Matthew D Perry

Matthew D Perry

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Matthew D Perry

Matthew D Perry

Publications by authors named "Matthew D Perry"

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High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants.

Heart Rhythm 2020 Mar 23;17(3):492-500. Epub 2019 Sep 23.

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; St Vincent's Clinical School, UNSW Sydney, Darlinghurst, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2019.09.020DOI Listing
March 2020

Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization.

Cardiovasc Res 2019 Sep 13. Epub 2019 Sep 13.

Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, New South Wales 2010, Australia.

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http://dx.doi.org/10.1093/cvr/cvz247DOI Listing
September 2019

Protocol-Dependent Differences in IC Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding.

Mol Pharmacol 2019 05 15;95(5):537-550. Epub 2019 Feb 15.

Victor Chang Cardiac Research Institute (W.L., M.J.W., M.D.P., J.I.V., A.P.H.) and St Vincent's Clinical School (W.L., M.J.W., M.D.P., J.I.V., A.P.H.), University of New South Wales, Darlinghurst, New South Wales, Australia

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http://dx.doi.org/10.1124/mol.118.115220DOI Listing
May 2019

Recent advances in understanding and prevention of sudden cardiac death.

F1000Res 2017 31;6:1614. Epub 2017 Aug 31.

St Vincent's Clinical School, University of New South Wales, Darlinghurst, Australia.

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http://dx.doi.org/10.12688/f1000research.11855.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583740PMC
August 2017

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels.

J Biol Chem 2017 05 9;292(18):7688-7705. Epub 2017 Mar 9.

From the Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, New South Wales 2010,

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http://dx.doi.org/10.1074/jbc.M117.779298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418064PMC
May 2017

TECRL: connecting sequence to consequence for a new sudden cardiac death gene.

EMBO Mol Med 2016 12 1;8(12):1364-1365. Epub 2016 Dec 1.

Mark Cowley Lidwill Research Programme in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.

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http://dx.doi.org/10.15252/emmm.201606967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167129PMC
December 2016

Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes.

J Mol Cell Cardiol 2016 Nov 20;100:25-34. Epub 2016 Sep 20.

Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW 2010, Australia; St Vincent's Clinical School, University of New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.09.011DOI Listing
November 2016

Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation.

Am J Physiol Gastrointest Liver Physiol 2016 11 8;311(5):G785-G793. Epub 2016 Sep 8.

Leeds Institute of Biomedical and Clinical Sciences, St James's University Hospital, Leeds, United Kingdom;

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http://dx.doi.org/10.1152/ajpgi.00181.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130553PMC
November 2016

Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation.

J Biol Chem 2016 08 17;291(33):17293-302. Epub 2016 Jun 17.

From the Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst and the St. Vincent's Clinical School, University of New South Wales, Victoria Street, Darlinghurst, New South Wales 2010, Australia and

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http://dx.doi.org/10.1074/jbc.M116.729392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016128PMC
August 2016

Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations.

J Physiol 2016 07 27;594(14):4031-49. Epub 2016 May 27.

Victor Chang Cardiac Research Institute, Molecular Cardiology and Biophysics Division, Darlinghurst, NSW, 2010, Australia.

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http://dx.doi.org/10.1113/JP271805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945714PMC
July 2016

Getting to the heart of hERG K(+) channel gating.

J Physiol 2015 Jun;593(12):2575-85

Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW 2010, Australia.

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http://doi.wiley.com/10.1113/JP270095
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http://dx.doi.org/10.1113/JP270095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500344PMC
June 2015

Can many subunits make light work of ion channel inactivation?

J Physiol 2014 Oct;592(20):4411-2

Victor Chang Cardiac Research Institute, Level 6, 405 Liverpool Street, Darlinghurst, NSW 2010, Australia St Vincent's Clinical School, University of New South Wales, Victoria Street, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.1113/jphysiol.2014.281568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287733PMC
October 2014

Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels.

J Biol Chem 2014 Sep 29;289(37):25822-32. Epub 2014 Jul 29.

From the Victor Chang Cardiac Research Institute and St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales 2010, Australia.

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http://dx.doi.org/10.1074/jbc.M114.558379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162183PMC
September 2014

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2.

Nat Commun 2014 Sep 25;5:5069. Epub 2014 Sep 25.

1] Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1038/ncomms6069DOI Listing
September 2014

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.

PLoS One 2013 25;8(10):e77032. Epub 2013 Oct 25.

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia ; St Vincent's Clinical School, University of New South Wales, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077032PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808384PMC
August 2014

Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.

J Biol Chem 2014 May 2;289(20):13782-91. Epub 2014 Apr 2.

From the Mark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, 405 Liverpool Street and St. Vincent's Clinical School, University of New South Wales, Victoria Street, Darlinghurst, New South Wales 2010, Australia

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http://dx.doi.org/10.1074/jbc.M113.531277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022852PMC
May 2014

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels.

J Gen Physiol 2013 Sep;142(3):275-88

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.

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http://www.jgp.org/lookup/doi/10.1085/jgp.201310975
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http://dx.doi.org/10.1085/jgp.201310975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753607PMC
September 2013

Pore helices play a dynamic role as integrators of domain motion during Kv11.1 channel inactivation gating.

J Biol Chem 2013 Apr 7;288(16):11482-91. Epub 2013 Mar 7.

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia.

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http://dx.doi.org/10.1074/jbc.M113.461442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630859PMC
April 2013

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels.

J Gen Physiol 2012 Sep 13;140(3):293-306. Epub 2012 Aug 13.

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia.

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http://dx.doi.org/10.1085/jgp.201110761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434099PMC
September 2012

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.

PLoS One 2012 16;7(2):e31640. Epub 2012 Feb 16.

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031640PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280985PMC
August 2012

hERG K(+) channels: structure, function, and clinical significance.

Physiol Rev 2012 Jul;92(3):1393-478

Mark Cowley Lidwill Research Programme in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1152/physrev.00036.2011DOI Listing
July 2012

Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.

Cardiovasc Res 2011 Sep 23;91(4):694-702. Epub 2011 May 23.

Department of Cell Physiology and Pharmacology, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1093/cvr/cvr137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156907PMC
September 2011

The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation.

PLoS One 2011 Jan 13;6(1):e16191. Epub 2011 Jan 13.

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016191PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020963PMC
January 2011

Molecular determinants of high-affinity drug binding to HERG channels.

Curr Opin Drug Discov Devel 2003 Sep;6(5):667-74

University of Leicester, Department of Cell Physiology and Pharmacology, Maurice Shock Medical Sciences Building, University Road, Leicester, LE1 9HN, UK.

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September 2003