Publications by authors named "Massimo Milione"

100Publications

Beyond Traditional Morphological Characterization of Lung Neuroendocrine Neoplasms: In Silico Study of Next-Generation Sequencing Mutations Analysis across the Four World Health Organization Defined Groups.

Cancers (Basel) 2020 Sep 24;12(10). Epub 2020 Sep 24.

1st Pathology Division, Department of Pathology and Laboratory Medicine, Fondazione IRCCS (Scientific Institute for Research, Hospitalization and Healthcare) Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.3390/cancers12102753DOI Listing
September 2020

Prognostic Impact of Primary Side and RAS/RAF Mutations in a Surgical Series of Colorectal Cancer with Peritoneal Metastases.

Ann Surg Oncol 2020 Sep 24. Epub 2020 Sep 24.

Peritoneal Malignancy Program, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1245/s10434-020-09161-7DOI Listing
September 2020

Colorectal Adenocarcinomas Harboring ALK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 12 Cases and Review of the Literature.

Am J Surg Pathol 2020 09;44(9):1224-1234

*Laboratory of Pathology, National Cancer Institute, Bethesda, MD Departments of †Molecular Diagnostics ##Clinical Oncology ††††Surgical Pathology, Holycross Cancer Center §Division of Medical Biology, Institute of Biology ***Faculty of Health Sciences, Jan Kochanowski University, Kielce Departments of ‡Biology and Genetics ††Pathomorphology ****Pathology and Neuropathology, Medical University of Gdansk, Gdansk §§Department of Pathology, Pomeranian Medical University ¶¶¶¶Independent Laboratory of Pathology, Zdunomed, Szczecin ∥∥Health Sciences and Physical Education, University of Technology and Humanities, Radom ¶¶Department of Pathology, West Pomeranian Specialist Hospital, Gryfice †††Department of Pathology, Central Clinical Hospital of the Ministry of Interior ‡‡‡Faculty of Medicine, Lazarski University §§§§Department of Pathology, Prof. Orłowski-Memorial Independent Public Clinical Hospital and Center for Medical Postgraduate Education, Warszawa §§§Department of Pathomorphology and Oncological Cytology, Medical University of Wroclaw, Wrocław ‡‡‡‡Department of Pathomorphology, Jagiellonian University ∥∥∥∥Department of Tumor Pathology, Maria Sklodowska-Curie National Research Institute of Oncology, Kraków, Poland ∥Ignyta Inc., San Diego, CA ¶Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China **Sikl's Institute of Pathology, Faculty of Medicine and Teaching Hospital in Plzen, Charles University, Plzen, Czech Republic #Institute of Pathology, University Hospital of Erlangen, Erlangen, Germany ‡‡Department of Pathology and Laboratory Medicine, Milan, Italy ∥∥∥Department of Pathology, Nagoya City East Medical Center ¶¶¶Education and Research Center for Advanced Medicine ###Department of Experimental Pathology and Tumor Biology, Nagoya City University, Nagoya, Japan.

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http://dx.doi.org/10.1097/PAS.0000000000001512DOI Listing
September 2020

Differential Diagnosis and Management of Diarrhea in Patients with Neuroendocrine Tumors.

J Clin Med 2020 Aug 1;9(8). Epub 2020 Aug 1.

Department of Medical Oncology, Gastro-entero-pancreatic and Neuroendocrine Unit 1, ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.3390/jcm9082468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464810PMC
August 2020

Reply to E. Hindié.

J Clin Oncol 2020 Sep 23;38(27):3238-3240. Epub 2020 Jul 23.

