Matthew Frosch

Matthew Frosch

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Matthew Frosch

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Alpha-synuclein: prion or prion-like?

Acta Neuropathol 2019 Oct 12;138(4):509-514. Epub 2019 Aug 12.

Brain and Mind Centre and Central Clinical School, University of Sydney, Sydney, NSW, 2050, Australia.

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http://dx.doi.org/10.1007/s00401-019-02057-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778512PMC
October 2019

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gennady Roshchupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 Sep;51(9):1423-1424

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0495-7DOI Listing
September 2019

Different microvascular alterations underlie microbleeds and microinfarcts.

Ann Neurol 2019 Aug 14;86(2):279-292. Epub 2019 Jun 14.

J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/ana.25512DOI Listing
August 2019

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.

Cell 2019 Aug 18;178(4):835-849.e21. Epub 2019 Jul 18.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703186PMC
August 2019

Diagnostic evaluation and monitoring of patients with posterior cortical atrophy.

Neurodegener Dis Manag 2019 Aug 8;9(4):217-239. Epub 2019 Aug 8.

Posterior Cortical Atrophy Program, Frontotemporal Disorders Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.2217/nmt-2018-0052DOI Listing
August 2019

Spinal cord α-synuclein deposition associated with myoclonus in patients with MSA-C.

Neurology 2019 Aug;93(7):302-309

From Harvard Medical School (J.H., J.D.S.); Harvard T.H. Chan School of Public Health (J.H.), Boston, MA; Department of Neurology (A.M.B.), Columbia University Medical Center, New York, NY; Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology (F.M.), Boston University School of Medicine, MA; and Departments of Pathology (D.H.O., M.P.F.) and Ataxia Unit, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology (J.D.H.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000007949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715505PMC
August 2019

Cerebellar Microbleed Distribution Patterns and Cerebral Amyloid Angiopathy.

Stroke 2019 Jul 4;50(7):1727-1733. Epub 2019 Jun 4.

Hemorrhagic Stroke Research Program, Department of Neurology, J. Philip Kistler Stroke Research Center (M.P., T.P., A.C., S.D.S., L.X., A.D.W., A.V., M.E.G., S.M.G.), Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1161/STROKEAHA.119.024843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599711PMC
July 2019

Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease.

Neurology 2019 Jul 26;93(5):e476-e484. Epub 2019 Jun 26.

From the Departments of Neurology (J.S., R.Y., K.A.J., T.G.-I., J.H.G., S.N.G.), Pathology (N.C., M.F.), and Radiology (S.K., A.S., K.A.J.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000007855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693430PMC
July 2019

The Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms.

JAMA Neurol 2019 Jul 15. Epub 2019 Jul 15.

Massachusetts Alzheimer's Disease Research Center, Boston.

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http://dx.doi.org/10.1001/jamaneurol.2019.1667DOI Listing
July 2019

PrP-grafted antibodies bind certain amyloid β-protein aggregates, but do not prevent toxicity.

Brain Res 2019 May 26;1710:125-135. Epub 2018 Dec 26.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2018.12.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431553PMC
May 2019

Secondary Bleeding During Acute Experimental Intracerebral Hemorrhage.

Stroke 2019 May;50(5):1210-1215

From the Neurovascular Research Laboratory, Department of Radiology (F.S., M.B., T.Q., I.T., P.F., C.A.), Massachusetts General Hospital, Harvard Medical School, Charlestown.

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.021732
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.118.021732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478448PMC
May 2019

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.

Brain 2019 May;142(5):1441-1457

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/brain/awz066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487330PMC
May 2019

Wide Range of Clinical Outcomes in Patients with Gliomatosis Cerebri Growth Pattern: A Clinical, Radiographic, and Histopathologic Study.

Oncologist 2019 Mar 10;24(3):402-413. Epub 2018 Aug 10.

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA

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http://dx.doi.org/10.1634/theoncologist.2018-0086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519760PMC
March 2019

Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage.

J Neurol 2019 Mar 8;266(3):625-630. Epub 2019 Jan 8.

Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, 175 Cambridge Street, #300, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s00415-018-09177-wDOI Listing
March 2019

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gennady Roshchupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy.

Stroke 2019 02;50(2):328-335

MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital, Charlestown (W.M.F., B.J.B., M.P.F., S.J.v.V.).

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http://dx.doi.org/10.1161/STROKEAHA.118.023788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415745PMC
February 2019

Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy.

Neurology 2019 02 30;92(9):e933-e943. Epub 2019 Jan 30.

From the J. Philip Kistler Stroke Research Center, Department of Neurology (S.J.v.V., Y.D.R., A.C., G.A.R., A.V., S.M.G.), and Neuropathology Service, C.S. Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Boston; MassGeneral Institute for Neurodegenerative Disease (S.J.v.V., B.J.B., M.P.F.), Charlestown Navy Yard, MA; Department of Neurology, Brain Center Rudolf Magnus (Y.D.R.), and Image Sciences Institute (A.L.), University Medical Center Utrecht, Utrecht University, the Netherlands; and Athinoula A. Martinos Center for Biomedical Imaging (A.J.v.d.K.), Department of Radiology, Massachusetts General Hospital, Charlestown.

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http://dx.doi.org/10.1212/WNL.0000000000007005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404469PMC
February 2019

Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann's area 32 and area 21.

Brain Struct Funct 2019 Jan 17;224(1):351-362. Epub 2018 Oct 17.

Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 02118, USA.

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http://dx.doi.org/10.1007/s00429-018-1777-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369026PMC
January 2019

"When sex influences the brain: implications for Alzheimer disease".

Authors:
Matthew P Frosch

Acta Neuropathol 2018 12;136(6):855-856

C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s00401-018-1931-yDOI Listing
December 2018

Different tau species lead to heterogeneous tau pathology propagation and misfolding.

Acta Neuropathol Commun 2018 11 29;6(1):132. Epub 2018 Nov 29.

Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, School of Medicine, 1 rue Polonovski, 59045, Lille, France.

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http://dx.doi.org/10.1186/s40478-018-0637-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263555PMC
November 2018

Enhanced Dendritic Compartmentalization in Human Cortical Neurons.

Cell 2018 10;175(3):643-651.e14

McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183110
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http://dx.doi.org/10.1016/j.cell.2018.08.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197488PMC
October 2018

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain.

Acta Neuropathol 2018 07 23;136(1):19-40. Epub 2018 Apr 23.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00401-018-1846-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647843PMC
July 2018

Malignant Melanoma Metastatic to Oligodendroglioma: Case Report and Literature Review of Tumor-to-Tumor Metastasis to Gliomas.

J Neuropathol Exp Neurol 2018 07;77(7):549-554

Department of Neurosurgery at Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/jnen/nly029DOI Listing
July 2018

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease.

Nat Commun 2018 07 11;9(1):2676. Epub 2018 Jul 11.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-018-05068-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041266PMC
July 2018

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain.

Front Neurosci 2018 24;12:267. Epub 2018 Apr 24.

Department of Neurology, Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, United States.

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http://dx.doi.org/10.3389/fnins.2018.00267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928393PMC
April 2018

as-PSOCT: Volumetric microscopic imaging of human brain architecture and connectivity.

Neuroimage 2018 01 7;165:56-68. Epub 2017 Oct 7.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2017.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732037PMC
January 2018

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP.

J Neurosci 2017 12 3;37(49):11947-11966. Epub 2017 Nov 3.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115,

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http://dx.doi.org/10.1523/JNEUROSCI.2009-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719975PMC
December 2017

Retracted: Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.

Hum Mol Genet 2017 11;26(21):4314

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/hmg/ddx303DOI Listing
November 2017

Cost-effectiveness of IDH testing in diffuse gliomas according to the 2016 WHO classification of tumors of the central nervous system recommendations.

Neuro Oncol 2017 Nov;19(12):1640-1650

Department of Pathology; Department of Neurology, Division of Neuro-Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/nox120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716163PMC
November 2017

Microglial dysfunction as a key pathological change in adrenomyeloneuropathy.

