Massimo Loda

Massimo Loda

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Massimo Loda

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Loss of PTEN Expression Detected by Fluorescence Immunohistochemistry Predicts Lethal Prostate Cancer in Men Treated with Prostatectomy.

Eur Urol Oncol 2019 Sep 4;2(5):475-482. Epub 2018 Oct 4.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2018.09.003DOI Listing
September 2019

Aneuploidy drives lethal progression in prostate cancer.

Proc Natl Acad Sci U S A 2019 Jun 13;116(23):11390-11395. Epub 2019 May 13.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1902645116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561291PMC
June 2019

When fat goes down, prostate cancer is on the ropes.

Mol Cell Oncol 2019 16;6(3):1595308. Epub 2019 Apr 16.

Dana-Farber Cancer Institute, Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1080/23723556.2019.1595308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512936PMC
April 2019

Re: Melissa Assel, Anders Dahlin, David Ulmert, et al. Association Between Lead Time and Prostate Cancer Grade: Evidence of Grade Progression from Long-term Follow-up of Large Population-based Cohorts Not Subject to Prostate-specific Antigen Screening. Eur Urol 2018;73:961-7.

Eur Urol 2019 03 12;75(3):e54-e55. Epub 2018 Oct 12.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183074
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http://dx.doi.org/10.1016/j.eururo.2018.10.004DOI Listing
March 2019

AKT1 quiescent cancer cells in ductal carcinoma in situ of the breast.

NPJ Breast Cancer 2019 21;5:10. Epub 2019 Mar 21.

5Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114 USA.

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http://dx.doi.org/10.1038/s41523-019-0105-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428812PMC
March 2019

The Metabolic Landscape of Prostate Cancer.

Eur Urol Oncol 2019 Feb 19;2(1):28-36. Epub 2018 Jul 19.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.euo.2018.06.010DOI Listing
February 2019

Transcriptome Deconvolution of Heterogeneous Tumor Samples with Immune Infiltration.

iScience 2018 Nov 2;9:451-460. Epub 2018 Nov 2.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2018.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249353PMC
November 2018

Metabolic Vulnerabilities of Prostate Cancer: Diagnostic and Therapeutic Opportunities.

Cold Spring Harb Perspect Med 2018 10 1;8(10). Epub 2018 Oct 1.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1101/cshperspect.a030569DOI Listing
October 2018

Specific F-FDHT Accumulation in Human Prostate Cancer Xenograft Murine Models Is Facilitated by Prebinding to Sex Hormone-Binding Globulin.

J Nucl Med 2018 10 31;59(10):1538-1543. Epub 2018 May 31.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts

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http://dx.doi.org/10.2967/jnumed.118.208785DOI Listing
October 2018

A Prospective Study of Aspirin Use and Prostate Cancer Risk by Status.

Cancer Epidemiol Biomarkers Prev 2018 10 14;27(10):1231-1233. Epub 2018 Aug 14.

National Cancer Institute, Division of Cancer Epidemiology and Genetics, Epidemiology and Biostatistics Program, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170677PMC
October 2018

LSD1: A single target to combat lineage plasticity in lethal prostate cancer.

Proc Natl Acad Sci U S A 2018 05 16;115(18):4530-4531. Epub 2018 Apr 16.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1804205115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939118PMC
May 2018

MYC Overexpression at the Protein and mRNA Level and Cancer Outcomes among Men Treated with Radical Prostatectomy for Prostate Cancer.

Cancer Epidemiol Biomarkers Prev 2018 02 15;27(2):201-207. Epub 2017 Nov 15.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-17-0637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831163PMC
February 2018

AKT1 quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer.

Breast Cancer Res 2017 Aug 1;19(1):88. Epub 2017 Aug 1.

Massachusetts General Hospital Cancer Center, Richard B. Simches Research Building, 185 Cambridge Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1186/s13058-017-0877-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540189PMC
August 2017

Metformin and longevity (METAL): a window of opportunity study investigating the biological effects of metformin in localised prostate cancer.

BMC Cancer 2017 Jul 21;17(1):494. Epub 2017 Jul 21.

Division of Cancer Studies, Cancer Epidemiology Group, Research Oncology, King's College London, 3rd Floor, Bermondsey Wing, Guy's Hospital, London, SE1 9RT, UK.

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http://dx.doi.org/10.1186/s12885-017-3458-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520293PMC
July 2017

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

Proc Natl Acad Sci U S A 2017 06 13;114(26):E5207-E5215. Epub 2017 Jun 13.