Andrea Maurichi, MD, Melanoma and Sarcoma Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy; Rosalba Miceli, PhD, Medical Statistics, Biometry and Bioinformatics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy; Hanna Eriksson, MD, PhD, Department of Oncology, Theme Cancer, Karolinska University Hospital, and Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden; Julia Newton-Bishop, MD, FRCP; Jérémie Nsengimana, PhD; and May Chan, PGD, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom; Andrew J. Hayes, MA, MBBS, MD, PhD and Kara Heelan, MB, BCH, BAO, MRCPI, MD, Sarcoma and Melanoma Units and Skin Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom; David Adams, PhD, Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom; Roberto Patuzzo, MD, Melanoma and Sarcoma Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy; Francesco Barretta, MS, PhD, Medical Statistics, Biometry and Bioinformatics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy; Gianfranco Gallino, MD, Melanoma and Sarcoma Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy; Catherine Harwood, MA, MD, PhD, FRCP and Daniele Bergamaschi, PhD, Queen Mary University of London, London, United Kingdom; Dorothy Bennett, FMedSci, PhD, Molecular and Clinical Sciences Research Institute, St George's, University of London, London, United Kingdom; Konstantinos Lasithiotakis, MD, PhD, York Teaching Hospital NHS Foundation Trust, York, United Kingdom and Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy; Paola Ghiorzo, MD, PhD and Bruna Dalmasso, MD, University Hospital of Genoa, Genoa, Italy; Ausilia Manganoni, MD and Francesca Consoli, MD, University Hospital of Brescia, Brescia, Italy; Ilaria Mattavelli, MD; Consuelo Barbieri, MD; and Andrea Leva, MD, Melanoma and Sarcoma Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy; Umberto Cortinovis, MD, Plastic and Reconstructive Surgical Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy; Vittoria Espeli, MD and Cristina Mangas, MD, PhD, Istituto Oncologico Svizzera Italiana, Ospedale Regionale Bellinzona e Valli, Bellinzona, Switzerland; Pietro Quaglino, MD; Simone Ribero, MD, PhD; and Paolo Broganelli, MD, University Hospital of Turin, Turin, Italy; Giovanni Pellacani, MD, University Hospital of Modena, Modena, Italy; Caterina Longo, MD, Arcispedale S. Maria Nuova, Reggio Emilia, Italy; Corrado Del Forno, MD, University Hospital of Pavia, Pavia, Italy; Lorenzo Borgognoni, MD and Serena Sestini, MD, Ospedale S. Maria Annunziata, Tuscan Cancer Institute, Florence, Italy; Nicola Pimpinelli, MD, PhD and Sara Fortunato, MD, Division of Dermatology, University of Florence, Florence, Italy; Alessandra Chiarugi, MD and Paolo Nardini, MD, Institute for Cancer Research and Prevention, Florence, Italy; Elena Morittu, PhD and Antonio Florita, PhD, Scientific Director's Office, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy; Mara Cossa, MD, PhD; Barbara Valeri, MD; Massimo Milione, MD, PhD; and Giancarlo Pruneri, MD, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy; Odysseas Zoras, MD, PhD, University Hospital of Heraklion, Heraklion, Greece; Andrea Anichini, PhD and Roberta Mortarini, PhD, Immunobiology of Human Cancers Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy; and Mario Santinami, MD, Melanoma and Sarcoma Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

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http://dx.doi.org/10.1200/JCO.20.01460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499609PMC
September 2020

Are Cyclin-Dependent Kinase 4/6 Inhibitors Without Future in Neuroendocrine Tumors?

Oncologist 2020 May 20. Epub 2020 May 20.

Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1634/theoncologist.2020-0298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418349PMC
May 2020

Statin Use Decreases the Incidence of Hepatocellular Carcinoma: An Updated Meta-Analysis.

Cancers (Basel) 2020 Apr 3;12(4). Epub 2020 Apr 3.

Section of Gastroenterology, Department of Medical Sciences, University of Foggia, 71122 Foggia, Italy.

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http://dx.doi.org/10.3390/cancers12040874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225931PMC
April 2020

TLR3 Expression Induces Apoptosis in Human Non-Small-Cell Lung Cancer.

Int J Mol Sci 2020 Feb 20;21(4). Epub 2020 Feb 20.

Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, 20133 Milan, Italy.

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http://dx.doi.org/10.3390/ijms21041440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073031PMC
February 2020

Neoadjuvant chemo-radiotherapy for cT3N0 rectal cancer: any benefit over upfront surgery? A propensity score-matched study.

Int J Colorectal Dis 2019 Dec 18;34(12):2161-2169. Epub 2019 Nov 18.

Colorectal Surgery Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133, Milan, Italy.

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http://dx.doi.org/10.1007/s00384-019-03446-4DOI Listing
December 2019

Coated cationic lipid-nanoparticles entrapping miR-660 inhibit tumor growth in patient-derived xenografts lung cancer models.

J Control Release 2019 08 9;308:44-56. Epub 2019 Jul 9.

Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.07.006DOI Listing
August 2019

Metronomic Capecitabine With Cyclophosphamide Regimen in Unresectable or Relapsed Pseudomyxoma Peritonei.

Clin Colorectal Cancer 2019 06 1;18(2):e179-e190. Epub 2019 Apr 1.

Medical Oncology Department, Istituto Nazionale dei Tumori di Milano, Fondazione IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2019.03.002DOI Listing
June 2019

Treatment of Advanced Merkel Cell Carcinoma: Current Therapeutic Options and Novel Immunotherapy Approaches.

