Mathias Jucker

Mathias Jucker

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Mathias Jucker

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Prion-like spreading of Alzheimer's disease within the brain's connectome.

J R Soc Interface 2019 Oct 16;16(159):20190356. Epub 2019 Oct 16.

Living Matter Laboratory, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1098/rsif.2019.0356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833337PMC
October 2019

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease.

Alzheimers Dement 2019 05 4;15(5):655-665. Epub 2019 Mar 4.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511459PMC
May 2019

Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease.

Alzheimers Dement 2018 11 25;14(11):1427-1437. Epub 2018 Sep 25.

Section for Dementia Research, Department of Cellular Neurology, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.

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http://dx.doi.org/10.1016/j.jalz.2018.06.3059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322213PMC
November 2018

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease.

Neurology 2018 10 14;91(14):e1295-e1306. Epub 2018 Sep 14.

From the Department of Neurology (E.M., J.H., V.B., A.M.F., D.M.H., J.C.M., K.P., R.J.B.), Division of Biostatistics (G.W., C.X.), Department of Radiology (B.A.G., T.L.S.B., D.S.M.), and Department of Pathology (N.J.C.), Washington University School of Medicine, Saint Louis, MO; Department of Neuroscience (A.M.J.), Icahn School of Medicine at Mount Sinai, New York, NY; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) (R.A.), Instituto de Investigaciones Neurológicas Raúl Correa, Buenos Aires, Argentina; University of Pittsburgh School of Medicine (S.B.B., W.K.), PA; College of Physicians and Surgeons (J.N.), Columbia University, New York, NY; Department of Neurology (J.R.), Keck School of Medicine of University of Southern California, Los Angeles; Department of Neurology (B.G., M.F.), Indiana University, Indianapolis; Massachusetts General Hospital (R.A.S., J.C.), Harvard Medical School, Boston; Butler Hospital and Brown University (S.S.), Providence, RI; Department of Neurology (N.R.G.-R.), Mayo Clinic Jacksonville, FL; Neuroscience Research Australia (P.R.S.); School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; The Florey Institute and the University of Melbourne (C.M.), Parkville, Australia; Dementia Research Centre, Institute of Neurology (M.N.R., N.C.F.), University College London, UK; German Center for Neurodegenerative Diseases (DZNE) Munich (J.L.); Department of Neurology (J.L.), Ludwig-Maximilians Universität München; German Center for Neurodegenerative Diseases (DZNE) Tübingen (M.J.); and Hertie-Institute for Clinical Brain Research (M.J.), University of Tübingen, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000006277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177272PMC
October 2018

Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases.

Nat Neurosci 2018 10 26;21(10):1341-1349. Epub 2018 Sep 26.

Department of Neurology and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.

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http://www.nature.com/articles/s41593-018-0238-6
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http://dx.doi.org/10.1038/s41593-018-0238-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375686PMC
October 2018

Infectious prions do not induce Aβ deposition in an in vivo seeding model.

Acta Neuropathol 2018 06 16;135(6):965-967. Epub 2018 Apr 16.

German Center for Neurodegenerative Diseases (DZNE), Tübingen, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00401-018-1848-5DOI Listing
June 2018

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging.

Nat Neurosci 2017 Oct 28;20(10):1371-1376. Epub 2017 Aug 28.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1038/nn.4631DOI Listing
October 2017

Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis.

EMBO Rep 2017 09 12;18(9):1536-1544. Epub 2017 Jul 12.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

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http://dx.doi.org/10.15252/embr.201744067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579388PMC
September 2017

Aβ seeds and prions: How close the fit?

Prion 2017 07 28;11(4):215-225. Epub 2017 Jun 28.

d Department of Neurology and Yerkes National Primate Research Center , Emory University , Atlanta , GA , USA.

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http://dx.doi.org/10.1080/19336896.2017.1334029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553305PMC
July 2017

Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition.

Alzheimers Dement 2017 Jun 14;13(6):701-709. Epub 2016 Oct 14.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.09.005DOI Listing
June 2017

The Exceptional Vulnerability of Humans to Alzheimer's Disease.

Trends Mol Med 2017 06 5;23(6):534-545. Epub 2017 May 5.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, and the German Center for Neurodegenerative Diseases (DZNE), D-72076 Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521004PMC
June 2017

Immune receptor for pathogenic α-synuclein.

Science 2016 09;353(6307):1498-1499

Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1126/science.aai9377DOI Listing
September 2016

The Prion-Like Properties of Amyloid-β Assemblies: Implications for Alzheimer's Disease.

