Publications by authors named "Massimo Mantegazza"

52Publications

Cholinergic modulation inhibits cortical spreading depression in mouse neocortex through activation of muscarinic receptors and decreased excitatory/inhibitory drive.

Neuropharmacology 2020 04 13;166:107951. Epub 2020 Jan 13.

Université Côte d'Azur, Valbonne-Sophia Antipolis, France; CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France; Inserm, Valbonne-Sophia Antipolis, France. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2020.107951DOI Listing
April 2020

SCN1A/Na 1.1 channelopathies: Mechanisms in expression systems, animal models, and human iPSC models.

Epilepsia 2019 12;60 Suppl 3:S25-S38

San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1111/epi.14700DOI Listing
December 2019

Modeling cortical spreading depression induced by the hyperactivity of interneurons.

J Comput Neurosci 2019 12 17;47(2-3):125-140. Epub 2019 Oct 17.

Université Côte d'Azur, 06108, Nice Cedex 2, France.

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http://dx.doi.org/10.1007/s10827-019-00730-8DOI Listing
December 2019

Na1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age.

Sci Rep 2019 09 9;9(1):12886. Epub 2019 Sep 9.

Université Côte d'Azur, 660 Route des Lucioles, 06560, Valbonne - Sophia Antipolis, France.

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http://dx.doi.org/10.1038/s41598-019-49392-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733925PMC
September 2019

Hyperexcitability in Cultured Cortical Neuron Networks from the G93A-SOD1 Amyotrophic Lateral Sclerosis Model Mouse and its Molecular Correlates.

Neuroscience 2019 09 7;416:88-99. Epub 2019 Aug 7.

World Research Hub Initiative (WRHI), Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan; Complex Systems Theory Department, Institute of Nuclear Physics, Polish Academy of Sciences (IFJ-PAN), 31-342 Kraków, Poland; Center for Mind/Brain Sciences (CIMeC), University of Trento, 38123 Trento, Italy.

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http://dx.doi.org/10.1016/j.neuroscience.2019.07.041DOI Listing
September 2019

A two-hit story: Seizures and genetic mutation interaction sets phenotype severity in SCN1A epilepsies.

Neurobiol Dis 2019 05 17;125:31-44. Epub 2019 Jan 17.

Université Côte d'Azur (UCA), INSERM, CNRS UMR 7275, Institute of Molecular and Cellular Pharmacology (IPMC), Team Pathophysiology of Voltage-Gated Na(+) channels and of Neuronal Excitability, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.01.006DOI Listing
May 2019

Hyperactive and anxiolytic-like behaviors result from loss of COUP-TFI/Nr2f1 in the mouse cortex.

Genes Brain Behav 2019 09 10;18(7):e12556. Epub 2019 Feb 10.

iBV - Institute of Biology Valrose, Université Côte d'Azur (UCA), CNRS, Inserm, Nice, France.

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http://doi.wiley.com/10.1111/gbb.12556
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http://dx.doi.org/10.1111/gbb.12556DOI Listing
September 2019

Rare coding variants in genes encoding GABA receptors in genetic generalised epilepsies: an exome-based case-control study.

Authors:
Patrick May Simon Girard Merle Harrer Dheeraj R Bobbili Julian Schubert Stefan Wolking Felicitas Becker Pamela Lachance-Touchette Caroline Meloche Micheline Gravel Cristina E Niturad Julia Knaus Carolien De Kovel Mohamad Toliat Anne Polvi Michele Iacomino Rosa Guerrero-López Stéphanie Baulac Carla Marini Holger Thiele Janine Altmüller Kamel Jabbari Ann-Kathrin Ruppert Wiktor Jurkowski Dennis Lal Raffaella Rusconi Sandrine Cestèle Benedetta Terragni Ian D Coombs Christopher A Reid Pasquale Striano Hande Caglayan Auli Siren Kate Everett Rikke S Møller Helle Hjalgrim Hiltrud Muhle Ingo Helbig Wolfram S Kunz Yvonne G Weber Sarah Weckhuysen Peter De Jonghe Sanjay M Sisodiya Rima Nabbout Silvana Franceschetti Antonietta Coppola Maria S Vari Dorothée Kasteleijn-Nolst Trenité Betul Baykan Ugur Ozbek Nerses Bebek Karl M Klein Felix Rosenow Dang K Nguyen François Dubeau Lionel Carmant Anne Lortie Richard Desbiens Jean-François Clément Cécile Cieuta-Walti Graeme J Sills Pauls Auce Ben Francis Michael R Johnson Anthony G Marson Bianca Berghuis Josemir W Sander Andreja Avbersek Mark McCormack Gianpiero L Cavalleri Norman Delanty Chantal Depondt Martin Krenn Fritz Zimprich Sarah Peter Marina Nikanorova Robert Kraaij Jeroen van Rooij Rudi Balling M Arfan Ikram André G Uitterlinden Giuliano Avanzini Stephanie Schorge Steven Petrou Massimo Mantegazza Thomas Sander Eric LeGuern Jose M Serratosa Bobby P C Koeleman Aarno Palotie Anna-Elina Lehesjoki Michael Nothnagel Peter Nürnberg Snezana Maljevic Federico Zara Patrick Cossette Roland Krause Holger Lerche

