Matthew Chang

Matthew Chang

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Engineering Yarrowia lipolytica towards food waste bioremediation: Production of fatty acid ethyl esters from vegetable cooking oil.

J Biosci Bioeng 2020 Jan 15;129(1):31-40. Epub 2019 Jul 15.

NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Centre for Life Sciences, National University of Singapore, 28 Medical Drive, 117456, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117596, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jbiosc.2019.06.009DOI Listing
January 2020

Trends in EMR for nonmalignant colorectal polyps in the United States.

Gastrointest Endosc 2020 01 19;91(1):124-131.e4. Epub 2019 Aug 19.

Division of Gastroenterology, San Francisco Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1016/j.gie.2019.08.004DOI Listing
January 2020

Synthetic genetic circuits for programmable biological functionalities.

Biotechnol Adv 2019 11 30;37(6):107393. Epub 2019 Apr 30.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.015DOI Listing
November 2019

Engineering commensal bacteria to rewire host-microbiome interactions.

Curr Opin Biotechnol 2019 Oct 22;62:116-122. Epub 2019 Oct 22.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117596, Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Centre for Life Sciences, National University of Singapore, 28 Medical Drive, 117456, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2019.09.007DOI Listing
October 2019

Patients Prescribed Direct-Acting Oral Anticoagulants Have Low Risk of Postpolypectomy Complications.

Clin Gastroenterol Hepatol 2019 Sep 29;17(10):2000-2007.e3. Epub 2018 Nov 29.

Division of Gastroenterology, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565183132
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http://dx.doi.org/10.1016/j.cgh.2018.11.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541555PMC
September 2019

Meta-Omics- and Metabolic Modeling-Assisted Deciphering of Human Microbiota Metabolism.

Biotechnol J 2019 Sep 8;14(9):e1800445. Epub 2019 Jul 8.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore.

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http://dx.doi.org/10.1002/biot.201800445DOI Listing
September 2019

A novel synchronization approach using synthetic magnetic .

Synth Syst Biotechnol 2019 Sep 15;4(3):130-131. Epub 2019 Jun 15.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.

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http://dx.doi.org/10.1016/j.synbio.2019.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582162PMC
September 2019

Phage-boosted chemotherapy.

Nat Biomed Eng 2019 Sep;3(9):680-681

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41551-019-0450-zDOI Listing
September 2019

Antiviral therapy and the development of osteopenia/osteoporosis among Asians with chronic hepatitis B.

J Med Virol 2019 07 27;91(7):1288-1294. Epub 2019 Feb 27.

Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, California.

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http://dx.doi.org/10.1002/jmv.25433DOI Listing
July 2019

Synthetic Biology Toolkits for Metabolic Engineering of Cyanobacteria.

Biotechnol J 2019 Jun 17;14(6):e1800496. Epub 2019 May 17.

Department of Biochemistry Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore.

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http://dx.doi.org/10.1002/biot.201800496DOI Listing
June 2019

Melanoma Metastatic to the Jejunum Diagnosed by Double-Balloon Enteroscopy.

ACG Case Rep J 2019 Jun 27;6(6):e00109. Epub 2019 Jun 27.

Department of Gastroenterology, Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA.

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http://dx.doi.org/10.14309/crj.0000000000000109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722337PMC
June 2019

Correction to: Hospital Cirrhosis Volume and Readmission in Patients with Cirrhosis in California.

Dig Dis Sci 2019 May;64(5):1392-1394

Department of Gastroenterology, Kaiser Permanente, Northern California, San Francisco, CA, USA.

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http://link.springer.com/10.1007/s10620-019-05558-x
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http://dx.doi.org/10.1007/s10620-019-05558-xDOI Listing
May 2019

Synthetic biology toolkits and applications in Saccharomyces cerevisiae.

Biotechnol Adv 2018 11 18;36(7):1870-1881. Epub 2018 Jul 18.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117596, Singapore; NUS Synthetic Biology for Clinical and Technological Innovation, Centre for Life Sciences, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.biotechadv.2018.07.005DOI Listing
November 2018

Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer.

