Matthew Bogyo

Matthew Bogyo

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Matthew Bogyo

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Leveraging Peptide Substrate Libraries to Design Inhibitors of Bacterial Lon Protease.

ACS Chem Biol 2019 Sep 10. Epub 2019 Sep 10.

Department of Bioorganic Chemistry, Faculty of Chemistry , Wrocław University of Science and Technology , Wrocław , Poland.

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http://dx.doi.org/10.1021/acschembio.9b00529DOI Listing
September 2019

Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis.

Biochimie 2019 Jun 15. Epub 2019 Jun 15.

Department of Oral Immunity and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2019.06.010DOI Listing
June 2019

Validation of near infrared fluorescence (NIRF) probes in vivo with dual laser NIRF endoscope.

PLoS One 2018 2;13(11):e0206568. Epub 2018 Nov 2.

Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206568PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214553PMC
April 2019

Fluorescent Triazole Urea Activity-Based Probes for the Single-Cell Phenotypic Characterization of Staphylococcus aureus.

Angew Chem Int Ed Engl 2019 Apr 22;58(17):5643-5647. Epub 2019 Mar 22.

Stanford University School of Medicine, Department of Pathology, 300 Pasteur Drive, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1002/anie.201900511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456404PMC
April 2019

Catalytic linkage between caspase activity and proteostasis in Archaea.

Environ Microbiol 2019 Jan 8;21(1):286-298. Epub 2019 Jan 8.

Department of Marine and Coastal Sciences, Rutgers University, New Brunswick, NJ, USA.

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http://doi.wiley.com/10.1111/1462-2920.14456
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http://dx.doi.org/10.1111/1462-2920.14456DOI Listing
January 2019

Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases.

Cell Chem Biol 2019 01 1;26(1):35-47.e7. Epub 2018 Nov 1.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456183033
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http://dx.doi.org/10.1016/j.chembiol.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338520PMC
January 2019

Covalent Modifiers of Botulinum Neurotoxin Counteract Toxin Persistence.

ACS Chem Biol 2019 01 8;14(1):76-87. Epub 2019 Jan 8.

Department of Urology, Boston Children's Hospital, and Department of Microbiology and Immunobiology, Department of Surgery, Harvard Medical School, Boston , Massachusetts 02115 , United States.

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http://pubs.acs.org/doi/10.1021/acschembio.8b00937
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http://dx.doi.org/10.1021/acschembio.8b00937DOI Listing
January 2019

Molecular imaging and validation of margins in surgically excised nonmelanoma skin cancer specimens.

J Med Imaging (Bellingham) 2019 Jan 18;6(1):016001. Epub 2019 Mar 18.

Case Western Reserve University, Department of Biomedical Engineering, Cleveland, Ohio, United States.

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http://dx.doi.org/10.1117/1.JMI.6.1.016001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423324PMC
January 2019

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors.

J Am Chem Soc 2018 09 29;140(36):11424-11437. Epub 2018 Aug 29.

Department of Pathology and Microbiology , University of Nebraska Medical Center , Omaha , Nebraska 68198 , United States.

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http://pubs.acs.org/doi/10.1021/jacs.8b06656
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http://dx.doi.org/10.1021/jacs.8b06656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407133PMC
September 2018

The Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture.

mSphere 2018 09 19;3(5). Epub 2018 Sep 19.

Department of Pathology, Stanford University School of Medicine, Stanford, California, USA

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http://dx.doi.org/10.1128/mSphere.00393-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147133PMC
September 2018

Optimization of a Protease Activated Probe for Optical Surgical Navigation.

Mol Pharm 2018 03 14;15(3):750-758. Epub 2017 Dec 14.

Intuitive Surgical Inc. , 1020 Kifer Road , Sunnyvale , California 94086 , United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00822DOI Listing
March 2018

New Blood Test SEEKs To Detect and Localize Cancer before It's Too Late.

