Matthew J Bown

Matthew J Bown

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Matthew J Bown

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Lack of an effective drug therapy for abdominal aortic aneurysm.

J Intern Med 2019 Jul 6. Epub 2019 Jul 6.

Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1111/joim.12958DOI Listing
July 2019

The Impact of Endovascular Aneurysm Repair on Long Term Renal Function Based on Hard Renal Outcomes.

Eur J Vasc Endovasc Surg 2019 Jul 18. Epub 2019 Jul 18.

Leicester Vascular Institute and National Institute for Health Research (NIHR) Leicester Biomedical Research Centre, Leicester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejvs.2019.03.024DOI Listing
July 2019

promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and expression in vascular smooth muscle cells.

Clin Epigenetics 2018 2;10:29. Epub 2018 Mar 2.

1Department of Cardiovascular Sciences and the NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, LE2 7LX UK.

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http://dx.doi.org/10.1186/s13148-018-0460-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833080PMC
February 2019

Beyond the AAA Guidelines: Core Outcome Sets to Make Life Better for Patients.

Eur J Vasc Endovasc Surg 2019 01 10;57(1):6-7. Epub 2018 Dec 10.

Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejvs.2018.10.028DOI Listing
January 2019

Diabetes mellitus and abdominal aortic aneurysms: A review of the mechanisms underlying the negative relationship.

Diab Vasc Dis Res 2018 09 6;15(5):367-374. Epub 2018 Jun 6.

Department of Cardiovascular Sciences, NIHR Leicester Cardiovascular Biomedical Research Unit and British Heart Foundation Cardiovascular Research Centre, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1177/1479164118780799DOI Listing
September 2018

Using multiple classifiers for predicting the risk of endovascular aortic aneurysm repair re-intervention through hybrid feature selection.

Proc Inst Mech Eng H 2017 Nov 19;231(11):1048-1063. Epub 2017 Sep 19.

2 School of Engineering and Applied Science, Aston University, Birmingham, UK.

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http://dx.doi.org/10.1177/0954411917731592DOI Listing
November 2017

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Authors:
Philip C Haycock Stephen Burgess Aayah Nounu Jie Zheng George N Okoli Jack Bowden Kaitlin Hazel Wade Nicholas J Timpson David M Evans Peter Willeit Abraham Aviv Tom R Gaunt Gibran Hemani Massimo Mangino Hayley Patricia Ellis Kathreena M Kurian Karen A Pooley Rosalind A Eeles Jeffrey E Lee Shenying Fang Wei V Chen Matthew H Law Lisa M Bowdler Mark M Iles Qiong Yang Bradford B Worrall Hugh Stephen Markus Rayjean J Hung Chris I Amos Amanda B Spurdle Deborah J Thompson Tracy A O'Mara Brian Wolpin Laufey Amundadottir Rachael Stolzenberg-Solomon Antonia Trichopoulou N Charlotte Onland-Moret Eiliv Lund Eric J Duell Federico Canzian Gianluca Severi Kim Overvad Marc J Gunter Rosario Tumino Ulrika Svenson Andre van Rij Annette F Baas Matthew J Bown Nilesh J Samani Femke N G van t'Hof Gerard Tromp Gregory T Jones Helena Kuivaniemi James R Elmore Mattias Johansson James Mckay Ghislaine Scelo Robert Carreras-Torres Valerie Gaborieau Paul Brennan Paige M Bracci Rachel E Neale Sara H Olson Steven Gallinger Donghui Li Gloria M Petersen Harvey A Risch Alison P Klein Jiali Han Christian C Abnet Neal D Freedman Philip R Taylor John M Maris Katja K Aben Lambertus A Kiemeney Sita H Vermeulen John K Wiencke Kyle M Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew-Kee Low Krina T Zondervan Grant W Montgomery Dale R Nyholt David A van Heel Karen Hunt Dan E Arking Foram N Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand Mary E Comeau W Mark Brown Edwin K Silverman John E Hokanson Michael H Cho Jennie Hui Manuel A Ferreira Philip J Thompson Alanna C Morrison Janine F Felix Nicholas L Smith Angela M Christiano Lynn Petukhova Regina C Betz Xing Fan Xuejun Zhang Caihong Zhu Carl D Langefeld Susan D Thompson Feijie Wang Xu Lin David A Schwartz Tasha Fingerlin Jerome I Rotter Mary Frances Cotch Richard A Jensen Matthias Munz Henrik Dommisch Arne S Schaefer Fang Han Hanna M Ollila Ryan P Hillary Omar Albagha Stuart H Ralston Chenjie Zeng Wei Zheng Xiao-Ou Shu Andre Reis Steffen Uebe Ulrike Hüffmeier Yoshiya Kawamura Takeshi Otowa Tsukasa Sasaki Martin Lloyd Hibberd Sonia Davila Gang Xie Katherine Siminovitch Jin-Xin Bei Yi-Xin Zeng Asta Försti Bowang Chen Stefano Landi Andre Franke Annegret Fischer David Ellinghaus Carlos Flores Imre Noth Shwu-Fan Ma Jia Nee Foo Jianjun Liu Jong-Won Kim David G Cox Olivier Delattre Olivier Mirabeau Christine F Skibola Clara S Tang Merce Garcia-Barcelo Kai-Ping Chang Wen-Hui Su Yu-Sun Chang Nicholas G Martin Scott Gordon Tracey D Wade Chaeyoung Lee Michiaki Kubo Pei-Chieng Cha Yusuke Nakamura Daniel Levy Masayuki Kimura Shih-Jen Hwang Steven Hunt Tim Spector Nicole Soranzo Ani W Manichaikul R Graham Barr Bratati Kahali Elizabeth Speliotes Laura M Yerges-Armstrong Ching-Yu Cheng Jost B Jonas Tien Yin Wong Isabella Fogh Kuang Lin John F Powell Kenneth Rice Caroline L Relton Richard M Martin George Davey Smith

