Matthew G Vander Heiden

Matthew G Vander Heiden

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Matthew G Vander Heiden

Publications by authors named "Matthew G Vander Heiden"

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Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.

Nat Commun 2019 Dec 6;10(1):5604. Epub 2019 Dec 6.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41467-019-13419-4DOI Listing
December 2019

Tumour Dormancy and Reawakening: Opportunities and Challenges.

Trends Cancer 2019 Dec 25;5(12):762-765. Epub 2019 Nov 25.

Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Hospital, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.trecan.2019.10.010DOI Listing
December 2019

A framework for examining how diet impacts tumour metabolism.

Nat Rev Cancer 2019 Nov 17;19(11):651-661. Epub 2019 Sep 17.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41568-019-0198-5DOI Listing
November 2019

Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.

FEBS Lett 2019 Oct 23. Epub 2019 Oct 23.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1002/1873-3468.13648DOI Listing
October 2019

Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation.

Nat Metab 2019 Sep 16;1(9):861-867. Epub 2019 Sep 16.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/s42255-019-0108-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785045PMC
September 2019

Increased PHGDH expression promotes aberrant melanin accumulation.

BMC Cancer 2019 Jul 22;19(1):723. Epub 2019 Jul 22.

Koch Institute for Integrative Cancer Research, Cambridge, 02139, MA, USA.

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http://dx.doi.org/10.1186/s12885-019-5933-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647269PMC
July 2019

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting.

Cell Metab 2019 Jun 21;29(6):1410-1421.e4. Epub 2019 Mar 21.

Koch Institute for Integrative Cancer Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131193012
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http://dx.doi.org/10.1016/j.cmet.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551255PMC
June 2019

Determinants of nutrient limitation in cancer.

Crit Rev Biochem Mol Biol 2019 Jun 4;54(3):193-207. Epub 2019 Jun 4.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology , Cambridge , MA , USA.

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http://dx.doi.org/10.1080/10409238.2019.1611733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715536PMC
June 2019

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1.

PLoS Biol 2019 Jun 10;17(6):e2004413. Epub 2019 Jun 10.

La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2004413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586363PMC
June 2019

Putting the K in Kaloric Restriction.

Immunity 2019 05;50(5):1129-1131

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.04.016DOI Listing
May 2019

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability.

Elife 2019 04 16;8. Epub 2019 Apr 16.

Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.

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https://elifesciences.org/articles/44235
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http://dx.doi.org/10.7554/eLife.44235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510537PMC
April 2019

Protocols for Studies on TMPRSS2/ERG in Prostate Cancer.

Methods Mol Biol 2018 ;1786:131-151

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7845-8_8DOI Listing
February 2019

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.

Cell Metab 2018 11 16;28(5):706-720.e6. Epub 2018 Aug 16.

Institute of Biochemistry, Graz University of Technology, Humboldtstrasse 46/III, 8010 Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390946PMC
November 2018

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.

Cell Metab 2018 10 12;28(4):573-587.e13. Epub 2018 Jul 12.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven 3000, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven 3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.009DOI Listing
October 2018

PKM2 is not required for pancreatic ductal adenocarcinoma.

Cancer Metab 2018 23;6:17. Epub 2018 Oct 23.

1Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

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http://dx.doi.org/10.1186/s40170-018-0188-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198443PMC
October 2018

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies.

Dis Model Mech 2018 08 7;11(8). Epub 2018 Aug 7.

Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

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http://dx.doi.org/10.1242/dmm.035758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124553PMC
August 2018

Aspartate is an endogenous metabolic limitation for tumour growth.

Nat Cell Biol 2018 07 25;20(7):782-788. Epub 2018 Jun 25.

The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://www.nature.com/articles/s41556-018-0125-0
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http://dx.doi.org/10.1038/s41556-018-0125-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051729PMC
July 2018

The nutrient environment affects therapy.

