Publications by authors named "Mathew Blurton-Jones"

53Publications

Human iPSC-derived microglia: A growing toolset to study the brain's innate immune cells.

Glia 2020 04 11;68(4):721-739. Epub 2020 Jan 11.

Department of Neurobiology and Behavior, University of California Irvine, Irvine, California.

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http://dx.doi.org/10.1002/glia.23781DOI Listing
April 2020

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.

Neuron 2019 09 30;103(6):1016-1033.e10. Epub 2019 Jul 30.

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92696, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92696, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92696, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138101PMC
September 2019

Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions.

Stem Cell Reports 2019 03 7;12(3):451-460. Epub 2019 Feb 7.

Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine CA 92697, USA; Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409424PMC
March 2019

Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk.

J Mol Biol 2019 04 7;431(9):1805-1817. Epub 2019 Feb 7.

Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2019.01.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475606PMC
April 2019

Development and validation of a simplified method to generate human microglia from pluripotent stem cells.

Mol Neurodegener 2018 12 22;13(1):67. Epub 2018 Dec 22.

Department of Neurobiology & Behavior, University of California, 3014 Gross Hall, 845 Health Science Rd, Irvine, CA, 92697-4545, USA.

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http://dx.doi.org/10.1186/s13024-018-0297-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303871PMC
December 2018

Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia.

Neurosci Res 2018 Apr 10;129:40-46. Epub 2018 Feb 10.

Department of Anatomy and Neurobiology, University of California Irvine, United States; Center for the Neurobiology of Learning and Memory, University of California Irvine, United States; Japan Science and Technology Agency, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neures.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059556PMC
April 2018

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation.

Neuron 2017 12;96(6):1290-1302.e6

Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Rehabilitation, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273173108
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http://dx.doi.org/10.1016/j.neuron.2017.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806703PMC
December 2017

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice.

Stem Cell Reports 2018 01 7;10(1):58-72. Epub 2017 Dec 7.

Institute for Memory Impairment and Neurological Disorders, University of California, Irvine, 3400 Biological Sciences III, Irvine, CA 92697-4545, USA; Department of Neurobiology & Behavior, University of California, Irvine, 3400 Biological Sciences III, Irvine, CA 92697-4545, USA; Department of Psychiatry & Human Behavior, University of California, Irvine, 3400 Biological Sciences III, Irvine, CA 92697-4545, USA; Sue and Bill Gross Stem Cell Center, University of California, Irvine, Gross Hall, Room 3219, 845 Health Sciences Road, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768890PMC
January 2018

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.

Neuron 2017 Apr;94(2):278-293.e9

Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.03.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482419PMC
April 2017

Neural stem cell therapy for neurodegenerative disorders: The role of neurotrophic support.

Neurochem Int 2017 Jun 20;106:94-100. Epub 2017 Feb 20.

Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA 92697, USA; Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2017.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446923PMC
June 2017

HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease.

Stem Cell Reports 2017 02;8(2):235-248

Department of Neurobiology & Behavior, University of California Irvine, 845 Health Sciences Road, 3200 Gross Hall, Irvine, CA 92697, USA; Sue & Bill Gross Stem Cell Research Center, University of California Irvine, 845 Health Sciences Road, 3200 Gross Hall, Irvine, CA 92697, USA; Institute for Memory Impairments & Neurological Disorders, University of California Irvine, 845 Health Sciences Road, 3200 Gross Hall, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312253PMC
February 2017

Response to StemCells Inc.

Stem Cell Reports 2017 02;8(2):195-197

Sue & Bill Gross Stem Cell Research Center, University of California-Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments & Neurological Disorders, University of California-Irvine, Irvine, CA 92697, USA; Department of Physical & Medical Rehabilitation, University of California-Irvine, Irvine, CA 92697, USA; Department of Anatomy & Neurobiology, University of California-Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312268PMC
February 2017

Increased tauopathy drives microglia-mediated clearance of beta-amyloid.

Acta Neuropathol Commun 2016 06 23;4(1):63. Epub 2016 Jun 23.

Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA, 92697, USA.

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http://dx.doi.org/10.1186/s40478-016-0336-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918195PMC
June 2016

Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.

Brain 2016 Apr 26;139(Pt 4):1265-81. Epub 2016 Feb 26.

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697-4545, USA

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http://dx.doi.org/10.1093/brain/aww016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006229PMC
April 2016

The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function.

Proc Natl Acad Sci U S A 2016 Mar 16;113(9):E1316-25. Epub 2016 Feb 16.

Department of Neurobiology and Behavior, University of California, Irvine, CA 92697; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA 92697; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697;

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http://dx.doi.org/10.1073/pnas.1525466113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780638PMC
March 2016

Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism.

Stem Cell Reports 2015 Nov 17;5(5):791-804. Epub 2015 Oct 17.

