 2018

Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.

Authors:
Mitchell J Machiela Jonathan N Hofmann Robert Carreras-Torres Kevin M Brown Mattias Johansson Zhaoming Wang Matthieu Foll Peng Li Nathaniel Rothman Sharon A Savage Valerie Gaborieau James D McKay Yuanqing Ye Marc Henrion Fiona Bruinsma Susan Jordan Gianluca Severi Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Mannisto Stephanie Weinstein Peter E Clark Todd E Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard S Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Leandro M Colli Joshua N Sampson Celine Besse Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Mirjana Mijuskovic Miodrag Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot H Bas Bueno-de-Mesquita Federico Canzian Eric J Duell Börje Ljungberg Raviprakash T Sitaram Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen James Larkin Toni K Choueiri G Mark Lathrop Bin Tean Teh Jean-Francois Deleuze Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock Ghislaine Scelo Mark P Purdue

Eur Urol 2017 11 7;72(5):747-754. Epub 2017 Aug 7.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838173063
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http://dx.doi.org/10.1016/j.eururo.2017.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641242PMC
November 2017

Genome-wide association study identifies multiple risk loci for renal cell carcinoma.

Authors:
Ghislaine Scelo Mark P Purdue Kevin M Brown Mattias Johansson Zhaoming Wang Jeanette E Eckel-Passow Yuanqing Ye Jonathan N Hofmann Jiyeon Choi Matthieu Foll Valerie Gaborieau Mitchell J Machiela Leandro M Colli Peng Li Joshua N Sampson Behnoush Abedi-Ardekani Celine Besse Helene Blanche Anne Boland Laurie Burdette Amelie Chabrier Geoffroy Durand Florence Le Calvez-Kelm Egor Prokhortchouk Nivonirina Robinot Konstantin G Skryabin Magdalena B Wozniak Meredith Yeager Gordana Basta-Jovanovic Zoran Dzamic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Laura Baglietto Heiner Boeing Kay-Tee Khaw Elisabete Weiderpass Borje Ljungberg Raviprakash T Sitaram Fiona Bruinsma Susan J Jordan Gianluca Severi Ingrid Winship Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard D Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen Marc Henrion James Larkin Poulami Barman Bradley C Leibovich Toni K Choueiri G Mark Lathrop Nathaniel Rothman Jean-Francois Deleuze James D McKay Alexander S Parker Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock

Nat Commun 2017 06 9;8:15724. Epub 2017 Jun 9.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms15724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472706PMC
June 2017

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci.

Br J Cancer 2017 Feb 19;116(4):524-535. Epub 2017 Jan 19.

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1038/bjc.2016.426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318969PMC
February 2017

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

Authors:
Gordon Fehringer Peter Kraft Paul D Pharoah Rosalind A Eeles Nilanjan Chatterjee Fredrick R Schumacher Joellen M Schildkraut Sara Lindström Paul Brennan Heike Bickeböller Richard S Houlston Maria Teresa Landi Neil Caporaso Angela Risch Ali Amin Al Olama Sonja I Berndt Edward L Giovannucci Henrik Grönberg Zsofia Kote-Jarai Jing Ma Kenneth Muir Meir J Stampfer Victoria L Stevens Fredrik Wiklund Walter C Willett Ellen L Goode Jennifer B Permuth Harvey A Risch Brett M Reid Stephane Bezieau Hermann Brenner Andrew T Chan Jenny Chang-Claude Thomas J Hudson Jonathan K Kocarnik Polly A Newcomb Robert E Schoen Martha L Slattery Emily White Muriel A Adank Habibul Ahsan Kristiina Aittomäki Laura Baglietto Carl Blomquist Federico Canzian Kamila Czene Isabel Dos-Santos-Silva A Heather Eliassen Jonine D Figueroa Dieter Flesch-Janys Olivia Fletcher Montserrat Garcia-Closas Mia M Gaudet Nichola Johnson Per Hall Aditi Hazra Rebecca Hein Albert Hofman John L Hopper Astrid Irwanto Mattias Johansson Rudolf Kaaks Muhammad G Kibriya Peter Lichtner Jianjun Liu Eiliv Lund Enes Makalic Alfons Meindl Bertram Müller-Myhsok Taru A Muranen Heli Nevanlinna Petra H Peeters Julian Peto Ross L Prentice Nazneen Rahman Maria Jose Sanchez Daniel F Schmidt Rita K Schmutzler Melissa C Southey Rulla Tamimi Ruth C Travis Clare Turnbull Andre G Uitterlinden Zhaoming Wang Alice S Whittemore Xiaohong R Yang Wei Zheng Daniel D Buchanan Graham Casey David V Conti Christopher K Edlund Steven Gallinger Robert W Haile Mark Jenkins Loïc Le Marchand Li Li Noralene M Lindor Stephanie L Schmit Stephen N Thibodeau Michael O Woods Thorunn Rafnar Julius Gudmundsson Simon N Stacey Kari Stefansson Patrick Sulem Y Ann Chen Jonathan P Tyrer David C Christiani Yongyue Wei Hongbing Shen Zhibin Hu Xiao-Ou Shu Kouya Shiraishi Atsushi Takahashi Yohan Bossé Ma'en Obeidat David Nickle Wim Timens Matthew L Freedman Qiyuan Li Daniela Seminara Stephen J Chanock Jian Gong Ulrike Peters Stephen B Gruber Christopher I Amos Thomas A Sellers Douglas F Easton David J Hunter Christopher A Haiman Brian E Henderson Rayjean J Hung

Cancer Res 2016 09 20;76(17):5103-14. Epub 2016 Apr 20.

Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010493PMC
September 2016

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.

Authors:
Siddhartha P Kar Jonathan Beesley Ali Amin Al Olama Kyriaki Michailidou Jonathan Tyrer ZSofia Kote-Jarai Kate Lawrenson Sara Lindstrom Susan J Ramus Deborah J Thompson Adam S Kibel Agnieszka Dansonka-Mieszkowska Agnieszka Michael Aida K Dieffenbach Aleksandra Gentry-Maharaj Alice S Whittemore Alicja Wolk Alvaro Monteiro Ana Peixoto Andrzej Kierzek Angela Cox Anja Rudolph Anna Gonzalez-Neira Anna H Wu Annika Lindblom Anthony Swerdlow Argyrios Ziogas Arif B Ekici Barbara Burwinkel Beth Y Karlan Børge G Nordestgaard Carl Blomqvist Catherine Phelan Catriona McLean Celeste Leigh Pearce Celine Vachon Cezary Cybulski Chavdar Slavov Christa Stegmaier Christiane Maier Christine B Ambrosone Claus K Høgdall Craig C Teerlink Daehee Kang Daniel C Tessier Daniel J Schaid Daniel O Stram Daniel W Cramer David E Neal Diana Eccles Dieter Flesch-Janys Digna R Velez Edwards Dominika Wokozorczyk Douglas A Levine Drakoulis Yannoukakos Elinor J Sawyer Elisa V Bandera Elizabeth M Poole Ellen L Goode Elza Khusnutdinova Estrid Høgdall Fengju Song Fiona Bruinsma Florian Heitz Francesmary Modugno Freddie C Hamdy Fredrik Wiklund Graham G Giles Håkan Olsson Hans Wildiers Hans-Ulrich Ulmer Hardev Pandha Harvey A Risch Hatef Darabi Helga B Salvesen Heli Nevanlinna Henrik Gronberg Hermann Brenner Hiltrud Brauch Hoda Anton-Culver Honglin Song Hui-Yi Lim Iain McNeish Ian Campbell Ignace Vergote Jacek Gronwald Jan Lubiński Janet L Stanford Javier Benítez Jennifer A Doherty Jennifer B Permuth Jenny Chang-Claude Jenny L Donovan Joe Dennis Joellen M Schildkraut Johanna Schleutker John L Hopper Jolanta Kupryjanczyk Jong Y Park Jonine Figueroa Judith A Clements Julia A Knight Julian Peto Julie M Cunningham Julio Pow-Sang Jyotsna Batra Kamila Czene Karen H Lu Kathleen Herkommer Kay-Tee Khaw Keitaro Matsuo Kenneth Muir Kenneth Offitt Kexin Chen Kirsten B Moysich Kristiina Aittomäki Kunle Odunsi Lambertus A Kiemeney Leon F A G Massuger Liesel M Fitzgerald Linda S Cook Lisa Cannon-Albright Maartje J Hooning Malcolm C Pike Manjeet K Bolla Manuel Luedeke Manuel R Teixeira Marc T Goodman Marjanka K Schmidt Marjorie Riggan Markus Aly Mary Anne Rossing Matthias W Beckmann Matthieu Moisse Maureen Sanderson Melissa C Southey Michael Jones Michael Lush Michelle A T Hildebrandt Ming-Feng Hou Minouk J Schoemaker Montserrat Garcia-Closas Natalia Bogdanova Nazneen Rahman Nhu D Le Nick Orr Nicolas Wentzensen Nora Pashayan Paolo Peterlongo Pascal Guénel Paul Brennan Paula Paulo Penelope M Webb Per Broberg Peter A Fasching Peter Devilee Qin Wang Qiuyin Cai Qiyuan Li Radka Kaneva Ralf Butzow Reidun Kristin Kopperud Rita K Schmutzler Robert A Stephenson Robert J MacInnis Robert N Hoover Robert Winqvist Roberta Ness Roger L Milne Ruth C Travis Sara Benlloch Sara H Olson Shannon K McDonnell Shelley S Tworoger Sofia Maia Sonja Berndt Soo Chin Lee Soo-Hwang Teo Stephen N Thibodeau Stig E Bojesen Susan M Gapstur Susanne Krüger Kjær Tanja Pejovic Teuvo L J Tammela Thilo Dörk Thomas Brüning Tiina Wahlfors Tim J Key Todd L Edwards Usha Menon Ute Hamann Vanio Mitev Veli-Matti Kosma Veronica Wendy Setiawan Vessela Kristensen Volker Arndt Walther Vogel Wei Zheng Weiva Sieh William J Blot Wojciech Kluzniak Xiao-Ou Shu Yu-Tang Gao Fredrick Schumacher Matthew L Freedman Andrew Berchuck Alison M Dunning Jacques Simard Christopher A Haiman Amanda Spurdle Thomas A Sellers David J Hunter Brian E Henderson Peter Kraft Stephen J Chanock Fergus J Couch Per Hall Simon A Gayther Douglas F Easton Georgia Chenevix-Trench Rosalind Eeles Paul D P Pharoah Diether Lambrechts

Cancer Discov 2016 09 17;6(9):1052-67. Epub 2016 Jul 17.