Science 2018 06;360(6392):962-963

Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aar5986
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http://dx.doi.org/10.1126/science.aar5986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368963PMC
June 2018

The redox requirements of proliferating mammalian cells.

J Biol Chem 2018 05 16;293(20):7490-7498. Epub 2018 Jan 16.

From the Koch Institute for Integrative Cancer Research and

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http://dx.doi.org/10.1074/jbc.TM117.000239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961062PMC
May 2018

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma.

Cancer Metab 2018 31;6. Epub 2018 May 31.

1David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

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https://cancerandmetabolism.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40170-018-0179-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977456PMC
May 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

PKM2 is not required for colon cancer initiated by APC loss.

Cancer Metab 2017 30;5:10. Epub 2017 Nov 30.

Koch Institute for Integrative Cancer Research and the Department of Biology at Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

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http://dx.doi.org/10.1186/s40170-017-0172-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707917PMC
November 2017

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

Cell 2017 Oct;171(3):642-654.e12

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704964PMC
October 2017

Targeting Metabolism for Cancer Therapy.

Cell Chem Biol 2017 Sep;24(9):1161-1180

The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744685PMC
September 2017

Metabolism and Congenital Malformations - NAD's Effects on Development.

N Engl J Med 2017 Aug;377(6):509-511

From the Koch Institute for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA; and the Dana-Farber Cancer Institute, Boston.

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http://dx.doi.org/10.1056/NEJMp1707487DOI Listing
August 2017

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition.

Elife 2017 08 15;6. Epub 2017 Aug 15.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.

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http://dx.doi.org/10.7554/eLife.27713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589418PMC
August 2017

Nature and Nurture: What Determines Tumor Metabolic Phenotypes?

Cancer Res 2017 06 5;77(12):3131-3134. Epub 2017 Jun 5.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0165DOI Listing
June 2017

When cancer needs what's non-essential.

Nat Cell Biol 2017 May 19;19(5):418-420. Epub 2017 Apr 19.

Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/ncb3523DOI Listing
May 2017

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.

Immunity 2017 05;46(5):703-713

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660630PMC
May 2017

Understanding the Intersections between Metabolism and Cancer Biology.

Cell 2017 02;168(4):657-669

Children's Medical Center Research Institute, Department of Pediatrics, and Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX 75390. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329766PMC
February 2017

Critical Functions of the Lysosome in Cancer Biology.

Annu Rev Pharmacol Toxicol 2017 01 12;57:481-507. Epub 2016 Oct 12.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; email: ,

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http://dx.doi.org/10.1146/annurev-pharmtox-010715-103101DOI Listing
January 2017

Endothelial Cells Get β-ox-ed In to Support Lymphangiogenesis.

Dev Cell 2017 01;40(2):118-119

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807173000
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http://dx.doi.org/10.1016/j.devcel.2017.01.004DOI Listing
January 2017

PKM2, cancer metabolism, and the road ahead.

EMBO Rep 2016 12 17;17(12):1721-1730. Epub 2016 Nov 17.

David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

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http://dx.doi.org/10.15252/embr.201643300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283597PMC
December 2016

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.

Cell Metab 2016 11 13;24(5):716-727. Epub 2016 Oct 13.

The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102768PMC
November 2016

Altered metabolite levels in cancer: implications for tumour biology and cancer therapy.

Nat Rev Cancer 2016 11 23;16(11):680-693. Epub 2016 Sep 23.

The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nrc.2016.85DOI Listing
November 2016

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

Science 2016 09;353(6304):1161-5

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Broad Institute, Seven Cambridge Center, Cambridge, MA 02142, USA. Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aaf5171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245791PMC
September 2016

The importance of serine metabolism in cancer.

J Cell Biol 2016 08 25;214(3):249-57. Epub 2016 Jul 25.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 Dana-Farber Cancer Institute, Boston, MA 02215 Broad Institute, Cambridge, MA 02139

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http://dx.doi.org/10.1083/jcb.201604085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970329PMC
August 2016

Circadian Rhythm Disruption Promotes Lung Tumorigenesis.