JAMA Oncol 2017 May;3(5):636-651

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.

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http://dx.doi.org/10.1001/jamaoncol.2016.5945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638008PMC
May 2017

Abdominal aortic aneurysm-an independent disease to atherosclerosis?

Cardiovasc Pathol 2017 Mar - Apr;27:71-75. Epub 2017 Jan 29.

Department of Cardiovascular Sciences and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1016/j.carpath.2017.01.008DOI Listing
March 2017

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Authors:
Gregory T Jones Gerard Tromp Helena Kuivaniemi Solveig Gretarsdottir Annette F Baas Betti Giusti Ewa Strauss Femke N G Van't Hof Thomas R Webb Robert Erdman Marylyn D Ritchie James R Elmore Anurag Verma Sarah Pendergrass Iftikhar J Kullo Zi Ye Peggy L Peissig Omri Gottesman Shefali S Verma Jennifer Malinowski Laura J Rasmussen-Torvik Kenneth M Borthwick Diane T Smelser David R Crosslin Mariza de Andrade Evan J Ryer Catherine A McCarty Erwin P Böttinger Jennifer A Pacheco Dana C Crawford David S Carrell Glenn S Gerhard David P Franklin David J Carey Victoria L Phillips Michael J A Williams Wenhua Wei Ross Blair Andrew A Hill Thodor M Vasudevan David R Lewis Ian A Thomson Jo Krysa Geraldine B Hill Justin Roake Tony R Merriman Grzegorz Oszkinis Silvia Galora Claudia Saracini Rosanna Abbate Raffaele Pulli Carlo Pratesi Athanasios Saratzis Ana R Verissimo Suzannah Bumpstead Stephen A Badger Rachel E Clough Gillian Cockerill Hany Hafez D Julian A Scott T Simon Futers Simon P R Romaine Katherine Bridge Kathryn J Griffin Marc A Bailey Alberto Smith Matthew M Thompson Frank M van Bockxmeer Stefan E Matthiasson Gudmar Thorleifsson Unnur Thorsteinsdottir Jan D Blankensteijn Joep A W Teijink Cisca Wijmenga Jacqueline de Graaf Lambertus A Kiemeney Jes S Lindholt Anne Hughes Declan T Bradley Kathleen Stirrups Jonathan Golledge Paul E Norman Janet T Powell Steve E Humphries Stephen E Hamby Alison H Goodall Christopher P Nelson Natzi Sakalihasan Audrey Courtois Robert E Ferrell Per Eriksson Lasse Folkersen Anders Franco-Cereceda John D Eicher Andrew D Johnson Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Leonard Lipovich Anne M Drolet Eric L Verhoeven Clark J Zeebregts Robert H Geelkerken Marc R van Sambeek Steven M van Sterkenburg Jean-Paul de Vries Kari Stefansson John R Thompson Paul I W de Bakker Panos Deloukas Robert D Sayers Seamus C Harrison Andre M van Rij Nilesh J Samani Matthew J Bown

Circ Res 2017 Jan 29;120(2):341-353. Epub 2016 Nov 29.

For the author affiliations, please see the Appendix.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253231PMC
January 2017

Type II endoleaks: challenges and solutions.