VIB Vesalius Research Center, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010513PMC
September 2016

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

Authors:
Kate Lawrenson Siddhartha Kar Karen McCue Karoline Kuchenbaeker Kyriaki Michailidou Jonathan Tyrer Jonathan Beesley Susan J Ramus Qiyuan Li Melissa K Delgado Janet M Lee Kristiina Aittomäki Irene L Andrulis Hoda Anton-Culver Volker Arndt Banu K Arun Brita Arver Elisa V Bandera Monica Barile Rosa B Barkardottir Daniel Barrowdale Matthias W Beckmann Javier Benitez Andrew Berchuck Maria Bisogna Line Bjorge Carl Blomqvist William Blot Natalia Bogdanova Anders Bojesen Stig E Bojesen Manjeet K Bolla Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Paul Brennan Hermann Brenner Fiona Bruinsma Joan Brunet Shaik Ahmad Buhari Barbara Burwinkel Ralf Butzow Saundra S Buys Qiuyin Cai Trinidad Caldes Ian Campbell Rikki Canniotto Jenny Chang-Claude Jocelyne Chiquette Ji-Yeob Choi Kathleen B M Claes Linda S Cook Angela Cox Daniel W Cramer Simon S Cross Cezary Cybulski Kamila Czene Mary B Daly Francesca Damiola Agnieszka Dansonka-Mieszkowska Hatef Darabi Joe Dennis Peter Devilee Orland Diez Jennifer A Doherty Susan M Domchek Cecilia M Dorfling Thilo Dörk Martine Dumont Hans Ehrencrona Bent Ejlertsen Steve Ellis Christoph Engel Eunjung Lee D Gareth Evans Peter A Fasching Lidia Feliubadalo Jonine Figueroa Dieter Flesch-Janys Olivia Fletcher Henrik Flyger Lenka Foretova Florentia Fostira William D Foulkes Brooke L Fridley Eitan Friedman Debra Frost Gaetana Gambino Patricia A Ganz Judy Garber Montserrat García-Closas Aleksandra Gentry-Maharaj Maya Ghoussaini Graham G Giles Rosalind Glasspool Andrew K Godwin Mark S Goldberg David E Goldgar Anna González-Neira Ellen L Goode Marc T Goodman Mark H Greene Jacek Gronwald Pascal Guénel Christopher A Haiman Per Hall Emily Hallberg Ute Hamann Thomas V O Hansen Patricia A Harrington Mikael Hartman Norhashimah Hassan Sue Healey Florian Heitz Josef Herzog Estrid Høgdall Claus K Høgdall Frans B L Hogervorst Antoinette Hollestelle John L Hopper Peter J Hulick Tomasz Huzarski Evgeny N Imyanitov Claudine Isaacs Hidemi Ito Anna Jakubowska Ramunas Janavicius Allan Jensen Esther M John Nichola Johnson Maria Kabisch Daehee Kang Miroslav Kapuscinski Beth Y Karlan Sofia Khan Lambertus A Kiemeney Susanne Kruger Kjaer Julia A Knight Irene Konstantopoulou Veli-Matti Kosma Vessela Kristensen Jolanta Kupryjanczyk Ava Kwong Miguel de la Hoya Yael Laitman Diether Lambrechts Nhu Le Kim De Leeneer Jenny Lester Douglas A Levine Jingmei Li Annika Lindblom Jirong Long Artitaya Lophatananon Jennifer T Loud Karen Lu Jan Lubinski Arto Mannermaa Siranoush Manoukian Loic Le Marchand Sara Margolin Frederik Marme Leon F A G Massuger Keitaro Matsuo Sylvie Mazoyer Lesley McGuffog Catriona McLean Iain McNeish Alfons Meindl Usha Menon Arjen R Mensenkamp Roger L Milne Marco Montagna Kirsten B Moysich Kenneth Muir Anna Marie Mulligan Katherine L Nathanson Roberta B Ness Susan L Neuhausen Heli Nevanlinna Silje Nord Robert L Nussbaum Kunle Odunsi Kenneth Offit Edith Olah Olufunmilayo I Olopade Janet E Olson Curtis Olswold David O'Malley Irene Orlow Nick Orr Ana Osorio Sue Kyung Park Celeste L Pearce Tanja Pejovic Paolo Peterlongo Georg Pfeiler Catherine M Phelan Elizabeth M Poole Katri Pylkäs Paolo Radice Johanna Rantala Muhammad Usman Rashid Gad Rennert Valerie Rhenius Kerstin Rhiem Harvey A Risch Gus Rodriguez Mary Anne Rossing Anja Rudolph Helga B Salvesen Suleeporn Sangrajrang Elinor J Sawyer Joellen M Schildkraut Marjanka K Schmidt Rita K Schmutzler Thomas A Sellers Caroline Seynaeve Mitul Shah Chen-Yang Shen Xiao-Ou Shu Weiva Sieh Christian F Singer Olga M Sinilnikova Susan Slager Honglin Song Penny Soucy Melissa C Southey Marie Stenmark-Askmalm Dominique Stoppa-Lyonnet Christian Sutter Anthony Swerdlow Sandrine Tchatchou Manuel R Teixeira Soo H Teo Kathryn L Terry Mary Beth Terry Mads Thomassen Maria Grazia Tibiletti Laima Tihomirova Silvia Tognazzo Amanda Ewart Toland Ian Tomlinson Diana Torres Thérèse Truong Chiu-Chen Tseng Nadine Tung Shelley S Tworoger Celine Vachon Ans M W van den Ouweland Helena C van Doorn Elizabeth J van Rensburg Laura J Van't Veer Adriaan Vanderstichele Ignace Vergote Joseph Vijai Qin Wang Shan Wang-Gohrke Jeffrey N Weitzel Nicolas Wentzensen Alice S Whittemore Hans Wildiers Robert Winqvist Anna H Wu Drakoulis Yannoukakos Sook-Yee Yoon Jyh-Cherng Yu Wei Zheng Ying Zheng Kum Kum Khanna Jacques Simard Alvaro N Monteiro Juliet D French Fergus J Couch Matthew L Freedman Douglas F Easton Alison M Dunning Paul D Pharoah Stacey L Edwards Georgia Chenevix-Trench Antonis C Antoniou Simon A Gayther