Cell Metab 2016 08 28;24(2):324-31. Epub 2016 Jul 28.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367626PMC
August 2016

Metabolic requirements for cancer cell proliferation.

Cancer Metab 2016 18;4:16. Epub 2016 Aug 18.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

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http://dx.doi.org/10.1186/s40170-016-0156-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989334PMC
August 2016

Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.

J Natl Cancer Inst 2016 Jun 11;108(6):djv409. Epub 2016 Jan 11.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (CY, ZRQ, DAR, KN, SO, MGVH, CSF, BMW); Broad Institute of MIT and Harvard University, Cambridge, MA (CBC, MGVH); Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China (CW); Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA (JRM, MET, MGVH); Department of Epidemiology (PK, SST, ELG, SO, MJS, JM, HDS, JEM), Department of Biostatistics (PK), and Department of Nutrition (ELG, MJS), Harvard School of Public Health, Boston, MA; Department of Pathology (SO), and Channing Division of Network Medicine (MKT, SST, YB, ELG, MJS, JM, JEM, CSF) and Division of Preventive Medicine (JMG, HDS, JEM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (MZ, LTA); Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (JMG); Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (GLA); University of Washington School of Nursing, Seattle, WA (BBC); Division of Genomic Stability and DNA repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA (ACK).

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http://dx.doi.org/10.1093/jnci/djv409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849356PMC
June 2016

Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence.

Cancer Epidemiol Biomarkers Prev 2016 06 6;25(6):887-906. Epub 2016 Apr 6.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-1223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891222PMC
June 2016

Targeting MTHFD2 in acute myeloid leukemia.

J Exp Med 2016 06 20;213(7):1285-306. Epub 2016 Jun 20.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215 Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215 Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142

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http://dx.doi.org/10.1084/jem.20151574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925018PMC
June 2016

InterFeriNg with Acetγlation: Stress-Levels of Acetate Improve Memory T Cell Function.

Immunity 2016 06;44(6):1243-5

The Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.06.004DOI Listing
June 2016

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Genes Dev 2016 05 28;30(9):1020-33. Epub 2016 Apr 28.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.278549.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863734PMC
May 2016

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.

Cell Metab 2016 Mar 4;23(3):517-28. Epub 2016 Feb 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/cell-metabolism/pdf/S1550-4131(16)00041-
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http://linkinghub.elsevier.com/retrieve/pii/S155041311600041
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http://dx.doi.org/10.1016/j.cmet.2016.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785096PMC
March 2016

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.

Dev Cell 2016 Mar;36(5):540-9

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2016.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766004PMC
March 2016

Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes.

J Cell Biol 2016 Feb;212(4):439-47

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://dx.doi.org/10.1083/jcb.201506118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754715PMC
February 2016

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Cell 2016 Feb;164(5):884-95

Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819986PMC
February 2016

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819002PMC
December 2015

The Role of Pyruvate Kinase M2 in Cancer Metabolism.

Brain Pathol 2015 Nov;25(6):781-3

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1111/bpa.12311DOI Listing
November 2015

Stopping the Clock with MYC.

Mol Cell 2015 Nov;60(4):511-3

Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.11.008DOI Listing
November 2015

Lack of Evidence for PKM2 Protein Kinase Activity.

Mol Cell 2015 Sep 20;59(5):850-7. Epub 2015 Aug 20.

Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/molecular-cell/pdf/S1097-2765(15)00571-7
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http://dx.doi.org/10.1016/j.molcel.2015.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548833PMC
September 2015

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.

Cell 2015 Jul;162(3):552-63

The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522278PMC
July 2015

Pyruvate kinase: Function, regulation and role in cancer.

