Dr. Matthew Brecher, PhD - GlaxoSmithKline Vaccines - Scientist

Dr. Matthew Brecher

PhD

GlaxoSmithKline Vaccines

Scientist

Rockville, MD | United States

ORCID logohttps://orcid.org/0000-0003-1151-2290

Dr. Matthew Brecher, PhD - GlaxoSmithKline Vaccines - Scientist

Dr. Matthew Brecher

PhD

Introduction

Primary Affiliation: GlaxoSmithKline Vaccines - Rockville, MD , United States

Education

Sep 2003 - May 2011
University of Virginia
Ph.D.
Microbiology
Sep 1998 - May 2002
Cornell University
B.S.
Biology

Publications

16Publications

242Reads

128Profile Views

640PubMed Central Citations

Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes.

PLoS One 2018 7;13(9):e0198303. Epub 2018 Sep 7.

Stony Brook University, Department of Molecular Genetics and Microbiology, Stony Brook University School of Medicine, Stony Brook, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198303PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128446PMC
February 2019
3 Reads
3.234 Impact Factor

DNA forms of arboviral RNA genomes are generated following infection in mosquito cell cultures.

Virology 2016 11 30;498:164-171. Epub 2016 Aug 30.

Wadsworth Center, Griffin Laboratory, New York State Department of Health, 5668 State Farm Road, Slingerlands, NY 12159, USA; Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2016.08.022DOI Listing
November 2016
26 Reads
4 Citations
3.321 Impact Factor

Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase.

PLoS One 2015 22;10(6):e0130062. Epub 2015 Jun 22.

Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY, 12208 United States of America; Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, PO Box 509, New York, 12201, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130062PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476580PMC
April 2016
25 Reads
13 Citations
3.234 Impact Factor

Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase.

ACS Infect Dis 2015 Aug 31;1(8):340-9. Epub 2015 Jul 31.

Wadsworth Center, New York State Department of Health , 120 New Scotland Avenue, Albany, New York 12208, United States.

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http://dx.doi.org/10.1021/acsinfecdis.5b00070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696607PMC
August 2015
10 Reads
6 Citations

Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins.

J Biol Chem 2015 Jun 7;290(25):15746-57. Epub 2015 May 7.

From the Wadsworth Center, New York State Department of Health, Albany, New York 12201, the Department of Biomedical Sciences, School of Public Health, University at Albany, SUNY, Albany, New York 12201, and

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http://dx.doi.org/10.1074/jbc.M115.650655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505484PMC
June 2015
25 Reads
2 Citations
4.573 Impact Factor

Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase.

Protein Sci 2015 Jan 11;24(1):117-28. Epub 2014 Dec 11.

Wadsworth Center, New York State Department of Health, Albany, New York, 12208.

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http://dx.doi.org/10.1002/pro.2594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282417PMC
January 2015
30 Reads
3 Citations
2.854 Impact Factor

Pfit is a structurally novel Crohn's disease-associated superantigen.

PLoS Pathog 2013 26;9(12):e1003837. Epub 2013 Dec 26.

Wadsworth Center, New York State Department of Health, Albany, New York, United States of America ; Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873459PMC
September 2014
10 Reads
1 Citation

S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase.

PLoS One 2013 9;8(10):e76900. Epub 2013 Oct 9.

Wadsworth Center, New York State Department of Health, Albany, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076900PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793912PMC
June 2014
23 Reads
8 Citations
3.234 Impact Factor

Structural basis of conformational transitions in the active site and 80's loop in the FK506-binding protein FKBP12.

Biochem J 2014 Mar;458(3):525-36

*Wadsworth Center, New York State Department of Health Empire State Plaza, Albany, NY 12201, U.S.A.

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http://dx.doi.org/10.1042/BJ20131429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940039PMC
March 2014
14 Reads
6 Citations
4.400 Impact Factor

The flavivirus protease as a target for drug discovery.

Virol Sin 2013 Dec 14;28(6):326-36. Epub 2013 Nov 14.

Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY, 12208, USA.

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http://dx.doi.org/10.1007/s12250-013-3390-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927373PMC
December 2013
6 Reads
9 Citations

Visualization of the two-step fusion process of the retrovirus avian sarcoma/leukosis virus by cryo-electron tomography.

J Virol 2012 Nov 29;86(22):12129-37. Epub 2012 Aug 29.

Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/JVI.01880-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486472PMC
November 2012
12 Reads
12 Citations
4.440 Impact Factor

Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change.

J Virol 2012 Jan 26;86(1):364-72. Epub 2011 Oct 26.

Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1128/JVI.05708-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255896PMC
January 2012
11 Reads
54 Citations
4.440 Impact Factor

The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell binding.

J Virol 2009 Apr 14;83(7):2883-91. Epub 2009 Jan 14.

Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908-0732, USA.

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http://dx.doi.org/10.1128/JVI.01956-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655554PMC
April 2009
23 Reads
75 Citations
4.440 Impact Factor

Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.

Crit Rev Biochem Mol Biol 2008 May-Jun;43(3):189-219

Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908-0732, USA.

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http://dx.doi.org/10.1080/10409230802058320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649671PMC
August 2008
4 Reads
293 Citations
7.714 Impact Factor

Influenza virus pleiomorphy characterized by cryoelectron tomography.

Proc Natl Acad Sci U S A 2006 Dec 4;103(50):19123-7. Epub 2006 Dec 4.

Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0607614103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1748186PMC
December 2006
7 Reads
143 Citations
9.810 Impact Factor