Mats Rudling

Mats Rudling

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Mats Rudling

Publications by authors named "Mats Rudling"

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Gallbladder bile supersaturated with cholesterol in gallstone patients preferentially develops from shortage of bile acids.

J Lipid Res 2019 Mar 4;60(3):498-505. Epub 2019 Jan 4.

Metabolism Unit, Endocrinology, Metabolism and Diabetes, and Integrated CardioMetabolic Center (ICMC), Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1194/jlr.S091199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399503PMC
March 2019

An FXR Agonist Reduces Bile Acid Synthesis Independently of Increases in FGF19 in Healthy Volunteers.

Gastroenterology 2018 10 19;155(4):1012-1016. Epub 2018 Jun 19.

Metabolism Unit and Integrated Cardio Metabolic Center, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183466
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http://dx.doi.org/10.1053/j.gastro.2018.06.038DOI Listing
October 2018

Cholestyramine treatment of healthy humans rapidly induces transient hypertriglyceridemia when treatment is initiated.

Am J Physiol Endocrinol Metab 2017 08 9;313(2):E167-E174. Epub 2017 May 9.

Metabolism Unit C2:94 and KI/AZ Integrated CardioMetabolic Center, Department of Medicine, and Center for Innovative Medicine, Department of Biosciences and Nutrition, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden

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http://dx.doi.org/10.1152/ajpendo.00416.2016DOI Listing
August 2017

Understanding mouse bile acid formation: Is it time to unwind why mice and rats make unique bile acids?

Authors:
Mats Rudling

J Lipid Res 2016 12 24;57(12):2097-2098. Epub 2016 Oct 24.

Metabolism Unit and KI/AZ Integrated Cardio Metabolic Center, Department of Medicine, Center for Innovative Medicine, Department of Biosciences and Nutrition, Karolinska Institute at Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden

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http://dx.doi.org/10.1194/jlr.C072876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321220PMC
December 2016

Mice Abundant in Muricholic Bile Acids Show Resistance to Dietary Induced Steatosis, Weight Gain, and to Impaired Glucose Metabolism.

PLoS One 2016 29;11(1):e0147772. Epub 2016 Jan 29.

Department of Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147772PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732983PMC
July 2016

Circulating Hepcidin-25 Is Reduced by Endogenous Estrogen in Humans.

PLoS One 2016 11;11(2):e0148802. Epub 2016 Feb 11.

Department of Endocrinology, Metabolism and Diabetes, Departments of Medicine and Molecular Medicine and Surgery, Karolinska Institutet at Karolinska University Hospital, S-141 86 Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148802PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750915PMC
July 2016

Impaired Cholesterol Efflux Capacity of High-Density Lipoprotein Isolated From Interstitial Fluid in Type 2 Diabetes Mellitus-Brief Report.

Arterioscler Thromb Vasc Biol 2016 05 31;36(5):787-91. Epub 2016 Mar 31.

From the Metabolism Unit (J.A., P.P., B.A., M.R.) and KI/AZ Integrated CardioMetabolic Center (J.A., B.A., M.R.), Department of Medicine and Department of Biosciences and Nutrition (J.A., B.A., M.R.), Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden. Department of Pediatrics, The University of Groningen, University Medical Center Groningen, Groningen, The Netherlands (U.J.F.T., A.D.); and Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden (P.P.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845764PMC
May 2016

Stimulation of apical sodium-dependent bile acid transporter expands the bile acid pool and generates bile acids with positive feedback properties.

Dig Dis 2015 27;33(3):376-81. Epub 2015 May 27.

Metabolism Unit, Department of Endocrinology, Metabolism and Diabetes, KI/AZ Integrated CardioMetabolic Center, Department of Medicine, and Molecular Nutrition Unit, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1159/000371690DOI Listing
March 2016

Letter to the Editor: Potential Role for FGF21 as a Mediator of Thyroid Hormone Effects on Metabolic Regulation.

J Clin Endocrinol Metab 2015 Dec;100(12):L130-1

Metabolism Unit (Y.B., B.O., M.R.), Center for Endocrinology, Metabolism, and Diabetes, Department of Medicine, and Molecular Nutrition Unit (Y.B., B.O., M.R.), Center for Biosciences and Nutrition, Karolinska Institute, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1210/jc.2015-3548DOI Listing
December 2015

Levels of atherogenic lipoproteins are unexpectedly reduced in interstitial fluid from type 2 diabetes patients.