Semin Cell Dev Biol 2015 Jul 13;43:43-51. Epub 2015 Aug 13.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2015.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662905PMC
July 2015

Antibody-mediated neutralization of perfringolysin o for intracellular protein delivery.

Mol Pharm 2015 Jun 4;12(6):1992-2000. Epub 2015 May 4.

†Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/mp500797nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876977PMC
June 2015

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

Nature 2015 Apr 8;520(7547):363-7. Epub 2015 Apr 8.

1] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [4] Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA [5] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature14363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533874PMC
April 2015

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.

Cancer Metab 2015 29;3. Epub 2015 Apr 29.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Dana-Farber Cancer Institute, Boston, MA 02215 USA ; Broad Institute, Cambridge, MA 02139 USA.

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http://dx.doi.org/10.1186/s40170-015-0131-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414297PMC
April 2015

Famine versus feast: understanding the metabolism of tumors in vivo.

Trends Biochem Sci 2015 Mar 29;40(3):130-40. Epub 2015 Jan 29.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard University, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2015.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340757PMC
March 2015

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.

ACS Chem Biol 2015 Feb 18;10(2):510-6. Epub 2014 Nov 18.

Lewis-Sigler Institute for Integrative Genomics, Princeton University , Princeton, New Jersey 08544, United States.

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http://dx.doi.org/10.1021/cb500683cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340346PMC
February 2015

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.

Mol Cell 2015 Jan 4;57(1):95-107. Epub 2014 Dec 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289430PMC
January 2015

Acetate metabolism in cancer cells.

Cancer Metab 2014 11;2(1):27. Epub 2014 Dec 11.

Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Dana-Farber Cancer Institute, Boston, MA 02115 USA.

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http://dx.doi.org/10.1186/s40170-014-0027-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263044PMC
December 2014

Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.

Cell 2014 Sep;158(6):1309-1323

Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197056PMC
September 2014

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.

Mol Cell 2014 Jul 29;55(2):253-63. Epub 2014 May 29.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Institute of Engineering and Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106038PMC
July 2014

Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.

Clin Cancer Res 2014 Jun 8;20(11):2898-909. Epub 2014 Apr 8.

Authors' Affiliations: Department of Neurosurgery; Division of Hematology/Oncology, Department of Neurology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Translational Research Laboratory; Department of Pathology; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge; Translational Neuro-Oncology Laboratory; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Vesalius Research Center, VIB and Department of Oncology, KU Leuven, Leuven, BelgiumAuthors' Affiliations: Department of Neurosurgery; Division of Hematology/Oncology, Department of Neurology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Translational Research Laboratory; Department of Pathology; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge; Translational Neuro-Oncology Laboratory; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Vesalius Research Center, VIB and Department of Oncology, KU Leuven, Leuven, BelgiumAuthors' Affiliations: Department of Neurosurgery; Division of Hematology/Oncology, Department of Neurology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Translational Research Laboratory; Department of Pathology; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge; Translational Neuro-Oncology Laboratory; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Vesalius Research Center, VIB and Department of Oncology, KU Leuven, Leuven, Belgium

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070445PMC
June 2014

IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism.

Cancer Res 2014 Jun 22;74(12):3317-31. Epub 2014 Apr 22.

Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, CaliforniaAuthors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0772-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885639PMC
June 2014

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Nat Commun 2014 Apr 3;5:3608. Epub 2014 Apr 3.

1] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Spain [3] Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010 Catalonia, Spain.

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http://dx.doi.org/10.1038/ncomms4608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988805PMC
April 2014

Metabolic targets for cancer therapy.

Nat Rev Drug Discov 2013 11 11;12(11):829-46. Epub 2013 Oct 11.

1] Université Paris Descartes, Sorbonne Paris Cité, F-75006 Paris, France. [2] Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, F-75006 Paris, France. [3] Gustave Roussy, F-94805 Villejuif, France.

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http://dx.doi.org/10.1038/nrd4145DOI Listing
November 2013