Publications Authored by Matteo Cesaroni

Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.

Authors:

Michela Serresi Bjorn Siteur Danielle Hulsman Carlos Company Matthias J Schmitt Cor Lieftink Ben Morris Matteo Cesaroni Natalie Proost Roderick L Beijersbergen Maarten van Lohuizen Gaetano Gargiulo

J Exp Med 2018 12 28;215(12):3115-3135. Epub 2018 Nov 28.

Molecular Oncology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

View Article

Download full-text PDF	Source
http://www.jem.org/lookup/doi/10.1084/jem.20180801	Publisher Site
http://dx.doi.org/10.1084/jem.20180801	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279402	PMC

December 2018

Digital Restriction Enzyme Analysis of Methylation (DREAM).

Authors:

Jaroslav Jelinek Justin T Lee Matteo Cesaroni Jozef Madzo Shoudan Liang Yue Lu Jean-Pierre J Issa

Methods Mol Biol 2018 ;1708:247-265

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1007/978-1-4939-7481-8_13	DOI Listing

July 2018

Activated plasmacytoid dendritic cells regulate type 2 innate lymphoid cell-mediated airway hyperreactivity.

Authors:

Hadi Maazi Homayon Banie German R Aleman Muench Nisheel Patel Bowen Wang Ishwarya Sankaranarayanan Vipul Bhargava Takahiro Sato Gavin Lewis Matteo Cesaroni James Karras Anuk Das Pejman Soroosh Omid Akbari

J Allergy Clin Immunol 2018 03 1;141(3):893-905.e6. Epub 2017 Jun 1.

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, Calif. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.jaci.2017.04.043	DOI Listing

March 2018

Estrogen Receptor α Signaling Exacerbates Immune-Mediated Nephropathies through Alteration of Metabolic Activity.

Authors:

Chelsea Corradetti Neelakshi R Jog Matteo Cesaroni Michael Madaio Roberto Caricchio

J Immunol 2018 01 13;200(2):512-522. Epub 2017 Dec 13.

Rheumatology Section, Department of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140;

View Article

Download full-text PDF	Source
http://dx.doi.org/10.4049/jimmunol.1700770	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760359	PMC

January 2018

Correction: Human mutations in integrator complex subunits link transcriptome integrity to brain development.

PLoS Genet 2017 Aug 1;13(8):e1006923. Epub 2017 Aug 1.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1371/journal.pgen.1006923	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538630	PMC

August 2017

Human mutations in integrator complex subunits link transcriptome integrity to brain development.

PLoS Genet 2017 May 25;13(5):e1006809. Epub 2017 May 25.

Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1371/journal.pgen.1006809	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466333	PMC

May 2017

Transcriptional Selectivity of Epigenetic Therapy in Cancer.

Authors:

Takahiro Sato Matteo Cesaroni Woonbok Chung Shoghag Panjarian Anthony Tran Jozef Madzo Yasuyuki Okamoto Hanghang Zhang Xiaowei Chen Jaroslav Jelinek Jean-Pierre J Issa

Cancer Res 2017 01 22;77(2):470-481. Epub 2016 Nov 22.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-0834	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243171	PMC

January 2017

Prion-like Aggregation of Mitochondrial Antiviral Signaling Protein in Lupus Patients Is Associated With Increased Levels of Type I Interferon.

Authors:

Wen-Hai Shao Daniel H Shu Yuxuan Zhen Brendan Hilliard Stephen O Priest Matteo Cesaroni Jenny P-Y Ting Philip L Cohen

Arthritis Rheumatol 2016 11;68(11):2697-2707

Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079845	PMC
http://dx.doi.org/10.1002/art.39733	DOI Listing

November 2016

Identification of MEF2B, EBF1, and IL6R as Direct Gene Targets of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Critical for EBV-Infected B-Lymphocyte Survival.