Division of Molecular and Cellular Oncology, Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1617467114
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http://dx.doi.org/10.1073/pnas.1617467114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495225PMC
June 2017

Circulating Antioxidant Levels and Risk of Prostate Cancer by TMPRSS2:ERG.

Prostate 2017 May 19;77(6):647-653. Epub 2017 Jan 19.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/pros.23312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354965PMC
May 2017

Metabolic Profiling in Formalin-Fixed and Paraffin-Embedded Prostate Cancer Tissues.

Mol Cancer Res 2017 04 10;15(4):439-447. Epub 2017 Jan 10.

Department of Medical Oncology, Center of Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552883PMC
April 2017

Pathology-Driven Comprehensive Proteomic Profiling of the Prostate Cancer Tumor Microenvironment.

Mol Cancer Res 2017 03 5;15(3):281-293. Epub 2017 Jan 5.

UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0358DOI Listing
March 2017

Overexpression of the Long Non-coding RNA SChLAP1 Independently Predicts Lethal Prostate Cancer.

Eur Urol 2016 10 24;70(4):549-552. Epub 2015 Dec 24.

Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, Ann Arbor, MI, USA; Howard Hughes Medical Institute, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919276PMC
October 2016

Challenging Roadblocks to Cancer Cure.

Authors:
Massimo Loda

Cancer Res 2016 09 12;76(17):4924-30. Epub 2016 Aug 12.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts. The Broad Institute, Cambridge, Massachusetts. Division of Cancer Studies, King's College, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1443DOI Listing
September 2016

Expression Levels of DNA Damage Repair Proteins Are Associated With Overall Survival in Platinum-Treated Advanced Urothelial Carcinoma.

Clin Genitourin Cancer 2016 08 24;14(4):352-9. Epub 2015 Dec 24.

Bladder Cancer Center, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2015.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508512PMC
August 2016

Vascular morphology differentiates prostate cancer mortality risk among men with higher Gleason grade.

Cancer Causes Control 2016 08 5;27(8):1043-7. Epub 2016 Jul 5.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s10552-016-0782-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958547PMC
August 2016

Calcium-Sensing Receptor Tumor Expression and Lethal Prostate Cancer Progression.

J Clin Endocrinol Metab 2016 06 26;101(6):2520-7. Epub 2016 Apr 26.

Departments of Epidemiology (T.U.A., K.M.W., E.N., H.D.S., E.G., L.A.M., I.M.S.) and Department of Nutrition (E.G.), Harvard T. H. Chan School of Public Health, Department of Medical Oncology (R.L., M.L.), Dana-Farber Cancer Institute, Divisions of Preventive Medicine (H.D.S.), and Channing Division of Network Medicine (K.M.W., E.G., L.A.M.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Histopathology Research (N.T., S.F.), Trinity College, Dublin 8, Ireland; and Public Health Sciences Division (I.M.S.), Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.

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http://dx.doi.org/10.1210/jc.2016-1082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891799PMC
June 2016

Untargeted metabolomics for profiling oncogene-specific metabolic signatures of prostate cancer.

Mol Cell Oncol 2015 Oct-Dec;2(4):e1001197. Epub 2015 Jan 23.

Pathology, Brigham and Women's Hospital, and Medical Oncology; Dana-Farber Cancer Institute; Harvard Medical School ; Boston, MA, USA.

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http://dx.doi.org/10.1080/23723556.2014.1001197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905328PMC
June 2016

Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes.

Cancer Epidemiol Biomarkers Prev 2016 05 3;25(5):745-9. Epub 2016 Mar 3.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-1078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873420PMC
May 2016

The Proliferative Activity of Mammary Epithelial Cells in Normal Tissue Predicts Breast Cancer Risk in Premenopausal Women.

Cancer Res 2016 04 3;76(7):1926-34. Epub 2016 Mar 3.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873436PMC
April 2016

Pre-diagnostic circulating sex hormone levels and risk of prostate cancer by ERG tumour protein expression.

Br J Cancer 2016 Apr 17;114(8):939-44. Epub 2016 Mar 17.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/bjc.2016.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984801PMC
April 2016

A Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer.

J Natl Cancer Inst 2016 Feb 27;108(2). Epub 2015 Nov 27.