Lancet Neurol 2018 08 17;17(8):699-708. Epub 2018 Jul 17.

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http://dx.doi.org/10.1016/S1474-4422(18)30215-1DOI Listing
August 2018

iPSC-derived neurons of CREBBP- and EP300-mutated Rubinstein-Taybi syndrome patients show morphological alterations and hypoexcitability.

Stem Cell Res 2018 07 30;30:130-140. Epub 2018 May 30.

Laboratory of Medical Cytogenetics and Molecular Genetics, Centro di Ricerche e Tecnologie Biomediche, IRCCS Istituto Auxologico Italiano, 20145 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.05.019DOI Listing
July 2018

Pathophysiological mechanisms of migraine and epilepsy: Similarities and differences.

Neurosci Lett 2018 02 10;667:92-102. Epub 2017 Nov 10.

Université Côte d'Azur (UCA), 660 route des Lucioles, 06560 Valbonne, Sophia Antipolis, France; Institute of Molecular and Cellular Pharmacology (IPMC), CNRS UMR7275, 660 Route des Lucioles, 06560 Valbonne, Sophia Antipolis, France.

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http://dx.doi.org/10.1016/j.neulet.2017.11.025DOI Listing
February 2018

Epilepsy: Advances in genetics and pathophysiology.

Neurosci Lett 2018 02 18;667:1-3. Epub 2017 Oct 18.

Université Côte d'Azur (UCA), 660 route des Lucioles, 06560 Valbonne, Sophia Antipolis, France; Institute of Molecular and Cellular Pharmacology (IPMC), Laboratory of Excellence "Ion Channel Science and Therapeutics" (ICST), CNRS UMR7275,660 Route des Lucioles, 06560 Valbonne, Sophia Antipolis, France. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2017.10.026DOI Listing
February 2018

Post-translational dysfunctions in channelopathies of the nervous system.

Neuropharmacology 2018 04 29;132:31-42. Epub 2017 May 29.

Institute of Molecular and Cellular Pharmacology (IPMC), CNRS UMR7275, 06560, Valbonne-Sophia Antipolis, France; University Côte d'Azur (UCA), 06560, Valbonne-Sophia Antipolis, France. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.05.028DOI Listing
April 2018

The impact of genetic and experimental studies on classification and therapy of the epilepsies.

Neurosci Lett 2018 02 15;667:17-26. Epub 2017 May 15.

Dept. of Neurophysiology and Diagnostic Epileptology, Foundation IRCCS Neurological Institute C. Besta, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.neulet.2017.05.026DOI Listing
February 2018

Ranolazine vs phenytoin: greater effect of ranolazine on the transient Na(+) current than on the persistent Na(+) current in central neurons.

Neuropharmacology 2016 11 19;110(Pt A):223-236. Epub 2016 Jul 19.

Institute of Molecular and Cellular Pharmacology (IPMC), CNRS UMR7275, 06560, Valbonne-Sophia Antipolis, France; University of the Côte d'Azur (UCA), 06560, Valbonne-Sophia Antipolis, France; Inserm, 06560, Valbonne-Sophia Antipolis, France. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.06.029DOI Listing
November 2016

Unaltered Network Activity and Interneuronal Firing During Spontaneous Cortical Dynamics In Vivo in a Mouse Model of Severe Myoclonic Epilepsy of Infancy.

Cereb Cortex 2016 Apr 26;26(4):1778-94. Epub 2016 Jan 26.

Optical Approaches to Brain Function Laboratory Neural Coding Laboratory, Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, Genova, Italy.