Vasc Health Risk Manag 2016 2;12:53-63. Epub 2016 Mar 2.

Department of Vascular Surgery, Queens Medical Centre, University of Nottingham, Nottingham, UK; Department of Cardiovascular Sciences, National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.2147/VHRM.S81275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780400PMC
November 2016

Intervention Associated Acute Kidney Injury and Long-Term Cardiovascular Outcomes.

Am J Nephrol 2015 24;42(4):285-94. Epub 2015 Oct 24.

Department of Cardiovascular Sciences and NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester Royal Infirmary, Leicester, UK.

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http://dx.doi.org/10.1159/000440986DOI Listing
September 2016

Impact of hospital volume on outcomes following treatment of thoracic aortic aneurysms and type-B dissections.

Interact Cardiovasc Thorac Surg 2016 09 24;23(3):477-85. Epub 2016 May 24.

Department of Cardiovascular Sciences and Leicester NIHR Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1093/icvts/ivw155DOI Listing
September 2016

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.

J Am Heart Assoc 2016 07 14;5(7). Epub 2016 Jul 14.

Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

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http://dx.doi.org/10.1161/JAHA.115.002603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015357PMC
July 2016

Renal Function is the Main Predictor of Acute Kidney Injury after Endovascular Abdominal Aortic Aneurysm Repair.

Ann Vasc Surg 2016 Feb 30;31:52-9. Epub 2015 Nov 30.

Department of Cardiovascular Sciences and NIHR Leicester Cardiovascular Biomedical Research Unit, Leicester Royal Infirmary, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1016/j.avsg.2015.10.010DOI Listing
February 2016

Impact of Fenestrated Endovascular Abdominal Aortic Aneurysm Repair on Renal Function.

J Endovasc Ther 2015 Dec 10;22(6):889-96. Epub 2015 Sep 10.

Department of Cardiovascular Sciences and the NIHR Leicester Biomedical Research Unit, University of Leicester, Leicester Royal Infirmary, Leicester, UK.

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http://jet.sagepub.com/content/early/2015/09/09/152660281560
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http://jet.sagepub.com/lookup/doi/10.1177/1526602815605311
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http://dx.doi.org/10.1177/1526602815605311DOI Listing
December 2015

Long-Term Renal Function after Endovascular Aneurysm Repair.

Clin J Am Soc Nephrol 2015 Nov 20;10(11):1930-6. Epub 2015 Oct 20.

Department of Cardiovascular Sciences and Leicester NIHR Cardiovascular Biomedical Research Unit, Leicester, United Kingdom; and.

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http://dx.doi.org/10.2215/CJN.04870515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633790PMC
November 2015

Commentary: Late Rupture After Endovascular Aneurysm Repair: Addressing the "Achilles' Heel" of EVAR.

J Endovasc Ther 2015 Oct;22(5):745-7

Department of Cardiovascular Sciences and NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester Royal Infirmary, Leicester, UK.

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http://dx.doi.org/10.1177/1526602815601837DOI Listing
October 2015

The potential role of DNA methylation in the pathogenesis of abdominal aortic aneurysm.

Atherosclerosis 2015 Jul 7;241(1):121-9. Epub 2015 May 7.

University of Leicester, Department of Cardiovascular Sciences and the NIHR Leicester Cardiovascular Biomedical Research Unit, Leicester, UK.

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.05.001DOI Listing
July 2015

Association between seven single nucleotide polymorphisms involved in inflammation and proteolysis and abdominal aortic aneurysm.

J Vasc Surg 2015 May 7;61(5):1120-8.e1. Epub 2014 Mar 7.

Department of Research and Development, Dudley Group of Hospitals, Dudley, United Kingdom.

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http://dx.doi.org/10.1016/j.jvs.2013.11.099DOI Listing
May 2015

Cardiac rehabilitation versus standard care after aortic aneurysm repair (Aneurysm CaRe): study protocol for a randomised controlled trial.

Trials 2015 Apr 15;16:162. Epub 2015 Apr 15.

Department of Outcomes Research, St George's Vascular Institute, St George's Healthcare NHS Trust, Room 4.007, Blackshaw Road, London, SW17 0QT, UK.

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http://dx.doi.org/10.1186/s13063-015-0669-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407427PMC
April 2015

Debate: Whether evidence supports reducing the threshold diameter to 5 cm for elective interventions in women with abdominal aortic aneurysms.

J Vasc Surg 2014 Dec 21;60(6):1695-701. Epub 2014 Nov 21.

