Matilda Katan

Matilda Katan

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Matilda Katan

Matilda Katan

Publications by authors named "Matilda Katan"

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NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074.

Biomol NMR Assign 2018 10 26;12(2):231-235. Epub 2018 Mar 26.

Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1007/s12104-018-9814-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132846PMC
October 2018

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.

Structure 2018 03 22;26(3):446-458.e8. Epub 2018 Feb 22.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower St, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846801PMC
March 2018

Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis.

Oncotarget 2017 Nov 25;8(61):102898-102911. Epub 2017 Oct 25.

Proteomics and Molecular Cell Dynamics, Center for Nephrology, School of Life and Medical Sciences, University College London, London NW3 2PF, United Kingdom.

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http://dx.doi.org/10.18632/oncotarget.22048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732698PMC
November 2017

Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach.

Mol Cell Proteomics 2016 Feb 24;15(2):715-25. Epub 2015 Nov 24.

From the ‡Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, UK;

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http://dx.doi.org/10.1074/mcp.O115.054429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739684PMC
February 2016

Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.

Adv Biol Regul 2016 Jan 26;60:6-13. Epub 2015 Sep 26.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower St, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2015.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739061PMC
January 2016

Homo-FRET Based Biosensors and Their Application to Multiplexed Imaging of Signalling Events in Live Cells.

Int J Mol Sci 2015 Jun 30;16(7):14695-716. Epub 2015 Jun 30.

Photonics Group, Department of Physics, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.3390/ijms160714695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519867PMC
June 2015

PLCγ1 participates in protein transport and diacylglycerol production triggered by cargo arrival at the Golgi.

Traffic 2015 Mar 6;16(3):250-66. Epub 2015 Jan 6.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, C/ Casanova, 143, 08036, Barcelona, Spain; Current address: Vlaams Instituut voor Biotechnologie (VIB), Centre for the Biology of Disease and KU Leuven, Department of Human Genetics, Campus Gasthuisberg, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1111/tra.12246DOI Listing
March 2015

Evaluation of phosphopeptide enrichment strategies for quantitative TMT analysis of complex network dynamics in cancer-associated cell signalling.

EuPA Open Proteom 2015 Mar;6:10-15

Proteomics and Molecular Cell Dynamics, Center for Nephrology, School of Life and Medical Sciences, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, United Kingdom.

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http://dx.doi.org/10.1016/j.euprot.2015.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398868PMC
March 2015

Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.

Structure 2014 Dec;22(12):1831-1843

Division of Biosciences, Institute of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2014.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342408PMC
December 2014

Dysfunction of phospholipase Cγ in immune disorders and cancer.

Trends Biochem Sci 2014 Dec 30;39(12):603-11. Epub 2014 Oct 30.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2014.09.004DOI Listing
December 2014

Tumor suppressor role of phospholipase C epsilon in Ras-triggered cancers.

Proc Natl Acad Sci U S A 2014 Mar 3;111(11):4239-44. Epub 2014 Mar 3.

Division of Biosciences, Institute of Structural and Molecular Biology, and Department of Cell and Developmental Biology, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1311500111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964118PMC
March 2014

PLCɛ and the RASSF family in tumour suppression and other functions.

Adv Biol Regul 2013 Sep 1;53(3):258-79. Epub 2013 Aug 1.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.jbior.2013.07.008DOI Listing
September 2013

Comparative analysis of interactions of RASSF1-10.

Adv Biol Regul 2013 May 11;53(2):190-201. Epub 2013 Jan 11.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.jbior.2012.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221134PMC
May 2013

Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF.

J Cell Sci 2012 Dec 19;125(Pt 23):5758-69. Epub 2012 Sep 19.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.110007
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http://dx.doi.org/10.1242/jcs.110007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575709PMC
December 2012

PLC regulation: emerging pictures for molecular mechanisms.

Trends Biochem Sci 2011 Feb 1;36(2):88-96. Epub 2010 Oct 1.

The Institute of Cancer Research, Section for Cell and Molecular Biology, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.tibs.2010.08.003DOI Listing
February 2011

Phosphoinositide signalling in cancer: beyond PI3K and PTEN.

Nat Rev Cancer 2010 May;10(5):342-52

The Institute of Cancer Research, Section for Cell and Molecular Biology, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK.