Authors:

Italo Tempera Alessandra De Leo Andrew V Kossenkov Matteo Cesaroni Hui Song Noor Dawany Louise Showe Fang Lu Priyankara Wikramasinghe Paul M Lieberman

J Virol 2016 01 14;90(1):345-55. Epub 2015 Oct 14.

The Wistar Institute, Philadelphia, Pennsylvania, USA

View Article

Download full-text PDF	Source
http://jvi.asm.org/content/90/1/345.full.pdf	Web Search
http://jvi.asm.org/lookup/doi/10.1128/JVI.02318-15	Publisher Site
http://dx.doi.org/10.1128/JVI.02318-15	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702570	PMC

January 2016

Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer.

Authors:

Michela Serresi Gaetano Gargiulo Natalie Proost Bjorn Siteur Matteo Cesaroni Martijn Koppens Huafeng Xie Kate D Sutherland Danielle Hulsman Elisabetta Citterio Stuart Orkin Anton Berns Maarten van Lohuizen

Cancer Cell 2016 Jan;29(1):17-31

Division of Molecular Genetics, Centre for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands; Cancer Genomics Centre (CGC.nl), Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.ccell.2015.12.006	DOI Listing

January 2016

Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2.

Authors:

Kayla A Martin Matteo Cesaroni Michael F Denny Lena N Lupey Italo Tempera

Mol Cell Biol 2015 Dec 14;35(23):3934-44. Epub 2015 Sep 14.

Fels Institute for Cancer and Molecular Biology, Temple University, Philadelphia, Pennsylvania, USA Department of Microbiology and Immunology, Temple University, Philadelphia, Pennsylvania, USA

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1128/MCB.00635-15	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628063	PMC

December 2015

G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition.

Authors:

Geoffroy Laumet Judit Garriga Shao-Rui Chen Yuhao Zhang De-Pei Li Trevor M Smith Yingchun Dong Jaroslav Jelinek Matteo Cesaroni Jean-Pierre Issa Hui-Lin Pan

Nat Neurosci 2015 Dec 9;18(12):1746-55. Epub 2015 Nov 9.

Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/nn.4165	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661086	PMC

December 2015

Hypomethylation of TET2 Target Genes Identifies a Curable Subset of Acute Myeloid Leukemia.

Authors:

Jumpei Yamazaki Rodolphe Taby Jaroslav Jelinek Noel J M Raynal Matteo Cesaroni Sherry A Pierce Steven M Kornblau Carlos E Bueso-Ramos Farhad Ravandi Hagop M Kantarjian Jean-Pierre J Issa

J Natl Cancer Inst 2015 Nov 13;108(2). Epub 2015 Nov 13.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA (JY, JJ, NJMR, MC, JPJI); Department of Leukemia (JY, RT, JJ, NJMR, SAP, SMK, FR, HMK, JPJI) and Department of Hematopathology (CEBR), The University of Texas MD Anderson Cancer Center, Houston, TX.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1093/jnci/djv323	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862435	PMC

November 2015

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.

Authors:

Jumpei Yamazaki Jaroslav Jelinek Yue Lu Matteo Cesaroni Jozef Madzo Frank Neumann Rong He Rodolphe Taby Aparna Vasanthakumar Trisha Macrae Kelly R Ostler Hagop M Kantarjian Shoudan Liang Marcos R Estecio Lucy A Godley Jean-Pierre J Issa

Cancer Res 2015 Jul 13;75(14):2833-43. Epub 2015 May 13.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-0739	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506197	PMC

July 2015

Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain.

Authors:

Bryant M Schultz Gwendolyn A Gallicio Matteo Cesaroni Lena N Lupey Nora Engel

Nucleic Acids Res 2015 Jan 24;43(2):745-59. Epub 2014 Dec 24.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1093/nar/gku1324	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333379	PMC

January 2015

In vivo shRNA screens in solid tumors.

