Matthew D Neal

Matthew D Neal

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Matthew D Neal

Matthew D Neal

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A systematic review and meta-analysis of traumatic intracranial hemorrhage in patients taking prehospital antiplatelet therapy: Is there a role for platelet transfusions?

J Trauma Acute Care Surg 2020 Jun;88(6):847-854

From the Department of Surgery (J.A., S.P.M., M.R.R., M.D.N.), University of Pittsburgh Medical Center; University of Pittsburgh Health Sciences Library System (C.B.W.); Department of Neurological Surgery (D.O.O.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Department of Surgery (B.J.), University of Arizona, Tucson, Arizona; The Iowa Clinic (C.P.), Des Moines, Iowa; Warren Alpert Medical School of Brown University (C.D.), Providence, Rhode Island; Division of Neurological Surgery (A.R.G.), University of Missouri School of Medicine, Columbia, Missouri; and Department of Critical Care Medicine (M.R.R., M.D.N.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000002640DOI Listing
June 2020

Accelerating availability of clinically-relevant parameter estimates from thromboelastogram point-of-care device.

J Trauma Acute Care Surg 2020 May;88(5):654-660

From the Department of Chemical and Petroleum Engineering (M.A.P., R.S.P., G.C.), Swanson School of Engineering, Department of Critical Care Medicine (R.S.P., M.D.N., J.L.S., G.C.), Department of Surgery (M.D.N., J.L.S.), and Department of Bioengineering (R.S.P., G.C.), Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1097/TA.0000000000002608DOI Listing
May 2020

Forgot calcium? Admission ionized-calcium in two civilian randomized controlled trials of prehospital plasma for traumatic hemorrhagic shock.

J Trauma Acute Care Surg 2020 May;88(5):588-596

From the School of Medicine, Department of Surgery, University of Colorado Anschutz Medical Campus (H.B.M., E.E.M., M.J.C., M.P.C., A.S.), Aurora, CO; University of Colorado Anschutz Medical Campus, School of Public Health, Department of Health Systems, Management and Policy (A.S.); Aurora, Colorado; University of Pittsburgh (M.T.T., J.L.S., F.X.G., J.B.B., M.N., B.Z.), Pittsburgh, Pennsylvania; Ernest E. Moore Shock Trauma Center at Denver Health (E.E.M., M.J.C.), Denver, Colorado; and Combat Casualty Care Research Program (A.E.P.), US Army Medical Research Materiel Command, Fort Detrick, Maryland.

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http://dx.doi.org/10.1097/TA.0000000000002614DOI Listing
May 2020

Whole-Blood Resuscitation of Injured Patients: Innovating from the Past.

JAMA Surg 2020 May 13. Epub 2020 May 13.

Pittsburgh Trauma Research Center, University of Pittsburgh Medical Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1001/jamasurg.2020.0811DOI Listing
May 2020

Traumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity.

Transfusion 2020 May 22. Epub 2020 May 22.

Pittsburgh Trauma Research Center and the Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1111/trf.15856DOI Listing
May 2020

Venous thromboembolism after tranexamic acid administration: legitimate risk or statistical confounder?

ANZ J Surg 2020 Apr;90(4):425-426

Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1111/ans.15670DOI Listing
April 2020

A comparison between the TEG 6s and TEG 5000 analyzers to assess coagulation in trauma patients.

