Massimo Squatrito

Massimo Squatrito

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Massimo Squatrito

Massimo Squatrito

Publications by authors named "Massimo Squatrito"

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29Publications

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Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling.

Nat Commun 2018 Apr 13;9(1):1466. Epub 2018 Apr 13.

Seve Ballesteros Foundation Brain Tumor Group, Cancer Cell Biology Program, Spanish National Cancer Research Center, CNIO, 28029, Madrid, Spain.

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April 2018

Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts.

Cancer Cell 2017 Nov;32(5):590-607.e4

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid, 28029, Spain. Electronic address:

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November 2017

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

Oncotarget 2017 Oct 20;8(49):84671-84684. Epub 2017 Jul 20.

Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Karolinska Institutet, Stockholm, Sweden.

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October 2017

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.

Cancer Cell 2017 07;32(1):42-56.e6

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. Electronic address:

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July 2017

Targeting tyrosine receptor kinase B in gliomas.

Neuro Oncol 2017 01 14;19(1):138-139. Epub 2016 Sep 14.

Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, Brazil (K.V.P., C.A., M.B., M.S.G., A.T., G.S., C.B.F., R.R.); Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil (K.V.P., C.A., M.B., M.S.G., A.T., R.R.); Department of Internal Medicine, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil (G.S.), Children's Cancer Institute, Porto Alegre, Brazil (C.B.F.).

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January 2017

GlioVis data portal for visualization and analysis of brain tumor expression datasets.

Neuro Oncol 2017 01 9;19(1):139-141. Epub 2016 Nov 9.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA (R.L.B.); Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (Q.W., R.G.V.); Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (Q.W.); Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (Q.W., R.G.V.); Bioinformatics unit, Structural Biology and Biocomputing Programme, Centro Nacional de Investigaciones Oncológicas, CNIO, Madrid, Spain (A.C.); Department of Computational Biology, The Jackson Laboratory, Farmington, Connecticut, USA (R.G.V.); Seve Ballesteros Foundation Brain Tumor Group, Cancer Cell Biology Programme, Centro Nacional de Investigaciones Oncológicas, CNIO, Madrid, Spain (M.S.)

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January 2017

Take It Down a NOTCH in Forebrain Tumors.

Cancer Cell 2015 Dec;28(6):681-682

Cancer Cell Biology Programme, Seve Ballesteros Foundation Brain Tumor Group, Centro Nacional de Investigaciones Oncológicas, CNIO, 28029 Madrid, Spain. Electronic address:

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December 2015

Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma.

Cancer Cell 2014 Aug;26(2):288-300

Division of Human Biology and Solid Tumor Translational Research, Fred Hutchinson Cancer Research Center, Department of Neurosurgery and Alvord Brain Tumor Center, University of Washington, Seattle, WA 98109, USA. Electronic address:

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August 2014

Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation.

Cancer Res 2013 Oct 13;73(20):6323-33. Epub 2013 Aug 13.

Authors' Affiliations: Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, University of Copenhagen; The Danish Stem Cell Center (Danstem), Copenhagen, Denmark; and F-BBVA Cancer Cell Biology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

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October 2013

53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma.

Cancer Res 2012 Oct 21;72(20):5250-60. Epub 2012 Aug 21.

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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October 2012

Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment.

PLoS One 2012 29;7(2):e32453. Epub 2012 Feb 29.

Biochemistry, Cell, and Molecular Biology Program, Weill Medical College of Cornell University, New York, New York, United States of America.

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July 2012

An essential role for p38 MAPK in cerebellar granule neuron precursor proliferation.

Acta Neuropathol 2012 Apr;123(4):573-86

Departments of Neurological Surgery and Cancer Biology, Vanderbilt University, Nashville, TN, 37212, USA; Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.

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April 2012

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas.

EMBO J 2011 Sep 13;30(19):4084-97. Epub 2011 Sep 13.

Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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September 2011

DNA damage response and growth factor signaling pathways in gliomagenesis and therapeutic resistance.

Cancer Res 2011 Sep 13;71(18):5945-9. Epub 2011 Sep 13.

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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September 2011

Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.

Cancer Cell 2010 Dec;18(6):619-29

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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December 2010

Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells.

Cell Stem Cell 2010 Feb;6(2):141-52

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.

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February 2010

Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas.

Genes Dev 2009 Dec;23(24):2806-11

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.

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December 2009

Glioma formation, cancer stem cells, and akt signaling.

Stem Cell Rev 2008 Sep;4(3):203-10

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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September 2008

Radiation resistance and stem-like cells in brain tumors.

Cancer Cell 2006 Dec;10(6):454-6

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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December 2006

Tip60 in DNA damage response and growth control: many tricks in one HAT.

Trends Cell Biol 2006 Sep 9;16(9):433-42. Epub 2006 Aug 9.

Department of Experimental Oncology, European Institute of Oncology (IEO), IFOM-IEO Campus, Milan 20139, Italy.

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September 2006

Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation.

Biochem Biophys Res Commun 2006 Jun 19;344(3):859-68. Epub 2006 Apr 19.

European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy.

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June 2006

Dual mode of degradation of Cdc25 A phosphatase.

EMBO J 2002 Sep;21(18):4875-84

European Institute of Oncology, 435 Via Ripamonti, I-20141 Milan, Italy.

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September 2002