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649255PMC
November 2015

Soluble aβ promotes wild-type tau pathology in vivo.

J Neurosci 2012 Nov;32(48):17345-50

Department of Neurobiology and Behavior, Institute for Memory Impairment and Neurological Disorders, and Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, California 92697, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0172-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586232PMC
November 2012

Concise review: Can stem cells be used to treat or model Alzheimer's disease?

Stem Cells 2012 Dec;30(12):2612-8

Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697-4545, USA.

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http://dx.doi.org/10.1002/stem.1240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508338PMC
December 2012

Examining the mechanisms that link β-amyloid and α-synuclein pathologies.

Alzheimers Res Ther 2012 30;4(2):11. Epub 2012 Apr 30.

Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92697-4545, USA ; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA 92697, USA ; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1186/alzrt109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054672PMC
August 2014

Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.

J Biol Chem 2011 Jul 23;286(27):24264-74. Epub 2011 May 23.

Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697, USA.

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http://dx.doi.org/10.1074/jbc.M111.227421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129207PMC
July 2011

Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.

J Neurosci 2010 May;30(21):7281-9

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-4545, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0490-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308018PMC
May 2010

Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.

Am J Pathol 2010 Jul 14;177(1):300-10. Epub 2010 May 14.

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 3212 Biological Sciences III, Irvine, CA 92697-4545, USA.

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http://dx.doi.org/10.2353/ajpath.2010.090750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893673PMC
July 2010

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.

Proc Natl Acad Sci U S A 2009 Aug 24;106(32):13594-9. Epub 2009 Jul 24.

Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1073/pnas.0901402106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715325PMC
August 2009

β-Amyloid impairs axonal BDNF retrograde trafficking.

Neurobiol Aging 2011 May 21;32(5):821-33. Epub 2009 Jun 21.

Institute for Brain Aging and Dementia, University of California, Irvine, 1226 Gillespie NRF, Irvine, CA 92697, United States.

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http://dx.doi.org/10.1016/j.neurobiolaging.2009.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038182PMC
May 2011

Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology.

J Alzheimers Dis 2009 ;16(3):541-9

Center for Neuroscience and Cell Biology, Faculty of Medicine, Biochemistry Institute, University of Coimbra, Coimbra, Portugal.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-2009-0993DOI Listing
May 2009

Neural stem cells improve memory in an inducible mouse model of neuronal loss.

J Neurosci 2007 Oct;27(44):11925-33

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1627-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673368PMC
October 2007

Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex.

Brain Struct Funct 2007 Sep 1;212(2):133-48. Epub 2007 Sep 1.

Department of Anatomy and Neurobiology, School of Medicine, University of California at Irvine, Irvine, CA 92697-1275, USA.

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http://dx.doi.org/10.1007/s00429-007-0151-3DOI Listing
September 2007

Abeta inhibits the proteasome and enhances amyloid and tau accumulation.

Neurobiol Aging 2008 Nov 1;29(11):1607-18. Epub 2007 Jun 1.

Department of Neurobiology and Behavior, University of California, 1109 Gillespie Neuroscience Research Facility, Irvine, CA 92697-4545, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664168PMC
November 2008

Pathways by which Abeta facilitates tau pathology.

Curr Alzheimer Res 2006 Dec;3(5):437-48

Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-4545, USA.

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http://dx.doi.org/10.2174/156720506779025242DOI Listing
December 2006

Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF.

J Comp Neurol 2006 Dec;499(4):603-12

Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697-4540, USA.

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http://dx.doi.org/10.1002/cne.21122DOI Listing
December 2006

A microfluidic culture platform for CNS axonal injury, regeneration and transport.

Nat Methods 2005 Aug;2(8):599-605

Department of Biomedical Engineering, University of California, Irvine, 204 Rockwell Engineering, Irvine, California 92697, USA.

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http://dx.doi.org/10.1038/nmeth777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1558906PMC
August 2005

The role of caspase cleavage of tau in Alzheimer disease neuropathology.

J Neuropathol Exp Neurol 2005 Feb;64(2):104-12

Institute for Brain Aging and Dementia, University of California, Irvine, 92697, USA.

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http://dx.doi.org/10.1093/jnen/64.2.104DOI Listing
February 2005

Caspase-mediated degeneration in Alzheimer's disease.

Am J Pathol 2004 Aug;165(2):353-5

Institute for Brain Aging and Dementia, Irvine CA 92697-4540, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618562PMC
http://dx.doi.org/10.1016/S0002-9440(10)63302-0DOI Listing
August 2004

Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats.

J Comp Neurol 2002 Oct;452(3):276-87

Department of Neurosciences, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0626, USA.

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http://dx.doi.org/10.1002/cne.10393DOI Listing
October 2002