Mathias W Hornef

Mathias W Hornef

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Mathias W Hornef

Mathias W Hornef

Publications by authors named "Mathias W Hornef"

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The Timed Pathway to Homeostasis.

Immunity 2019 05;50(5):1127-1129

Institute of Medical Microbiology, University Clinic RWTH Aachen, Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.04.012DOI Listing
May 2019

Pathways of host cell exit by intracellular pathogens.

Microb Cell 2018 Oct 18;5(12):525-544. Epub 2018 Oct 18.

Division of Cellular and Applied Infection Biology, Institute of Biology II, RWTH Aachen University, Germany.

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http://microbialcell.com/researcharticles/pathways-of-host-c
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http://dx.doi.org/10.15698/mic2018.12.659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282021PMC
October 2018

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

J Clin Invest 2018 08 16;128(8):3535-3545. Epub 2018 Jul 16.

Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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https://www.jci.org/articles/view/97065
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http://dx.doi.org/10.1172/JCI97065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063483PMC
August 2018

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.

Nature 2018 08 8;560(7719):489-493. Epub 2018 Aug 8.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1038/s41586-018-0395-5DOI Listing
August 2018

CD4 T Cell Dependent Colitis Exacerbation Following Re-Exposure of ssp. .

Front Cell Infect Microbiol 2017 16;7:75. Epub 2017 Mar 16.

Molecular Immunology, Helmholtz Centre for Infection ResearchBraunschweig, Germany; Institute of Immunology, Hannover Medical SchoolHannover, Germany.

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http://dx.doi.org/10.3389/fcimb.2017.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352692PMC
September 2017

Cell Polarization and Epigenetic Status Shape the Heterogeneous Response to Type III Interferons in Intestinal Epithelial Cells.

Front Immunol 2017 12;8:671. Epub 2017 Jun 12.

Research Group Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.00671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467006PMC
June 2017

Gut Colonization by Methanogenic Archaea Is Associated with Organic Dairy Consumption in Children.

Front Microbiol 2017 10;8:355. Epub 2017 Mar 10.

Department of Medical Microbiology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical CentreMaastricht, Netherlands; Department of Medical Microbiology, Care and Public Health Research Institute, Maastricht University Medical CentreMaastricht, Netherlands.

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http://dx.doi.org/10.3389/fmicb.2017.00355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344914PMC
March 2017

The Neonatal Window of Opportunity: Setting the Stage for Life-Long Host-Microbial Interaction and Immune Homeostasis.

J Immunol 2017 01;198(2):557-563

Institute of Medical Microbiology, RWTH Aachen University Hospital, 52074 Aachen, Germany

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1601253
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http://dx.doi.org/10.4049/jimmunol.1601253DOI Listing
January 2017

The viral dsRNA analogue poly (I:C) induces necrotizing enterocolitis in neonatal mice.

Pediatr Res 2016 Apr 17;79(4):596-602. Epub 2015 Dec 17.

Center of Pediatric Surgery, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1038/pr.2015.261DOI Listing
April 2016

Real friends: Faecalibacterium prausnitzii supports mucosal immune homeostasis.

Gut 2016 Mar 3;65(3):365-7. Epub 2015 Nov 3.

Institute of Molecular Medicine, RWTH University Hospital, Aachen, Germany.

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http://dx.doi.org/10.1136/gutjnl-2015-310027DOI Listing
March 2016

On the origin of species: Factors shaping the establishment of infant's gut microbiota.

Birth Defects Res C Embryo Today 2015 Dec 26;105(4):240-51. Epub 2015 Nov 26.

Department of Medical Microbiology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/bdrc.21113DOI Listing
December 2015

The intestinal epithelium as guardian of gut barrier integrity.

Cell Microbiol 2015 Nov 15;17(11):1561-9. Epub 2015 Sep 15.

Institute for Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany.

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http://dx.doi.org/10.1111/cmi.12501DOI Listing
November 2015

Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa.

Gut Microbes 2014 ;5(6):761-5

a Institute of Medical Microbiology and Hospital Epidemiology; Hannover Medical School ; Hannover , Germany.

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http://dx.doi.org/10.4161/19490976.2014.972238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615892PMC
September 2015

Transcriptional profiling of intestinal CD4(+) T cells in the neonatal and adult mice.

Genom Data 2015 Sep 15;5:371-4. Epub 2015 Jul 15.

Institute of Medical Microbiology, RWTH University Hospital, Pauwelsstr. 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.gdata.2015.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583700PMC
September 2015

Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period.

Nat Commun 2015 Jul 21;6:7725. Epub 2015 Jul 21.

1] Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany [2] Institute of Medical Microbiology, RWTH University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.1038/ncomms8725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518322PMC
July 2015

Interleukin-13-mediated paneth cell degranulation and antimicrobial peptide release.