J Trauma Acute Care Surg 2020 Feb;88(2):279-285

From the Departments of Surgery, Critical Care Medicine, and the Clinical and Translational Science Institute (CTSI) (M.D.N.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Ernest E Moore Shock Trauma Center at Denver Health (E.E.M.), Denver, Colorado; Memorial Hospital of South Bend (M.W., S.T.), South Bend, Indiana; Department of Surgery (R.A.C., L.Z.K.), Zuckerberg San Francisco General Hospital, University of California San Francisco (UCSF), San Francisco, California; Division of Trauma, Critical Care & Acute Care Surgery, Department of Surgery (M.S.), Oregon Health & Science University, Portland, Oregon; Wright State University (A.P.E.), Dayton, Ohio; Stony Brook Department of Emergency Medicine (A.J.S.), Stony Brook University, Stony Brook, New York; Department of Surgery, Florida Atlantic University, St. Mary's Medical Center (L.L.), West Palm Beach, Florida; Division of Trauma, Acute Care, and Critical Care Surgery (M.F.), Baylor University Medical Center, Dallas, Texas; Division of Acute Care Surgery, Department of Surgery (S.E.), Carolinas Medical Center, Charlotte, North Carolina; University of Kansas Medical Center (R.D.W.), University of Kansas, Kansas City, Kansas; Department of Surgery (M.D.G.), University of Cincinnati, Cincinnati, Ohio; SSM Health (C.F.), Saint Louis University Hospital, St Louis, Missouri; Division of Trauma and Acute Care Surgery (D.M.), Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Surgery (N.S.), Massachusetts General Hospital, Boston; and Haemonetics Corporation (J.H., H.E.A.), Braintree, Massachusetts.

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http://dx.doi.org/10.1097/TA.0000000000002545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004476PMC
February 2020

Correlation of Thromboelastography with Apparent Rivaroxaban Concentration: Has Point-of-Care Testing Improved?

Anesthesiology 2020 02;132(2):280-290

From the Department of General Surgery, The University of Pittsburgh Medical Center (S.P.M., M.R.D., A.H., J.B.B., J.L.S., M.R.R., M.D.N.) the Institute for Transfusion Medicine (M.P.M.) the Pittsburgh Surgical Outcomes Research Center, University of Pittsburgh (M.R.R.), Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/ALN.0000000000003061DOI Listing
February 2020

Prehospital plasma in injured patients is associated with survival principally in blunt injury: Results from two randomized prehospital plasma trials.

J Trauma Acute Care Surg 2020 Jan;88(1):33-41

From the Department of Surgery (K.M.R., A.H., J.B.B., B.S.Z., M.D.N., J.L.S.), University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Surgery (H.B.M., A.S., E.E.M., M.P.C.), University of Colorado and Denver Health Medical Center, Denver, Colorado; Department of Emergency Medicine (F.X.G.), University of Pittsburgh, Pittsburgh, Pennsylvania; US Army Institute of Surgical Research (A.E.P.), JBSA Fort Sam Houston, San Antonio, Texas; Department of Surgery (B.J.D.), University of Tennessee Health Science Center, Knoxville; Department of Surgery (R.S.M.), Vanderbilt University Medical Center, Nashville, Tennessee; University of Louisville (B.G.H.), Louisville, Kentucky; MetroHealth Medical Center (J.A.C.), Case Western Reserve University, Cleveland, Ohio; Department of Surgery (H.A.P.), University of Texas Southwestern, Parkland Memorial Hospital, Dallas, Texas; Department of Pathology (M.H.Y.), University of Pittsburgh and Institute for Transfusion Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000002485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923541PMC
January 2020

Alterations in platelet behavior after major trauma: adaptive or maladaptive?

Platelets 2020 Jan 27:1-10. Epub 2020 Jan 27.

Pittsburgh Trauma Research Center and Division of Trauma and Acute Care Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1080/09537104.2020.1718633DOI Listing
January 2020

Implementation of a prehospital air medical thawed plasma program: Is it even feasible?

J Trauma Acute Care Surg 2019 11;87(5):1077-1081

From the Division of Trauma and General Surgery, Department of Surgery (P.W.A., K.A.W., J.B.B., A.T.P., B.S.Z., M.D.N., J.L.S.), and Department of Emergency Medicine (F.X.G.), University of Pittsburgh Medical Center; Vitalant, and Department of Pathology (M.H.Y.), University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Surgery (B.J.D.), University of Tennessee Health Science Center, Knoxville; Department of Surgery (R.S.M.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Surgery (B.G.H.), University of Louisville, Louisville, Kentucky; MetroHealth Medical Center (J.A.C.), Case Western Reserve University, Cleveland, Ohio; Department of Surgery (H.A.P.), University of Texas Southwestern, Parkland Hospital, Dallas; and Health Harris Methodist Hospital (W.R.W.), Fort Worth, Texas.