Cold Spring Harb Perspect Med 2016 07 1;6(7). Epub 2016 Jul 1.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany German Center for Neurodegenerative Diseases (DZNE), D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1101/cshperspect.a024398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930920PMC
July 2016

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Neuron 2016 07 9;91(1):56-66. Epub 2016 Jun 9.

German Center for Neurodegenerative Diseases (DZNE), Tuebingen, D-72076 Tuebingen, Germany; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, D-72076 Tuebingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.05.018DOI Listing
July 2016

The Malignant Protein Puzzle.

Cerebrum 2016 Mar-Apr;2016. Epub 2016 Mar 1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938261PMC
July 2016

Highly potent intracellular membrane-associated Aβ seeds.

Sci Rep 2016 06 17;6:28125. Epub 2016 Jun 17.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1038/srep28125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911570PMC
June 2016

Cerebral β-Amyloidosis in Mice Investigated by Ultramicroscopy.

PLoS One 2015 27;10(5):e0125418. Epub 2015 May 27.

Department of Bioelectronics, FKE, Vienna University of Technology, Vienna, Austria; Section of Bioelectronics, Center for Brain Research (MUW), Vienna, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125418PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446269PMC
May 2016

Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model.

J Neurosci 2016 05;36(18):5084-93

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen D-72076, Germany, DZNE, German Center for Neurodegenerative Diseases, Tübingen D-72076, Germany,

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http://dx.doi.org/10.1523/JNEUROSCI.0258-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601857PMC
May 2016

Progression of Seed-Induced Aβ Deposition within the Limbic Connectome.

Brain Pathol 2015 Nov 24;25(6):743-52. Epub 2015 Mar 24.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1111/bpa.12252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530099PMC
November 2015

Persistence of Aβ seeds in APP null mouse brain.

Nat Neurosci 2015 Nov 9;18(11):1559-61. Epub 2015 Sep 9.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1038/nn.4117DOI Listing
November 2015

Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease.

J Exp Med 2015 Oct 12;212(11):1803-9. Epub 2015 Oct 12.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany

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http://dx.doi.org/10.1084/jem.20150478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612086PMC
October 2015

Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease.

Neurology 2015 Sep 5;85(9):790-8. Epub 2015 Aug 5.

From the Departments of Neurology (F.W., D.C.R., S.M., A.M.F., N.J.C., J.C.M., R.J.B.), Radiology (B.A.G., D.S.M., T.L.S.B.), Biostatistics (C.X.), Psychology (J.H.), Neurological Surgery (T.L.S.B.), and Psychiatry (A.G.), Washington University School of Medicine, Saint Louis, MO; Department of Neurology (E.M.), University of Pittsburgh, PA; Mary S. Easton Center for Alzheimer's Disease Research at UCLA (J.M.R.), Los Angeles, CA; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; Department of Pathology and Laboratory Medicine (B.G.) and Department of Neurology (M.R.F.), Indiana University School of Medicine, Indianapolis; Center for Alzheimer Research and Treatment (R.S.), Brigham and Women's Hospital and Massachusetts General Hospital, Boston, MA; Department of Neurology (S.S.), Butler Hospital and Warren Alpert Medical School, Brown University, Providence, RI; Neuroscience Research Australia (P.R.S.) and University of New South Wales, Sydney, Australia; Mental Health Research Institute (C.L.M.), University of Melbourne, Parkville, Australia; Centre of Excellence for Alzheimer's Disease Research and Care (R.N.M.), School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, Australia; Dementia Research Centre (M.N.R., C.A.S.L.), UCL Institute of Neurology, London, UK; German Center for Neurodegenerative Diseases (M.J.) and Hertie Institute for Clinical Brain Research, Tübingen, Germany; Neurologische Klinik Ludwig-Maximilians-Universität Munich (A.D.) and German Center for Neurodegenerative Diseases (S.F.), Klinik und Poliklinik für Nuklearmedizin & TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; and Department of Neurology (F.W.), Xuan Wu Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1212/WNL.0000000000001903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553024PMC
September 2015

Neurodegeneration: Amyloid-β pathology induced in humans.

Nature 2015 Sep;525(7568):193-4

Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1038/525193aDOI Listing
September 2015

Neurodegenerative diseases: expanding the prion concept.

Annu Rev Neurosci 2015 Jul 30;38:87-103. Epub 2015 Mar 30.

Yerkes National Primate Research Center and.

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http://dx.doi.org/10.1146/annurev-neuro-071714-033828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803040PMC
July 2015

Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.

Neurobiol Aging 2015 Jul 25;36(7):2241-2247. Epub 2015 Mar 25.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457564PMC
July 2015

Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models.