Department of Surgery and Cancer, Imperial College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2014.07.022DOI Listing
December 2014

In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias.

J Clin Epidemiol 2014 Aug 29;67(8):897-903. Epub 2014 Apr 29.

Department of Cardiovascular Sciences, and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, University Road, Leicester, LE1 7RD, UK.

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http://dx.doi.org/10.1016/j.jclinepi.2014.03.003DOI Listing
August 2014

The genetic basis for aortic aneurysmal disease.

Heart 2014 Jun;100(12):916-22

Department of Cardiovascular Sciences and NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1136/heartjnl-2013-305130DOI Listing
June 2014

Effect of anticoagulation and antiplatelet therapy on incidence of endoleaks and sac size expansions after endovascular aneurysm repair.

Ann Vasc Surg 2014 Apr 3;28(3):554-9. Epub 2013 Oct 3.

Vascular Surgery Research Group, University of Leicester, Leicester Royal Infirmary, Leicester, UK.

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http://dx.doi.org/10.1016/j.avsg.2013.03.013DOI Listing
April 2014

A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size.

J Vasc Surg 2014 Feb;59(2):528-535.e4

Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1016/j.jvs.2013.10.088DOI Listing
February 2014

Endovascular aortic aneurysm repair in patients with hostile neck anatomy.

J Endovasc Ther 2013 Oct;20(5):623-37

Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, UK.

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http://dx.doi.org/10.1583/13-4320MR.1DOI Listing
October 2013

Differential microRNA expression profiles in peripheral arterial disease.

Circ Cardiovasc Genet 2013 Oct;6(5):490-7

Department of Cardiovascular Sciences and Department of Genetics and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000053DOI Listing
October 2013

Sexual dimorphism of abdominal aortic aneurysms: a striking example of "male disadvantage" in cardiovascular disease.

Atherosclerosis 2012 Nov 9;225(1):22-8. Epub 2012 Jul 9.

Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2012.06.057DOI Listing
November 2012

Changing epidemiology of abdominal aortic aneurysms in England and Wales: older and more benign?

Circulation 2012 Apr 23;125(13):1617-25. Epub 2012 Feb 23.

Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.111.077503DOI Listing
April 2012

The ectatic aorta: no benefit in surveillance.

Ann Vasc Surg 2010 Oct 13;24(7):908-11. Epub 2010 May 13.

Department of Vascular Surgery, Leicester Royal Infirmary, Leicester, United Kingdom.

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http://dx.doi.org/10.1016/j.avsg.2010.02.035DOI Listing
October 2010

Optimal technique for imaging iliac segments during endovascular repair of abdominal aortic aneurysms.

J Endovasc Ther 2009 Jun;16(3):373-9

Regional Vascular Unit, Royal Liverpool University Hospital, Liverpool, UK.

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http://dx.doi.org/10.1583/09-2736.1DOI Listing
June 2009

Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysm.

Circ Cardiovasc Genet 2008 Oct;1(1):39-42

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1161/CIRCGENETICS.108.789727DOI Listing
October 2008

Repair of ruptured abdominal aortic aneurysms by endovascular techniques.

Adv Surg 2007 ;41:63-80

Department of Surgery, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK.

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December 2007

The interleukin-10-1082 'A' allele and abdominal aortic aneurysms.

J Vasc Surg 2007 Oct;46(4):687-93

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1016/j.jvs.2007.06.025DOI Listing
October 2007

Scoring systems do not accurately predict outcome following abdominal aortic aneurysm repair.

ANZ J Surg 2007 Apr;77(4):275-82

Department of Cardiovascular Sciences, Division of Surgery, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/j.1445-2197.2007.04033.xDOI Listing
April 2007

The pro-inflammatory and chemotactic cytokine microenvironment of the abdominal aortic aneurysm wall: a protein array study.

J Vasc Surg 2007 Mar;45(3):574-80

Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1016/j.jvs.2006.11.020DOI Listing
March 2007

The Surgical Acute Care Unit (SACU): effects on surgical workload and mortality.

ANZ J Surg 2004 Oct;74(10):881-4

Department of Surgery, Leicester General Hospital, Leicester, United Kingdom.

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http://dx.doi.org/10.1111/j.1445-1433.2004.03194.xDOI Listing
October 2004

Evaluation of level 1 care facilities for vascular patients.

ANZ J Surg 2004 May;74(5):346-9

Department of Surgery, Leicester General Hospital, and University of Leicester, Leicester, England, UK.

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http://dx.doi.org/10.1111/j.1445-1433.2004.02984.xDOI Listing
May 2004