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http://dx.doi.org/10.1097/TA.0000000000002406DOI Listing
November 2019

Early versus late venous thromboembolism: A secondary analysis of data from the PROPPR trial.

Surgery 2019 09 21;166(3):416-422. Epub 2019 Jun 21.

Department of General Surgery, The University of Pittsburgh Medical Center, Pittsburgh, PA.

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http://dx.doi.org/10.1016/j.surg.2019.04.014DOI Listing
September 2019

Pass interference: Getting in the way of platelets.

J Thromb Haemost 2019 Sep 12;17(9):1414-1416. Epub 2019 Jul 12.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1111/jth.14536DOI Listing
September 2019

A Systematic Review of Gender-Based Differences in Hirsch Index Among Academic Surgeons.

J Surg Res 2019 04 3;236:22-29. Epub 2018 Dec 3.

Department of General Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1016/j.jss.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534118PMC
April 2019

Hernia Management in Cirrhosis: Risk Assessment, Operative Approach, and Perioperative Care.

J Surg Res 2019 03 23;235:1-7. Epub 2018 Oct 23.

Division of Trauma and Acute Care Surgery, Department of Surgery, UPMC, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1016/j.jss.2018.09.052DOI Listing
March 2019

Tranexamic acid administration is associated with an increased risk of posttraumatic venous thromboembolism.

J Trauma Acute Care Surg 2019 01;86(1):20-27

From the Department of General Surgery (S.P.M., M.R.R., J.L.S., A.B.P., J.B.B., M.D.N.), The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and Division of Trauma and Critical Care (M.E.K.), The University of Mississippi Medical Center, Jackson, Mississippi.

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http://dx.doi.org/10.1097/TA.0000000000002061DOI Listing
January 2019

Perceptions Regarding Mentorship Among General Surgery Trainees With Academic Career Intentions.

J Surg Educ 2019 Jul - Aug;76(4):916-923. Epub 2019 Jan 28.

Department of General Surgery, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1016/j.jsurg.2018.12.006DOI Listing
January 2019

Blunt cerebrovascular injury in elderly fall patients: are we screening enough?

World J Emerg Surg 2018 4;13:30. Epub 2018 Jul 4.

Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213 USA.

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http://dx.doi.org/10.1186/s13017-018-0188-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031193PMC
December 2018

Reversing anti-factor Xa agents and the unmet needs in trauma patients.

Blood 2018 12 11;132(23):2441-2445. Epub 2018 Oct 11.

Department of Anesthesia and Trauma Centre, Centre of Head and Orthopedics, and.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-06
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http://dx.doi.org/10.1182/blood-2018-06-850396DOI Listing
December 2018

Design and implementation of the Western Pennsylvania regional Stop the Bleed initiative.

J Trauma Acute Care Surg 2018 10;85(4):684-690

From the Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (M.D.N., B.R.R., D.B., A.B.P., R.M.F.), and Department of Emergency Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (K.J.M.).

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http://dx.doi.org/10.1097/TA.0000000000002027DOI Listing
October 2018

ADAMTS13: origins, applications, and prospects.

Transfusion 2018 10 12;58(10):2453-2462. Epub 2018 Sep 12.

Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1111/trf.14804DOI Listing
October 2018

Bacterial contamination of platelets for transfusion: strategies for prevention.

Crit Care 2018 10 27;22(1):271. Epub 2018 Oct 27.

Thomas Jefferson University Hospital, 111 S. 11th Street, Philadelphia, PA, 19107, USA.