J Innate Immun 2014 19;6(4):530-41. Epub 2014 Feb 19.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1159/000357644DOI Listing
May 2015

Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide.

Gut 2015 Feb 7;64(2):222-32. Epub 2014 May 7.

Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1136/gutjnl-2014-307150DOI Listing
February 2015

Experimental colitis is exacerbated by concomitant infection with Mycobacterium avium ssp. paratuberculosis.

Inflamm Bowel Dis 2014 Nov;20(11):1962-71

*Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany; †Mouse Pathology, Helmholtz Centre for Infection Research, Braunschweig, Germany; ‡Institute for Microbiology, University of Veterinary Medicine Hannover, Hannover, Germany; §Central Facility for Microscopy, Helmholtz Centre for Infection Research, Braunschweig, Germany; ‖Institute of Transplant Immunology, Integrated Research and Treatment Center, Hannover, Germany; and ¶Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1097/MIB.0000000000000157DOI Listing
November 2014

Facts, myths and hypotheses on the zoonotic nature of Mycobacterium avium subspecies paratuberculosis.

Int J Med Microbiol 2014 Oct 25;304(7):858-67. Epub 2014 Jul 25.

Helmholtz Centre for Infection Research, Molecular Immunology, Inhoffenstraße 7, 38124 Braunschweig, Germany.

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http://dx.doi.org/10.1016/j.ijmm.2014.07.006DOI Listing
October 2014

TRIF signaling drives homeostatic intestinal epithelial antimicrobial peptide expression.

J Immunol 2014 Oct 10;193(8):4223-34. Epub 2014 Sep 10.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, D-30625 Hannover, Germany;

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http://dx.doi.org/10.4049/jimmunol.1302708DOI Listing
October 2014

Ontogeny of intestinal epithelial innate immune responses.

Front Immunol 2014 9;5:474. Epub 2014 Oct 9.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School , Hannover , Germany.

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http://dx.doi.org/10.3389/fimmu.2014.00474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191320PMC
October 2014

Age-dependent enterocyte invasion and microcolony formation by Salmonella.

PLoS Pathog 2014 Sep 11;10(9):e1004385. Epub 2014 Sep 11.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1004385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161480PMC
September 2014

Maturation of the enteric mucosal innate immune system during the postnatal period.

Immunol Rev 2014 Jul;260(1):21-34

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/imr.12190DOI Listing
July 2014

Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice.

Inflamm Bowel Dis 2014 Mar;20(3):431-43

*Institute of Laboratory Animal Science, Hannover Medical School, Hannover, Germany; †BioDoc, Hannover, Germany; ‡Department of Physiology, University of Veterinary Medicine Hannover, Hannover, Germany; §Institute for Clinical Biochemistry, Hannover Medical School, Hannover, Germany; ‖Medical Clinic 1, Friedrich-Alexander-University Erlangen-Nuernberg, Erlangen, Germany; ¶Institute of Pharmacology, Hannover Medical School, Hannover, Germany; **Department of Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany; and ††Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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https://academic.oup.com/ibdjournal/article/20/3/431-443/457
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http://dx.doi.org/10.1097/01.MIB.0000441346.86827.edDOI Listing
March 2014

MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury.

EMBO Mol Med 2012 Dec 9;4(12):1308-19. Epub 2012 Nov 9.

Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/emmm.201201298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531605PMC
December 2012

The mammalian intestinal epithelium as integral player in the establishment and maintenance of host-microbial homeostasis.

Semin Immunol 2012 Feb 3;24(1):25-35. Epub 2011 Dec 3.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl-Neuberg Str. 1, D-30625 Hannover, Germany.

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http://dx.doi.org/10.1016/j.smim.2011.11.002DOI Listing
February 2012

Establishment of intestinal homeostasis during the neonatal period.

Cell Mol Life Sci 2011 Nov 28;68(22):3699-712. Epub 2011 Sep 28.

Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://www.springerlink.com/index/G5464X7426U22180.pdf
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http://link.springer.com/content/pdf/10.1007/s00018-011-0831
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http://dx.doi.org/10.1007/s00018-011-0831-2DOI Listing
November 2011

Between vigilance and tolerance: the immune function of the intestinal epithelium.

Cell Mol Life Sci 2011 Nov 4;68(22):3619-21. Epub 2011 Oct 4.

Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://link.springer.com/10.1007/s00018-011-0820-5
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http://dx.doi.org/10.1007/s00018-011-0820-5DOI Listing
November 2011

IFN-lambda determines the intestinal epithelial antiviral host defense.