Ann Neurol 2017 Nov 11;82(5):813-827. Epub 2017 Nov 11.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/ana.25085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725816PMC
November 2017

Activity-Dependent Dysfunction in Visual and Olfactory Sensory Systems in Mouse Models of Down Syndrome.

J Neurosci 2017 10 12;37(41):9880-9888. Epub 2017 Sep 12.

MassGeneral Institute for Neurodegenerative Disease, Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129.

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http://dx.doi.org/10.1523/JNEUROSCI.1045-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637117PMC
October 2017

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:
Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Shahzad Ahmad Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039PMC
September 2017

Targeted sequencing of SMO and AKT1 in anterior skull base meningiomas.

J Neurosurg 2017 08 25;127(2):438-444. Epub 2016 Nov 25.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.3171/2016.8.JNS161076DOI Listing
August 2017

Emerging concepts in sporadic cerebral amyloid angiopathy.

Brain 2017 Jul;140(7):1829-1850

Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/brain/awx047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059159PMC
July 2017

Enhanced Tau Aggregation in the Presence of Amyloid β.

Am J Pathol 2017 Jul 10;187(7):1601-1612. Epub 2017 May 10.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440173008
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http://dx.doi.org/10.1016/j.ajpath.2017.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500829PMC
July 2017

Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.

Am J Pathol 2017 Jun 11;187(6):1399-1412. Epub 2017 Apr 11.

Alzheimer's Disease Research Laboratory, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455060PMC
June 2017

Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease.

J Neuropathol Exp Neurol 2017 May;76(5):376-383

From the Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts (EAM, DM, MPF, BTH, ASR); and Tufts Medical Center, Boston, Massachusetts (NL).

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http://dx.doi.org/10.1093/jnen/nlx020DOI Listing
May 2017

Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy.

Acta Neuropathol 2017 03 22;133(3):409-415. Epub 2016 Oct 22.

Department of Neurology, J. Philip Kistler Stroke Research Center, Harvard Medical School, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston, MA, 02114, USA.

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http://link.springer.com/10.1007/s00401-016-1635-0
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http://dx.doi.org/10.1007/s00401-016-1635-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325834PMC
March 2017

Hemorrhagic primary CNS angiitis and vasoconstrictive drug exposure.

Neurol Clin Pract 2017 Feb;7(1):26-34

Massachusetts General Hospital and Harvard Medical School (MAT, MPF, ABS), Boston; Neurology Department (MAT), Hacettepe University Hospitals, Ankara, Turkey; Safar Center for Resuscitation (RMJ), University of Pittsburgh Medical Center, PA; and Government Medical College (JG), Kottayam, India.

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http://dx.doi.org/10.1212/CPJ.0000000000000324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310206PMC
February 2017

Susceptibility Etching on MRI in Patients with Microangiopathy.

J Neuroimaging 2017 01 19;27(1):43-49. Epub 2016 Aug 19.

Department of Neuroradiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1111/jon.12384DOI Listing
January 2017

A 63-Year-Old Man With Progressive Visual Symptoms.

JAMA Neurol 2017 Jan;74(1):114-118

Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston.

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http://dx.doi.org/10.1001/jamaneurol.2016.2210DOI Listing
January 2017

Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity.

Acta Neuropathol Commun 2017 01 10;5(1). Epub 2017 Jan 10.

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.

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http://dx.doi.org/10.1186/s40478-016-0403-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223451PMC
January 2017

Case 1-2017. A 70-Year-Old Woman with Gradually Progressive Loss of Language.

N Engl J Med 2017 01;376(2):158-167

From the Department of Neurology, Northwestern Medicine, Chicago (M.-M.M.); and the Departments of Neurology (B.C.D., J.C.S., K.A.J.), Psychiatry (J.C.S.), Speech, Language, and Swallowing Disorders and Reading Disabilities (D.H.), Radiology (R.G.G., K.A.J.), and Pathology (M.P.F.), Massachusetts General Hospital, and the Departments of Neurology (B.C.D.), Psychiatry (J.C.S.), Radiology (R.G.G., K.A.J.), and Pathology (M.P.F.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1613459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264551PMC
January 2017

Microbleed and microinfarct detection in amyloid angiopathy: a high-resolution MRI-histopathology study.

