Publications by authors named "Mateus Lima"

7 Publications

  • Page 1 of 1

Influence of HRT and carbon source on the enhancement of nutrient removal in an Anaerobic-Oxic-Anoxic (AOA) system.

Environ Technol 2021 Feb 16:1-14. Epub 2021 Feb 16.

Chemistry and Biology Academic Department, The Federal University of Technology - Paraná (UTFPR), Curitiba, Brazil.

The eutrophication and increase in toxicity promoted by the continuous or abundant supply of nutrients in water bodies threaten the safety of drinking water and human health. In this regard, this study proposes the investigation of wastewater treatment focusing on the simultaneous removal of nitrogen and phosphorus in the anaerobic-oxic-anoxic (AOA) system. The AOA system was operated in three different stages to verify the influence of the external carbon source addition in the anoxic reactor and the reduction of hydraulic retention time (HRT) in the anaerobic and oxic reactors for nutrient removal optimization. Results showed that the best performance of the AOA system on nutrient removal was obtained in Stage 3, with the reduction of the HRT in the anaerobic and oxic reactors (HRT = 4 h) while maintaining HRT of 6.4 h in the anoxic reactor with no addition of the external carbon source. Under these conditions, the average removal efficiencies reached 98% for Chemical Oxygen Demand (COD), 88% for Total Ammonia Nitrogen (TAN), 81% for Total Kjeldahl Nitrogen (TKN), and 70% for Total Phosphorus (TP). The results also demonstrate that the highest phosphorus removal efficiency was achieved in the anoxic reactor, thus indicating the occurrence of denitrifying phosphorous removal by Denitrifying Phosphate Accumulating Organisms (DNPAOs). This configuration was efficient regarding the simultaneous removal of nitrogen and phosphorus; besides, the advantages of this system include robust configuration and excellent performance on the nutrient removal.
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February 2021

Magnitude and temporal trend of leprosy indicators in Goiás, Brazil: an ecological study 2001-2017.

Epidemiol Serv Saude 2020 6;29(5):e2019575. Epub 2020 Nov 6.

Universidade Federal de Goiás, Faculdade de Enfermagem, Goiânia, GO, Brasil.

Objective: To analyze the trend of leprosy indicators in Goiás between 2001 and 2017.

Methods: An ecological time series study was conducted. Leprosy morbidity and operational indicators were calculated using Notifiable Health Conditions Information System data. Prais-Winsten regression was used for trend analysis.

Results: There was a falling trend in the detection rate in the general population (Annual Percent Change [APC] = -6.8 - 95%CI -8.2;-5.4) and in children under 15 years old (APC = -7.2 - 95%CI -8.5;-5.9); a rising trend in the proportion of grade 2 disability (APC = 3.7 - 95%CI 2.0;5.3) and in the proportion of examined physical disability (APC = 0.6 - 95%CI 0.3;0.8); healing and examined contacts proportions were stable.

Conclusion: Detection rates decreased while the proportions of grade 2 physical disability and examined physical disability increased.
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September 2021

Construction waste as substrate in vertical subsuperficial constructed wetlands treating organic matter, ibuprofenhene, acetaminophen and ethinylestradiol from low-strength synthetic wastewater.

Sci Total Environ 2020 Aug 19;728:138771. Epub 2020 Apr 19.

The Federal University of Technology - Paraná (UTFPR), Civil Construction Academic Department, Deputado Heitor de Alencar Furtado St., 5000, Ecoville, 81280-340 Curitiba, Paraná, Brazil. Electronic address:

This study aimed to evaluate the removal of chemical oxygen demand (COD), total Kjeldahl nitrogen (TKN), total ammonia nitrogen (TAN), total phosphorus (TP), ibuprofen, acetaminophen and ethinylestradiol of synthetic effluent simulating low-strength sewage by sequencing-batch mode constructed wetlands (CWs). To verify the feasibility of using a floating macrophyte in CWs and compare different substrates, three CWs containing light expanded clay aggregates (CWL), expanded clay with porcelain tiles (CWLP) and bricks (CWB) were planted with Pistia stratiotes. The results showed that CWB achieved the highest removals of TKN (78%), TAN (70%) and TP (46%), and CWLP achieved the highest COD removal (75%). LECA favored the removal of ibuprofen (92%, p < 0.05) when compared to bricks (77%), probably by the combination of biodegradation and sorption in the systems. The highest acetaminophen removal (71% to 96%) was observed in CWL, probably via biodegradation, but no significant differences were found between the CWs (p > 0.05). Ethinylestradiol was removed 76% in CWLP and 73% in CWB, both differing statistically from CWL (p < 0.05), demonstrating that brick and the combination of clay with porcelain were better than just clay in this hormone removal. After 188 days of operation, P. stratiotes was able to uptake nitrogen and phosphorus of approximately 0.28 g and 0.25 g in CWL, 0.33 g and 0.21 g CWLP, and 0.22 g and 0.09 g in CWB of, respectively. Adsorption of nitrogen and phosphorus onto the substrates was 0.48 g and 6.84 g in CWL, 0.53 g and 5.69 g in CWLP, and 0.36 g and 10.18 g in CWB, respectively. The findings on this study suggest that adsorption was possible the main process for TP removal onto the evaluated substrates whereas microbial activity was the most probable mechanism for TN removal in the evaluated CW systems.
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August 2020

Prospective Patient Reported Outcomes (PRO) Study Assessing Outcomes of Surgically Managed Ankle Fractures.

Foot Ankle Int 2020 02 4;41(2):206-210. Epub 2019 Dec 4.

Department of Orthopedics, Division of Foot & Ankle Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Ankle fractures are a common cause of morbidity that have increased in incidence over the past decade. The purpose of this study was to compare the outcomes and prognosis of various fracture subtypes by using 2 validated patient-reported outcome measures: the Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) and Pain Interference (PI) Computer Adaptive Tests (CATs).