Proc Natl Acad Sci U S A 2011 May 25;108(19):7944-9. Epub 2011 Apr 25.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 30625 Hannover, Germany.

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http://dx.doi.org/10.1073/pnas.1100552108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093475PMC
May 2011

miR-146a mediates protective innate immune tolerance in the neonate intestine.

Cell Host Microbe 2010 Oct;8(4):358-68

Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 30625 Hannover, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S19313128100030
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http://dx.doi.org/10.1016/j.chom.2010.09.005DOI Listing
October 2010

Cesarean delivery is associated with celiac disease but not inflammatory bowel disease in children.

Pediatrics 2010 Jun 17;125(6):e1433-40. Epub 2010 May 17.

Department of Pediatrics, Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://pediatrics.aappublications.org/content/pediatrics/125
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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2009-2260DOI Listing
June 2010

Internalization-dependent recognition of Mycobacterium avium ssp. paratuberculosis by intestinal epithelial cells.

Cell Microbiol 2009 Dec 13;11(12):1802-15. Epub 2009 Aug 13.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://doi.wiley.com/10.1111/j.1462-5822.2009.01372.x
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http://dx.doi.org/10.1111/j.1462-5822.2009.01372.xDOI Listing
December 2009

O-antigen delays lipopolysaccharide recognition and impairs antibacterial host defense in murine intestinal epithelial cells.

PLoS Pathog 2009 Sep 4;5(9):e1000567. Epub 2009 Sep 4.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1000567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729928PMC
September 2009

The function and biological role of toll-like receptors in infectious diseases: an update.

Curr Opin Infect Dis 2008 Jun;21(3):304-12

Department of Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1097/QCO.0b013e3282f88ba3DOI Listing
June 2008

Developmental switch of intestinal antimicrobial peptide expression.

J Exp Med 2008 Jan 7;205(1):183-93. Epub 2008 Jan 7.

Swedish Institute for Infectious Disease Control, Karolinska Institute, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1084/jem.20071022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234368PMC
January 2008

Cytokine-mediated control of lipopolysaccharide-induced activation of small intestinal epithelial cells.

Immunology 2007 Nov 18;122(3):306-15. Epub 2007 May 18.

Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Clinic of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/j.1365-2567.2007.02639.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266023PMC
November 2007

Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressin.

J Exp Med 2007 Nov 29;204(12):2837-52. Epub 2007 Oct 29.

Institut National de la Santé et de la Recherche Médicale, U773, Centre de Recherche Biomédicale Bichat-Beaujon, BP 416, 75018 Paris, France.

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http://dx.doi.org/10.1084/jem.20071032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118508PMC
November 2007

Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells.

J Exp Med 2006 Apr 10;203(4):973-84. Epub 2006 Apr 10.

Department for Medical Microbiology and Hygiene, University Clinic of Freiburg, 79104 Freiburg, Germany.

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http://dx.doi.org/10.1084/jem.20050625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118301PMC
April 2006

The role of epithelial Toll-like receptor expression in host defense and microbial tolerance.

J Endotoxin Res 2005 ;11(2):124-8

Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany.

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http://dx.doi.org/10.1179/096805105X35224DOI Listing
August 2005

Bacterial evasion of innate defense at epithelial linings.

Chem Immunol Allergy 2005 ;86:72-98

Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany.

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http://dx.doi.org/10.1159/000086652DOI Listing
August 2005

Increased diversity of intestinal antimicrobial peptides by covalent dimer formation.

Nat Immunol 2004 Aug 4;5(8):836-43. Epub 2004 Jul 4.

Institute of Medical Microbiology and Hygiene, University of Freiburg, D-79104 Freiburg, Germany.

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http://dx.doi.org/10.1038/ni1094DOI Listing
August 2004

Growth control of small-colony variants by genetic regulation of the hemin uptake system.

Infect Immun 2004 Apr;72(4):2254-62

Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Department of Bacteriology, University Hospital Grosshadern, Luwig-Maximilian University, D-81377 Munich, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC375170PMC
http://dx.doi.org/10.1128/iai.72.4.2254-2262.2004DOI Listing
April 2004

Persistent infection with Helicobacter pylori and the development of gastric cancer.

Adv Cancer Res 2003 ;90:63-89

Microbiology and Tumor Biology Center and Smittskyddsinstitutet, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/s0065-230x(03)90002-9DOI Listing
February 2004

Bacterial strategies for overcoming host innate and adaptive immune responses.

Nat Immunol 2002 Nov;3(11):1033-40

Microbiology and Tumor Biology Center, Karolinska Institutet, Nobelsväg 16, SE-17177 Stockholm, Sweden.

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http://www.nature.com/articles/ni1102-1033
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http://dx.doi.org/10.1038/ni1102-1033DOI Listing
November 2002