Mathew J Garnett

Mathew J Garnett

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Mathew J Garnett

Mathew J Garnett

Publications by authors named "Mathew J Garnett"

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Drug Sensitivity Assays of Human Cancer Organoid Cultures.

Methods Mol Biol 2019 ;1576:339-351

Wellcome Trust Sanger Institute, Cambridge, CB10 1SA, UK.

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http://dx.doi.org/10.1007/7651_2016_10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527507PMC
January 2019

Erratum to: Drug Sensitivity Assays of Human Cancer Organoid Cultures.

Methods Mol Biol 2019;1576:353

Wellcome Trust Sanger Institute, Cambridge, CB10 1SA, UK.

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http://dx.doi.org/10.1007/7651_2018_138DOI Listing
January 2019

The germline genetic component of drug sensitivity in cancer cell lines.

Nat Commun 2018 08 23;9(1):3385. Epub 2018 Aug 23.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

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http://www.nature.com/articles/s41467-018-05811-3
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http://dx.doi.org/10.1038/s41467-018-05811-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107640PMC
August 2018

Itraconazole targets cell cycle heterogeneity in colorectal cancer.

J Exp Med 2018 07 31;215(7):1891-1912. Epub 2018 May 31.

Cancer Research UK (CRUK) Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge, England, UK

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http://dx.doi.org/10.1084/jem.20171385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028508PMC
July 2018

GDSCTools for mining pharmacogenomic interactions in cancer.

Bioinformatics 2018 04;34(7):1226-1228

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.

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http://dx.doi.org/10.1093/bioinformatics/btx744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031019PMC
April 2018

Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer.

Cancer Res 2018 02 11;78(3):769-780. Epub 2017 Dec 11.

European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522379PMC
February 2018

Perturbation-response genes reveal signaling footprints in cancer gene expression.

Nat Commun 2018 01 2;9(1):20. Epub 2018 Jan 2.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, CB10 1SD, UK.

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http://dx.doi.org/10.1038/s41467-017-02391-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750219PMC
January 2018

Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type-Specific Dynamic Logic Models.

Cancer Res 2017 06 5;77(12):3364-3375. Epub 2017 Apr 5.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433282PMC
June 2017

A Road Map for Precision Cancer Medicine Using Personalized Models.

Cancer Discov 2017 05;7(5):456-458

Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0268DOI Listing
May 2017

Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy.

Sci Rep 2016 11 23;6:36812. Epub 2016 Nov 23.

Netherlands Cancer Institute, Amsterdam, and The Faculty of EEMCS, Delft University of Technology, Delft, The Netherlands.

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http://dx.doi.org/10.1038/srep36812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120272PMC
November 2016

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.

Cell 2016 09 15;167(1):260-274.e22. Epub 2016 Sep 15.

Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK; Cambridge Breast Unit, NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre at Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 2QQ, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037319PMC
http://dx.doi.org/10.1016/j.cell.2016.08.041DOI Listing
September 2016

What role could organoids play in the personalization of cancer treatment?

Pharmacogenomics 2015 20;16(14):1523-6. Epub 2015 Oct 20.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.

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http://dx.doi.org/10.2217/pgs.15.114DOI Listing
July 2016

Multilevel models improve precision and speed of IC50 estimates.

Pharmacogenomics 2016 05 16;17(7):691-700. Epub 2016 May 16.

Center for Personalized Cancer Treatment (CPCT), Utrecht/Amsterdam, The Netherlands.

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http://dx.doi.org/10.2217/pgs.16.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455999PMC
May 2016

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells.

Proc Natl Acad Sci U S A 2015 Jul 10;112(29):E3800-5. Epub 2015 Jul 10.

Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1500925112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517206PMC
July 2015

Fast randomization of large genomic datasets while preserving alteration counts.

Bioinformatics 2014 Sep;30(17):i617-23

Fondazione Bruno Kessler, I-38100 Povo (Trento), Italy, European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge CB10 1SD, UK, Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK and Universitat Pompeu Fabra, Barcelona 08003, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btu474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147926PMC
September 2014

The evolving role of cancer cell line-based screens to define the impact of cancer genomes on drug response.

Curr Opin Genet Dev 2014 Feb 5;24:114-9. Epub 2014 Mar 5.

Cancer Genome Project, Wellcome Trust Sanger Institute Hinxton, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2013.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003351PMC
February 2014

Exploiting genetic complexity in cancer to improve therapeutic strategies.

Drug Discov Today 2012 Mar 8;17(5-6):188-93. Epub 2012 Feb 8.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1016/j.drudis.2012.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672976PMC
March 2012

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.

Nat Cell Biol 2009 Nov 11;11(11):1363-9. Epub 2009 Oct 11.

University of Cambridge, Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge, CB2 OXZ, UK.

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http://www.nature.com/articles/ncb1983
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http://dx.doi.org/10.1038/ncb1983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875106PMC
November 2009

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.

Mol Cell 2005 Dec;20(6):963-9

Signal Transduction Team, The Institute of Cancer Research, Cancer Research UK Centre of Cell and Molecular Biology, London.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765050171
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http://dx.doi.org/10.1016/j.molcel.2005.10.022DOI Listing
December 2005

Guilty as charged: B-RAF is a human oncogene.

Cancer Cell 2004 Oct;6(4):313-9

Signal Transduction Team, Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United Kingdom.

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http://dx.doi.org/10.1016/j.ccr.2004.09.022DOI Listing
October 2004

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.

Cell 2004 Mar;116(6):855-67

Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/s0092-8674(04)00215-6DOI Listing
March 2004

ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation.

Oncogene 2002 Aug;21(37):5684-95

Department of Pathology, BC Research Institute for Children's and Women's Health, and the University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.1038/sj.onc.1205669DOI Listing
August 2002