Nat Commun 2016 09 7;7:12675. Epub 2016 Sep 7.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1038/ncomms12675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023955PMC
September 2016

Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors.

JCI Insight 2016 Aug;1(13)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.87988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017158PMC
August 2016

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.

Authors:
Alexander Gusev Huwenbo Shi Gleb Kichaev Mark Pomerantz Fugen Li Henry W Long Sue A Ingles Rick A Kittles Sara S Strom Benjamin A Rybicki Barbara Nemesure William B Isaacs Wei Zheng Curtis A Pettaway Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Anand P Chokkalingam Esther M John Adam B Murphy Lisa B Signorello John Carpten M Cristina Leske Suh-Yuh Wu Anslem J M Hennis Christine Neslund-Dudas Ann W Hsing Lisa Chu Phyllis J Goodman Eric A Klein John S Witte Graham Casey Sam Kaggwa Michael B Cook Daniel O Stram William J Blot Rosalind A Eeles Douglas Easton Zsofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Kenneth Muir Graham G Giles Melissa C Southey Liesel M Fitzgerald Henrik Gronberg Fredrik Wiklund Markus Aly Brian E Henderson Johanna Schleutker Tiina Wahlfors Teuvo L J Tammela Børge G Nordestgaard Tim J Key Ruth C Travis David E Neal Jenny L Donovan Freddie C Hamdy Paul Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Christiane Maier Walther Vogel Manuel Luedeke Kathleen Herkommer Adam S Kibel Cezary Cybulski Dominika Wokolorczyk Wojciech Kluzniak Lisa Cannon-Albright Craig Teerlink Hermann Brenner Aida K Dieffenbach Volker Arndt Jong Y Park Thomas A Sellers Hui-Yi Lin Chavdar Slavov Radka Kaneva Vanio Mitev Jyotsna Batra Amanda Spurdle Judith A Clements Manuel R Teixeira Hardev Pandha Agnieszka Michael Paula Paulo Sofia Maia Andrzej Kierzek David V Conti Demetrius Albanes Christine Berg Sonja I Berndt Daniele Campa E David Crawford W Ryan Diver Susan M Gapstur J Michael Gaziano Edward Giovannucci Robert Hoover David J Hunter Mattias Johansson Peter Kraft Loic Le Marchand Sara Lindström Carmen Navarro Kim Overvad Elio Riboli Afshan Siddiq Victoria L Stevens Dimitrios Trichopoulos Paolo Vineis Meredith Yeager Gosia Trynka Soumya Raychaudhuri Frederick R Schumacher Alkes L Price Matthew L Freedman Christopher A Haiman Bogdan Pasaniuc

Nat Commun 2016 Apr 7;7:10979. Epub 2016 Apr 7.

Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/ncomms10979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829663PMC
April 2016

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer.

