Mathew Sloane

Disruption of a -35 kb Enhancer Impairs CTCF Binding and Expression in Colorectal Cells.

Authors:

Qing Liu Julie A I Thoms Andrea C Nunez Yizhou Huang Kathy Knezevic Deborah Packham Rebecca C Poulos Rachel Williams Dominik Beck Nicholas J Hawkins Robyn L Ward Jason W H Wong Luke B Hesson Mathew A Sloane John E Pimanda

Clin Cancer Res 2018 09 13;24(18):4602-4611. Epub 2018 Jun 13.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Sydney, Sydney, New South Wales, Australia.

View Article and Find Full Text PDF

September 2018

Pathogenic germline MCM9 variants are rare in Australian Lynch-like syndrome patients.

Authors:

Qing Liu Luke B Hesson Andrea C Nunez Deborah Packham Nicholas J Hawkins Robyn L Ward Mathew A Sloane

Cancer Genet 2016 Nov 11;209(11):497-500. Epub 2016 Oct 11.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Australia, Sydney, New South Wales 2052, Australia. Electronic address:

View Article and Find Full Text PDF

November 2016

Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors.

Authors:

Luke B Hesson Benedict Ng Peter Zarzour Sameer Srivastava Chau-To Kwok Deborah Packham Andrea C Nunez Dominik Beck Regina Ryan Ashraf Dower Caroline E Ford John E Pimanda Mathew A Sloane Nicholas J Hawkins Michael J Bourke Jason W H Wong Robyn L Ward

Mol Cancer Res 2016 12 26;14(12):1217-1228. Epub 2016 Sep 26.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Australia, Sydney, New South Wales, Australia.

View Article and Find Full Text PDF

December 2016

The molecular characteristics of colonic neoplasms in serrated polyposis: a systematic review and meta-analysis.

Authors:

Emily Y He Lucy Wyld Mathew A Sloane Karen Canfell Robyn L Ward

J Pathol Clin Res 2016 Jul 22;2(3):127-37. Epub 2016 Apr 22.

Prince of Wales Clinical School, University of New South WalesSydney, Australia; Office of the Deputy Vice-Chancellor (Research), University of QueenslandBrisbane, Australia.

View Article and Find Full Text PDF

July 2016

Defining the criteria for identifying constitutional epimutations.

Authors:

Mathew A Sloane Robyn L Ward Luke B Hesson

Clin Epigenetics 2016 18;8:39. Epub 2016 Apr 18.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Australia, Kensington, Sydney, New South Wales 2052 Australia.

View Article and Find Full Text PDF

December 2016

Understanding the Pathogenicity of Noncoding Mismatch Repair Gene Promoter Variants in Lynch Syndrome.

Authors:

Qing Liu Bryony A Thompson Robyn L Ward Luke B Hesson Mathew A Sloane

Hum Mutat 2016 May 18;37(5):417-26. Epub 2016 Mar 18.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Australia, Sydney, New South Wales, Australia.

View Article and Find Full Text PDF

May 2016

A cryptic paracentric inversion of MSH2 exons 2-6 causes Lynch syndrome.

Authors:

Qing Liu Luke B Hesson Andrea C Nunez Deborah Packham Rachel Williams Robyn L Ward Mathew A Sloane

Carcinogenesis 2016 Jan 24;37(1):10-17. Epub 2015 Oct 24.

Adult Cancer Program , Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Australia , Sydney New South Wales 2052 , Australia.

View Article and Find Full Text PDF

January 2016

The search for cis-regulatory driver mutations in cancer genomes.

Authors:

Rebecca C Poulos Mathew A Sloane Luke B Hesson Jason W H Wong

Oncotarget 2015 Oct;6(32):32509-25

Prince of Wales Clinical School and Lowy Cancer Research Centre, UNSW Australia, Sydney, Australia.

View Article and Find Full Text PDF

October 2015

Mosaic Epigenetic Inheritance as a Cause of Early-Onset Colorectal Cancer.

Authors:

Mathew A Sloane Andrea C Nunez Deborah Packham Chau-To Kwok Graeme Suthers Luke B Hesson Robyn L Ward

JAMA Oncol 2015 Oct;1(7):953-7

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia4Brian Wilson Chancellery, University of Queensland, Brisbane, Queensland, Australia.

