Publications by authors named "Mathias Frederiksen"

16Publications

The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.

Authors:
Carrow I Wells Hassan Al-Ali David M Andrews Christopher R M Asquith Alison D Axtman Ivan Dikic Daniel Ebner Peter Ettmayer Christian Fischer Mathias Frederiksen Robert E Futrell Nathanael S Gray Stephanie B Hatch Stefan Knapp Ulrich Lücking Michael Michaelides Caitlin E Mills Susanne Müller Dafydd Owen Alfredo Picado Kumar S Saikatendu Martin Schröder Alexandra Stolz Mariana Tellechea Brandon J Turunen Santiago Vilar Jinhua Wang William J Zuercher Timothy M Willson David H Drewry

Int J Mol Sci 2021 Jan 8;22(2). Epub 2021 Jan 8.

Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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January 2021

Systematic Chemogenetic Library Assembly.

Authors:
Stephen M Canham Yuan Wang Allen Cornett Douglas S Auld Daniel K Baeschlin Maude Patoor Philip R Skaanderup Ayako Honda Luis Llamas Greg Wendel Felipa A Mapa Peter Aspesi Nancy Labbé-Giguère Gabriel G Gamber Daniel S Palacios Ansgar Schuffenhauer Zhan Deng Florian Nigsch Mathias Frederiksen Simon M Bushell Deborah Rothman Rishi K Jain Horst Hemmerle Karin Briner Jeffery A Porter John A Tallarico Jeremy L Jenkins

Cell Chem Biol 2020 Sep 23;27(9):1124-1129. Epub 2020 Jul 23.

Novartis Institute for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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September 2020

IRF2 is a master regulator of human keratinocyte stem cell fate.

Authors:
Nicolas Mercado Gabi Schutzius Christian Kolter David Estoppey Sebastian Bergling Guglielmo Roma Caroline Gubser Keller Florian Nigsch Adrian Salathe Remi Terranova John Reece-Hoyes John Alford Carsten Russ Judith Knehr Dominic Hoepfner Alexandra Aebi Heinz Ruffner Tanner C Beck Sajjeev Jagannathan Calla M Olson Hadley E Sheppard Selma Z Elsarrag Tewis Bouwmeester Mathias Frederiksen Felix Lohmann Charles Y Lin Susan Kirkland

Nat Commun 2019 10 14;10(1):4676. Epub 2019 Oct 14.

Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056, Basel, Switzerland.

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October 2019

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors.

Authors:
Siem Jakob Veenstra Heinrich Rueeger Markus Voegtle Rainer Lueoend Philipp Holzer Konstanze Hurth Marina Tintelnot-Blomley Mathias Frederiksen Jean-Michel Rondeau Laura Jacobson Matthias Staufenbiel Ulf Neumann Rainer Machauer

Bioorg Med Chem Lett 2018 07 3;28(12):2195-2200. Epub 2018 May 3.

Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland. Electronic address:

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July 2018

Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization.

Authors:
Ewa Surdziel Ieuan Clay Florian Nigsch Anke Thiemeyer Cyril Allard Gregory Hoffman John S Reece-Hoyes Tanushree Phadke Romain Gambert Caroline Gubser Keller Marie-Gabrielle Ludwig Birgit Baumgarten Mathias Frederiksen Dirk Schübeler Klaus Seuwen Tewis Bouwmeester Barna D Fodor

PLoS One 2017 24;12(8):e0183679. Epub 2017 Aug 24.

Novartis Institutes for Biomedical Research, Basel, Switzerland.

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October 2017

Progress towards a public chemogenomic set for protein kinases and a call for contributions.

Authors:
David H Drewry Carrow I Wells David M Andrews Richard Angell Hassan Al-Ali Alison D Axtman Stephen J Capuzzi Jonathan M Elkins Peter Ettmayer Mathias Frederiksen Opher Gileadi Nathanael Gray Alice Hooper Stefan Knapp Stefan Laufer Ulrich Luecking Michael Michaelides Susanne Müller Eugene Muratov R Aldrin Denny Kumar S Saikatendu Daniel K Treiber William J Zuercher Timothy M Willson

PLoS One 2017 2;12(8):e0181585. Epub 2017 Aug 2.

Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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October 2017

Corrigendum: The promise and peril of chemical probes.

Authors:
Cheryl H Arrowsmith James E Audia Christopher Austin Jonathan Baell Jonathan Bennett Julian Blagg Chas Bountra Paul E Brennan Peter J Brown Mark E Bunnage Carolyn Buser-Doepner Robert M Campbell Adrian J Carter Philip Cohen Robert A Copeland Ben Cravatt Jayme L Dahlin Dashyant Dhanak Aled M Edwards Mathias Frederiksen Stephen V Frye Nathanael Gray Charles E Grimshaw David Hepworth Trevor Howe Kilian V M Huber Jian Jin Stefan Knapp Joanne D Kotz Ryan G Kruger Derek Lowe Mary M Mader Brian Marsden Anke Mueller-Fahrnow Susanne Müller Ronan C O'Hagan John P Overington Dafydd R Owen Saul H Rosenberg Ruth Ross Bryan Roth Matthieu Schapira Stuart L Schreiber Brian Shoichet Michael Sundström Giulio Superti-Furga Jack Taunton Leticia Toledo-Sherman Chris Walpole Michael A Walters Timothy M Willson Paul Workman Robert N Young William J Zuercher

Nat Chem Biol 2015 Nov;11(11):887

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November 2015

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.