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https://ccforum.biomedcentral.com/articles/10.1186/s13054-01
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http://dx.doi.org/10.1186/s13054-018-2212-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204059PMC
October 2018

A qualitative study of gender differences in the experiences of general surgery trainees.

J Surg Res 2018 08 7;228:127-134. Epub 2018 Apr 7.

Department of Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1016/j.jss.2018.02.043DOI Listing
August 2018

Overresuscitation with plasma is associated with sustained fibrinolysis shutdown and death in pediatric traumatic brain injury.

J Trauma Acute Care Surg 2018 07;85(1):12-17

From the Division of General Surgery and Trauma, Department of Surgery (C.M.L., M.D.N., T.R.B., J.L.S.), Division of Pediatric General and Thoracic Surgery, University of Pittsburgh Medical Center; and Children's Hospital of Pittsburgh of UPMC (C.M.L., B.A.G.), Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000001836DOI Listing
July 2018

Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock.

N Engl J Med 2018 Jul;379(4):315-326

From the Division of Trauma and General Surgery, Department of Surgery (J.L.S., J.B.B., L.H.A., B.S.Z., M.D.N., M.R.R., R.M.F., T.R.B., A.B.P., M.S.Z.), and the Departments of Emergency Medicine (F.X.G., C.W.C., D.M.Y.) and Critical Care Medicine (B.J.E.-Y., P.W.A.), University of Pittsburgh Medical Center, and the Department of Pathology, University of Pittsburgh and Institute for Transfusion Medicine (M.H.Y., D.J.T.), Pittsburgh, and University of Pittsburgh Medical Center, Altoona Hospital, Altoona (A.T.P.) - all in Pennsylvania; the Department of Surgery, University of Tennessee Health Science Center, Knoxville (B.J.D.), and the Department of Surgery, Vanderbilt University Medical Center, Nashville (R.S.M.) - both in Tennessee; the Department of Surgery, University of Louisville, Louisville, KY (B.G.H.); MetroHealth Medical Center, Case Western Reserve University, Cleveland (J.A.C.); and the Department of Surgery, University of Texas Southwestern, Parkland Memorial Hospital, Dallas (H.A.P.) and Texas Health Harris Methodist Hospital (W.R.W.) and the John Peter Smith Health Network (T.M.D.), Fort Worth - all in Texas.

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http://dx.doi.org/10.1056/NEJMoa1802345DOI Listing
July 2018

Intravenous administration of synthetic platelets (SynthoPlate) in a mouse liver injury model of uncontrolled hemorrhage improves hemostasis.

J Trauma Acute Care Surg 2018 06;84(6):917-923

From the Department of Surgery (M.R.D., S.H., P.L., M.D.N.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Department of Pathology (D.H.), Department of Biomedical Engineering (C.P., A.S.G.), Case Western Reserve University, Cleveland, Ohio; and Center for Biological Imaging (P.L.), University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000001893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970031PMC
June 2018

Principal component analysis of coagulation assays in severely injured children.

Surgery 2018 04 13;163(4):827-831. Epub 2017 Dec 13.

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2017.09.031DOI Listing
April 2018

Precision Correction of Coagulopathy or Prothrombin Complex Concentrates?: Reversal Options for Dabigatran following Trauma.

Anesthesiology 2017 11;127(5):744-746

From the Division of Trauma and Acute Care Surgery, Department of Surgery and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (M.D.N.); and the Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina (J.H.L.).

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http://dx.doi.org/10.1097/ALN.0000000000001857DOI Listing
November 2017

Trending Fibrinolytic Dysregulation: Fibrinolysis Shutdown in the Days After Injury Is Associated With Poor Outcome in Severely Injured Children.

Ann Surg 2017 09;266(3):508-515

*Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA †Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

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http://Insights.ovid.com/crossref?an=00000658-201709000-0001
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http://dx.doi.org/10.1097/SLA.0000000000002355DOI Listing
September 2017

Is Coagulopathy an Appropriate Therapeutic Target During Critical Illness Such as Trauma or Sepsis?