J Lipid Res 2015 Aug 19;56(8):1633-9. Epub 2015 Jun 19.

Metabolism Unit Karolinska Institutet at Karolinska University Hospital Huddinge, C2-84, S-141 86 Stockholm, Sweden KI/AZ Integrated CardioMetabolic Center, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, C2-84, S-141 86 Stockholm, Sweden Molecular Nutrition Unit, Center for Innovative Medicine, Department of Biosciences and Nutrition, Karolinska Institutet at Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden.

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http://www.jlr.org/lookup/doi/10.1194/jlr.P058842
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http://dx.doi.org/10.1194/jlr.P058842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514004PMC
August 2015

Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study.

Am J Clin Nutr 2015 Jul 27;102(1):20-30. Epub 2015 May 27.

Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden;

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http://dx.doi.org/10.3945/ajcn.115.107045DOI Listing
July 2015

Influence of dietary sugar on cholesterol and bile acid metabolism in the rat: Marked reduction of hepatic Abcg5/8 expression following sucrose ingestion.

Biochem Biophys Res Commun 2015 Jun 22;461(4):592-7. Epub 2015 Apr 22.

Metabolism Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, C2-84, S-141 86 Stockholm, Sweden; KI/AZ Integrated CardioMetabolic Center, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, C2-84, S-141 86 Stockholm, Sweden; Molecular Nutrition Unit, Center for Innovative Medicine, Department of Biosciences and Nutrition, Karolinska Institutet at Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2015.04.070DOI Listing
June 2015

Authors' response: bile acids are important in the pathophysiology of IBS.

Gut 2015 May 23;64(5):851-2. Epub 2014 Jul 23.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden University of Gothenburg Centre for Person-Centred Care (GPCC), Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1136/gutjnl-2014-308037DOI Listing
May 2015

Influence of physiological changes in endogenous estrogen on circulating PCSK9 and LDL cholesterol.

J Lipid Res 2015 Feb 22;56(2):463-9. Epub 2014 Dec 22.

Metabolism Unit, Department of Endocrinology, Metabolism, and Diabetes, Karolinska Institutet at Karolinska University Hospital Huddinge, C2-94, S-141 86 Stockholm, Sweden Molecular Nutrition Unit, Center for Innovative Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, C2-94, S-141 86 Stockholm, Sweden Karolinska Institutet/AstraZeneca Integrated CardioMetabolic Center, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, C2-94, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1194/jlr.M055780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306699PMC
February 2015

Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS.

Gut 2015 Jan 12;64(1):84-92. Epub 2014 Apr 12.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden University of Gothenburg Centre for Person-Centred Care (GPCC), Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1136/gutjnl-2013-305965DOI Listing
January 2015

Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans.

J Lipid Res 2014 Nov 29;55(11):2408-15. Epub 2014 Aug 29.

Metabolism Unit, Department of Endocrinology, Metabolism, and Diabetes, and KI/AZ Integrated CardioMetabolic Center, Department of Medicine Molecular Nutrition Unit, Center for Innovative Medicine, Department of Biosciences and Nutrition.

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http://dx.doi.org/10.1194/jlr.M051664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617142PMC
November 2014

Role of dietary fats in modulating cardiometabolic risk during moderate weight gain: a randomized double-blind overfeeding trial (LIPOGAIN study).

J Am Heart Assoc 2014 Oct 15;3(5):e001095. Epub 2014 Oct 15.

Unit for Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden (D.I., F.R., U.R.).

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http://dx.doi.org/10.1161/JAHA.114.001095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323808PMC
October 2014

Interstitial fluid lipoproteins.

Curr Opin Lipidol 2013 Aug;24(4):327-31

Department of Medicine, Metabolism Unit, Center for Endocrinology, Metabolism and Diabetes, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1097/MOL.0b013e3283630846DOI Listing
August 2013

Effects of food or sleep deprivation during civilian survival training on clinical chemistry variables.

Wilderness Environ Med 2013 Jun 21;24(2):146-52. Epub 2013 Feb 21.

Department of Clinical Pharmacology, Karolinska University Hospital at Huddinge, Karolinska Institute, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.wem.2012.11.008DOI Listing
June 2013

Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice.

PLoS One 2012 25;7(5):e37787. Epub 2012 May 25.