Department of Epidemiology (TUA, AP, EME, TG, REG, KMW, JRR, HDS, ELG, MJS, LAM) and Department of Nutrition (ELG, MJS), Harvard T. H. Chan School of Public Health, Boston, MA; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (AP); Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA (REG); Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD (CLM, JLH, AMDM, TLL); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (JRR, ELG, MJS, LAM, KMW); Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA (HDS); Pathology Unit, Addarii Institute, S. Orsola-Malpighi Hospital, Bologna, Italy (MF); Department of Histopathology Research, Trinity College, Dublin, Ireland (RF, SF); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (ML); Department of Oncology (AMDM, TLL) and Department of Urology (ADMD), Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1093/jnci/djv346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862436PMC
February 2016

Detecting metastatic prostate carcinoma in pelvic lymph nodes following neoadjuvant hormone therapy: the eyes have it!

Histopathology 2016 Jan 14;68(2):303-7. Epub 2015 Jul 14.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/his.12739DOI Listing
January 2016

MicroRNA MIR21 and T Cells in Colorectal Cancer.

Cancer Immunol Res 2016 Jan 29;4(1):33-40. Epub 2015 Sep 29.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703429PMC
January 2016

Advanced neuroendocrine prostate tumors regress to stemness.

Proc Natl Acad Sci U S A 2015 Nov 17;112(47):14406-7. Epub 2015 Nov 17.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, MA 02115; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA 02115; Division of Cancer Studies, King's College London, London SE1 9RT, United Kingdom

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http://dx.doi.org/10.1073/pnas.1519151112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664372PMC
November 2015

Measuring PI3K Activation: Clinicopathologic, Immunohistochemical, and RNA Expression Analysis in Prostate Cancer.

Mol Cancer Res 2015 Oct 29;13(10):1431-40. Epub 2015 Jun 29.

Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Division of Cancer Studies, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618038PMC
October 2015

Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies.

Mol Cancer Res 2015 Jul 8;13(7):1059-72. Epub 2015 May 8.

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts. Department of Pathology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts. The Broad Institute, Cambridge, Massachusetts. Division of Cancer Studies, King's College London, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504770PMC
July 2015

The TMPRSS2:ERG fusion and response to androgen deprivation therapy for prostate cancer.

Prostate 2015 Jun 1;75(9):897-906. Epub 2015 Mar 1.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1002/pros.22973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424159PMC
June 2015

Innovation in metabolomics to improve personalized healthcare.

Ann N Y Acad Sci 2015 Jun 26;1346(1):57-62. Epub 2015 May 26.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/nyas.12775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839187PMC
June 2015

Integrative clinical genomics of advanced prostate cancer.

Cell 2015 May;161(5):1215-1228

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484602PMC
May 2015

A phase I study of everolimus and docetaxel in patients with castration-resistant prostate cancer.

Clin Genitourin Cancer 2015 Apr 22;13(2):113-23. Epub 2014 Oct 22.

Medical Oncology, Dana-Farber Cancer Institute and Internal Medicine, Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2014.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418946PMC
April 2015

26th Pezcoller symposium: cancers driven by hormones.

Cancer Res 2015 Apr 18;75(7):1177-80. Epub 2015 Mar 18.

Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-14-2902DOI Listing
April 2015

Association of prostate cancer risk variants with gene expression in normal and tumor tissue.

Cancer Epidemiol Biomarkers Prev 2015 Jan 4;24(1):255-60. Epub 2014 Nov 4.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0694-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294966PMC
January 2015

A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression.

Am J Pathol 2015 Jan 6;185(1):252-65. Epub 2014 Nov 6.

Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts; Department of Pediatric Hematology/Oncology, Melanoma Program in Medical Oncology, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ajpath.2014.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278358PMC
January 2015

AKT1 and MYC induce distinctive metabolic fingerprints in human prostate cancer.

Cancer Res 2014 Dec 16;74(24):7198-204. Epub 2014 Oct 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts. Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts. The Broad Institute, Cambridge, Massachusetts. Division of Cancer Studies, King's College London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267915PMC
December 2014

Serum glucose and risk of cancer: a meta-analysis.

BMC Cancer 2014 Dec 19;14:985. Epub 2014 Dec 19.

King's College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, UK.

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http://dx.doi.org/10.1186/1471-2407-14-985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320469PMC
December 2014

Intense androgen-deprivation therapy with abiraterone acetate plus leuprolide acetate in patients with localized high-risk prostate cancer: results of a randomized phase II neoadjuvant study.

J Clin Oncol 2014 Nov 13;32(33):3705-15. Epub 2014 Oct 13.

