Matthew B Boxer

Matthew B Boxer

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Matthew B Boxer

Matthew B Boxer

Publications by authors named "Matthew B Boxer"

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45Publications

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Discovery of novel inhibitors of human galactokinase by virtual screening.

J Comput Aided Mol Des 2019 Apr 26;33(4):405-417. Epub 2019 Feb 26.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD, 20850, USA.

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http://dx.doi.org/10.1007/s10822-019-00190-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459016PMC
April 2019

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

ACS Cent Sci 2018 Dec 5;4(12):1727-1741. Epub 2018 Dec 5.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

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http://dx.doi.org/10.1021/acscentsci.8b00747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311695PMC
December 2018

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Bioorg Med Chem 2018 05 27;26(8):1727-1739. Epub 2018 Feb 27.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.bmc.2018.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891386PMC
May 2018

PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose.

Oncotarget 2017 Oct 26;8(53):90959-90968. Epub 2017 Jul 26.

Department of Radiology, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.19630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710897PMC
October 2017

Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity.

Antimicrob Agents Chemother 2016 10 23;60(10):6023-33. Epub 2016 Sep 23.

Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, USA

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http://dx.doi.org/10.1128/AAC.00914-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038330PMC
October 2016

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.

Proc Natl Acad Sci U S A 2016 08 1;113(34):9587-92. Epub 2016 Aug 1.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202

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http://dx.doi.org/10.1073/pnas.1610099113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003239PMC
August 2016

Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery.

Cell 2016 Jun 26;165(7):1698-1707. Epub 2016 May 26.

Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.05.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931924PMC
June 2016

A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics.

EBioMedicine 2016 Jun 16;8:49-59. Epub 2016 Apr 16.

Systems Biology of Lipid Metabolism, Heinrich Heine University Düsseldorf, Germany; Institute for Mathematical Modeling of Biological Systems, Heinrich Heine University Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919474PMC
June 2016

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.

Mol Cell 2015 Nov 17;60(4):571-83. Epub 2015 Oct 17.

Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA; Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656111PMC
November 2015

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.

Nature 2015 Jun 20;522(7555):216-20. Epub 2015 Apr 20.

1] Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA [2] Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1038/nature14335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528969PMC
June 2015

Structure activity relationships of human galactokinase inhibitors.

Bioorg Med Chem Lett 2015 Feb 13;25(3):721-7. Epub 2014 Dec 13.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.11.061DOI Listing
February 2015

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.

Nat Commun 2015 Feb 5;6:6220. Epub 2015 Feb 5.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, 5841 South Maryland Avenue, MC2050, Chicago, Illinois 60637, USA.

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http://www.nature.com/articles/ncomms7220
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http://dx.doi.org/10.1038/ncomms7220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427252PMC
February 2015

GALK inhibitors for classic galactosemia.

Future Med Chem 2014 Jun;6(9):1003-15

Division of Medical Genetics, Department of Pediatrics, University of Utah, 50 N Medical Drive, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.4155/fmc.14.43DOI Listing
June 2014

Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.

J Biol Chem 2014 May 25;289(20):13717-25. Epub 2014 Mar 25.

From the NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20892,

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http://dx.doi.org/10.1074/jbc.M113.511030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022846PMC
May 2014

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Nat Commun 2014 Apr 3;5:3608. Epub 2014 Apr 3.

1] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Spain [3] Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010 Catalonia, Spain.

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http://dx.doi.org/10.1038/ncomms4608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988805PMC
April 2014

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.

Proc Natl Acad Sci U S A 2014 Feb 27;111(6):2349-54. Epub 2014 Jan 27.

Division of Preclinical Innovation, National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, Metabolism Branch, Center for Cancer Research, and Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1311846111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926026PMC
February 2014

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.

ACS Med Chem Lett 2014 Jan 30;5(1):12-7. Epub 2013 Oct 30.

National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

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http://dx.doi.org/10.1021/ml400259dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027769PMC
January 2014

Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.

Biochem Biophys Res Commun 2013 Aug 10;438(2):243-8. Epub 2013 Jul 10.

Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.bbrc.2013.06.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094369PMC
August 2013

Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.

Bioorg Med Chem Lett 2013 Feb 10;23(3):682-6. Epub 2012 Dec 10.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.11.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547291PMC
February 2013

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Bioorg Med Chem Lett 2011 Nov 14;21(21):6322-7. Epub 2011 Sep 14.

NIH Chemical Genomics Center, NIH Center for Translational Therapeutics, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.08.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224553PMC
November 2011

Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction.

Tetrahedron Lett 2010 Dec;51(52):6852-6855

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00404039100189
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http://dx.doi.org/10.1016/j.tetlet.2010.10.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079232PMC
December 2010

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Bioorg Med Chem Lett 2010 Jun 11;20(11):3387-93. Epub 2010 Apr 11.

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874658PMC
June 2010

A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety.

ChemMedChem 2010 May;5(5):730-8

National Institutes of Health, National Human Genome Research Institute, NIH Chemical Genomics Center, Rockville, Maryland 20850, USA.

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http://doi.wiley.com/10.1002/cmdc.200900531
Publisher Site
http://dx.doi.org/10.1002/cmdc.200900531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062473PMC
May 2010

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.

J Med Chem 2010 Feb;53(3):1048-55

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, MSC 3370 Bethesda, Maryland 20850, USA.

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http://dx.doi.org/10.1021/jm901577gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818804PMC
February 2010

Super silyl group for a sequential diastereoselective aldol-polyhalomethyllithium addition reaction.

Org Lett 2008 Feb 9;10(3):453-5. Epub 2008 Jan 9.

Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/ol702825pDOI Listing
February 2008

Ketone super silyl enol ethers in sequential reactions: diastereoselective generation of tertiary carbinols in one pot.

J Am Chem Soc 2008 Feb 15;130(5):1580-2. Epub 2008 Jan 15.

Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/ja7102586DOI Listing
February 2008

Triflimide (HNTf2)-catalyzed aldehyde cross-aldol reaction using "super silyl" enol ethers.

Nat Protoc 2006 ;1(5):2434-8

Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.

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http://www.nature.com/doifinder/10.1038/nprot.2006.389
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http://dx.doi.org/10.1038/nprot.2006.389DOI Listing
October 2007

"Super silyl" group for diastereoselective sequential reactions: access to complex chiral architecture in one pot.

J Am Chem Soc 2007 Mar 20;129(10):2762-3. Epub 2007 Feb 20.

Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/ja0693542DOI Listing
March 2007

Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition.

Bioorg Med Chem 2007 Jan 10;15(1):555-62. Epub 2006 Oct 10.

Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5-35131 Padova, Italy.

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http://dx.doi.org/10.1016/j.bmc.2006.09.029DOI Listing
January 2007

Tris(trimethylsilyl)silyl-governed aldehyde cross-aldol cascade reaction.

J Am Chem Soc 2006 Jan;128(1):48-9

Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, IL 60637, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja054725k
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http://dx.doi.org/10.1021/ja054725kDOI Listing
January 2006

Remarkable tris(trimethylsilyl)silyl group for diastereoselective [2 + 2] cyclizations.

Org Lett 2005 Jul;7(14):3127-9

Department of Chemistry, University of Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/ol0512334DOI Listing
July 2005