Biochemistry 2018 03 28;57(10):1561-1562. Epub 2018 Feb 28.

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http://dx.doi.org/10.1021/acs.biochem.8b00179DOI Listing
March 2018

Development of an activity-based probe for acyl-protein thioesterases.

PLoS One 2018 24;13(1):e0190255. Epub 2018 Jan 24.

Cancer Biology Program, Stanford University School of Medicine, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190255PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783350PMC
February 2018

Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity-Based Probe.

Methods Mol Biol 2017 ;1491:145-159

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, RadboudUMC, Geert Grooteplein 26/28, 6525, GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-6439-0_11DOI Listing
January 2018

Detection of Active Caspases During Apoptosis Using Fluorescent Activity-Based Probes.

Methods Mol Biol 2016 ;1419:27-39

Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, USA.

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http://dx.doi.org/10.1007/978-1-4939-3581-9_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091214PMC
December 2017

Protein Degradation Systems as Antimalarial Therapeutic Targets.

Trends Parasitol 2017 09 5;33(9):731-743. Epub 2017 Jul 5.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2017.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656264PMC
September 2017

Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion.

PLoS One 2016 17;11(8):e0160522. Epub 2016 Aug 17.

The Institute of Drug Research, The School of Pharmacy, The Faculty of Medicine, The Hebrew University, Jerusalem, 9112001, Israel.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160522PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988760PMC
July 2017

Activity-based probes for the multicatalytic proteasome.

FEBS J 2017 05 7;284(10):1540-1554. Epub 2017 Feb 7.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1111/febs.14016DOI Listing
May 2017

Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights.

FEBS J 2017 05 10;284(10):1555-1576. Epub 2017 Mar 10.

Early Discovery Biochemistry, Genentech, South San Francisco, CA, USA.

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http://dx.doi.org/10.1111/febs.14039DOI Listing
May 2017

Introduction to the Special Issue on Proteases and Proteolysis in Health and Disease.

Authors:
Matthew Bogyo

FEBS J 2017 05;284(10):1392-1393

Department of Pathology, School of Medicine, Stanford University, CA, USA.

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http://dx.doi.org/10.1111/febs.14089DOI Listing
May 2017

Chemical Strategies To Target Bacterial Virulence.

Chem Rev 2017 Mar 24;117(5):4422-4461. Epub 2017 Feb 24.

Cancer Biology Program, ‡Department of Pathology, §Department of Microbiology and Immunology, and ∥Department of Chemical and Systems Biology, Stanford University School of Medicine , 300 Pasteur Drive, Stanford, California 94305, United States.

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http://dx.doi.org/10.1021/acs.chemrev.6b00676DOI Listing
March 2017

Rapid visualization of nonmelanoma skin cancer.

J Am Acad Dermatol 2017 Feb 19;76(2):209-216.e9. Epub 2016 Nov 19.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Case Western Reserve University, Cleveland, Ohio; National Foundation for Cancer Research Center for Molecular Imaging, Case Western Reserve University, Cleveland, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2016.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341746PMC
February 2017

The cryo-EM structure of the Plasmodium falciparum 20S proteasome and its use in the fight against malaria.

FEBS J 2016 12 2;283(23):4238-4243. Epub 2016 Jul 2.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1111/febs.13780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140733PMC
December 2016

Response to Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".

Sci Transl Med 2016 Dec;8(370):370tr2

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf3410DOI Listing
December 2016

Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation.

J Nucl Med 2016 Oct 19;57(10):1583-1590. Epub 2016 May 19.

Department of Pathology, Stanford University School of Medicine, Stanford, California Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California

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http://dx.doi.org/10.2967/jnumed.115.171553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367444PMC
October 2016

Legumain is activated in macrophages during pancreatitis.

Am J Physiol Gastrointest Liver Physiol 2016 09 11;311(3):G548-60. Epub 2016 Aug 11.

Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia; and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia.