View Article and Find Full Text PDF

October 2015

Lynch syndrome associated with two MLH1 promoter variants and allelic imbalance of MLH1 expression.

Authors:

Luke B Hesson Deborah Packham Chau-To Kwok Andrea C Nunez Benedict Ng Christa Schmidt Michael Fields Jason W H Wong Mathew A Sloane Robyn L Ward

Hum Mutat 2015 Jun 17;36(6):622-30. Epub 2015 Apr 17.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Australia, Sydney, New South Wales, Australia.

View Article and Find Full Text PDF

June 2015

Nucleosome positioning is unaltered at MLH1 splice site mutations in cells derived from Lynch syndrome patients.

Authors:

Mathew A Sloane Luke B Hesson Andrea C Nunez Bryony A Thompson Robyn L Ward

Clin Epigenetics 2014 13;6(1):32. Epub 2014 Dec 13.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW Australia.

View Article and Find Full Text PDF

December 2014

Altered promoter nucleosome positioning is an early event in gene silencing.

Authors:

Luke B Hesson Mathew A Sloane Jason Wh Wong Andrea C Nunez Sameer Srivastava Benedict Ng Nicholas J Hawkins Michael J Bourke Robyn L Ward

Epigenetics 2014 Oct;9(10):1422-30

a Adult Cancer Program; Lowy Cancer Research Center and Prince of Wales Clinical School; UNSW ; Sydney , Australia.

View Article and Find Full Text PDF

October 2014

Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.

Authors:

Mathew A Sloane Jason W H Wong Dilmi Perera Andrea C Nunez John E Pimanda Nicholas J Hawkins Oliver M Sieber Michael J Bourke Luke B Hesson Robyn L Ward

Epigenetics 2014 Aug 16;9(8):1092-100. Epub 2014 May 16.

Adult Cancer Program; Lowy Cancer Research Centre and Prince of Wales Clinical School; Sydney, NSW Australia.

View Article and Find Full Text PDF

August 2014

Reassembly of nucleosomes at the MLH1 promoter initiates resilencing following decitabine exposure.

Authors:

Luke B Hesson Vibha Patil Mathew A Sloane Andrea C Nunez Jia Liu John E Pimanda Robyn L Ward

PLoS Genet 2013 25;9(7):e1003636. Epub 2013 Jul 25.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia.

View Article and Find Full Text PDF

January 2014

Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis.

Authors:

Andrea Perne Markus K Muellner Magdalena Steinrueck Nils Craig-Mueller Julia Mayerhofer Ilse Schwarzinger Mathew Sloane Iris Z Uras Gregor Hoermann Sebastian M B Nijman Matthias Mayerhofer

PLoS One 2009 Dec 16;4(12):e8292. Epub 2009 Dec 16.

Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria.

View Article and Find Full Text PDF

December 2009

H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome.

Authors:

Florian M Pauler Mathew A Sloane Ru Huang Kakkad Regha Martha V Koerner Ido Tamir Andreas Sommer Andras Aszodi Thomas Jenuwein Denise P Barlow

Genome Res 2009 Feb 1;19(2):221-33. Epub 2008 Dec 1.

CeMM Research Center for Molecular Medicine, Austrian Academy of Sciences, A1030 Vienna, Austria.

View Article and Find Full Text PDF

February 2009

Silencing and transcriptional properties of the imprinted Airn ncRNA are independent of the endogenous promoter.

Authors:

Stefan H Stricker Laura Steenpass Florian M Pauler Federica Santoro Paulina A Latos Ru Huang Martha V Koerner Mathew A Sloane Katarzyna E Warczok Denise P Barlow

EMBO J 2008 Dec 13;27(23):3116-28. Epub 2008 Nov 13.

CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

View Article and Find Full Text PDF

December 2008

Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome.

Authors:

Kakkad Regha Mathew A Sloane Ru Huang Florian M Pauler Katarzyna E Warczok Balázs Melikant Martin Radolf Joost H A Martens Gunnar Schotta Thomas Jenuwein Denise P Barlow

Mol Cell 2007 Aug;27(3):353-66

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Institute of Genetics, Max F. Perutz Laboratories, Vienna Biocenter, Dr. Bohr-Gasse 9/4, A-1030 Vienna, Austria.

View Article and Find Full Text PDF

August 2007