Brain 2016 12 19;139(Pt 12):3151-3162. Epub 2016 Sep 19.

1 J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/brain/aww229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840880PMC
December 2016

Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart.

J Am Coll Cardiol 2016 Dec;68(22):2395-2407

Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Division of Cardiology Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://content.onlinejacc.org/data/Journals/JAC/935902/08073
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http://dx.doi.org/10.1016/j.jacc.2016.08.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142757PMC
December 2016

Rapid Neurological Recovery Following Partial Surgical Resection of Spinal Glioblastoma Multiforme in a Pediatric Patient Presenting With Complete Paraplegia.

J Pediatr Hematol Oncol 2016 11;38(8):e286-e290

Departments of *Neurosurgery ‡Pathology ∥Pediatrics §Radiation Oncology, Massachusetts General Hospital †Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/MPH.0000000000000637DOI Listing
November 2016

Microbleeds on MRI are associated with microinfarcts on autopsy in cerebral amyloid angiopathy.

Neurology 2016 Oct 9;87(14):1488-1492. Epub 2016 Sep 9.

From the Hemorrhagic Stroke Research Program (A.L., S.J.v.V., A.C., D.R., A.V., A.A., S.M.-R., E.M.G., S.M.G., A.V.), Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston; Department of Neurology (S.J.v.V., G.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Pathology (C.M.W.), New York University Langone Medical Center, New York University School of Medicine; Department of Medicine (D.R.), Faculty of Medicine, Naresuan University, Phitsanulok, Thailand; and C.S. Kubik Laboratory for Neuropathology (M.F.), Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000003184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075970PMC
October 2016

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint.

Alzheimers Dement 2016 09 26;12(9):996-1013. Epub 2016 Apr 26.

School of Life Sciences, Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.03.011DOI Listing
September 2016

Novel Compound Heterozygous Mutations Expand the Recognized Phenotypes of FARS2-Linked Disease.

J Child Neurol 2016 08 19;31(9):1127-37. Epub 2016 Apr 19.

Department of Neurology, Division of Child Neurology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1177/0883073816643402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981184PMC
August 2016

Zika and histopathology in first trimester infections.

Lancet 2016 Aug 29;388(10047):847-9. Epub 2016 Jun 29.

C S Kubik Laboratory for Neuropathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/S0140-6736(16)30930-8DOI Listing
August 2016

Mitochondrial Encephalopathy and Optic Neuropathy Due to m.10158 MT-ND3 Complex I Mutation Presenting in an Adult Patient: Case Report and Review of the Literature.

Neurologist 2016 Jul;21(4):61-5

*Harvard Medical School †Department of Neurology, Massachusetts General Hospital ‡Massachusetts Eye and Ear Infirmary, Neuro-Ophthalmology Service §Massachusetts General Hospital, Neuropathology Service, Boston, MA.

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http://dx.doi.org/10.1097/NRL.0000000000000084DOI Listing
July 2016

Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum.

J Neuropathol Exp Neurol 2016 06 22;75(6):516-26. Epub 2016 Apr 22.

From the Department of Neurology of the University of Iowa Hospitals & Clinics, Iowa City, Iowa (AS-P); Department of Biostatistics and Epidemiology of the University of Massachusetts, Amherst, Massachusetts (JQ); Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts (AM); Department of Biostatistics, University of Washington, Seattle, Washington (SEM); Department of Pathology, School of Medicine of the University of Washington, Seattle, Washington (TJM); C. S. Kubik Laboratory for Neuropathology of the Massachusetts General Hospital (MPF), Department of Neurology of the Massachusetts General Hospital, Boston, Massachusetts (BTH); Department of Biostatistics of the Harvard T. H. Chan School of Public Health, Boston, Massachusetts (RAB); and Massachusetts Alzheimer Disease Research Center, Charlestown, Massachusetts (MPF, RAB, BTH).

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http://dx.doi.org/10.1093/jnen/nlw026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250207PMC
June 2016

Spinal cord glioblastoma: 25years of experience from a single institution.