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http://www.physiology.org/doi/10.1152/ajpgi.00047.2016
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http://dx.doi.org/10.1152/ajpgi.00047.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075999PMC
September 2016

Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection.

Cell Chem Biol 2016 07 14;23(7):793-804. Epub 2016 Jul 14.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982764PMC
July 2016

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death.

Elife 2016 Mar 24;5:e13663. Epub 2016 Mar 24.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, United States.

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http://dx.doi.org/10.7554/eLife.13663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846378PMC
March 2016

Cysteine Cathepsin Inhibitors as Anti-Ebola Agents.

ACS Infect Dis 2016 Mar 20;2(3):173-179. Epub 2016 Jan 20.

Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, United States.

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http://dx.doi.org/10.1021/acsinfecdis.5b00130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918641PMC
March 2016

Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes.

Nat Protoc 2016 Jan 30;11(1):184-91. Epub 2015 Dec 30.

Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/nprot.2016.004DOI Listing
January 2016

A Bright Future for Precision Medicine: Advances in Fluorescent Chemical Probe Design and Their Clinical Application.

Cell Chem Biol 2016 Jan;23(1):122-136

Cancer Biology Program, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Chemical and Systems Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779185PMC
January 2016

The protease cathepsin L regulates Th17 cell differentiation.

J Autoimmun 2015 Dec 3;65:56-63. Epub 2015 Sep 3.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://bogyolab.stanford.edu/pdf/HouJAutoimmunity2015.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S089684111530024
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http://dx.doi.org/10.1016/j.jaut.2015.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679515PMC
December 2015

Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase.

J Biol Chem 2015 Nov 18;290(45):27248-60. Epub 2015 Sep 18.

From the Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, 30-387 Krakow, Poland, Malopolska Center of Biotechnology, Jagiellonian University, 30-387 Krakow, Poland Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, Kentucky 40202, and.

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http://dx.doi.org/10.1074/jbc.M115.648782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646396PMC
November 2015

Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria.

ACS Med Chem Lett 2015 Nov 2;6(11):1145-9. Epub 2015 Oct 2.

Department of Pharmaceutical Chemistry and Department of Medicine, University of California San Francisco , 1700 Fourth Street, San Francisco, California 94158, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645246PMC
November 2015

Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.

Cell Host Microbe 2015 Oct;18(4):501-11

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://www.cell.com/cell-host-microbe/pdf/S1931-3128(15)0037
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http://linkinghub.elsevier.com/retrieve/pii/S193131281500375
Publisher Site
http://dx.doi.org/10.1016/j.chom.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694575PMC
October 2015

A small-molecule antivirulence agent for treating Clostridium difficile infection.

Sci Transl Med 2015 Sep 23;7(306):306ra148. Epub 2015 Sep 23.

Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5124, USA.

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http://dx.doi.org/10.1126/scitranslmed.aac9103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025901PMC
September 2015

Subfamily-Specific Fluorescent Probes for Cysteine Proteases Display Dynamic Protease Activities during Seed Germination.

Plant Physiol 2015 Aug 5;168(4):1462-75. Epub 2015 Jun 5.

Plant Chemetics Laboratory, Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom (H.L., B.C., J.C.M.-V., R.A.L.v.d.H.);Plant Chemetics Laboratory, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany (H.L., B.C., J.C.M.-V., T.S., R.A.L.v.d.H.);Center for Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, 45117 Essen, Germany (J.O., Z.W., M.K.); andDepartment of Pathology, Stanford School for Medicine, Stanford, California 94305-5324 (M.B.)

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http://dx.doi.org/10.1104/pp.114.254466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528725PMC
August 2015

Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation.

J Immunol 2015 Aug 20;195(4):1685-97. Epub 2015 Jul 20.

Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655;

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http://dx.doi.org/10.4049/jimmunol.1500509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530060PMC
August 2015

Design and Synthesis of Activity-Based Probes and Inhibitors for Bleomycin Hydrolase.