Methods: Twelve-month postoperative PF and PI CATs were collected for 126 ankle fracture patients presenting between 2014 and 2017. Patients were stratified by ankle fracture subtype and refined by the presence/absence of concomitant deltoid injury or posterior malleolar fracture. Patients defined as members of vulnerable populations and patients presenting more than 2 weeks from time of injury or with prior acute ipsilateral fracture were excluded. The distribution of PF and PI T scores were assessed via a Shapiro-Wilk test and a 1-way analysis of variance. If significant differences were found between groups, pairwise comparisons were tested via Dwass, Steel, and Critchlow-Fligner multiple comparison analysis.

Results: Mean values for the PROMIS PF and PI for each fracture subtype were calculated and compared to reference population mean (SD) T scores of 50 (10): isolated lateral malleolar (PF: 50/PI: 51), isolated medial malleolar (PF: 52/PI: 49), bimalleolar (PF: 48/PI: 50), trimalleoar (PF: 47/PI: 51), isolated posterior malleolar (PF: 53/PI: 44), and isolated syndesmotic injury (PF: 60/PI: 46). Shapiro-Wilk test indicated a nonnormal distribution for the postoperative PROMIS PF T scores across all fracture patients ( = .0421).

Conclusion: Operative fixation of an ankle fracture was able to return most patients to the population mean with regard to PROMIS function and pain regardless of fracture type.

Level Of Evidence: Level II, prospective comparative study.
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February 2020

Prevalence of Salmonella spp. in poultry carcasses samples collected in slaughterhouses of Southern Brazil from 2006 to 2015.

J Infect Dev Ctries 2018 11 30;12(11):1034-1038. Epub 2018 Nov 30.

Universidade Federal do Rio Grande do Sul (ICTA/UFRGS), Porto Alegre/RS, Brasil.

Introduction: This study aimed to evaluate the prevalence of Salmonella on poultry carcasses produced in slaughterhouses of Southern Brazil participating of the Official Pathogen Reduction Program conducted by the Ministry of Agriculture, Livestock, and Supply.

Methodology: From 2006 to 2015, 77,165 poultry carcasses were analyzed for presence/absence of Salmonella spp. and the results were statistically evaluated.

Results: Prevalence varied from 2.92% to 5.24%, with a mean percentage of 4.04%. The difference in prevalence numbers was not significant during all the period analyzed. Higher Salmonella prevalence has been reported worldwide, indicating the efficacy of Brazilian control measures implemented in the productive chain and the low risk associated to Brazilian poultry meat consumption. However, additional information about the acceptable and safe prevalence of Salmonella on poultry should be defined by risk analysis studies, considering the reality of Brazilian companies and scientific data.

Conclusions: The results of the present study can be the first step for a national Risk Assessment and may contribute to improvements in self-controlling programs and with the current Brazilian poultry regulation.
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November 2018

New-Onset Status Epilepticus in Pediatric Patients: Causes, Characteristics, and Outcomes.

Pediatr Neurol 2018 03 1;80:61-69. Epub 2017 Dec 1.

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Many pediatric patients presenting with status epilepticus have no history of seizures.

Methods: We retrospectively analyzed the clinical characteristics of patients aged one month to 21 years who presented during six consecutive years with convulsive status epilepticus and without a history of seizures. New-onset refractory status epilepticus was defined as status epilepticus refractory to two lines of treatment, without an identified cause in the first 48 hours.

Results: Of 460 patients with status epilepticus, 79 (17.2%) presented with new-onset status epilepticus, including four (0.9%) with new-onset refractory status epilepticus. Of those patients, 54.4% were female, and the median age was 3.5 years (IQR: 1.08 to 6.75). The median seizure duration was 20 minutes (IQR: 10 to 40 minutes). Etiology was unknown in 36.7%, symptomatic in 30.3%, provoked in 16.5%, and provoked with an existing symptomatic etiology in 16.5%. Patients were followed for a median duration of 63 months (IQR: 21 to 97). The mortality rate was 3.8%. Of 55 patients who were developmentally normal at baseline, 29.1% had a significant cognitive impairment at the last follow-up, and 20% had academic difficulties or behavioral problems. Patients with symptomatic etiology had greater odds of having cognitive and behavioral problems compared with patients with unknown etiology (odds ratio = 3.83, P = 0.012).

Conclusions: Patients with new-onset status epilepticus are at risk for recurrent seizures, recurrent status epilepticus, death, and subsequent cognitive-behavioral impairment. Specific monitoring and care interventions might be required in this high-risk population.
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March 2018

A Baseline Patient Model to Support Testing of Medical Cyber-Physical Systems.

Stud Health Technol Inform 2015 ;216:549-53

Embedded Systems and Pervasive Comp. Lab, Federal University of Campina Grande, Campina Grande, Brazil.

Medical Cyber-Physical Systems (MCPS) are currently a trending topic of research. The main challenges are related to the integration and interoperability of connected medical devices, patient safety, physiologic closed-loop control, and the verification and validation of these systems. In this paper, we focus on patient safety and MCPS validation. We present a formal patient model to be used in health care systems validation without jeopardizing the patient's health. To determine the basic patient conditions, our model considers the four main vital signs: heart rate, respiratory rate, blood pressure and body temperature. To generate the vital signs we used regression models based on statistical analysis of a clinical database. Our solution should be used as a starting point for a behavioral patient model and adapted to specific clinical scenarios. We present the modeling process of the baseline patient model and show its evaluation. The conception process may be used to build different patient models. The results show the feasibility of the proposed model as an alternative to the immediate need for clinical trials to test these medical systems.
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December 2016