Cancer Cell 2018 11 1;34(5):852-862.e4. Epub 2018 Nov 1.

Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234065PMC
November 2018

An oleaginous yeast platform for renewable 1-butanol synthesis based on a heterologous CoA-dependent pathway and an endogenous pathway.

Microb Cell Fact 2018 Oct 25;17(1):166. Epub 2018 Oct 25.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore.

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https://microbialcellfactories.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12934-018-1014-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201493PMC
October 2018

A time trend analysis of CT and MRI scan imaging in acute pancreatitis patients presenting to US emergency departments.

Am J Emerg Med 2018 09 1;36(9):1709-1710. Epub 2018 Feb 1.

Division of Gastroenterology, Hepatology, and Endoscopy, Center for Pancreatic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.ajem.2018.01.069DOI Listing
September 2018

Hospital Cirrhosis Volume and Readmission in Patients with Cirrhosis in California.

Dig Dis Sci 2018 Sep 19;63(9):2267-2274. Epub 2018 Feb 19.

Department of Gastroenterology, Kaiser Permanente, Northern California, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s10620-018-4964-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097881PMC
September 2018

Peripartum Care for Mothers Diagnosed with Hepatitis B During Pregnancy: A Survey of Provider Practices.

Matern Child Health J 2018 09;22(9):1345-1351

Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s10995-018-2515-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077093PMC
September 2018

Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity.

ACS Omega 2018 Sep 12;3(9):11050-11061. Epub 2018 Sep 12.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597, Singapore.

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http://pubs.acs.org/doi/10.1021/acsomega.8b01620
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http://dx.doi.org/10.1021/acsomega.8b01620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173508PMC
September 2018

Engineering microbes for targeted strikes against human pathogens.

Cell Mol Life Sci 2018 Aug 7;75(15):2719-2733. Epub 2018 May 7.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117596, Singapore.

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http://dx.doi.org/10.1007/s00018-018-2827-7DOI Listing
August 2018

Port site hernias following robotic colorectal surgery in people with obesity.

BMJ Case Rep 2018 Aug 23;2018. Epub 2018 Aug 23.

Division of General Surgery, Department of Surgery, NYU Langone Medical Center, Brooklyn, New York, USA.

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http://dx.doi.org/10.1136/bcr-2018-226155DOI Listing
August 2018

Clear cell "sugar" tumor of the lung: a case report and review of the literature.

AME Case Rep 2018 24;2:40. Epub 2018 Aug 24.

Department of Cardiothoracic Surgery, NYU Langone - Brooklyn, NY, USA.

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http://dx.doi.org/10.21037/acr.2018.08.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182013PMC
August 2018

Targeted Approaches for In Situ Gut Microbiome Manipulation.

Genes (Basel) 2018 Jul 12;9(7). Epub 2018 Jul 12.

Department of Biochemistry, Yong Loo Lin School of Medicine, 8 Medical Drive, Singapore 117596, Singapore.

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http://dx.doi.org/10.3390/genes9070351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071227PMC
July 2018

Immunomodulation as Therapy for Fungal Infection: Are We Closer?

Front Microbiol 2018 25;9:1612. Epub 2018 Jul 25.

Division of Infectious Diseases, University Medicine Cluster - National University Health System, Singapore, Singapore.

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https://www.frontiersin.org/article/10.3389/fmicb.2018.01612
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http://dx.doi.org/10.3389/fmicb.2018.01612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068232PMC
July 2018

Reprogramming Probiotic Lactobacillus reuteri as a Biosensor for Staphylococcus aureus Derived AIP-I Detection.

ACS Synth Biol 2018 05 13;7(5):1229-1237. Epub 2018 Apr 13.

Department of Biochemistry, Yong Loo Lin School of Medicine , National University of Singapore , 119077 , Singapore.

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http://dx.doi.org/10.1021/acssynbio.8b00063DOI Listing
May 2018

Rewriting the Metabolic Blueprint: Advances in Pathway Diversification in Microorganisms.

Front Microbiol 2018 12;9:155. Epub 2018 Feb 12.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.3389/fmicb.2018.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816047PMC
February 2018

Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention.