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http://www.nature.com/articles/nrc2842
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http://dx.doi.org/10.1038/nrc2842DOI Listing
May 2010

Regulatory links between PLC enzymes and Ras superfamily GTPases: signalling via PLCepsilon.

Adv Enzyme Regul 2009 ;49(1):54-8

Cancer Research UK Centre for Cell and Molecular Biology Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW36JB, UK.

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http://dx.doi.org/10.1016/j.advenzreg.2009.01.004DOI Listing
September 2009

Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

J Biol Chem 2009 Aug 16;284(34):23083-93. Epub 2009 Jun 16.

Section of Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London SW3 6JB, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.019265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755714PMC
August 2009

The identification of novel PLC-gamma inhibitors using virtual high throughput screening.

Bioorg Med Chem 2009 Apr 3;17(8):3169-76. Epub 2009 Mar 3.

Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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http://dx.doi.org/10.1016/j.bmc.2009.02.049DOI Listing
April 2009

In vitro reconstitution of activation of PLCepsilon by Ras and Rho GTPases.

Methods Mol Biol 2009 ;462:379-89

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1007/978-1-60327-115-8_24DOI Listing
February 2009

Multiple roles of phosphoinositide-specific phospholipase C isozymes.

BMB Rep 2008 Jun;41(6):415-34

Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Korea.

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http://dx.doi.org/10.5483/bmbrep.2008.41.6.415DOI Listing
June 2008

Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration.

J Biol Chem 2007 Oct 23;282(42):30629-42. Epub 2007 Aug 23.

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M704361200DOI Listing
October 2007

Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1.

Mol Cell Biol 2007 Aug 11;27(16):5790-805. Epub 2007 Jun 11.

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London SW3 6JB, United Kingdom.

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http://dx.doi.org/10.1128/MCB.00778-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952113PMC
August 2007

Phospholipase C epsilon: linking second messengers and small GTPases.

Trends Cell Biol 2006 Dec 7;16(12):640-8. Epub 2006 Nov 7.

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.tcb.2006.10.007DOI Listing
December 2006

Structural and mechanistic insights into ras association domains of phospholipase C epsilon.

Mol Cell 2006 Feb;21(4):495-507

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, United Kingdom.

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http://dx.doi.org/10.1016/j.molcel.2006.01.008DOI Listing
February 2006

New insights into the families of PLC enzymes: looking back and going forward.

Authors:
Matilda Katan

Biochem J 2005 Nov;391(Pt 3):e7-9

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK.

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http://dx.doi.org/10.1042/BJ20051506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276975PMC
November 2005

PLCgamma1 is essential for early events in integrin signalling required for cell motility.

J Cell Sci 2005 Jun;118(Pt 12):2695-706

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1242/jcs.02374DOI Listing
June 2005

Nuclear envelope assembly is promoted by phosphoinositide-specific phospholipase C with selective recruitment of phosphatidylinositol-enriched membranes.

Biochem J 2005 Apr;387(Pt 2):393-400

Cell Biophysics Laboratory, London Research Institute (LRI), Cancer Research UK (CR-UK), 44, Lincoln's Inn Fields, London, WC2A 3PX, UK.

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http://dx.doi.org/10.1042/BJ20040947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1134967PMC
April 2005

Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants.

Oncogene 2005 Jan;24(1):90-100

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1038/sj.onc.1208168DOI Listing
January 2005

Structural and mechanistic aspects of phospholipase Cgamma regulation.

Adv Enzyme Regul 2003 ;43:77-85

Chester Beatty Laboratories, Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

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January 2004

Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling.

Biochem J 2003 Aug;374(Pt 1):269-80

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

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http://biochemj.org/lookup/doi/10.1042/bj20021778
Publisher Site
http://dx.doi.org/10.1042/BJ20021778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223588PMC
August 2003

Irreversible inactivation of magnesium-dependent neutral sphingomyelinase 1 (NSM1) by peroxynitrite, a nitric oxide-derived oxidant.

FEBS Lett 2002 Nov;531(2):329-34

Protein Biochemistry Group, Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK.

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http://dx.doi.org/10.1016/s0014-5793(02)03551-2DOI Listing
November 2002

Biochemical identification of a neutral sphingomyelinase 1 (NSM1)-like enzyme as the major NSM activity in the DT40 B-cell line: absence of a role in the apoptotic response to endoplasmic reticulum stress.

Biochem J 2002 Jul;365(Pt 1):69-77

Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1042/BJ20020120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222658PMC
July 2002