Chem Biol 2015 Aug 6;22(8):995-1001. Epub 2015 Aug 6.

Departments of Pathology and Microbiology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2015.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546515PMC
August 2015

In vivo imaging and biochemical characterization of protease function using fluorescent activity-based probes.

Curr Protoc Chem Biol 2013 ;5(1):25-44

Cancer Biology Program, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1002/9780470559277.ch120235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691694PMC
March 2015

Activity-based profiling of proteases.

Annu Rev Biochem 2014 ;83:249-73

Departments of 1Chemical and Systems Biology.

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http://dx.doi.org/10.1146/annurev-biochem-060713-035352DOI Listing
January 2015

Probes to monitor activity of the paracaspase MALT1.

Chem Biol 2015 Jan 31;22(1):139-47. Epub 2014 Dec 31.

Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304901PMC
January 2015

Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins.

Chem Biol 2015 Jan 8;22(1):148-58. Epub 2015 Jan 8.

Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353655PMC
January 2015

Microscopic detection of quenched activity-based optical imaging probes using an antibody detection system: localizing protease activity.

Mol Imaging Biol 2014 Oct;16(5):608-18

Department of Radiology, Case Center for Imaging Research, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH, 44106-5056, USA.

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http://link.springer.com/10.1007/s11307-014-0736-1
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http://dx.doi.org/10.1007/s11307-014-0736-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240007PMC
October 2014

Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome.

J Am Chem Soc 2014 Oct 19;136(39):13562-5. Epub 2014 Sep 19.

Department of Chemical and Systems Biology and ‡ Department of Pathology, Stanford University School of Medicine , 300 Pasteur Drive, Stanford, California 94305-5324, United States.

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http://dx.doi.org/10.1021/ja507692yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183598PMC
October 2014

A biocompatible "split luciferin" reaction and its application for non-invasive bioluminescent imaging of protease activity in living animals.

Curr Protoc Chem Biol 2014 Sep 9;6(3):169-89. Epub 2014 Sep 9.

Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/9780470559277.ch140047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219325PMC
September 2014

Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes.

ACS Chem Biol 2014 Aug 19;9(8):1869-76. Epub 2014 Jun 19.

Department of Chemical and Systems Biology and ‡Department of Pathology, Stanford University School of Medicine , 300 Pasteur Drive, Stanford, California 94305-5324, United States.

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http://dx.doi.org/10.1021/cb5001263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136710PMC
August 2014

Phosphoramidates as novel activity-based probes for serine proteases.

Chembiochem 2014 May 9;15(8):1106-10. Epub 2014 May 9.

Lehrstuhl für Chemie der Biopolymere, Technische Universität München, Weihenstephaner Berg 3, 85354 Freising (Germany).

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http://doi.wiley.com/10.1002/cbic.201400013
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http://dx.doi.org/10.1002/cbic.201400013DOI Listing
May 2014

Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo.

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):18244-9. Epub 2013 Oct 21.

Departments of Pathology and Microbiology and Immunology, Stanford School of Medicine, Stanford, CA 94305.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1312782110
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http://dx.doi.org/10.1073/pnas.1312782110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831501PMC
November 2013

Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets.

Antimicrob Agents Chemother 2013 Oct 8;57(10):4645-52. Epub 2013 Jul 8.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.02495-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811399PMC
October 2013

Improved quenched fluorescent probe for imaging of cysteine cathepsin activity.

J Am Chem Soc 2013 Oct 19;135(39):14726-30. Epub 2013 Sep 19.

Departments of †Pathology, ‡Cancer Biology Program, and §Microbiology and Immunology, Stanford School of Medicine , 300 Pasteur Drive, Stanford, California 94305-5324, United States.

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http://dx.doi.org/10.1021/ja4056068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826460PMC
October 2013

Acid-mediated tumor proteolysis: contribution of cysteine cathepsins.