EMBO Mol Med 2015 Jul;7(7):895-903

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research University of Tübingen, Tübingen, Germany DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany

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http://dx.doi.org/10.15252/emmm.201505026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520655PMC
July 2015

Blood platelets in the progression of Alzheimer's disease.

PLoS One 2014 28;9(2):e90523. Epub 2014 Feb 28.

Department of Clinical and Experimental Hemostasis, Hemotherapy and Transfusion Medicine, Heinrich-Heine-University, Düsseldorf, Germany ; Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard-Karls-Universität, Tübingen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090523PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938776PMC
June 2015

Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts.

Acta Neuropathol 2015 Jan 4;129(1):157-9. Epub 2014 Nov 4.

German Center for Neurodegenerative Diseases (DZNE), 72076, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00401-014-1360-5DOI Listing
January 2015

Aβ seeds resist inactivation by formaldehyde.

Acta Neuropathol 2014 Oct 6;128(4):477-84. Epub 2014 Sep 6.

German Center for Neurodegenerative Diseases (DZNE), 72076, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00401-014-1339-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169116PMC
October 2014

Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.

J Neurosci 2014 Jul;34(31):10264-73

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany, German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany, and

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http://dx.doi.org/10.1523/JNEUROSCI.1608-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608275PMC
July 2014

Homeostatic and injury-induced microglia behavior in the aging brain.

Aging Cell 2014 Feb 18;13(1):60-9. Epub 2013 Sep 18.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076, Tübingen, Germany.

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http://dx.doi.org/10.1111/acel.12149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326865PMC
February 2014

Membrane-anchored Aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice.

J Neurosci 2013 Dec;33(49):19284-94

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany, Graduate School for Cellular and Molecular Neuroscience, University of Tübingen, D-72076 Tübingen, Germany, German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany, and Animal Health and Veterinary Laboratories Agency, Lasswade Laboratory, Penicuik EH26 0PZ, Midlothian, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.2542-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618790PMC
December 2013

Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice.

EMBO Rep 2013 Nov 3;14(11):1017-22. Epub 2013 Sep 3.

1] Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany [2] DZNE, German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1038/embor.2013.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818077PMC
November 2013

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.

Nature 2013 Sep;501(7465):45-51

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://www.nature.com/articles/nature12481
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http://dx.doi.org/10.1038/nature12481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963807PMC
September 2013

Replacement of osmotic minipumps to extend the intracerebral infusion time of compounds into the mouse brain.

Biotechniques 2013 Aug;55(2):75-8

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.2144/000114064DOI Listing
August 2013

Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein.

Sci Transl Med 2013 Jul;5(194):194re2

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1126/scitranslmed.3006446DOI Listing
July 2013

Seeds of dementia.

Sci Am 2013 May;308(5):52-7

Yerkes National Primate Research Center, USA.

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http://dx.doi.org/10.1038/scientificamerican0513-52DOI Listing
May 2013

Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes.

Am J Pathol 2012 Dec 4;181(6):1953-60. Epub 2012 Oct 4.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Mueller Strasse 2, Tübingen, Germany.

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http://dx.doi.org/10.1016/j.ajpath.2012.08.031DOI Listing
December 2012

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.

Proc Natl Acad Sci U S A 2012 Oct 15;109(44):18150-5. Epub 2012 Oct 15.

German Center for Neurodegenerative Diseases, DZNE, and Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.

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http://dx.doi.org/10.1073/pnas.1210150109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497743PMC
October 2012

Repeatable target localization for long-term in vivo imaging of mice with 2-photon microscopy.

J Neurosci Methods 2012 Apr 6;205(2):357-63. Epub 2011 Nov 6.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1016/j.jneumeth.2011.10.029DOI Listing
April 2012

Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats.

J Neurochem 2012 Mar 18;120(5):660-6. Epub 2011 Nov 18.

Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07551.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293176PMC
March 2012

The amyloid state of proteins in human diseases.

Cell 2012 Mar;148(6):1188-203

Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, Los Angeles CA 90095-1570, USA.

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http://dx.doi.org/10.1016/j.cell.2012.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353745PMC
March 2012

The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain.

Acta Neuropathol 2012 Jan 20;123(1):31-7. Epub 2011 Nov 20.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00401-011-0912-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297471PMC
January 2012

Early onset amyloid lesions lead to severe neuritic abnormalities and local, but not global neuron loss in APPPS1 transgenic mice.

Neurobiol Aging 2011 Dec 22;32(12):2324.e1-6. Epub 2010 Oct 22.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.08.014DOI Listing
December 2011

BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).