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http://dx.doi.org/10.1093/cercor/bhw002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785957PMC
April 2016

Rescuable folding defective NaV1.1 (SCN1A) mutants in epilepsy: properties, occurrence, and novel rescuing strategy with peptides targeted to the endoplasmic reticulum.

Neurobiol Dis 2015 Mar 6;75:100-14. Epub 2015 Jan 6.

Institute of Molecular and Cellular Pharmacology (IPMC), LabEx ICST, CNRS UMR7275 and University of Nice-Sophia Antipolis, 06560 Valbonne, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.12.028DOI Listing
March 2015

Action potential initiation in neocortical inhibitory interneurons.

PLoS Biol 2014 Sep 9;12(9):e1001944. Epub 2014 Sep 9.

State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, School of Brain and Cognitive Sciences, Beijing Normal University, Beijing, China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.

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http://dx.doi.org/10.1371/journal.pbio.1001944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159120PMC
September 2014

Genetic epilepsy syndromes without structural brain abnormalities: clinical features and experimental models.

Neurotherapeutics 2014 Apr;11(2):269-85

Pediatric Neurology Unit and Laboratories, Children's Hospital A. Meyer-University of Florence, Viale Pieraccini 24, 50139, Florence, Italy,

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http://link.springer.com/content/pdf/10.1007/s13311-014-0267
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http://link.springer.com/10.1007/s13311-014-0267-0
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http://dx.doi.org/10.1007/s13311-014-0267-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996114PMC
April 2014

Nonfunctional NaV1.1 familial hemiplegic migraine mutant transformed into gain of function by partial rescue of folding defects.

Proc Natl Acad Sci U S A 2013 Oct 7;110(43):17546-51. Epub 2013 Oct 7.

Institute of Molecular and Cellular Pharmacology, Laboratoire d'Excellence Canaux Ioniques d'Intérêt Thérapeutique, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7275, and University of Nice Sophia Antipolis, 06560 Valbonne, France.

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http://dx.doi.org/10.1073/pnas.1309827110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808640PMC
October 2013

Hippocampal hyperexcitability and specific epileptiform activity in a mouse model of Dravet syndrome.

Epilepsia 2013 Jul 10;54(7):1251-61. Epub 2013 May 10.

Institute of Molecular and Cellular Pharmacology, CNRS UMR7275, University of Nice-Sophia Antipolis, Valbonne, France.

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http://dx.doi.org/10.1111/epi.12213DOI Listing
July 2013

Divergent effects of the T1174S SCN1A mutation associated with seizures and hemiplegic migraine.

Epilepsia 2013 May 8;54(5):927-35. Epub 2013 Feb 8.

Institute of Molecular and Cellular Pharmacology, LabEx ICST, CNRS UMR7275, University of Nice-Sophia Antipolis, Valbonne, France.

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http://dx.doi.org/10.1111/epi.12123DOI Listing
May 2013

Phenytoin inhibits the persistent sodium current in neocortical neurons by modifying its inactivation properties.

PLoS One 2013 29;8(1):e55329. Epub 2013 Jan 29.

Department of Neurophysiopathology, Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055329PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558486PMC
July 2013

The 22nd ion channel meeting, september 2011, france.

Channels (Austin) 2012 May-Jun;6(3):149-53. Epub 2012 May 1.

Neurobiologie des Canaux Ioniques, INSERM-Université de la Méditerranée, Marseille, France.

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http://dx.doi.org/10.4161/chan.20795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431583PMC
December 2012

Pure haploinsufficiency for Dravet syndrome Na(V)1.1 (SCN1A) sodium channel truncating mutations.

Epilepsia 2012 Jan 9;53(1):87-100. Epub 2011 Dec 9.

Department of Neurophysiopathology, Besta Foundation Neurological Institute, Milan, Italy.

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http://dx.doi.org/10.1111/j.1528-1167.2011.03346.xDOI Listing
January 2012

Dravet syndrome: insights from in vitro experimental models.

Epilepsia 2011 Apr;52 Suppl 2:62-9

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR6097, University of Nice-Sophia Antipolis, Valbonne, France.

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http://dx.doi.org/10.1111/j.1528-1167.2011.03005.xDOI Listing
April 2011

Epileptogenic ion channel mutations: from bedside to bench and, hopefully, back again.

Epilepsy Res 2010 Nov 15;92(1):1-29. Epub 2010 Sep 15.