Nat Biomed Eng 2018 01 10;2(1):27-37. Epub 2018 Jan 10.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41551-017-0181-yDOI Listing
January 2018

Applying the design-build-test paradigm in microbiome engineering.

Curr Opin Biotechnol 2017 12 15;48:85-93. Epub 2017 Apr 15.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 117456, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2017.03.021DOI Listing
December 2017

Fusions in solid tumours: diagnostic strategies, targeted therapy, and acquired resistance.

Nat Rev Clin Oncol 2017 Dec 31;14(12):735-748. Epub 2017 Aug 31.

Department of Medicine 1275 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nrclinonc.2017.127DOI Listing
December 2017

Autoinducer Sensing Microarrays by Reporter Bacteria Encapsulated in Hybrid Supramolecular-Polysaccharide Hydrogels.

Macromol Biosci 2017 11 25;17(11). Epub 2017 Jul 25.

Physical Chemistry I and Research Center of Micro and Nanochemistry and Engineering (Cμ), Department of Chemistry and Biology, University of Siegen, Adolf-Reichwein-Str. 2, 57076, Siegen, Germany.

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http://dx.doi.org/10.1002/mabi.201700176DOI Listing
November 2017

Designer probiotics for the prevention and treatment of human diseases.

Curr Opin Chem Biol 2017 Oct 4;40:8-16. Epub 2017 May 4.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13675931173005
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http://dx.doi.org/10.1016/j.cbpa.2017.04.011DOI Listing
October 2017

Management of Chronic Hepatitis B in Pregnancy.

J Clin Gastroenterol 2017 Oct;51(9):789-795

*Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto ‡Department of Liver Transplant, Cedars Sinai Medical Center, Los Angeles, CA †Department of Infectious Disease, Shandong Provincial Hospital Affiliated to Shandong University, Ji'nan, Shandong, China.

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http://dx.doi.org/10.1097/MCG.0000000000000908DOI Listing
October 2017

Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes.

Nat Commun 2017 09 4;8(1):411. Epub 2017 Sep 4.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore.

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http://dx.doi.org/10.1038/s41467-017-00511-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583362PMC
September 2017

Isolated Reporter Bacteria in Supramolecular Hydrogel Microwell Arrays.

Langmuir 2017 08 31;33(31):7799-7809. Epub 2017 May 31.

Physical Chemistry I and Research Center of Micro and Nanochemistry and Engineering (Cμ), Department of Chemistry and Biology, University of Siegen , Adolf-Reichwein-Strasse 2, 57076, Siegen, Germany.

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http://dx.doi.org/10.1021/acs.langmuir.7b00749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740480PMC
August 2017

Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Authors:
Ahmet Zehir Ryma Benayed Ronak H Shah Aijazuddin Syed Sumit Middha Hyunjae R Kim Preethi Srinivasan Jianjiong Gao Debyani Chakravarty Sean M Devlin Matthew D Hellmann David A Barron Alison M Schram Meera Hameed Snjezana Dogan Dara S Ross Jaclyn F Hechtman Deborah F DeLair JinJuan Yao Diana L Mandelker Donavan T Cheng Raghu Chandramohan Abhinita S Mohanty Ryan N Ptashkin Gowtham Jayakumaran Meera Prasad Mustafa H Syed Anoop Balakrishnan Rema Zhen Y Liu Khedoudja Nafa Laetitia Borsu Justyna Sadowska Jacklyn Casanova Ruben Bacares Iwona J Kiecka Anna Razumova Julie B Son Lisa Stewart Tessara Baldi Kerry A Mullaney Hikmat Al-Ahmadie Efsevia Vakiani Adam A Abeshouse Alexander V Penson Philip Jonsson Niedzica Camacho Matthew T Chang Helen H Won Benjamin E Gross Ritika Kundra Zachary J Heins Hsiao-Wei Chen Sarah Phillips Hongxin Zhang Jiaojiao Wang Angelica Ochoa Jonathan Wills Michael Eubank Stacy B Thomas Stuart M Gardos Dalicia N Reales Jesse Galle Robert Durany Roy Cambria Wassim Abida Andrea Cercek Darren R Feldman Mrinal M Gounder A Ari Hakimi James J Harding Gopa Iyer Yelena Y Janjigian Emmet J Jordan Ciara M Kelly Maeve A Lowery Luc G T Morris Antonio M Omuro Nitya Raj Pedram Razavi Alexander N Shoushtari Neerav Shukla Tara E Soumerai Anna M Varghese Rona Yaeger Jonathan Coleman Bernard Bochner Gregory J Riely Leonard B Saltz Howard I Scher Paul J Sabbatini Mark E Robson David S Klimstra Barry S Taylor Jose Baselga Nikolaus Schultz David M Hyman Maria E Arcila David B Solit Marc Ladanyi Michael F Berger