Authors:
Kate Lawrenson Edwin S Iversen Jonathan Tyrer Rachel Palmieri Weber Patrick Concannon Dennis J Hazelett Qiyuan Li Jeffrey R Marks Andrew Berchuck Janet M Lee Katja K H Aben Hoda Anton-Culver Natalia Antonenkova Elisa V Bandera Yukie Bean Matthias W Beckmann Maria Bisogna Line Bjorge Natalia Bogdanova Louise A Brinton Angela Brooks-Wilson Fiona Bruinsma Ralf Butzow Ian G Campbell Karen Carty Jenny Chang-Claude Georgia Chenevix-Trench Ann Chen Zhihua Chen Linda S Cook Daniel W Cramer Julie M Cunningham Cezary Cybulski Joanna Plisiecka-Halasa Joe Dennis Ed Dicks Jennifer A Doherty Thilo Dörk Andreas du Bois Diana Eccles Douglas T Easton Robert P Edwards Ursula Eilber Arif B Ekici Peter A Fasching Brooke L Fridley Yu-Tang Gao Aleksandra Gentry-Maharaj Graham G Giles Rosalind Glasspool Ellen L Goode Marc T Goodman Jacek Gronwald Philipp Harter Hanis Nazihah Hasmad Alexander Hein Florian Heitz Michelle A T Hildebrandt Peter Hillemanns Estrid Hogdall Claus Hogdall Satoyo Hosono Anna Jakubowska James Paul Allan Jensen Beth Y Karlan Susanne Kruger Kjaer Linda E Kelemen Melissa Kellar Joseph L Kelley Lambertus A Kiemeney Camilla Krakstad Diether Lambrechts Sandrina Lambrechts Nhu D Le Alice W Lee Rikki Cannioto Arto Leminen Jenny Lester Douglas A Levine Dong Liang Jolanta Lissowska Karen Lu Jan Lubinski Lene Lundvall Leon F A G Massuger Keitaro Matsuo Valerie McGuire John R McLaughlin Heli Nevanlinna Iain McNeish Usha Menon Francesmary Modugno Kirsten B Moysich Steven A Narod Lotte Nedergaard Roberta B Ness Mat Adenan Noor Azmi Kunle Odunsi Sara H Olson Irene Orlow Sandra Orsulic Celeste L Pearce Tanja Pejovic Liisa M Pelttari Jennifer Permuth-Wey Catherine M Phelan Malcolm C Pike Elizabeth M Poole Susan J Ramus Harvey A Risch Barry Rosen Mary Anne Rossing Joseph H Rothstein Anja Rudolph Ingo B Runnebaum Iwona K Rzepecka Helga B Salvesen Agnieszka Budzilowska Thomas A Sellers Xiao-Ou Shu Yurii B Shvetsov Nadeem Siddiqui Weiva Sieh Honglin Song Melissa C Southey Lara Sucheston Ingvild L Tangen Soo-Hwang Teo Kathryn L Terry Pamela J Thompson Agnieszka Timorek Shelley S Tworoger Els Van Nieuwenhuysen Ignace Vergote Robert A Vierkant Shan Wang-Gohrke Christine Walsh Nicolas Wentzensen Alice S Whittemore Kristine G Wicklund Lynne R Wilkens Yin-Ling Woo Xifeng Wu Anna H Wu Hannah Yang Wei Zheng Argyrios Ziogas Gerhard A Coetzee Matthew L Freedman Alvaro N A Monteiro Joanna Moes-Sosnowska Jolanta Kupryjanczyk Paul D Pharoah Simon A Gayther Joellen M Schildkraut

Carcinogenesis 2015 Nov 29;36(11):1341-53. Epub 2015 Sep 29.

Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA, Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC 27710, USA,

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http://dx.doi.org/10.1093/carcin/bgv138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635670PMC
November 2015

Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions.

Hum Mol Genet 2015 Oct 10;24(19):5603-18. Epub 2015 Jul 10.

Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center,

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http://dx.doi.org/10.1093/hmg/ddv269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572069PMC
October 2015

Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.

Authors:
Siddhartha P Kar Jonathan P Tyrer Qiyuan Li Kate Lawrenson Katja K H Aben Hoda Anton-Culver Natalia Antonenkova Georgia Chenevix-Trench Helen Baker Elisa V Bandera Yukie T Bean Matthias W Beckmann Andrew Berchuck Maria Bisogna Line Bjørge Natalia Bogdanova Louise Brinton Angela Brooks-Wilson Ralf Butzow Ian Campbell Karen Carty Jenny Chang-Claude Yian Ann Chen Zhihua Chen Linda S Cook Daniel Cramer Julie M Cunningham Cezary Cybulski Agnieszka Dansonka-Mieszkowska Joe Dennis Ed Dicks Jennifer A Doherty Thilo Dörk Andreas du Bois Matthias Dürst Diana Eccles Douglas F Easton Robert P Edwards Arif B Ekici Peter A Fasching Brooke L Fridley Yu-Tang Gao Aleksandra Gentry-Maharaj Graham G Giles Rosalind Glasspool Ellen L Goode Marc T Goodman Jacek Grownwald Patricia Harrington Philipp Harter Alexander Hein Florian Heitz Michelle A T Hildebrandt Peter Hillemanns Estrid Hogdall Claus K Hogdall Satoyo Hosono Edwin S Iversen Anna Jakubowska James Paul Allan Jensen Bu-Tian Ji Beth Y Karlan Susanne K Kjaer Linda E Kelemen Melissa Kellar Joseph Kelley Lambertus A Kiemeney Camilla Krakstad Jolanta Kupryjanczyk Diether Lambrechts Sandrina Lambrechts Nhu D Le Alice W Lee Shashi Lele Arto Leminen Jenny Lester Douglas A Levine Dong Liang Jolanta Lissowska Karen Lu Jan Lubinski Lene Lundvall Leon Massuger Keitaro Matsuo Valerie McGuire John R McLaughlin Iain A McNeish Usha Menon Francesmary Modugno Kirsten B Moysich Steven A Narod Lotte Nedergaard Roberta B Ness Heli Nevanlinna Kunle Odunsi Sara H Olson Irene Orlow Sandra Orsulic Rachel Palmieri Weber Celeste Leigh Pearce Tanja Pejovic Liisa M Pelttari Jennifer Permuth-Wey Catherine M Phelan Malcolm C Pike Elizabeth M Poole Susan J Ramus Harvey A Risch Barry Rosen Mary Anne Rossing Joseph H Rothstein Anja Rudolph Ingo B Runnebaum Iwona K Rzepecka Helga B Salvesen Joellen M Schildkraut Ira Schwaab Xiao-Ou Shu Yurii B Shvetsov Nadeem Siddiqui Weiva Sieh Honglin Song Melissa C Southey Lara E Sucheston-Campbell Ingvild L Tangen Soo-Hwang Teo Kathryn L Terry Pamela J Thompson Agnieszka Timorek Ya-Yu Tsai Shelley S Tworoger Anne M van Altena Els Van Nieuwenhuysen Ignace Vergote Robert A Vierkant Shan Wang-Gohrke Christine Walsh Nicolas Wentzensen Alice S Whittemore Kristine G Wicklund Lynne R Wilkens Yin-Ling Woo Xifeng Wu Anna Wu Hannah Yang Wei Zheng Argyrios Ziogas Thomas A Sellers Alvaro N A Monteiro Matthew L Freedman Simon A Gayther Paul D P Pharoah

Cancer Epidemiol Biomarkers Prev 2015 Oct 24;24(10):1574-84. Epub 2015 Jul 24.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-1270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592449PMC
October 2015

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.