Shock 2017 08;48(2):159-167

*University of Colorado, Aurora, Colorado †University of Kansas Medical Center, Kansas City, Kansas ‡Ehime University Graduate School of Medicine, Ehime, Japan §University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/SHK.0000000000000854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511060PMC
August 2017

Should All Massively Transfused Patients Be Treated Equally? An Analysis of Massive Transfusion Ratios in the Nontrauma Setting.

Crit Care Med 2017 Aug;45(8):1311-1316

1Division of Trauma and Acute Care Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.2Department of Pediatrics, Johns Hopkins Children's Center, Baltimore, MD.3Division of Transfusion Medicine, Department of Pathology, University of North Carolina School of Medicine, Chapel Hill, NC.4Division of Transfusion Medicine, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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http://dx.doi.org/10.1097/CCM.0000000000002498DOI Listing
August 2017

Platelet Transfusion in Critical Care and Surgery: Evidence-Based Review of Contemporary Practice and Future Directions.

Shock 2017 05;47(5):537-549

*University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania †University of North Carolina School of Medicine, Chapel Hill, North Carolina ‡American University of Beirut, Beirut, Lebanon §Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1097/SHK.0000000000000794DOI Listing
May 2017

Management of anticoagulation with rivaroxaban in trauma and acute care surgery: Complications and reversal strategies as compared to warfarin therapy.

J Trauma Acute Care Surg 2017 03;82(3):542-549

From the Division of Trauma and General Surgery, Department of Surgery (S.P.M., E.R.D., J.C., L.A., M.K., J.B.B., M.D.N.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000001340DOI Listing
March 2017

Aged Human Stored Red Blood Cell Supernatant Inhibits Macrophage Phagocytosis in an HMGB1 Dependent Manner After Trauma in a Murine Model.

Shock 2017 02;47(2):217-224

*Department of Surgery, University of Pittsburgh College of Medicine, Pittsburgh, Pennsylvania †Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina ‡Department of Surgery, Minhang Hospital, Fudan University, Shanghai, China §Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/SHK.0000000000000716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235959PMC
February 2017

Surgical rescue: The next pillar of acute care surgery.

J Trauma Acute Care Surg 2017 02;82(2):280-286

From the Division of Trauma and General Surgery (M.E.K., J.L.S., M.R.R., D.M., M.K.H., M.D.N., L.H.A., G.A.W., J.C.P., G.M.B., V.D.S., A.F., T.Z., S.J.Z., T.R.B., R.M.F., B.S.Z., A.B.P.), Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; and Section of General Surgery (R.D.B.), Trauma, and Surgical Critical Care, Yale School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1097/TA.0000000000001312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703180PMC
February 2017

Abnormalities in fibrinolysis at the time of admission are associated with deep vein thrombosis, mortality, and disability in a pediatric trauma population.

J Trauma Acute Care Surg 2017 01;82(1):27-34

From the Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (C.M.L., M.D.N., J.L.S.); and Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania (C.M.L., C.M., B.A.G.).This article was presented at the 75th annual meeting of the American Association for the Surgery of Trauma, September 14-17, 2016, in Waikoloa, Hawaii.

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http://dx.doi.org/10.1097/TA.0000000000001308DOI Listing
January 2017

Dysbiosis Across Multiple Body Sites in Critically Ill Adult Surgical Patients.

Shock 2016 12;46(6):649-654

*Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania †Division of Pediatric General and Thoracic Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/SHK.0000000000000691DOI Listing
December 2016

Platelet-derived high-mobility group box 1 promotes recruitment and suppresses apoptosis of monocytes.

Biochem Biophys Res Commun 2016 09 20;478(1):143-148. Epub 2016 Jul 20.

Department of Cardiology and Cardiovascular Diseases, Eberhard Karls University Tübingen, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2016.07.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976924PMC
September 2016

Synthesis of -inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4).