Neoplasia 2013 Oct;15(10):1125-37

Cancer Biology Program, Wayne State University, Detroit, MI ; Department of Pharmacology, Wayne State University, Detroit, MI.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819629PMC
http://dx.doi.org/10.1593/neo.13946DOI Listing
October 2013

Applications of small molecule probes in dissecting mechanisms of bacterial virulence and host responses.

Biochemistry 2013 Sep 21;52(35):5985-96. Epub 2013 Aug 21.

Department of Chemical and Systems Biology, ‡Department of Microbiology and Immunology, and §Department of Pathology, Stanford University School of Medicine , 300 Pasteur Drive, Stanford, California 94305, United States.

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http://dx.doi.org/10.1021/bi400854dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838904PMC
September 2013

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

Mol Microbiol 2013 Aug 12;89(4):676-89. Epub 2013 Jul 12.

Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, Qld, 4059, Australia.

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http://dx.doi.org/10.1111/mmi.12306DOI Listing
August 2013

A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases.

J Am Chem Soc 2013 Jun 6;135(24):9130-8. Epub 2013 Jun 6.

Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1021/ja403521uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722599PMC
June 2013

A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice.

ACS Chem Biol 2013 May 29;8(5):987-99. Epub 2013 Mar 29.

Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne, LCBIM, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1021/cb3007314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836283PMC
May 2013

Activity profiling of vacuolar processing enzymes reveals a role for VPE during oomycete infection.

Plant J 2013 Feb 28;73(4):689-700. Epub 2012 Dec 28.

Plant Chemetics Laboratory, Max Planck Institute for Plant Breeding Research, 50829, Cologne, Germany.

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http://dx.doi.org/10.1111/tpj.12062DOI Listing
February 2013

Target deconvolution techniques in modern phenotypic profiling.

Curr Opin Chem Biol 2013 Feb 18;17(1):118-26. Epub 2013 Jan 18.

Department of Global Medical Science, Sungshin Women's University, Seoul 142-732, Republic of Korea.

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http://dx.doi.org/10.1016/j.cbpa.2012.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594516PMC
February 2013

New technologies and their impact on 'omics' research.

Curr Opin Chem Biol 2013 Feb;17(1):1-3

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http://dx.doi.org/10.1016/j.cbpa.2013.01.005DOI Listing
February 2013

Functional imaging of legumain in cancer using a new quenched activity-based probe.

J Am Chem Soc 2013 Jan 18;135(1):174-82. Epub 2012 Dec 18.

Cancer Biology Program, Department of Pathology, Stanford School of Medicine, 300 Pasteur Drive, Stanford, California 94305-5324, United States.

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http://bogyolab.stanford.edu/pdf/EdgingtonetalJACSLegumain.p
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http://pubs.acs.org/doi/abs/10.1021/ja307083b
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http://dx.doi.org/10.1021/ja307083bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429797PMC
January 2013

Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity.

Chem Biol 2012 Dec 8;19(12):1535-45. Epub 2012 Nov 8.

Graduate Program in Chemical and Systems Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA.

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http://dx.doi.org/10.1016/j.chembiol.2012.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529830PMC
December 2012

The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains.

Chem Biol 2012 Dec;19(12):1546-55

Zentrum für Medizinische Biotechnologie, Fakultät für Biologie, Universität Duisburg-Essen, Universitätsstr. 2, 45117 Essen, Germany.

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http://dx.doi.org/10.1016/j.chembiol.2012.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601557PMC
December 2012

Highlight: the universe of proteolytic networks and mechanisms.

Biol Chem 2012 Sep;393(9):841

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http://dx.doi.org/10.1515/hsz-2012-0262DOI Listing
September 2012

Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes.

Biol Chem 2012 Sep;393(9):971-7

Oral Health and Systemic Diseases Research Group, University of Louisville School of Dentistry, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1515/hsz-2012-0175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488288PMC
September 2012