Authors:
Kate Lawrenson Qiyuan Li Siddhartha Kar Ji-Heui Seo Jonathan Tyrer Tassja J Spindler Janet Lee Yibu Chen Alison Karst Ronny Drapkin Katja K H Aben Hoda Anton-Culver Natalia Antonenkova Helen Baker Elisa V Bandera Yukie Bean Matthias W Beckmann Andrew Berchuck Maria Bisogna Line Bjorge Natalia Bogdanova Louise A Brinton Angela Brooks-Wilson Fiona Bruinsma Ralf Butzow Ian G Campbell Karen Carty Jenny Chang-Claude Georgia Chenevix-Trench Anne Chen Zhihua Chen Linda S Cook Daniel W Cramer Julie M Cunningham Cezary Cybulski Agnieszka Dansonka-Mieszkowska Joe Dennis Ed Dicks Jennifer A Doherty Thilo Dörk Andreas du Bois Matthias Dürst Diana Eccles Douglas T Easton Robert P Edwards Ursula Eilber Arif B Ekici Peter A Fasching Brooke L Fridley Yu-Tang Gao Aleksandra Gentry-Maharaj Graham G Giles Rosalind Glasspool Ellen L Goode Marc T Goodman Jacek Grownwald Patricia Harrington Philipp Harter Hanis Nazihah Hasmad Alexander Hein Florian Heitz Michelle A T Hildebrandt Peter Hillemanns Estrid Hogdall Claus Hogdall Satoyo Hosono Edwin S Iversen Anna Jakubowska Paul James Allan Jensen Bu-Tian Ji Beth Y Karlan Susanne Kruger Kjaer Linda E Kelemen Melissa Kellar Joseph L Kelley Lambertus A Kiemeney Camilla Krakstad Jolanta Kupryjanczyk Diether Lambrechts Sandrina Lambrechts Nhu D Le Alice W Lee Shashi Lele Arto Leminen Jenny Lester Douglas A Levine Dong Liang Jolanta Lissowska Karen Lu Jan Lubinski Lene Lundvall Leon F A G Massuger Keitaro Matsuo Valerie McGuire John R McLaughlin Heli Nevanlinna Ian McNeish Usha Menon Francesmary Modugno Kirsten B Moysich Steven A Narod Lotte Nedergaard Roberta B Ness Mat Adenan Noor Azmi Kunle Odunsi Sara H Olson Irene Orlow Sandra Orsulic Rachel Palmieri Weber Celeste L Pearce Tanja Pejovic Liisa M Pelttari Jennifer Permuth-Wey Catherine M Phelan Malcolm C Pike Elizabeth M Poole Susan J Ramus Harvey A Risch Barry Rosen Mary Anne Rossing Joseph H Rothstein Anja Rudolph Ingo B Runnebaum Iwona K Rzepecka Helga B Salvesen Joellen M Schildkraut Ira Schwaab Thomas A Sellers Xiao-Ou Shu Yurii B Shvetsov Nadeem Siddiqui Weiva Sieh Honglin Song Melissa C Southey Lara Sucheston Ingvild L Tangen Soo-Hwang Teo Kathryn L Terry Pamela J Thompson Agnieszka Timorek Ya-Yu Tsai Shelley S Tworoger Anne M van Altena Els Van Nieuwenhuysen Ignace Vergote Robert A Vierkant Shan Wang-Gohrke Christine Walsh Nicolas Wentzensen Alice S Whittemore Kristine G Wicklund Lynne R Wilkens Yin-Ling Woo Xifeng Wu Anna H Wu Hannah Yang Wei Zheng Argyrios Ziogas Alvaro Monteiro Paul D Pharoah Simon A Gayther Matthew L Freedman

Nat Commun 2015 Sep 22;6:8234. Epub 2015 Sep 22.

Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncomms9234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580986PMC
September 2015

A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.

Cancer Discov 2015 Aug 1;5(8):878-91. Epub 2015 Jun 1.

Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California. Institute for Human Genetics, University of California, San Francisco, San Francisco, California. Department of Urology, University of California, San Francisco, San Francisco, California. UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527942PMC
August 2015

Inference of transcriptional regulation in cancers.

Proc Natl Acad Sci U S A 2015 Jun 8;112(25):7731-6. Epub 2015 Jun 8.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1424272112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485084PMC
June 2015

Association of prostate cancer risk variants with gene expression in normal and tumor tissue.

Cancer Epidemiol Biomarkers Prev 2015 Jan 4;24(1):255-60. Epub 2014 Nov 4.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0694-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294966PMC
January 2015

Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types.