Nat Med 2017 08;23(8):1004

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http://dx.doi.org/10.1038/nm0817-1004cDOI Listing
August 2017

AKT Inhibition in Solid Tumors With AKT1 Mutations.

J Clin Oncol 2017 Jul 10;35(20):2251-2259. Epub 2017 May 10.

David M. Hyman, Lillian M. Smyth, Mark T.A. Donoghue, Matthew T. Chang, Jonathan B. Reichel, Nancy Bouvier, S. Duygu Selcuklu, Tara E. Soumerai, Jean Torrisi, Joseph P. Erinjeri, Michael F. Berger, Sarat Chandarlapaty, David B. Solit, José Baselga, and Barry S. Taylor, Memorial Sloan Kettering Cancer Center; David B. Solit, Weill Cornell Medical College, Cornell University, New York, NY; J. Carl Barrett and Brian Dougherty, AstraZeneca, Waltham, MA; Helen Ambrose, Andrew Foxley, Justin P.O. Lindemann, Robert McEwen, Martin Pass, and Gaia Schiavon, AstraZeneca, Cambridge; Emma J. Dean, The Christie National Health Service Foundation, Manchester; Udai Banerji, Royal Marsden Hospital, London, United Kingdom; Shannon N. Westin, The University of Texas MD Anderson Cancer Center, Houston, TX; Philippe L. Bedard, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Hideaki Bando, National Cancer Center East Hospital, Kashiwa, Japan; Anthony B. El-Khoueiry, University of Southern California Norris Comprehensive Cancer Center; Alain Mita, Cedars-Sinai Medical Center, Los Angeles, CA; José A. Pérez-Fidalgo, Hospital Clinico de Valencia, Valencia, Spain; and Jan H.M. Schellens, Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2017.73.0143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501365PMC
July 2017

Encapsulation of Autoinducer Sensing Reporter Bacteria in Reinforced Alginate-Based Microbeads.

ACS Appl Mater Interfaces 2017 Jul 28;9(27):22321-22331. Epub 2017 Jun 28.

Physical Chemistry I and Research Center of Micro and Nanochemistry and Engineering (Cμ), Department of Chemistry and Biology, University of Siegen , Adolf-Reichwein-Str. 2, 57076 Siegen, Germany.

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http://pubs.acs.org/doi/10.1021/acsami.7b07166
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http://dx.doi.org/10.1021/acsami.7b07166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741077PMC
July 2017

OncoKB: A Precision Oncology Knowledge Base.

JCO Precis Oncol 2017 Jul 16;2017. Epub 2017 May 16.

, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Gynecologic Medical Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Breast Medicine Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Weill Cornell Medical College, New York, NY USA; , Breast Medicine Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA, Weill Cornell Medical College, New York, NY USA; , Head and Neck Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , , Department of Hematology and Oncology, Quest Diagnostics Nichols Institute, 33608 Ortega Highway, San Juan Capistrano, CA, 92675, USA; , Department of R&D and Bioinformatics, Quest Diagnostics Nichols Institute, 33608 Ortega Highway, San Juan Capistrano, CA, 92675, USA; , Head and Neck Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Weill Cornell Medical College, New York, NY USA; , Melanoma and Immunotherapeutics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Weill Cornell Medical College, New York, NY USA; , Gynecologic Medical Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Sarcoma Medical Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, Weill Cornell Medical College, New York, NY USA; Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Weill Cornell Medical College, New York, NY USA; , Developmental Therapeutics, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Sarcoma Medical Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, Weill Cornell Medical College, New York, NY USA; , Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Weill Cornell Medical College, New York, NY USA; , Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Department of Oncology and Internal Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Weill Cornell Medical College, New York, NY USA; , Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA , Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Developmental Therapeutics, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; , Breast Medicine Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Developmental Therapeutics, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Weill Cornell Medical College, New York, NY USA; , Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Weill Cornell Medical College, New York, NY USA; , Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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https://www.researchgate.net/profile/Debyani_Chakravarty/pub
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http://ascopubs.org/doi/10.1200/PO.17.00011
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586540PMC
http://dx.doi.org/10.1200/PO.17.00011DOI Listing
July 2017

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Authors:
Ahmet Zehir Ryma Benayed Ronak H Shah Aijazuddin Syed Sumit Middha Hyunjae R Kim Preethi Srinivasan Jianjiong Gao Debyani Chakravarty Sean M Devlin Matthew D Hellmann David A Barron Alison M Schram Meera Hameed Snjezana Dogan Dara S Ross Jaclyn F Hechtman Deborah F DeLair JinJuan Yao Diana L Mandelker Donavan T Cheng Raghu Chandramohan Abhinita S Mohanty Ryan N Ptashkin Gowtham Jayakumaran Meera Prasad Mustafa H Syed Anoop Balakrishnan Rema Zhen Y Liu Khedoudja Nafa Laetitia Borsu Justyna Sadowska Jacklyn Casanova Ruben Bacares Iwona J Kiecka Anna Razumova Julie B Son Lisa Stewart Tessara Baldi Kerry A Mullaney Hikmat Al-Ahmadie Efsevia Vakiani Adam A Abeshouse Alexander V Penson Philip Jonsson Niedzica Camacho Matthew T Chang Helen H Won Benjamin E Gross Ritika Kundra Zachary J Heins Hsiao-Wei Chen Sarah Phillips Hongxin Zhang Jiaojiao Wang Angelica Ochoa Jonathan Wills Michael Eubank Stacy B Thomas Stuart M Gardos Dalicia N Reales Jesse Galle Robert Durany Roy Cambria Wassim Abida Andrea Cercek Darren R Feldman Mrinal M Gounder A Ari Hakimi James J Harding Gopa Iyer Yelena Y Janjigian Emmet J Jordan Ciara M Kelly Maeve A Lowery Luc G T Morris Antonio M Omuro Nitya Raj Pedram Razavi Alexander N Shoushtari Neerav Shukla Tara E Soumerai Anna M Varghese Rona Yaeger Jonathan Coleman Bernard Bochner Gregory J Riely Leonard B Saltz Howard I Scher Paul J Sabbatini Mark E Robson David S Klimstra Barry S Taylor Jose Baselga Nikolaus Schultz David M Hyman Maria E Arcila David B Solit Marc Ladanyi Michael F Berger

Nat Med 2017 Jun 8;23(6):703-713. Epub 2017 May 8.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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June 2017

Epidemiology of hepatitis B and the role of vaccination.

Best Pract Res Clin Gastroenterol 2017 Jun 6;31(3):239-247. Epub 2017 Jun 6.

Division of Gastroenterology and Hepatology, Stanford University Medical Center, 300 Pasteur Drive, Palo Alto, CA 94304, USA. Electronic address:

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June 2017

Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models.

Nat Commun 2017 04 11;8:15028. Epub 2017 Apr 11.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394271PMC
April 2017

Microbiome engineering: Current applications and its future.

Biotechnol J 2017 Mar 30;12(3). Epub 2017 Jan 30.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1002/biot.201600099DOI Listing
March 2017

The Fungal Mycobiome and Its Interaction with Gut Bacteria in the Host.

Int J Mol Sci 2017 Feb 4;18(2). Epub 2017 Feb 4.

Division of Infectious Diseases, University Medicine Cluster, National University Health System, Singapore 119228, Singapore.