Mary-Ellen Taplin, Massimo Loda, Rosina T. Lis, Wanling Xie, Zhenyang Jiang, and Philip W. Kantoff, Dana-Farber Cancer Institute, Harvard Medical School; Glenn J. Bubley, Huihui Ye, and Steven P. Balk, Beth Israel Deaconess Medical Center; Jerome P. Richie, Massimo Loda, and Rosina T. Lis, Brigham and Women's Hospital, Boston, MA; Bruce Montgomery, Bruce L. Dalkin, Lawrence D. True, and Alvin M. Matsumoto, University of Washington; Brett T. Marck and Alvin M. Matsumoto, Geriatric Research, Education and Clinical Center, Veterans' Affairs Puget Sound Health Care System; Elahe A. Mostaghel and Peter S. Nelson, Fred Hutchinson Cancer Research Center, Seattle, WA; Christopher J. Logothetis, John W. Davis, and Patricia Troncoso, University of Texas MD Anderson Cancer Center, Houston, TX; Martin G. Sanda, Emory University School of Medicine, Atlanta, GA; Massimo Loda, King's College London, London, United Kingdom; Trevor M. Penning and Daniel Tamae, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and Christopher M. Haqq, NamPhuong Tran, Weimin Peng, Thian Kheoh, and Arturo Molina, Janssen Research and Development, Los Angeles, CA.

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http://dx.doi.org/10.1200/JCO.2013.53.4578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226804PMC
November 2014

c-Jun promotes cell migration and drives expression of the motility factor ENPP2 in soft tissue sarcomas.

J Pathol 2014 Oct 1;234(2):190-202. Epub 2014 Aug 1.

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA; Ludwig Center at Dana-Farber/Harvard Cancer Center, Boston, MA, USA.

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http://dx.doi.org/10.1002/path.4379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472460PMC
October 2014

Androgen receptor CAG repeat polymorphism and risk of TMPRSS2:ERG-positive prostate cancer.

Cancer Epidemiol Biomarkers Prev 2014 Oct 12;23(10):2027-31. Epub 2014 Jun 12.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184923PMC
October 2014

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.

Cancer Discov 2014 Aug 27;4(8):896-904. Epub 2014 May 27.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School; Department of Medicine; Divisions of

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http://dx.doi.org/10.1158/2159-8290.CD-13-0230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125493PMC
August 2014

Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib.

Cancer Discov 2014 May 13;4(5):546-53. Epub 2014 Mar 13.

Departments of 1Medical Oncology and 2Biostatistics and Computational Biology, 3Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute; Departments of 4Medicine and 5Pathology, Brigham and Women's Hospital, Harvard Medical School; 6Division of Hematology/Oncology, Massachusetts General Hospital, Boston; 7Broad Institute of Harvard and MIT; 8Department of Biology, Whitehead Institute for Biomedical Research; 9Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts; and 10Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122326PMC
May 2014

Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.

Clin Cancer Res 2014 Apr 31;20(7):1873-83. Epub 2014 Jan 31.

Authors' Affiliations: Departments of Biostatistics and Computational Biology, and Medical Oncology; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute; Department of Biostatistics, Harvard School of Public Health; Department of Pathology; Translational Medicine Division, Brigham and Women's Hospital, Boston; Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Sidney Kimmel Cancer Center; Department of Pathology, Johns Hopkins University, Baltimore, Maryland; Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York; and Hospital del Mar Research Institute-IMIM, Barcelona; and Hospital Parc Tauli, Sabadell, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975677PMC
April 2014

High-resolution array CGH and gene expression profiling of alveolar soft part sarcoma.

Clin Cancer Res 2014 Mar 3;20(6):1521-30. Epub 2014 Feb 3.

Authors' Affiliations: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute; Massachusetts General Hospital, Boston, Massachusetts; Carver College of Medicine, University of Iowa, Iowa City, Iowa; and Department of Pathology, St. James's Hospital, Dublin, Ireland.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-2090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962657PMC
March 2014

Dietary lycopene, angiogenesis, and prostate cancer: a prospective study in the prostate-specific antigen era.

J Natl Cancer Inst 2014 Feb 24;106(2):djt430. Epub 2014 Jan 24.

Affiliations of authors: Department of Nutrition (KZ, MJS, EG), Department of Epidemiology (LM, MJS, EG), and Department of Biostatistics (BAR), Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (LM, BAR, MJS, EG); Department of Internal Medicine, The Ohio State University, Columbus, OH (SKC); Department of Pathology, Dana-Farber Cancer Institute, Boston, MA (ML).

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http://dx.doi.org/10.1093/jnci/djt430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952200PMC
February 2014