Hum Mol Genet 2014 Oct 6;23(19):5294-302. Epub 2014 Jun 6.

Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana Farber Cancer Institute, Boston, MA, USA Program in Medical and Population Genetics, The Broad Institute, Cambridge, MA, USA

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http://dx.doi.org/10.1093/hmg/ddu228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215106PMC
October 2014

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

Authors:
Ali Amin Al Olama Zsofia Kote-Jarai Sonja I Berndt David V Conti Fredrick Schumacher Ying Han Sara Benlloch Dennis J Hazelett Zhaoming Wang Ed Saunders Daniel Leongamornlert Sara Lindstrom Sara Jugurnauth-Little Tokhir Dadaev Malgorzata Tymrakiewicz Daniel O Stram Kristin Rand Peggy Wan Alex Stram Xin Sheng Loreall C Pooler Karen Park Lucy Xia Jonathan Tyrer Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Merideth Yeager Laurie Burdette Charles C Chung Amy Hutchinson Kai Yu Chee Goh Mahbubl Ahmed Koveela Govindasami Michelle Guy Teuvo L J Tammela Anssi Auvinen Tiina Wahlfors Johanna Schleutker Tapio Visakorpi Katri A Leinonen Jianfeng Xu Markus Aly Jenny Donovan Ruth C Travis Tim J Key Afshan Siddiq Federico Canzian Kay-Tee Khaw Atsushi Takahashi Michiaki Kubo Paul Pharoah Nora Pashayan Maren Weischer Borge G Nordestgaard Sune F Nielsen Peter Klarskov Martin Andreas Røder Peter Iversen Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Janet L Stanford Suzanne Kolb Sarah Holt Beatrice Knudsen Antonio Hurtado Coll Susan M Gapstur W Ryan Diver Victoria L Stevens Christiane Maier Manuel Luedeke Kathleen Herkommer Antje E Rinckleb Sara S Strom Curtis Pettaway Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Anand P Chokkalingam Lisa Cannon-Albright Cezary Cybulski Dominika Wokołorczyk Wojciech Kluźniak Jong Park Thomas Sellers Hui-Yi Lin William B Isaacs Alan W Partin Hermann Brenner Aida Karina Dieffenbach Christa Stegmaier Constance Chen Edward L Giovannucci Jing Ma Meir Stampfer Kathryn L Penney Lorelei Mucci Esther M John Sue A Ingles Rick A Kittles Adam B Murphy Hardev Pandha Agnieszka Michael Andrzej M Kierzek William Blot Lisa B Signorello Wei Zheng Demetrius Albanes Jarmo Virtamo Stephanie Weinstein Barbara Nemesure John Carpten Cristina Leske Suh-Yuh Wu Anselm Hennis Adam S Kibel Benjamin A Rybicki Christine Neslund-Dudas Ann W Hsing Lisa Chu Phyllis J Goodman Eric A Klein S Lilly Zheng Jyotsna Batra Judith Clements Amanda Spurdle Manuel R Teixeira Paula Paulo Sofia Maia Chavdar Slavov Radka Kaneva Vanio Mitev John S Witte Graham Casey Elizabeth M Gillanders Daniella Seminara Elio Riboli Freddie C Hamdy Gerhard A Coetzee Qiyuan Li Matthew L Freedman David J Hunter Kenneth Muir Henrik Gronberg David E Neal Melissa Southey Graham G Giles Gianluca Severi Michael B Cook Hidewaki Nakagawa Fredrik Wiklund Peter Kraft Stephen J Chanock Brian E Henderson Douglas F Easton Rosalind A Eeles Christopher A Haiman

Nat Genet 2014 Oct 14;46(10):1103-9. Epub 2014 Sep 14.

1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA. [3].

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http://dx.doi.org/10.1038/ng.3094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383163PMC
October 2014

Deconvoluting complex tissues for expression quantitative trait locus-based analyses.

Philos Trans R Soc Lond B Biol Sci 2013 6;368(1620):20120363. Epub 2013 May 6.

Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1098/rstb.2012.0363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682728PMC
December 2013

Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations.

J Natl Cancer Inst 2013 Dec 7;105(24):1852-61. Epub 2013 Dec 7.

Affiliations of authors: Division of Cancer Epidemiology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (HN); Channing Division of Network Medicine, Department of Medicine (HN, DJH, ELG, CSF, ATC) and Department of Epidemiology (DJH, PK, ELG, SO), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Center for Molecular Oncologic Pathology (TM, YI, AK, MY, SO), Department of Medical Oncology (TM, MS, YI, AK, MY, CSF, SO, MLF), and Department of Biostatistics and Computational Biology (LW), Dana-Farber Cancer Institute, Boston, MA; Department of Epidemiology (DJH, ELG, SO) and Department of Nutrition, Harvard School of Public Health, Boston, MA (DJH, ELG); Broad Institute, Program in Medical and Population Genetics, Cambridge, MA (MLF); Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA (ATC).

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http://dx.doi.org/10.1093/jnci/djt331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866156PMC
December 2013

Clinical uncertainty of prostate cancer genetic risk panels.

Sci Transl Med 2013 Apr;5(182):182ed6

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http://dx.doi.org/10.1126/scitranslmed.3004696DOI Listing
April 2013

Integrative eQTL-based analyses reveal the biology of breast cancer risk loci.

