Matthew J Flick

Matthew J Flick

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Matthew J Flick

Matthew J Flick

Publications by authors named "Matthew J Flick"

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Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis.

J Thromb Haemost 2020 Jan 11;18(1):91-103. Epub 2019 Oct 11.

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1111/jth.14641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026906PMC
January 2020

Does fibrinogen serve the host or the microbe in Staphylococcus infection?

Curr Opin Hematol 2019 Sep;26(5):343-348

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000527DOI Listing
September 2019

Cancer-Associated Thrombosis: A Two-Way Street.

Semin Thromb Hemost 2019 Sep 5;45(6):559-568. Epub 2019 Aug 5.

Cancer and Blood Diseases Institute, The Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1055/s-0039-1693472DOI Listing
September 2019

The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin.

Mol Cancer Ther 2019 07 30;18(7):1217-1229. Epub 2019 Apr 30.

Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0709DOI Listing
July 2019

The multifaceted role of fibrinogen in tissue injury and inflammation.

Blood 2019 02 6;133(6):511-520. Epub 2018 Dec 6.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

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http://dx.doi.org/10.1182/blood-2018-07-818211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367649PMC
February 2019

Absence of functional compensation between coagulation factor VIII and plasminogen in double-knockout mice.

Blood Adv 2018 11;2(22):3126-3136

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Research Foundation, Cincinnati, OH.

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http://dx.doi.org/10.1182/bloodadvances.2018024851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258924PMC
November 2018

Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice.

Blood Adv 2018 01 3;2(1):25-35. Epub 2018 Jan 3.

Department of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina, Chapel Hill, NC; and.

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http://dx.doi.org/10.1182/bloodadvances.2017011890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761627PMC
January 2018

Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αβ integrin-dependent upregulation of Mmp12.

J Hepatol 2017 04 10;66(4):787-797. Epub 2016 Dec 10.

Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362307PMC
April 2017

The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits.

Blood 2016 10 25;128(15):1969-1978. Epub 2016 Aug 25.

Department of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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http://dx.doi.org/10.1182/blood-2016-04-712323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064719PMC
October 2016

Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.

Blood 2016 06 26;127(22):2751-62. Epub 2016 Feb 26.

Department of Pharmacology and Toxicology, Institute for Integrative Toxicology, and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI;

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http://dx.doi.org/10.1182/blood-2015-09-670703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891955PMC
June 2016

Fibrinogen Is at the Interface of Host Defense and Pathogen Virulence in Staphylococcus aureus Infection.

Semin Thromb Hemost 2016 Jun 7;42(4):408-21. Epub 2016 Apr 7.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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https://www.thieme-connect.de/products/ejournals/pdf/10.1055
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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1579635
Publisher Site
http://dx.doi.org/10.1055/s-0036-1579635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514417PMC
June 2016

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

Blood 2016 Mar 8;127(9):1085-96. Epub 2015 Dec 8.

Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD;

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http://dx.doi.org/10.1182/blood-2015-05-644260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778161PMC
March 2016

Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mice.

J Pharmacol Exp Ther 2014 Nov 19;351(2):288-97. Epub 2014 Aug 19.

Department of Pathobiology & Diagnostic Investigation (A.K.K., K.L.T., J.P.L.), Department of Pharmacology & Toxicology (N.J.), Michigan State University, East Lansing, Michigan; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (K.M.K., B.P.S.); and Cancer and Blood Diseases Institute, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, Ohio (M.J.F.)

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http://dx.doi.org/10.1124/jpet.114.218545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201275PMC
November 2014

Thrombin drives tumorigenesis in colitis-associated colon cancer.

Cancer Res 2014 Jun 7;74(11):3020-3030. Epub 2014 Apr 7.

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati OH, and ISIS Pharmaceuticals, Carlsbad CA.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288815PMC
June 2014

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia.

Blood 2013 Mar 8;121(10):1783-94. Epub 2013 Jan 8.

Division of Experimental Hematology and Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2012-09-453894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591798PMC
March 2013

Saposin C coupled lipid nanovesicles specifically target arthritic mouse joints for optical imaging of disease severity.

PLoS One 2012 28;7(3):e33966. Epub 2012 Mar 28.

Division of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033966PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314692PMC
August 2012

Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury.

Am J Pathol 2012 Jun 13;180(6):2321-9. Epub 2012 Apr 13.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.

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http://dx.doi.org/10.1016/j.ajpath.2012.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378852PMC
June 2012

Targeting the coagulation factor fibrinogen for arthritis therapy.

Curr Pharm Biotechnol 2011 Sep;12(9):1497-506

Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.2174/138920111798281144DOI Listing
September 2011

Mice with a selective impairment of IFN-gamma signaling in macrophage lineage cells demonstrate the critical role of IFN-gamma-activated macrophages for the control of protozoan parasitic infections in vivo.

J Immunol 2010 Jan 14;184(2):877-85. Epub 2009 Dec 14.

Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.4049/jimmunol.0902346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886308PMC
January 2010

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.

Blood 2009 Jul 30;114(2):425-36. Epub 2009 Mar 30.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2008-03-145821DOI Listing
July 2009

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

Blood 2009 Jan 16;113(3):696-704. Epub 2008 Oct 16.

Division of Pediatric Hematology/Oncology, Cincinnati Children's Hospital Research Foundation and University of Cincinnati College of Medicine, OH 45229-3039, USA.

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http://dx.doi.org/10.1182/blood-2008-07-169003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628376PMC
January 2009

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif.

J Clin Invest 2007 Nov;117(11):3224-35

Cincinnati Children's Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.

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http://dx.doi.org/10.1172/JCI30134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000806PMC
November 2007

Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.

Blood 2005 Jan 14;105(1):178-85. Epub 2004 Sep 14.

Division of Hematology/Oncology, Children's Hospital Research Foundation, and University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://www.bloodjournal.org/content/105/1/178.full.pdf
Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2004-06-22
Publisher Site
http://dx.doi.org/10.1182/blood-2004-06-2272DOI Listing
January 2005

Fibrin(ogen)-alpha M beta 2 interactions regulate leukocyte function and innate immunity in vivo.

Exp Biol Med (Maywood) 2004 Dec;229(11):1105-10

Children's Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1177/153537020422901104DOI Listing
December 2004

Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo.

J Clin Invest 2004 Jun;113(11):1596-606

Children's Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.

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http://dx.doi.org/10.1172/JCI20741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419487PMC
June 2004

Identification of putative mammalian D-lactate dehydrogenase enzymes.

Biochem Biophys Res Commun 2002 Jul;295(4):910-6

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1392, USA.

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http://dx.doi.org/10.1016/s0006-291x(02)00768-4DOI Listing
July 2002