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http://dx.doi.org/10.3390/ijms18020330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343866PMC
February 2017

Whole-cell biocatalytic and de novo production of alkanes from free fatty acids in Saccharomyces cerevisiae.

Biotechnol Bioeng 2017 01 19;114(1):232-237. Epub 2016 Jan 19.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132040PMC
January 2017

New Insights into Aldol Reactions of Methyl Isocyanoacetate Catalyzed by Heterogenized Homogeneous Catalysts.

Nano Lett 2017 01 16;17(1):584-589. Epub 2016 Dec 16.

Department of Chemistry and ‡Kavli Energy NanoScience Institute, University of California , Berkeley, California 94720, United States.

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January 2017

Engineered elastomer substrates for guided assembly of complex 3D mesostructures by spatially nonuniform compressive buckling.

Adv Funct Mater 2017 Jan 2;27(1). Epub 2016 Nov 2.

Department of Materials Science and Engineering, Chemistry, Mechanical Science and Engineering, Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (USA).

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http://dx.doi.org/10.1002/adfm.201604281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621772PMC
January 2017

Synthetic Biology in Asia: New Kids on the Block.

ACS Synth Biol 2016 11;5(11):1182-1183

Department of Biochemistry, Yong Loo Lin School of Medicine, and NUS Synthetic Biology for Clinical and Technological Innovations (SynCTI), National University of Singapore , 119077 Singapore.

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http://dx.doi.org/10.1021/acssynbio.6b00327DOI Listing
November 2016

Genome-scale metabolic modeling and in silico analysis of lipid accumulating yeast Candida tropicalis for dicarboxylic acid production.

Biotechnol Bioeng 2016 09 23;113(9):1993-2004. Epub 2016 Mar 23.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore.

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http://dx.doi.org/10.1002/bit.25955DOI Listing
September 2016

Genetic Engineering of an Unconventional Yeast for Renewable Biofuel and Biochemical Production.

J Vis Exp 2016 09 20(115). Epub 2016 Sep 20.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092062PMC
September 2016

A Two-Layer Gene Circuit for Decoupling Cell Growth from Metabolite Production.

Cell Syst 2016 08;3(2):133-143

Department of Biochemistry, Yong Loo Lin School of Medicine and NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.07.012DOI Listing
August 2016

Clinical application of pharmacogenetics: focusing on practical issues.

Pharmacogenomics 2015 28;16(15):1733-41. Epub 2015 Sep 28.

Department of Clinical Pharmacy, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.2217/pgs.15.112DOI Listing
July 2016

Postpartum Laboratory Follow-up in Women With Hepatitis B in Massachusetts From 2007 to 2012.

J Clin Gastroenterol 2016 07;50(6):e60-4

*Division of Gastroenterology, Hepatology, and Endoscopy ‡Department of Obstetrics and Gynecology, Brigham and Women's Hospital †Bureau of Infectious Disease, Massachusetts Department of Public Health §Division of Gastroenterology, Massachusetts General Hospital ¶Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA ∥Center for Liver Disease and Transplantation, Columbia University College of Physicians and Surgeons, New York, NY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899286PMC
July 2016

Reprogrammable microbial cell-based therapeutics against antibiotic-resistant bacteria.

Drug Resist Updat 2016 07 22;27:59-71. Epub 2016 Jun 22.

Department of Biochemistry, Yong Loo Lin School of Medicine, 8 Medical Drive, Singapore 117596, Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore; NUS Graduate School for Integrative Sciences & Engineering, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.drup.2016.06.002DOI Listing
July 2016

A Quality Improvement Initiative Reduces 30-Day Rate of Readmission for Patients With Cirrhosis.

Clin Gastroenterol Hepatol 2016 May 25;14(5):753-9. Epub 2015 Sep 25.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.cgh.2015.08.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394424PMC
May 2016

Engineering Saccharomyces cerevisiae to produce odd chain-length fatty alcohols.

Biotechnol Bioeng 2016 Apr 2;113(4):842-51. Epub 2015 Nov 2.

Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China.