Tetrahedron Lett 2015 Jun;56(23):3097-3100

Division of Pediatric Surgery, Children's Hospital of Pittsburgh of University of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh PA 15224, USA ; Division of Pediatric Surgery, Bloomberg Children's Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00404039140194
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http://dx.doi.org/10.1016/j.tetlet.2014.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518473PMC
June 2015

Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation.

Circ Cardiovasc Genet 2014 Oct 21;7(5):615-24. Epub 2014 Jul 21.

From the Department of Surgery, University of Pittsburgh, PA (N.D., G.C., R.H., P.A.L., T.R.B., M.D.N.); Department of Anesthesiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China (N.D.); Department of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, People's Republic of China (G.C.); and Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh of UPMC, PA (C.P.S., D.J.H.).

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270899PMC
October 2014

Massive transfusion protocol activation does not result in preferential use of older red blood cells.

J Blood Transfus 2014 10;2014:328967. Epub 2014 Sep 10.

Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1155/2014/328967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177085PMC
October 2014

Prehospital use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of trauma-induced coagulopathy.

Ann Surg 2014 Aug;260(2):378-82

*Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; †Department of Surgery, Denver Health Medical Center and The University of Colorado Health Sciences Center, Denver; ‡Division of General Surgery and Trauma, Harborview Medical Center and the Department of Surgery, University of Washington, Seattle; §Division of Burn, Trauma, Critical Care, Department of Surgery, University of Texas Southwestern Medical Center, Dallas; and ¶Department of Surgery, University of California, San Francisco.

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http://dx.doi.org/10.1097/SLA.0000000000000526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096620PMC
August 2014

A novel scoring system to predict the development of necrotizing enterocolitis totalis in premature infants.

J Pediatr Surg 2014 Jul 7;49(7):1053-6. Epub 2013 Nov 7.

Division of Pediatric Surgery Children's Hospital of Pittsburgh, Pittsburgh, PA, 15224; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15224. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00223468130085
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http://dx.doi.org/10.1016/j.jpedsurg.2013.10.023DOI Listing
July 2014

Simultaneous extracorporeal membrane oxygenation and therapeutic plasma exchange procedures are tolerable in both pediatric and adult patients.

Transfusion 2014 Apr 10;54(4):1158-65. Epub 2013 Oct 10.

Department of Surgery, University of Pittsburgh.

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http://dx.doi.org/10.1111/trf.12418DOI Listing
April 2014

Trauma-hemorrhagic shock induces a CD36-dependent RBC endothelial-adhesive phenotype.

Crit Care Med 2014 Mar;42(3):e200-10

1Department of Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ. 2Surgical Services, VA New Jersey Healthcare System, East Orange, NJ. 3Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ.

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http://dx.doi.org/10.1097/CCM.0000000000000119DOI Listing
March 2014

Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors.

PLoS One 2013 12;8(6):e65779. Epub 2013 Jun 12.

Division of Pediatric Surgery Children's Hospital of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065779PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680486PMC
January 2014

Use of a massive transfusion protocol in nontrauma patients: activate away.

J Am Coll Surg 2013 Jun 6;216(6):1103-9. Epub 2013 Apr 6.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.jamcollsurg.2013.02.008DOI Listing
June 2013

Innate immune activation after transfusion of stored red blood cells.

Transfus Med Rev 2013 Apr 21;27(2):113-8. Epub 2013 Feb 21.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.tmrv.2013.01.001DOI Listing
April 2013

Endoscopic retrograde cholangiopancreatography is safe and effective for the diagnosis and treatment of pancreaticobiliary disease following abdominal organ transplant in children.

Pediatr Transplant 2012 Dec 20;16(8):829-34. Epub 2012 Aug 20.

Division of Pediatric General and Thoracic Surgery, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.

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http://dx.doi.org/10.1111/j.1399-3046.2012.01771.xDOI Listing
December 2012

Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.

Gastroenterology 2012 Sep 13;143(3):708-718.e5. Epub 2012 Jul 13.