Karolinska Institute, Department of Endocrinology, Metabolism and Diabetes, and Molecular Nutrition Unit, Center for Biosciences, NOVUM, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037787PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360597PMC
December 2012

Circulating fibroblast growth factors as metabolic regulators--a critical appraisal.

Cell Metab 2012 Dec;16(6):693-705

Metabolism Unit, Center for Endocrinology, Metabolism, and Diabetes, Department of Medicine, and Molecular Nutrition Unit, Center for Biosciences NOVUM, Karolinska Institute at Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.cmet.2012.11.001DOI Listing
December 2012

Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex.

Hepatology 2012 Nov 14;56(5):1828-37. Epub 2012 Oct 14.

Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1002/hep.25861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533177PMC
November 2012

Endogenous estrogens lower plasma PCSK9 and LDL cholesterol but not Lp(a) or bile acid synthesis in women.

Arterioscler Thromb Vasc Biol 2012 Mar 29;32(3):810-4. Epub 2011 Dec 29.

Metabolism Unit, Department of Endocrinology, Metabolism and Diabetes, Karolinska Institute at Karolinska University Hospital Huddinge S-141 86 Stockholm, Sweden.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.111.242461
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http://dx.doi.org/10.1161/ATVBAHA.111.242461DOI Listing
March 2012

Thyromimetics: a journey from bench to bed-side.

Pharmacol Ther 2011 Jul 12;131(1):33-9. Epub 2011 Apr 12.

Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.pharmthera.2011.04.003DOI Listing
July 2011

Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans.

Arterioscler Thromb Vasc Biol 2010 Dec 30;30(12):2666-72. Epub 2010 Sep 30.

Department of Endocrinology, Center for Biosciences and Nutrition, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1161/ATVBAHA.110.214130DOI Listing
December 2010

Lipid lowering with thyroid hormone and thyromimetics.

Curr Opin Lipidol 2010 Dec;21(6):499-506

Metabolism Unit, Department of Endocrinology, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1097/MOL.0b013e3283402e9cDOI Listing
December 2010

Activation of VPAC1 receptors aggravates early atherosclerosis in hypercholesterolemic apolipoprotein E-deficient mice.

Biochem Biophys Res Commun 2010 Nov 15;402(3):471-6. Epub 2010 Oct 15.

Experimental Cardiovascular Research Unit, Center for Molecular Medicine, Department of Medicine at Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2010.10.052DOI Listing
November 2010

Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis.

Arterioscler Thromb Vasc Biol 2010 May 18;30(5):946-52. Epub 2010 Feb 18.

Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.109.202671
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http://dx.doi.org/10.1161/ATVBAHA.109.202671DOI Listing
May 2010

The genetic background of gallstone formation: an update.

Biochem Biophys Res Commun 2010 May;396(1):58-62

Department of Gastroenterology and Hepatology, Karolinska Institutet, Karolinska University Hospital at Huddinge, S-14186 Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1000377
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http://dx.doi.org/10.1016/j.bbrc.2010.02.143DOI Listing
May 2010

Biliary sphincterotomy does not relate to diarrhoea or major changes in bile acid synthesis or plasma lipids.

Scand J Gastroenterol 2009 ;44(9):1132-8

Department of Internal Medicine, Sahlgrenska University Hospital, Sahlgrenska Academy Göteborg, Sweden.

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http://dx.doi.org/10.1080/00365520903131981DOI Listing
February 2010

Osteoprotegerin promotes fibrous cap formation in atherosclerotic lesions of ApoE-deficient mice--brief report.

Arterioscler Thromb Vasc Biol 2009 Oct 10;29(10):1478-80. Epub 2009 Jul 10.

Department of Medicine, Center for Molecular Medicine, Stockholm, Sweden.

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http://dx.doi.org/10.1161/ATVBAHA.109.188185DOI Listing
October 2009

Importance of proprotein convertase subtilisin/kexin type 9 in the hormonal and dietary regulation of rat liver low-density lipoprotein receptors.

Endocrinology 2009 Mar 13;150(3):1140-6. Epub 2008 Nov 13.

Department of Endocrinology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1210/en.2008-1281DOI Listing
March 2009

The bile acid turnover rate assessed with the (75)SeHCAT test is stable in chronic diarrhoea but slightly decreased in healthy subjects after a long period of time.