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http://dx.doi.org/10.1002/bit.25856DOI Listing
April 2016

Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids.

Metab Eng 2016 Mar 22;34:36-43. Epub 2015 Dec 22.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597 Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, 117456 Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2015.12.005DOI Listing
March 2016

Engineering transcription factors to improve tolerance against alkane biofuels in Saccharomyces cerevisiae.

Biotechnol Biofuels 2015 30;8:231. Epub 2015 Dec 30.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597 Singapore, Singapore ; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, 117456 Singapore, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696261PMC
December 2015

Risk Factors for Rehospitalization Within 90 Days in Patients with Inflammatory Bowel Disease.

Inflamm Bowel Dis 2015 Nov;21(11):2583-9

Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000000537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189985PMC
November 2015

Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters biodiesel.

Biotechnol Biofuels 2015 4;8:177. Epub 2015 Nov 4.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, Singapore, 117597 Singapore ; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore, 117456 Singapore.

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http://dx.doi.org/10.1186/s13068-015-0361-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634726PMC
November 2015

Combinatorial metabolic engineering of Saccharomyces cerevisiae for terminal alkene production.

Metab Eng 2015 Sep 8;31:53-61. Epub 2015 Jul 8.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore. Electronic address:

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September 2015

Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That Guides an Effective Therapeutic Course.

J Natl Compr Canc Netw 2015 Jul;13(7):835-45

From the Departments of Obstetrics, Gynecology, and Reproductive Sciences, Medicine, Bioengineering and Therapeutic Sciences, Radiology and Biomedical Imaging, Pathology, Laboratory Medicine, and Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California; and (Present address) Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. From the Departments of Obstetrics, Gynecology, and Reproductive Sciences, Medicine, Bioengineering and Therapeutic Sciences, Radiology and Biomedical Imaging, Pathology, Laboratory Medicine, and Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California; and (Present address) Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. From the Departments of Obstetrics, Gynecology, and Reproductive Sciences, Medicine, Bioengineering and Therapeutic Sciences, Radiology and Biomedical Imaging, Pathology, Laboratory Medicine, and Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California; and (Present address) Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. From the Departments of Obstetrics, Gynecology, and Reproductive Sciences, Medicine, Bioengineering and Therapeutic Sciences, Radiology and Biomedical Imaging, Pathology, Laboratory Medicine, and Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California; and (Present address) Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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July 2015

Postpartum care for mothers diagnosed with hepatitis B during pregnancy.

Am J Obstet Gynecol 2015 Mar 30;212(3):365.e1-7. Epub 2014 Sep 30.

Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1016/j.ajog.2014.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346392PMC
March 2015

Bacterial XylRs and synthetic promoters function as genetically encoded xylose biosensors in Saccharomyces cerevisiae.

Biotechnol J 2015 Feb 7;10(2):315-22. Epub 2014 Aug 7.

School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Synthetic Biology Research Consortium, National University of Singapore, Singapore.

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http://dx.doi.org/10.1002/biot.201400159DOI Listing
February 2015

Therapeutic microbes for infectious disease.

Methods Mol Biol 2014 ;1151:117-33

School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore.

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http://dx.doi.org/10.1007/978-1-4939-0554-6_9DOI Listing
January 2015

Production of Fatty Acid-derived valuable chemicals in synthetic microbes.

Front Bioeng Biotechnol 2014 23;2:78. Epub 2014 Dec 23.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore , Singapore , Singapore ; Synthetic Biology Research Program, National University of Singapore , Singapore , Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275033PMC
January 2015

Microbial tolerance engineering toward biochemical production: from lignocellulose to products.

Curr Opin Biotechnol 2014 Oct 17;29:99-106. Epub 2014 Apr 17.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 117599, Singapore; Synthetic Biology Research Consortium, National University of Singapore, 28 Medical Drive, 117456, Singapore. Electronic address:

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October 2014

One-pot approach for examining the DNA methylation patterns using an engineered methyl-probe.

Biosens Bioelectron 2014 Aug 12;58:333-7. Epub 2014 Mar 12.

School of Chemical Engineering, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN 47907, USA.

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August 2014