Publications by authors named "Mathias Heikenwalder"

100Publications

PKCλ/ι Loss Induces Metabolic Reprogramming in Liver Cancer: Hitting Two Birds with One Stone?

Cancer Cell 2020 Aug;38(2):152-154

Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.07.003DOI Listing
August 2020

Mucosal or systemic microbiota exposures shape the B cell repertoire.

Nature 2020 08 5;584(7820):274-278. Epub 2020 Aug 5.

Maurice Müller Laboratories (DBMR), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1038/s41586-020-2564-6DOI Listing
August 2020

Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota.

Gut Microbes 2020 Jul 30;11(4):1077-1091. Epub 2020 Mar 30.

Microbiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences , Toledo, OH, USA.

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http://dx.doi.org/10.1080/19490976.2020.1743492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524287PMC
July 2020

Platelets in chronic liver disease, from bench to bedside.

JHEP Rep 2019 Dec 25;1(6):448-459. Epub 2019 Oct 25.

Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jhepr.2019.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005648PMC
December 2019

Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis.

Cell Death Dis 2020 02 3;11(2):80. Epub 2020 Feb 3.

Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/s41419-020-2283-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997423PMC
February 2020

Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice.

Gastroenterology 2020 05 28;158(6):1762-1775.e9. Epub 2020 Jan 28.

Institute of Virology, Technical University of Münich, Helmholtz Zentrum München, Münich, Germany; German Center for Infection Research, Münich, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.01.032DOI Listing
May 2020

Novel patient-derived preclinical models of liver cancer.

J Hepatol 2020 02;72(2):239-249

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, USA; Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, USA; Graduate School of Biomedical Sciences at Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.09.028DOI Listing
February 2020

A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.

J Hepatol 2020 May 15;72(5):960-975. Epub 2020 Jan 15.

Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Virology, Technical University of Munich and Helmholtz Zentrum München, Schneckenburgerstrasse 8, 81675 Munich, Germany; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.12.019DOI Listing
May 2020

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.

Cancer Cell 2019 09;36(3):250-267.e9

Institute of Virology, Technical University of Munich, 81675 Munich, Germany; Helmholtz Center Munich, 85764 Neuherberg, Germany; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.08.001DOI Listing
September 2019

The uric acid crystal receptor Clec12A potentiates type I interferon responses.

Proc Natl Acad Sci U S A 2019 09 26;116(37):18544-18549. Epub 2019 Aug 26.

Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany;

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http://dx.doi.org/10.1073/pnas.1821351116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744871PMC
September 2019

An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents.

Gastroenterology 2019 11 22;157(5):1383-1397.e11. Epub 2019 Jul 22.

Liver Cancer Translational Research Liver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Liver Unit, Universitat de Barcelona, Barcelona, Catalonia, Spain; Mount Sinai Liver Cancer Program, Department of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, USA; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815707PMC
November 2019

The role of polarisation of circulating tumour cells in cancer metastasis.

Cell Mol Life Sci 2019 Oct 19;76(19):3765-3781. Epub 2019 Jun 19.

Department of Molecular Biology and Genetics, Aarhus University, 8000, Aarhus, Denmark.

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http://dx.doi.org/10.1007/s00018-019-03169-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744547PMC
October 2019

Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection.

Sci Rep 2019 06 11;9(1):8492. Epub 2019 Jun 11.

Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, 81567, Germany.

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http://dx.doi.org/10.1038/s41598-019-44922-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560178PMC
June 2019

From NASH to HCC: current concepts and future challenges.

Nat Rev Gastroenterol Hepatol 2019 07;16(7):411-428

Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://www.nature.com/articles/s41575-019-0145-7
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http://dx.doi.org/10.1038/s41575-019-0145-7DOI Listing
July 2019

Characterization of HCC Mouse Models: Towards an Etiology-Oriented Subtyping Approach.

Mol Cancer Res 2019 07 9;17(7):1493-1502. Epub 2019 Apr 9.

Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1045DOI Listing
July 2019

PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice.

Antiviral Res 2019 01 12;161:134-143. Epub 2018 Nov 12.

Institute of Virology, Technische Universität München/Helmholtz Zentrum München, 81675, Munich, Germany; German Center for Infection Research (DZIF), Munich Partner Site, 81675, Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01663542183045
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http://dx.doi.org/10.1016/j.antiviral.2018.11.003DOI Listing
January 2019

When Soluble Fibers Meet Hepatocellular Carcinoma: The Dark Side of Fermentation.

Cell Metab 2018 11;28(5):673-675

Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, 81675 Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183064
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http://dx.doi.org/10.1016/j.cmet.2018.10.009DOI Listing
November 2018

Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice.

Nutr Metab (Lond) 2018 26;15:65. Epub 2018 Sep 26.

1Else Kroener-Fresenius-Center for Nutritional Medicine, Chair of Nutritional Medicine, Technical University of Munich, Freising, Germany.

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https://nutritionandmetabolism.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12986-018-0291-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158869PMC
September 2018

Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis.

Gastroenterology 2018 11 29;155(5):1539-1552.e12. Epub 2018 Jul 29.

Chair of Nutrition and Immunology, Technische Universität München, Freising, Germany; ZIEL -Institute for Food & Health, Technische Universität München, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.07.028DOI Listing
November 2018

Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance.

J Nutr Biochem 2018 07 7;57:189-196. Epub 2018 Apr 7.

Joint Research Division Molecular Metabolic Control, German Cancer Research Center, Center for Molecular Biology, Heidelberg University and Heidelberg University Hospital, 69120 Heidelberg, Germany; Nutrient Metabolism and Signalling Lab, Dept. of Biochemistry and Molecular Biology, School of Biomedical Sciences, and Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Clayton, 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2018.03.027DOI Listing
July 2018

The immunology of hepatocellular carcinoma.