Authors:
Stephen B Helliwell Shantanu Karkare Marc Bergdoll Alain Rahier Juliet R Leighton-Davis Celine Fioretto Thomas Aust Ireos Filipuzzi Mathias Frederiksen John Gounarides Dominic Hoepfner Andreas Hofmann Pierre-Eloi Imbert Rolf Jeker Richard Knochenmuss Philipp Krastel Anais Margerit Klaus Memmert Charlotte V Miault N Rao Movva Alban Muller Hans-Ulrich Naegeli Lukas Oberer Vivian Prindle Ralph Riedl Sven Schuierer Jessica A Sexton Jianshi Tao Trixie Wagner Hong Yin Juan Zhang Silvio Roggo Stefan Reinker Christian N Parker

Nat Commun 2015 Oct 12;6:8613. Epub 2015 Oct 12.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland.

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October 2015

The promise and peril of chemical probes.

Authors:
Cheryl H Arrowsmith James E Audia Christopher Austin Jonathan Baell Jonathan Bennett Julian Blagg Chas Bountra Paul E Brennan Peter J Brown Mark E Bunnage Carolyn Buser-Doepner Robert M Campbell Adrian J Carter Philip Cohen Robert A Copeland Ben Cravatt Jayme L Dahlin Dashyant Dhanak Aled M Edwards Mathias Frederiksen Stephen V Frye Nathanael Gray Charles E Grimshaw David Hepworth Trevor Howe Kilian V M Huber Jian Jin Stefan Knapp Joanne D Kotz Ryan G Kruger Derek Lowe Mary M Mader Brian Marsden Anke Mueller-Fahrnow Susanne Müller Ronan C O'Hagan John P Overington Dafydd R Owen Saul H Rosenberg Bryan Roth Brian Roth Ruth Ross Matthieu Schapira Stuart L Schreiber Brian Shoichet Michael Sundström Giulio Superti-Furga Jack Taunton Leticia Toledo-Sherman Chris Walpole Michael A Walters Timothy M Willson Paul Workman Robert N Young William J Zuercher

Nat Chem Biol 2015 Aug;11(8):536-41

1] UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Structural Genomics Consortium, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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August 2015

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.

Authors:
Dominic Hoepfner Stephen B Helliwell Heather Sadlish Sven Schuierer Ireos Filipuzzi Sophie Brachat Bhupinder Bhullar Uwe Plikat Yann Abraham Marc Altorfer Thomas Aust Lukas Baeriswyl Raffaele Cerino Lena Chang David Estoppey Juerg Eichenberger Mathias Frederiksen Nicole Hartmann Annika Hohendahl Britta Knapp Philipp Krastel Nicolas Melin Florian Nigsch Edward J Oakeley Virginie Petitjean Frank Petersen Ralph Riedl Esther K Schmitt Frank Staedtler Christian Studer John A Tallarico Stefan Wetzel Mark C Fishman Jeffrey A Porter N Rao Movva

Microbiol Res 2014 Feb-Mar;169(2-3):107-20. Epub 2013 Dec 1.

Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland.

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September 2014

An integrated approach for identification and target validation of antifungal compounds active against Erg11p.

Authors:
Dominic Hoepfner Shantanu Karkare Stephen B Helliwell Martin Pfeifer Markus Trunzer Sophie De Bonnechose Alfred Zimmerlin Jianshi Tao Daryl Richie Andreas Hofmann Stefan Reinker Mathias Frederiksen N Rao Movva Jeffrey A Porter Neil S Ryder Christian N Parker

Antimicrob Agents Chemother 2012 Aug 21;56(8):4233-40. Epub 2012 May 21.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland.

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August 2012

Detecting S-adenosyl-L-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay.

Authors:
Ying Lin Hong Fan Mathias Frederiksen Kehao Zhao Lei Jiang Zhaofu Wang Shaolian Zhou Weihui Guo Jun Gao Shu Li Edmund Harrington Peter Meier Clemens Scheufler Yao-Chang Xu Peter Atadja Chris Lu En Li X Justin Gu

Anal Biochem 2012 Apr 27;423(1):171-7. Epub 2012 Jan 27.

China Novartis Institute for Biomedical Research, Pudong New Area, Shanghai 201203, China.

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April 2012

Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.

Authors:
Albert Enz Dominik Feuerbach Mathias U Frederiksen Conrad Gentsch Konstanze Hurth Werner Müller Joachim Nozulak Bernard L Roy

Bioorg Med Chem Lett 2009 Mar 7;19(5):1287-91. Epub 2009 Feb 7.

Novartis Institutes for Biomedical Research, Neuroscience Disease Area, 4002 Basel, Switzerland.

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March 2009

Ruthenium-catalyzed reactions--a treasure trove of atom-economic transformations.

Authors:
Barry M Trost Mathias U Frederiksen Michael T Rudd

Angew Chem Int Ed Engl 2005 Oct;44(41):6630-66

Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.

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October 2005

Dinuclear asymmetric Zn aldol additions: formal asymmetric synthesis of fostriecin.

Authors:
Barry M Trost Mathias U Frederiksen Julien P N Papillon Paul E Harrington Seunghoon Shin Brock T Shireman

J Am Chem Soc 2005 Mar;127(11):3666-7

Department of Chemistry, Stanford University, Stanford, California, 94305-5080, USA.

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March 2005

Palladium-catalyzed asymmetric allylation of prochiral nucleophiles: synthesis of 3-allyl-3-aryl oxindoles.

Authors:
Barry M Trost Mathias U Frederiksen

Angew Chem Int Ed Engl 2004 Dec;44(2):308-10

Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.

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December 2004