J Clin Neurosci 2016 May 2;27:138-41. Epub 2016 Jan 2.

Department of Neurosurgery, Massachusetts General Hospital, 15 Parkman Street, WACC 021, Boston, MA 02115, USA; Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jocn.2015.11.011DOI Listing
May 2016

CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 15-2016. A 32-Year-Old Man with Olfactory Hallucinations and Paresthesias.

N Engl J Med 2016 May;374(20):1966-75

From the Department of Neurology, Beth Israel Deaconess Medical Center (M.R.), the Departments of Neurology (N.V., M.P.F.), Radiology (G.J.H.) and Pathology (M.P.F.), Massachusetts General Hospital, and the Departments of Neurology (M.R., N.V.), Radiology (G.J.H.), and Pathology (M.P.F.), Harvard Medical School - all in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1516449DOI Listing
May 2016

Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease.

Alzheimers Dement 2016 Feb 29;12(2):164-169. Epub 2015 Aug 29.

Department of Neurology, Massachusetts General Hospital, Charleston, MA, USA; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Charleston, MA, USA.

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http://dx.doi.org/10.1016/j.jalz.2015.07.492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562409PMC
February 2016

Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease.

Am J Pathol 2016 Feb 11;186(2):375-84. Epub 2015 Dec 11.

Massachusetts Alzheimer Disease Research Center, Massachusetts General Hospital, Charlestown, Massachusetts; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729270PMC
February 2016

Validation of Clinicoradiological Criteria for the Diagnosis of Cerebral Amyloid Angiopathy-Related Inflammation.

JAMA Neurol 2016 Feb;73(2):197-202

The J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston2The Inflammatory Cerebral Amyloid Angiopathy and Alzheimer's Disease ßiomarkers International Network, University of M.

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http://dx.doi.org/10.1001/jamaneurol.2015.4078DOI Listing
February 2016

Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems.

Cell 2015 Dec;163(6):1500-14

Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674150150
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http://dx.doi.org/10.1016/j.cell.2015.11.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5275966PMC
December 2015

The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species.

Alzheimers Dement 2015 Nov 4;11(11):1286-305. Epub 2015 Apr 4.

Laboratory for Neurodegenerative Research, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592782PMC
November 2015

Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy.

Neurobiol Aging 2015 Nov 16;36(11):2963-2971. Epub 2015 Jul 16.

Department of Neurology, Alzheimer Research Unit, Massachusetts General Hospital, Charlestown, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609585PMC
November 2015

Brain endothelial dysfunction in cerebral adrenoleukodystrophy.

Brain 2015 Nov 15;138(Pt 11):3206-20. Epub 2015 Sep 15.

1 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA 2 Center for Rare Neurological Diseases, Massachusetts General Hospital, Boston, MA, USA.

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http://brain.oxfordjournals.org/content/brain/early/2015/09/
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http://www.brain.oxfordjournals.org/lookup/doi/10.1093/brain
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http://dx.doi.org/10.1093/brain/awv250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731416PMC
November 2015

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.

Sci Rep 2015 Nov 13;5:16622. Epub 2015 Nov 13.

Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1038/srep16622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643219PMC
November 2015

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.

Nat Commun 2015 Oct 13;6:8490. Epub 2015 Oct 13.

Department of Neurology, Alzheimer's Disease Research Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/ncomms9490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608380PMC
October 2015

Estimating Total Cerebral Microinfarct Burden From Diffusion-Weighted Imaging.

Stroke 2015 Aug 9;46(8):2129-35. Epub 2015 Jul 9.

From the Department of Neurology, J. Philip Kistler Stroke Research Center (E.A., M.B.W., M.T.B., Y.R., S.M.-R., J.N., E.V.E., P.F., K.S., A. Vashkevich, G.B., M.E.G., A. Viswanathan, S.M.G.) and Department of Pathology, Neuropathology Service, C.S. Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown (A.P.Y., K.A.J., R.A.S., T.H.); and Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.A.S.).

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http://dx.doi.org/10.1161/STROKEAHA.115.009208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519384PMC
August 2015

A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI.