J Biol Chem 2011 Oct 26;286(43):37446-57. Epub 2011 Aug 26.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1074/jbc.M111.288373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199491PMC
October 2011

Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition.

J Neurosci 2011 Oct;31(41):14488-95

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.3088-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229270PMC
October 2011

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders.

Ann Neurol 2011 Oct;70(4):532-40

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1002/ana.22615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203752PMC
October 2011

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.

Alzheimers Dement 2011 Jul;7(4):386-395.e6

Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2011.05.2243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710290PMC
July 2011

Amyloid by default.

Nat Neurosci 2011 Jun;14(6):669-70

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http://dx.doi.org/10.1038/nn.2853DOI Listing
June 2011

The accessible cerebral vascular proteome in a mouse model of cerebral β-amyloidosis.

J Proteomics 2011 Apr 22;74(4):539-46. Epub 2011 Jan 22.

Department of Chemistry and Applied Biosciences, ETH Zürich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.jprot.2011.01.010DOI Listing
April 2011

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

Science 2010 Nov 21;330(6006):980-2. Epub 2010 Oct 21.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233904PMC
November 2010

The benefits and limitations of animal models for translational research in neurodegenerative diseases.

Authors:
Mathias Jucker

Nat Med 2010 Nov 21;16(11):1210-4. Epub 2010 Sep 21.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1038/nm.2224DOI Listing
November 2010

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.

Proc Natl Acad Sci U S A 2010 Apr 12;107(17):7969-74. Epub 2010 Apr 12.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1073/pnas.1001056107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867864PMC
April 2010

Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice.

Neurobiol Aging 2009 Aug 20;30(8):1227-37. Epub 2008 Feb 20.

Zentrum für Neuropathologie und Prionforschung, Ludwig-Maximilians Universität, München, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.10.016DOI Listing
August 2009

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation.

Proc Natl Acad Sci U S A 2009 Aug 21;106(31):12926-31. Epub 2009 Jul 21.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1073/pnas.0903200106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722323PMC
August 2009

Independent effects of intra- and extracellular Abeta on learning-related gene expression.

Am J Pathol 2009 Jul;175(1):271-82

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Germany.

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http://dx.doi.org/10.2353/ajpath.2009.090044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708813PMC
July 2009

E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition.

Am J Pathol 2009 Mar 13;174(3):722-6. Epub 2009 Feb 13.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller Strasse 27, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.2353/ajpath.2009.080790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665734PMC
March 2009

Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist.

Neuron 2008 Jul;59(1):8-10

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1016/j.neuron.2008.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676343PMC
July 2008

Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis.

Am J Pathol 2008 Jun 8;172(6):1520-8. Epub 2008 May 8.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.2353/ajpath.2008.060520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408413PMC
June 2008

Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance.

J Neurosci 2008 Apr;28(16):4283-92

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.4814-07.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844768PMC
April 2008

The value of incomplete mouse models of Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2008 Mar;35 Suppl 1:S70-4

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller Strasse 27, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00259-007-0704-yDOI Listing
March 2008

Cystatin C modulates cerebral beta-amyloidosis.

Nat Genet 2007 Dec 18;39(12):1437-9. Epub 2007 Nov 18.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller Strasse 27, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1038/ng.2007.23DOI Listing
December 2007

Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice.

Am J Pathol 2007 Dec 30;171(6):2012-20. Epub 2007 Nov 30.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller Str.27, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.2353/ajpath.2007.070403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111123PMC
December 2007

BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice.

Neurodegener Dis 2007 ;4(2-3):127-35

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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https://www.karger.com/Article/FullText/101837
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October 2007

MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier.

Brain Pathol 2007 Oct 4;17(4):347-53. Epub 2007 Jul 4.

Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University, Greifswald, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2007.00075.xDOI Listing
October 2007

Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin.

Mol Biol Cell 2007 Sep 11;18(9):3591-600. Epub 2007 Jul 11.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1091/mbc.e07-01-0035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951756PMC
September 2007

Lesion-induced axonal sprouting in the central nervous system.

Adv Exp Med Biol 2006 ;557:101-21

Institute of Clinical Neuroanatomy, Johann Wolfgang Goether-University, Frankfurt am Main, Germany.

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http://link.springer.com/10.1007/0-387-30128-3_6
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October 2006

Inducible proteopathies.

Trends Neurosci 2006 Aug 27;29(8):438-43. Epub 2006 Jun 27.

Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.tins.2006.06.010DOI Listing
August 2006

Koch's postulates and infectious proteins.

Acta Neuropathol 2006 Jul 16;112(1):1-4. Epub 2006 May 16.

Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA, 30322, USA.

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July 2006