Nat Immunol 2018 03 29;19(3):222-232. Epub 2018 Jan 29.

Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41590-018-0044-zDOI Listing
March 2018

Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression.

Cell Syst 2018 Jan 13;6(1):75-89.e11. Epub 2017 Dec 13.

Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany; Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.11.010DOI Listing
January 2018

Intrinsic and environmental factors in intrahepatic cholangiocarcinoma development.

Oncoscience 2017 Sep 1;4(9-10):117-119. Epub 2017 Oct 1.

Department of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology (SIBET), Chinese Academy of Sciences, Suzhou, China.

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http://dx.doi.org/10.18632/oncoscience.365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672891PMC
September 2017

Learning the Roles of the Hepatic Adaptive Immune System in Hepatocellular Carcinoma-Nature's Guide for Successful Cancer Immunotherapy.

Semin Liver Dis 2017 08 28;37(3):210-218. Epub 2017 Aug 28.

The Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1055/s-0037-1606255DOI Listing
August 2017

Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis.

Am J Pathol 2017 Nov 17;187(11):2558-2569. Epub 2017 Aug 17.

Institute of Pharmaceutical Sciences, ETH Zurich (Swiss Federal Institute of Technology), Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.07.008DOI Listing
November 2017

Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation.

Gut 2018 09 3;67(9):1663-1673. Epub 2017 Aug 3.

Department of Visceral and Transplantation Surgery, Swiss HPB Centre, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1136/gutjnl-2016-313458DOI Listing
September 2018

Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer.

Eur J Immunol 2017 08 4;47(8):1342-1353. Epub 2017 Jul 4.

Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1002/eji.201646765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600091PMC
August 2017

miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression.

Gut 2018 06 5;67(6):1124-1134. Epub 2017 Apr 5.

The Silberman Institute of Life Sciences and the Edmond and Lily Safra Center for Brain Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, Israel.

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http://dx.doi.org/10.1136/gutjnl-2016-312869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969364PMC
June 2018

The Liver at the Nexus of Host-Microbial Interactions.

Cell Host Microbe 2016 Nov;20(5):561-571

Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland. Electronic address:

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http://www.cell.com/cell-host-microbe/pdf/S1931-3128(16)3044
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http://dx.doi.org/10.1016/j.chom.2016.10.016DOI Listing
November 2016

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression.

Cancer Cell 2016 10;30(4):533-547

Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.09.003DOI Listing
October 2016

Immune receptor for pathogenic α-synuclein.

Science 2016 09;353(6307):1498-1499

Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1126/science.aai9377DOI Listing
September 2016

Focal and Local: Ectopic Lymphoid Structures and Aggregates of Myeloid and Other Immune Cells in Liver.

Gastroenterology 2016 11 28;151(5):780-783. Epub 2016 Sep 28.

Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg and Institute of Virology, Technische Universität München, Helmholtz Zentrum München, Munich, Germany.

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http://dx.doi.org/10.1053/j.gastro.2016.09.029DOI Listing
November 2016

Bcl-xL is an oncogenic driver in colorectal cancer.

Cell Death Dis 2016 08 18;7(8):e2342. Epub 2016 Aug 18.

National Center for Tumor Diseases, Department of Medical Oncology and Heidelberg University Hospital, Internal Medicine VI, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/cddis.2016.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108319PMC
August 2016

Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma.

Cancer Res 2016 09 3;76(18):5550-61. Epub 2016 Aug 3.

Department of Internal Medicine I, University Hospital Tuebingen, Tuebingen, Germany. Department for Clinical Pharmacology, University Hospital Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3453DOI Listing
September 2016

Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA.

EMBO Mol Med 2016 09 1;8(9):1082-98. Epub 2016 Sep 1.

Department of Infectious Diseases/Virology, Cluster of Excellence CellNetworks, Heidelberg University Hospital, Heidelberg, Germany BioQuant, University of Heidelberg, Heidelberg, Germany

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http://dx.doi.org/10.15252/emmm.201506172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009812PMC
September 2016

RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells.

Cancer Cell 2016 07;30(1):75-91

III. Medical Department for Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.06.002DOI Listing
July 2016

P(URI)fying Novel Drivers of NASH and HCC: A Feedforward Loop of IL17A via White Adipose Tissue.

Cancer Cell 2016 07;30(1):15-17

Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich 81675, Germany; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.06.010DOI Listing
July 2016

Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation.

Diabetologia 2016 09 7;59(9):2005-12. Epub 2016 Jun 7.

Lehrstuhl für Molekulare Ernährungsmedizin and Else Kröner-Fresenius Center, Technische Universität München, Gregor-Mendel-Str. 2, 85354, Freising (Weihenstephan), Germany.

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http://dx.doi.org/10.1007/s00125-016-4004-6DOI Listing
September 2016

Lymphotoxin β receptor signalling executes -driven gastric inflammation in a T4SS-dependent manner.

Gut 2017 08 13;66(8):1369-1381. Epub 2016 Apr 13.

Institut für Virologie, Technische Universität München, Helmholtz Zentrum München, Neuherberg, Germany.

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http://dx.doi.org/10.1136/gutjnl-2015-310783DOI Listing
August 2017

The maternal microbiota drives early postnatal innate immune development.

Science 2016 Mar;351(6279):1296-302

Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland.

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http://www.sciencemag.org/cgi/doi/10.1126/science.aad2571
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http://dx.doi.org/10.1126/science.aad2571DOI Listing
March 2016

NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.

Nature 2016 Mar 2;531(7593):253-7. Epub 2016 Mar 2.

Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature16969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786464PMC
March 2016