Dig Dis Sci 2008 Nov 25;53(11):2935-40. Epub 2008 Apr 25.

Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, 41345, Gothenburg, Sweden.

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http://dx.doi.org/10.1007/s10620-008-0256-4DOI Listing
November 2008

The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.

Cell Metab 2008 Aug;8(2):169-74

Department of Endocrinology, Metabolism and Diabetes, Molecular Nutrition Unit, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.cmet.2008.06.014DOI Listing
August 2008

Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by thyroid hormone.

Gastroenterology 2008 Apr 17;134(4):1127-36. Epub 2008 Jan 17.

Karolinska Institute, Center for Endocrinology, Metabolism, and Diabetes, Department of Medicine and Molecular Nutrition Unit, Center for Nutrition and Toxicology, Karolinska University Hospital, Huddinge, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1053/j.gastro.2008.01.032DOI Listing
April 2008

Age-induced hypercholesterolemia in the rat relates to reduced elimination but not increased intestinal absorption of cholesterol.

Am J Physiol Endocrinol Metab 2007 Sep 19;293(3):E737-42. Epub 2007 Jun 19.

Karolinska Institute at Center for Endocrinology, Metabolism, and Diabetes, Department of Medicine and Molecular Nutrition Unit, Center for Nutrition and Toxicology, NOVUM, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1152/ajpendo.00166.2007DOI Listing
September 2007

PPARalpha is a key regulator of hepatic FGF21.

Biochem Biophys Res Commun 2007 Aug 21;360(2):437-40. Epub 2007 Jun 21.

Center for Endocrinology, Metabolism, and Diabetes, Department of Medicine, M63, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2007.06.068DOI Listing
August 2007

Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease.

Hepatology 2007 May;45(5):1261-6

Department of Gastroenterology, Pontificia Universidad Católica, Santiago, Chile, and Center for Metabolism and Endocrinology, Karolinska Institute at Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/hep.21616DOI Listing
May 2007

[Lowering of LDL cholesterol prevents cardiovascular diseases. "Normal values" are too high--treatment time is a crucial factor].

Authors:
Mats Rudling

Lakartidningen 2006 Oct 25-31;103(43):3278-82

Kliniken för endokrinologi, metabolism och diabetes, institutionen för medicin, Karolinska Universitetssjukhuset Huddinge, samt Centrum för nutrition och toxikologi, Novum, Stockholm

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November 2006

Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice.

Biochem Biophys Res Commun 2006 Apr 28;342(4):1382-8. Epub 2006 Feb 28.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2006.02.108DOI Listing
April 2006

Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption.

Eur J Gastroenterol Hepatol 2006 Apr;18(4):397-403

Division of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.

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http://dx.doi.org/10.1097/00042737-200604000-00013DOI Listing
April 2006

Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis.

Gastroenterology 2005 Nov;129(5):1445-53

Center for Metabolism and Endocrinology and Center for Nutrition and Toxicology, Department of Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1053/j.gastro.2005.09.009DOI Listing
November 2005

Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment.

Biochim Biophys Acta 2005 Oct 9;1736(3):221-7. Epub 2005 Sep 9.

Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine and Molecular Nutrition Unit, Center for Nutrition and Toxicology, NOVUM, Karolinska Institute, M63, Karolinska University Hospital, Huddinge, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbalip.2005.08.012DOI Listing
October 2005

Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice.

Proc Natl Acad Sci U S A 2005 Jul 8;102(29):10297-302. Epub 2005 Jul 8.

Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine, and Molecular Nutrition Unit, Center for Nutrition and Toxicology, NOVUM, Karolinska Institute at Karolinska University Hospital-Huddinge, SE-141 86 Stockholm, Sweden.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0504379102
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http://dx.doi.org/10.1073/pnas.0504379102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177400PMC
July 2005

Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis.

Circ Res 2005 Mar 20;96(4):427-34. Epub 2005 Jan 20.

Department of Medicine and Centre for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1161/01.RES.0000156889.22364.f1DOI Listing
March 2005

Pituitary control of lipoprotein and bile acid metabolism in male rats: growth hormone effects are not mediated by prolactin.

Am J Physiol Endocrinol Metab 2004 Jul 16;287(1):E114-9. Epub 2004 Mar 16.

Dept. of Medicine, M63, Karolinska Univ. Hospital at Huddinge, S-141 86 Huddinge, Sweden.