Neuroimage 2015 Jul 29;115:117-37. Epub 2015 Apr 29.

Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Denmark; Department of Information and Computer Science, Aalto University, Finland; Department of Biomedical Engineering and Computational Science, Aalto University, Finland.

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http://nmr.mgh.harvard.edu/~koen/IglesiasNI2015.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S105381191500342
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http://dx.doi.org/10.1016/j.neuroimage.2015.04.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461537PMC
July 2015

A 20-year-old man with back pain and lower extremity weakness.

JAMA Neurol 2015 Mar;72(3):363-6

Department of Neurology, Massachusetts General Hospital, Boston3Department of Neurology, Harvard Medical School, Boston, Massachusetts6Division of Neuro-Oncology, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jamaneurol.2014.3833DOI Listing
March 2015

PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

Neurology 2015 Mar 6;84(10):972-80. Epub 2015 Feb 6.

From the John P. Hussman Institute for Human Genomics (G.W.B., W.K.S., E.R.M., K.N., L.W., D.M.D., M.A.P.-V., J.M.V.) and University of Miami Brain Endowment Bank (D.C.M.), Miller School of Medicine, University of Miami, FL; Departments of Neuroscience (D.W.D., O.A.R.) and Neurology (Z.K.W.), Mayo Clinic Florida, Jacksonville; Department of Pathology & Laboratory Medicine (G.S., J.Q.T., V.M.V.D., H.I.H.), Perelman School of Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia; Group Health Research Institute (E.B.L.), Seattle, WA; Departments of Psychiatry, and Genetics and Genomic Sciences (J.D.B.), Mount Sinai School of Medicine, New York, NY; Arizona Alzheimer's Consortium (T.G.B.), Phoenix; Sun Health Research Institute (T.G.B.), Sun City, AZ; Division of Neuropathology, Department of Pathology (J.C.T., O.P.), and Department of Neurology and the Solomon H. Snyder Department of Neuroscience (T.M.D.), Johns Hopkins University School of Medicine, Baltimore, MD; Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Charlestown, MA; Department of Pathology and Laboratory Medicine, Indiana Alzheimer Disease Center (B.G.), and Department of Medical and Molecular Genetics (T.M.F.), Indiana University School of Medicine, Indianapolis; Departments of Neurology (L.S.H., K.M.) and Psychiatry (K.M.), Gertrude H. Sergievsky Center, and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York; Department of Pathology and Cell Biology (J.P.V.), Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY; The Parkinson's Institute (S.M.G.), Sunnyvale, CA; Departments of Pathology and Laboratory Medicine (Neuropathology) and Neurology (H.V.V.), David Geffen School of Medicine at University of California Los Angeles; Department of Pathology (T.J.M.), University of Washington School of Medicine, Seattle; VA Puget Sound Health Care System (

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http://www.neurology.org/content/early/2015/02/06/WNL.000000
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000133
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http://dx.doi.org/10.1212/WNL.0000000000001332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352096PMC
March 2015

Cerebral amyloid angiopathy with and without hemorrhage: evidence for different disease phenotypes.

Neurology 2015 Mar 25;84(12):1206-12. Epub 2015 Feb 25.

From the Department of Brain Repair and Rehabilitation (A.C.), UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK; and the Hemorrhagic Stroke Research Program, Stroke Research Center, Department of Neurology (A.C., S.M.-R., A.S., J.O.-F., A. Vashkevich, A.A., J.R., M.E.G., S.M.G., A. Viswanathan), C.S. Kubik Laboratory for Neuropathology (M.F.), Division of Neurocritical Care and Emergency Neurology (J.R.), and Center for Human Genetic Research (J.R.), Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000001398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366086PMC
March 2015

Optical coherence tomography visualizes neurons in human entorhinal cortex.

Neurophotonics 2015 Feb;2(1):015004

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Department of Radiology, 149 Thirteen Street, Charlestown, Massachusetts 02129, United States ; MIT, Computer Science and AI Laboratory, the Stata Center, Building 32, 32 Vassar Street, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1117/1.NPh.2.1.015004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346095PMC
February 2015