Target Oncol 2018 10;13(5):567-582

Department of Medical Oncology Unit-1, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano and ENETS Center of Excellence, Via Venezian 1, 20133, Milan, Italy.

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http://dx.doi.org/10.1007/s11523-018-0585-yDOI Listing
October 2018

PD-L1 assessment in pediatric rhabdomyosarcoma: a pilot study.

BMC Cancer 2018 Jun 13;18(1):652. Epub 2018 Jun 13.

Department of Research, Tumor Genomics Unit, Genomics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, via venezian 1, 20133, Milan, Italy.

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http://dx.doi.org/10.1186/s12885-018-4554-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001160PMC
June 2018

Neuroendocrine neoplasms of rectum: A management update.

Cancer Treat Rev 2018 May 6;66:45-55. Epub 2018 Apr 6.

Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, Milano, Italy.

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http://dx.doi.org/10.1016/j.ctrv.2018.04.003DOI Listing
May 2018

Validation of the Recent PSOGI Pathological Classification of Pseudomyxoma Peritonei in a Single-Center Series of 265 Patients Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

Ann Surg Oncol 2018 Feb 20;25(2):404-413. Epub 2017 Nov 20.

Peritoneal Malignancy Program, Department of Surgery, National Cancer Institute, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

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http://link.springer.com/10.1245/s10434-017-6252-1
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http://dx.doi.org/10.1245/s10434-017-6252-1DOI Listing
February 2018

G3 GEP NENs category: are basic and clinical investigations well integrated?

Endocrine 2018 04 21;60(1):28-30. Epub 2017 Jul 21.

Unit of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, Milan, Italy.

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http://dx.doi.org/10.1007/s12020-017-1365-7DOI Listing
April 2018

Rationale and protocol of MetNET-2 trial: Lanreotide Autogel plus metformin in advanced gastrointestinal or lung neuroendocrine tumors.

Future Oncol 2017 Aug 5;13(19):1677-1683. Epub 2017 Jun 5.

Department of Medical Oncology, Unit 1, ENET Center of Excellence, Fondazione IRCCS Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milan, Italy.

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https://www.futuremedicine.com/doi/10.2217/fon-2017-0132
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http://dx.doi.org/10.2217/fon-2017-0132DOI Listing
August 2017

Prognostic factors for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): what's better?

Authors:
Massimo Milione

Endocrine 2018 01 17;59(1):1-3. Epub 2017 Apr 17.

Department of Pathology and Laboratory Medicine, 1st Division of Pathology, IRCCS Foundation National Cancer Institute, Milan, Italy.

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http://dx.doi.org/10.1007/s12020-017-1299-0DOI Listing
January 2018

Gastroenteropancreatic Neuroendocrine Carcinomas: The NET G3 Subcategory Is a Reality.

Oncologist 2017 03;22(3):359

1st Division of Pathology, Department of Pathology and Laboratory Medicine, IRCCS Foundation National Cancer Institute, Milan, Italy.

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http://dx.doi.org/10.1634/theoncologist.2016-0359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344638PMC
March 2017

IMP3 expression in small-intestine neuroendocrine neoplasms: a new predictor of recurrence.

Endocrine 2017 Nov 17;58(2):360-367. Epub 2017 Feb 17.

Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1007/s12020-017-1249-xDOI Listing
November 2017

mir-660-p53-mir-486 Network: A New Key Regulatory Pathway in Lung Tumorigenesis.

Int J Mol Sci 2017 Jan 23;18(1). Epub 2017 Jan 23.

Department of Experimental Oncology and Molecular Medicine, Unit of Tumor Genomics, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

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http://dx.doi.org/10.3390/ijms18010222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297851PMC
January 2017

MIF/CD74 axis is a target for novel therapies in colon carcinomatosis.

J Exp Clin Cancer Res 2017 01 23;36(1):16. Epub 2017 Jan 23.

Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, via G. Amadeo 42, Milan, 20133, Italy.

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http://dx.doi.org/10.1186/s13046-016-0475-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260021PMC
January 2017

Abdominosacral resection for locally recurring rectal cancer.

World J Gastrointest Surg 2016 Dec;8(12):770-778

Filiberto Belli, Carlo Corbellini, Ermanno Leo, Colorectal Surgery Unit, National Cancer Institute, 20133 Milan, Italy.

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http://dx.doi.org/10.4240/wjgs.v8.i12.770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183920PMC
December 2016

Pseudomyxoma Peritonei of Extra-Appendiceal Origin: A Comparative Study.

Ann Surg Oncol 2016 12 28;23(13):4222-4230. Epub 2016 Jun 28.