Division of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2012.05.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584415PMC
September 2012

Massive transfusion: an evidence-based review of recent developments.

Arch Surg 2012 Jun;147(6):563-71

Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, F675 Watson Surgical Education Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1001/archsurg.2011.2212DOI Listing
June 2012

Diverting loop ileostomy and colonic lavage: an alternative to total abdominal colectomy for the treatment of severe, complicated Clostridium difficile associated disease.

Ann Surg 2011 Sep;254(3):423-7; discussion 427-9

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1097/SLA.0b013e31822ade48DOI Listing
September 2011

An appraisal of endoscopic retrograde cholangiopancreatography (ERCP) for pancreaticobiliary disease in children: our institutional experience in 231 cases.

Surg Endosc 2011 Aug 27;25(8):2536-40. Epub 2011 Feb 27.

Division of Pediatric General and Thoracic Surgery, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Avenue, 15224, Pittsburgh, PA, USA.

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http://link.springer.com/10.1007/s00464-011-1582-8
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http://dx.doi.org/10.1007/s00464-011-1582-8DOI Listing
August 2011

Intestinal stem cells and their roles during mucosal injury and repair.

J Surg Res 2011 May 21;167(1):1-8. Epub 2010 May 21.

Department of Surgery, Division of Pediatric Surgery, Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh, Pittsburgh, Pennsylvania 15224, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00224804100042
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http://dx.doi.org/10.1016/j.jss.2010.04.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040212PMC
May 2011

DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma.

Am J Physiol Gastrointest Liver Physiol 2011 May 13;300(5):G862-73. Epub 2011 Jan 13.

Div. of Pediatric Surgery, Department of Surgery, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, PA 15224, USA.

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http://www.physiology.org/doi/10.1152/ajpgi.00373.2010
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http://dx.doi.org/10.1152/ajpgi.00373.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094143PMC
May 2011

Tension pneumopericardium in an infant.

Surgery 2011 Mar 3;149(3):457-8. Epub 2009 Dec 3.

Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.surg.2009.10.013DOI Listing
March 2011

Over reliance on computed tomography imaging in patients with severe abdominal injury: is the delay worth the risk?

J Trauma 2011 Feb;70(2):278-84

Department of Surgery, Division of General Surgery and Trauma, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1097/TA.0b013e31820930f9DOI Listing
February 2011

Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium.

Gastroenterology 2010 Sep 24;139(3):904-17, 917.e1-6. Epub 2010 May 24.

Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930126PMC
September 2010

Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness.

J Biol Chem 2010 Feb 11;285(7):4995-5002. Epub 2009 Dec 11.

Division of Pediatric Surgery, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15207, USA.

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http://dx.doi.org/10.1074/jbc.M109.067454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836103PMC
February 2010

Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis.

J Trauma 2009 Sep;67(3):476-82; discussion 482-4

Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1097/TA.0b013e3181ad66bbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004067PMC
September 2009

The use of pre-operative imaging and intraoperative parathyroid hormone level to guide surgical management of tertiary hyperparathyroidism from X-linked hypophosphatemic rickets: a case report.

Cases J 2009 Sep 10;2:7572. Epub 2009 Sep 10.

Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh Medical Center 200 Lothrop Street, Pittsburgh, PA 15213 USA.

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http://www.casesjournal.com/content/2/1/7572
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http://dx.doi.org/10.4076/1757-1626-2-7572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769362PMC
September 2009

Presence of pneumomediastinum after blunt trauma in children: what does it really mean?

J Pediatr Surg 2009 Jul;44(7):1322-7

Division of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.jpedsurg.2009.02.069DOI Listing
July 2009

Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier.

J Immunol 2006 Mar;176(5):3070-9

Division of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.4049/jimmunol.176.5.3070DOI Listing
March 2006

Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions.

J Biol Chem 2004 Jun 30;279(23):24592-600. Epub 2004 Mar 30.

Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M313620200
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http://dx.doi.org/10.1074/jbc.M313620200DOI Listing
June 2004