Authors:

Gaetano Gargiulo Michela Serresi Matteo Cesaroni Danielle Hulsman Maarten van Lohuizen

Nat Protoc 2014 Dec 20;9(12):2880-902. Epub 2014 Nov 20.

1] Division of Molecular Genetics, the Netherlands Cancer Institute, Amsterdam, the Netherlands. [2] Cancer Genomics Centre, the Netherlands.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/nprot.2014.185	DOI Listing

December 2014

Integrator regulates transcriptional initiation and pause release following activation.

Authors:

Alessandro Gardini David Baillat Matteo Cesaroni Deqing Hu Jill M Marinis Eric J Wagner Mitchell A Lazar Ali Shilatifard Ramin Shiekhattar

Mol Cell 2014 Oct 4;56(1):128-139. Epub 2014 Sep 4.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.molcel.2014.08.004	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292851	PMC

October 2014

Validation of methylation biomarkers that distinguish normal colon mucosa of cancer patients from normal colon mucosa of patients without cancer.

Authors:

Matteo Cesaroni Jasmine Powell Carmen Sapienza

Cancer Prev Res (Phila) 2014 Jul 7;7(7):717-26. Epub 2014 May 7.

Authors' Affiliations: Fels Institute for Cancer Research and Molecular Biology; and Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/1940-6207.CAPR-13-0407	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085775	PMC

July 2014

Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation.

Authors:

Alessandro Gardini David Baillat Matteo Cesaroni Ramin Shiekhattar

EMBO J 2014 Apr 3;33(8):890-905. Epub 2014 Mar 3.

The Wistar Institute, Philadelphia, PA, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1002/embj.201385567	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194113	PMC

April 2014

Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53.

Authors:

Silvia Licciulli Jacqueline L Avila Linda Hanlon Scott Troutman Matteo Cesaroni Smitha Kota Brian Keith M Celeste Simon Ellen Puré Fred Radtke Anthony J Capobianco Joseph L Kissil

Cancer Res 2013 Oct 13;73(19):5974-84. Epub 2013 Aug 13.

Authors' Affiliations: Department of Cancer Biology, The Scripps Research Institute, Jupiter; Molecular Oncology Program, DeWitt Daughtry Family Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida; The Wistar Institute; Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine; Department of Cancer Biology, Abramson Family Cancer Research Institute; and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; and Ecole Polytechnique Fédérale de Lausanne, EPFL SV ISREC, Lausanne, Switzerland.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-1384	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791518	PMC

October 2013

In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.

Authors:

Gaetano Gargiulo Matteo Cesaroni Michela Serresi Nienke de Vries Danielle Hulsman Sophia W Bruggeman Cesare Lancini Maarten van Lohuizen

Cancer Cell 2013 May;23(5):660-76

Division of Molecular Genetics and Centre for Biomedical Genetics, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.ccr.2013.03.030	DOI Listing

May 2013

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription.

Authors:

Fan Lai Ulf A Orom Matteo Cesaroni Malte Beringer Dylan J Taatjes Gerd A Blobel Ramin Shiekhattar

Nature 2013 Feb 17;494(7438):497-501. Epub 2013 Feb 17.

The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/nature11884	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109059	PMC

February 2013

Genome-wide mapping of human DNA-replication origins: levels of transcription at ORC1 sites regulate origin selection and replication timing.

Authors:

Gaetano Ivan Dellino Davide Cittaro Rossana Piccioni Lucilla Luzi Stefania Banfi Simona Segalla Matteo Cesaroni Ramiro Mendoza-Maldonado Mauro Giacca Pier Giuseppe Pelicci

Genome Res 2013 Jan 27;23(1):1-11. Epub 2012 Nov 27.

Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.

View Article

Download full-text PDF	Source
http://genome.cshlp.org/cgi/doi/10.1101/gr.142331.112	Publisher Site
http://dx.doi.org/10.1101/gr.142331.112	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530669	PMC