Peritoneal Malicnancy Program, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

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http://dx.doi.org/10.1245/s10434-016-5350-9DOI Listing
December 2016

Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.

Cancer Treat Rev 2016 Nov 28;50:61-67. Epub 2016 Aug 28.

1(st) Division of Pathology, Department of Pathology and Laboratory Medicine, IRCCS Foundation National Cancer Institute, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2016.08.006DOI Listing
November 2016

Update on medical treatment of small intestinal neuroendocrine tumors.

Expert Rev Anticancer Ther 2016 Sep 13;16(9):969-76. Epub 2016 Jul 13.

a Department of Medical Oncology , Fondazione IRCCS 'Istituto Nazionale dei Tumori' , Milan , Italy.

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http://dx.doi.org/10.1080/14737140.2016.1207534DOI Listing
September 2016

Four Neuroendocrine Tumor Types and Neuroendocrine Carcinoma of the Duodenum: Analysis of 203 Cases.

Neuroendocrinology 2017 25;104(2):112-125. Epub 2016 Feb 25.

Division of Pathology, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1159/000444803DOI Listing
May 2017

Metformin with everolimus and octreotide in pancreatic neuroendocrine tumor patients with diabetes.

Future Oncol 2016 May 18;12(10):1251-60. Epub 2016 Feb 18.

Medical Oncology Unit 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.2217/fon-2015-0077DOI Listing
May 2016

Endoscopic ultrasound-guided fine needle aspiration of splenic vein thrombosis: a novel approach to the portal venous system.

Endoscopy 2016 1;48 Suppl 1 UCTN:E40-1. Epub 2016 Feb 1.

Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

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http://dx.doi.org/10.1055/s-0042-100199DOI Listing
October 2016

ACTH-secreting pancreatic neoplasms associated with Cushing syndrome: clinicopathologic study of 11 cases and review of the literature.

Am J Surg Pathol 2015 Mar;39(3):374-82

*Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy ‡‡Department of Pathology, Ospedale di Circolo, Varese, Italy †Department of Molecular Medicine, University of Pavia, Pavia, Italy ‡Department of Pathology, San Raffaele Hospital, Milan, Italy §Department of Pathology, National Institute of Cancer, Milan, Italy #Department of Pathology, Multimedica, Milan, Italy **Department of Medicine, "G.B. Rossi" University Hospital, Verona, Italy ††ARC-NET Research Center and Department of Pathology and Diagnostics, University of Verona, Verona, Italy ∥Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY ¶Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru.

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http://pdfs.journals.lww.com/ajsp/2015/03000/ACTH_secreting_
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http://dx.doi.org/10.1097/PAS.0000000000000340DOI Listing
March 2015

FOLFOX-4 chemotherapy for patients with unresectable or relapsed peritoneal pseudomyxoma.

Oncologist 2014 Aug 20;19(8):845-50. Epub 2014 Jun 20.

Medical Oncology Department, Surgery Department, Pathology and Molecular Biology Department, Scientific Directorate, and Clinical Nutrition Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1634/theoncologist.2014-0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122474PMC
August 2014

TP53 mutations in advanced colorectal cancer: the dark side of the moon.

Oncology 2014 7;86(5-6):289-94. Epub 2014 Jun 7.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori (National Cancer Institute), Milan, Italy.

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http://dx.doi.org/10.1159/000360088DOI Listing
September 2014

Compassionate use of everolimus in a patient with a neuroendocrine tumor: a case report and discussion of the literature.

Oncol Res 2011 ;19(8-9):403-6

Fondazione IRCCS Istituto Nazionale dei Tumori of Milan, Milan, Italy.

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http://dx.doi.org/10.3727/096504011x13123323849799DOI Listing
April 2012

Giant condyloma acuminatum of the anorectum: successful radical surgery with anal reconstruction.

Tumori 2011 Nov-Dec;97(6):805-7

Division of General Surgery B, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, Milan, Italy.

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http://dx.doi.org/10.1700/1018.11100DOI Listing
April 2012

Somatostatin receptor subtype 2 A (SSTR2A) and HER2 expression in gastric adenocarcinoma.

Anticancer Res 2012 Jan;32(1):115-9

Department of Oncology, Sant'Andrea Hospital, La Sapienza University, via Grottarossa 1035, 00189, Rome, Italy.

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http://ar.iiarjournals.org/content/32/1/115.full.pdf
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January 2012

Neuroendocrine tumors of unknown primary site: gold dust or misdiagnosed neoplasms?

Tumori 2011 Sep-Oct;97(5):564-7

Oncologia Medica 2, Fondazione IRCCS Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1700/989.10712DOI Listing
April 2012