Cell 2013 Jan;152(3):633-41

Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cell.2012.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165609PMC
January 2013

The genetics of cancer risk.

Cancer J 2011 Nov-Dec;17(6):416-22

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1097/PPO.0b013e31823e5387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934208PMC
June 2012

Calling amplified haplotypes in next generation tumor sequence data.

Genome Res 2012 Feb 16;22(2):362-74. Epub 2011 Nov 16.

Department of Biomedical Informatics, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1101/gr.122564.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266043PMC
February 2012

Genetics of prostate cancer risk.

Mt Sinai J Med 2010 Nov-Dec;77(6):643-54

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1002/msj.20222DOI Listing
June 2011

Inherited variants in the chemokine CCL2 gene and prostate cancer aggressiveness in a Caucasian cohort.

Clin Cancer Res 2011 Mar 6;17(6):1546-52. Epub 2010 Dec 6.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060307PMC
March 2011

Single-nucleotide polymorphisms in p53 pathway and aggressiveness of prostate cancer in a Caucasian population.

Clin Cancer Res 2010 Nov 20;16(21):5244-51. Epub 2010 Sep 20.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-10-1261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970725PMC
November 2010

Allelic selection of amplicons in glioblastoma revealed by combining somatic and germline analysis.

PLoS Genet 2010 Sep 2;6(9):e1001086. Epub 2010 Sep 2.

Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932683PMC
September 2010

Inherited variations in AR, ESR1, and ESR2 genes are not associated with prostate cancer aggressiveness or with efficacy of androgen deprivation therapy.

Cancer Epidemiol Biomarkers Prev 2010 Jul;19(7):1871-8

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-10-0216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755451PMC
July 2010

Chromosome 8q24-Associated Cancers and MYC.

Genes Cancer 2010 Jun;1(6):555-9

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1177/1947601910381380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092220PMC
June 2010

A systematic approach to understand the functional consequences of non-protein coding risk regions.

Cell Cycle 2010 Jan 23;9(2):256-9. Epub 2010 Jan 23.

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319348PMC
http://dx.doi.org/10.4161/cc.9.2.10419DOI Listing
January 2010

An admixture scan in 1,484 African American women with breast cancer.

Cancer Epidemiol Biomarkers Prev 2009 Nov 20;18(11):3110-7. Epub 2009 Oct 20.

Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-0464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783219PMC
November 2009

Prostate cancer cognitive-behavioral factors in a West African population.

J Immigr Minor Health 2009 Aug 4;11(4):258-67. Epub 2008 Dec 4.

Department of Oncological Sciences, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.

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http://dx.doi.org/10.1007/s10903-008-9212-9DOI Listing
August 2009

Circulating colony stimulating factor-1 and breast cancer risk.

Cancer Res 2008 Jan;68(1):18-21

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-3234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821592PMC
January 2008

Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population.

J Clin Endocrinol Metab 2007 Sep 12;92(9):3660-6. Epub 2007 Jun 12.

Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94143-0794, USA.

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http://dx.doi.org/10.1210/jc.2007-0790DOI Listing
September 2007

Genetic determinants of prostate cancer risk.

BJU Int 2007 Aug 2;100(2):241-3. Epub 2007 Jun 2.

Lank Center for Genitourinary Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/j.1464-410X.2007.06996.xDOI Listing
August 2007

Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study.

Breast Cancer Res 2007 ;9(1):R18

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/bcr1655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851377PMC
May 2007

Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort.

Cancer Epidemiol Biomarkers Prev 2006 Oct;15(10):1993-7

Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California-San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-06-0361DOI Listing
October 2006

Common genetic variation at PTEN and risk of sporadic breast and prostate cancer.

Cancer Epidemiol Biomarkers Prev 2006 May;15(5):1021-5

University of Southern California/Norris Comprehensive Cancer Center, Room 4441, 1441 Eastlake Avenue, Los Angeles, CA 90089-9175, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-05-0896DOI Listing
May 2006

Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort.

J Natl Cancer Inst 2006 Jan;98(2):123-34

Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1093/jnci/djj013DOI Listing
January 2006

Igf-I genetic variation and breast cancer: the multiethnic cohort.

Cancer Epidemiol Biomarkers Prev 2006 Jan;15(1):172-4

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-05-0625DOI Listing
January 2006

Demonstrating stratification in a European American population.

Nat Genet 2005 Aug 24;37(8):868-72. Epub 2005 Jul 24.

Program in Genomics and Division of Endocrinology, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ng1607DOI Listing
August 2005

Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort.

J Clin Endocrinol Metab 2005 Apr 5;90(4):2198-204. Epub 2005 Jan 5.

University of Southern California/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1210/jc.2004-1417DOI Listing
April 2005

Systematic evaluation of genetic variation at the androgen receptor locus and risk of prostate cancer in a multiethnic cohort study.

Am J Hum Genet 2005 Jan 29;76(1):82-90. Epub 2004 Nov 29.

Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1086/427224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1196436PMC
January 2005

Assessing the impact of population stratification on genetic association studies.

Nat Genet 2004 Apr 28;36(4):388-93. Epub 2004 Mar 28.

Department of Medicine and Molecular Biology, Massachusetts General Hospital, Boston, and Program in Medical and Population Genetics, Broad Institute, Cambridge, USA.

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http://www.nature.com/articles/ng1333
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http://dx.doi.org/10.1038/ng1333DOI Listing
April 2004