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR6097 and University of Nice-Sophia Antipolis, 660 route des Lucioles, 06560 Valbonne, France.

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http://dx.doi.org/10.1016/j.eplepsyres.2010.08.003DOI Listing
November 2010

Na+ channelopathies and epilepsy: recent advances and new perspectives.

Expert Rev Clin Pharmacol 2010 May;3(3):371-84

Child Neurology Unit, Pediatric Hospital A. Meyer, University of Firenze, Viale Pieraccini, Florence, Italy.

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http://dx.doi.org/10.1586/ecp.10.20DOI Listing
May 2010

Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders.

Lancet Neurol 2010 Apr;9(4):413-24

Dipartimento di Neurofisiopatologia, Fondazione Istituto Neurologico C Besta, Milano, Italy.

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http://dx.doi.org/10.1016/S1474-4422(10)70059-4DOI Listing
April 2010

Progressive neurocognitive decline in two children with Dravet syndrome, de novo SCN1A truncations and different epileptic phenotypes.

Am J Med Genet A 2009 Oct;149A(10):2339-45

Developmental Neurology Unit, C Besta Foundation Neurological Institute, Milan, Italy.

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http://doi.wiley.com/10.1002/ajmg.a.33029
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http://dx.doi.org/10.1002/ajmg.a.33029DOI Listing
October 2009

A rescuable folding defective Nav1.1 (SCN1A) sodium channel mutant causes GEFS+: common mechanism in Nav1.1 related epilepsies?

Hum Mutat 2009 Jul;30(7):E747-60

Department of Neurophysiopathology, C.Besta Neurological Institute, 20133 Milano, Italy.

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http://dx.doi.org/10.1002/humu.21041DOI Listing
July 2009

Epileptogenic channelopathies: experimental models of human pathologies.

Epilepsia 2007 ;48 Suppl 2:51-64

Department ofNeurophysiopathology, Istituto Neurologico C. Besta, Milan, Italy.

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http://dx.doi.org/10.1111/j.1528-1167.2007.01067.xDOI Listing
July 2007

Electroclinical features of a family with simple febrile seizures and temporal lobe epilepsy associated with SCN1A loss-of-function mutation.

Epilepsia 2007 Sep 12;48(9):1691-1696. Epub 2007 Jun 12.

Institute of Neurology, University Magna Graecia, CatanzaroInstitute of Neurological Sciences, National Research Council, Piano Lago di Mangone, CosenzaDepartment of Neurophysiopathogy, Istituto Neurologico C. Besta, MilanoDepartment of Biotechnologies and Biosciences, University of Milano Bicocca, MilanoCenter for Child Epilepsy, Azienda Ospedaliera "Fatebenefratelli e Oftalmico," MilanoRegional Centre of Epilepsy, San Paolo Hospital, Milano, Italy.

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http://dx.doi.org/10.1111/j.1528-1167.2007.01153.xDOI Listing
September 2007

Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy.

Nat Neurosci 2006 Sep 20;9(9):1142-9. Epub 2006 Aug 20.

Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.

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http://dx.doi.org/10.1038/nn1754DOI Listing
September 2006

Beta-scorpion toxin effects suggest electrostatic interactions in domain II of voltage-dependent sodium channels.

J Physiol 2005 Oct 14;568(Pt 1):13-30. Epub 2005 Jul 14.

Dipartimento di Neurofisiopatologia, Istituto Neurologico Besta, Milano, Italy.

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http://doi.wiley.com/10.1113/jphysiol.2005.093484
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http://dx.doi.org/10.1113/jphysiol.2005.093484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474769PMC
October 2005

Molecular determinants for modulation of persistent sodium current by G-protein betagamma subunits.

J Neurosci 2005 Mar;25(13):3341-9

Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195-7280, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0104-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724911PMC
March 2005

First chemical synthesis of a scorpion alpha-toxin affecting sodium channels: the Aah I toxin of Androctonus australis hector.

J Pept Sci 2004 Nov;10(11):666-77

FRE 2738 CNRS-Université de la Méditerranée, Laboratoire de Biochimie and Laboratoire International Associé d'lngénierie Biomoleculaire, IFR Jean Roche, Faculté de Médecine Nord, Bd Pierre Dramard, 13916 Marseille, France.

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http://doi.wiley.com/10.1002/psc.582
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http://dx.doi.org/10.1002/psc.582DOI Listing
November 2004