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http://dx.doi.org/10.1152/ajpendo.00564.2003DOI Listing
July 2004

Bile acid synthesis is increased in Chilean Hispanics with gallstones and in gallstone high-risk Mapuche Indians.

Gastroenterology 2004 Mar;126(3):741-8

Center for Metabolim and Endocrinology, and Department of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1053/j.gastro.2003.12.009DOI Listing
March 2004

Growth hormone induces low-density lipoprotein clearance but not bile acid synthesis in humans.

Arterioscler Thromb Vasc Biol 2004 Feb 4;24(2):349-56. Epub 2003 Dec 4.

Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine, Novum, Sweden.

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http://dx.doi.org/10.1161/01.ATV.0000110657.67317.90DOI Listing
February 2004

CD1d-dependent activation of NKT cells aggravates atherosclerosis.

J Exp Med 2004 Feb 26;199(3):417-22. Epub 2004 Jan 26.

Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1084/jem.20030997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211791PMC
February 2004

Growth hormone-mediated alteration of fuel metabolism in the aged rat as determined from transcript profiles.

Physiol Genomics 2004 Jan 15;16(2):261-7. Epub 2004 Jan 15.

Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1152/physiolgenomics.00093.2002DOI Listing
January 2004

Disruption of TGF-beta signaling in T cells accelerates atherosclerosis.

J Clin Invest 2003 Nov 20;112(9):1342-50. Epub 2003 Oct 20.

Center for Molecular Medicine, L8:03 Karolinska Hospital, SE-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1172/JCI18607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC228445PMC
November 2003

Leptin induces the hepatic high density lipoprotein receptor scavenger receptor B type I (SR-BI) but not cholesterol 7alpha-hydroxylase (Cyp7a1) in leptin-deficient (ob/ob) mice.

J Biol Chem 2003 Oct 13;278(44):43224-8. Epub 2003 Aug 13.

Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine and Molecular Nutrition Unit, Center for Nutrition and Toxicology, Novum, Karolinska Institutet at Huddinge University Hospital, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M302645200DOI Listing
October 2003

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice.

Cardiovasc Res 2003 Jul;59(1):234-40

Department of Medicine at Karolinska Hospital and Center for Molecular Medicine L8:03, Karolinska Institute, SE-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1016/s0008-6363(03)00343-2DOI Listing
July 2003

Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood.

J Lipid Res 2003 Apr 16;44(4):859-66. Epub 2003 Jan 16.

Metabolism Unit, Center for Metabolism and Endocrinology, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1194/jlr.D200043-JLR200DOI Listing
April 2003

Pharmacological interference with intestinal bile acid transport reduces plasma cholesterol in LDL receptor/apoE deficiency.

FASEB J 2003 Feb 3;17(2):265-7. Epub 2002 Dec 3.

Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine, Karolinska Institute at Huddinge University Hospital, Stockholm, Sweden

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http://dx.doi.org/10.1096/fj.02-0341fjeDOI Listing
February 2003

Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver.

J Clin Endocrinol Metab 2002 Sep;87(9):4307-13

Centers for Metabolism and Endocrinology, Karolinska Institute at Huddinge University Hospital, S-141 86 Stockholm, Sweden.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2002-012041DOI Listing
September 2002

Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in mice.

Mol Endocrinol 2002 Aug;16(8):1767-77

Department of Cell and Molecular Biology, Karolinska Institute, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1210/me.2002-0009DOI Listing
August 2002

Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver. No coordinate regulation of CYP7A1 and CYP27A1.

J Biol Chem 2002 Jul 13;277(30):26804-7. Epub 2002 May 13.

Department of Pharmaceutical Biosciences, Division of Biochemistry, University of Uppsala, Box 578, S-751 23 Uppsala, Sweden.

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http://dx.doi.org/10.1074/jbc.M202343200DOI Listing
July 2002

Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol.

Endocrinology 2002 May;143(5):1809-16

Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine, NOVUM, Karolinska Institute at Huddinge University Hospital, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1210/endo.143.5.8816DOI Listing
May 2002

Interleukin-6-deficient mice develop mature-onset obesity.

Nat Med 2002 Jan;8(1):75-9

Research Center for Endocrinology and Metabolism, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.

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http://dx.doi.org/10.1038/nm0102-75DOI Listing
January 2002