Publications by authors named "Massimo Levrero"

90Publications

[Management of immune checkpoint inhibitors-induced liver toxicity in cancer].

Bull Cancer 2020 Oct 17;107(10):1056-1068. Epub 2020 Sep 17.

Hospices civils de Lyon, unité d'hépatologie et gastroentérologie de l'hôpital de la Croix-Rousse, Lyon, France; Centre de recherche en cancérologie de Lyon, Inserm U1052, Lyon, France; Université Claude-Bernard Lyon 1, Lyon, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bulcan.2020.06.011DOI Listing
October 2020

Preliminary evidence for hdv exposure in apparently non-HBV-infected patients.

Hepatology 2020 Jul 6. Epub 2020 Jul 6.

CIRI, Centre International de Recherche en Infectiologie, Team EVIR, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.31453DOI Listing
July 2020

Inducing and Characterizing Vesicular Steatosis in Differentiated HepaRG Cells.

J Vis Exp 2019 07 18(149). Epub 2019 Jul 18.

Department of Molecular Medicine, Sapienza University; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia;

View Article

Download full-text PDF

Source
https://www.jove.com/video/59843/inducing-characterizing-ves
Publisher Site
http://dx.doi.org/10.3791/59843DOI Listing
July 2019

Non-invasive biomarkers for chronic hepatitis B virus infection management.

Antiviral Res 2019 09 6;169:104553. Epub 2019 Jul 6.

INSERM U1052-Cancer Research Center of Lyon (CRCL), 69008, Lyon, France; University of Lyon, University Claude Bernard Lyon 1 (UCBL1), Lyon, France; Department of Virology, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.antiviral.2019.104553DOI Listing
September 2019

Update of the statements on biology and clinical impact of occult hepatitis B virus infection.

J Hepatol 2019 08 18;71(2):397-408. Epub 2019 Apr 18.

Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01688278193025
Publisher Site
http://dx.doi.org/10.1016/j.jhep.2019.03.034DOI Listing
August 2019

Serum hepatitis B core-related antigen (HBcrAg) correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients.

J Hepatol 2019 04 7;70(4):615-625. Epub 2018 Dec 7.

INSERM U1052-Cancer Research Center of Lyon (CRCL), 69008 Lyon, France; University of Lyon, UMR_S1052, CRCL, 69008 Lyon, France; Department of Hepatology, Croix Rousse Hospital, Hospices Civils de Lyon, France. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01688278183258
Publisher Site
http://dx.doi.org/10.1016/j.jhep.2018.11.030DOI Listing
April 2019

[Hepatitis delta virus replication and the role of the small hepatitis delta protein S-HDAg].

Med Sci (Paris) 2018 Oct 19;34(10):833-841. Epub 2018 Nov 19.

Inserm, U1052 - UMR CNRS 5286, Centre de recherche en cancérologie de Lyon, Lyon, France - Laboratoire de microbiologie clinique, groupe des Hôpitaux universitaires de Paris-Seine Saint Denis, UFR santé médecine, biologie humaine, université Paris 13, Bobigny, France.

View Article

Download full-text PDF

Source
https://www.medecinesciences.org/10.1051/medsci/2018209
Publisher Site
http://dx.doi.org/10.1051/medsci/2018209DOI Listing
October 2018

Non-Coding RNAs and Hepatitis C Virus-Induced Hepatocellular Carcinoma.

Viruses 2018 10 30;10(11). Epub 2018 Oct 30.

Cancer Research Center of Lyon (CRCL), UMR Inserm 1052 CNRS 5286 Mixte CLB, Université de Lyon 1 (UCBL1), 69003 Lyon, France.

View Article

Download full-text PDF

Source
http://www.mdpi.com/1999-4915/10/11/591
Publisher Site
http://dx.doi.org/10.3390/v10110591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265700PMC
October 2018

Hepatitis B.

Nat Rev Gastroenterol Hepatol 2018 Sep 20. Epub 2018 Sep 20.

Cancer Research Center of Lyon (CRCL) - INSERM Unit 1052, Lyon, France.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41575-018-0060-3
Publisher Site
http://dx.doi.org/10.1038/s41575-018-0060-3DOI Listing
September 2018

Perspectives and limitations for nucleo(t)side analogs in future HBV therapies.

Curr Opin Virol 2018 06 16;30:80-89. Epub 2018 May 16.

INSERM U1052 - Cancer Research Center of Lyon (CRCL), 69008 Lyon, France; University of Lyon, UMR_S1052, CRCL, 69008 Lyon, France; Department of Hepatology, Croix Rousse Hospital, Hospices Civils de Lyon, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coviro.2018.04.006DOI Listing
June 2018

Challenges to a Cure for HBV Infection.

Semin Liver Dis 2017 08 28;37(3):231-242. Epub 2017 Aug 28.

INSERM, U1052, Lyon, France.

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1606212
Publisher Site
http://dx.doi.org/10.1055/s-0037-1606212DOI Listing
August 2017

Detection of the hepatitis B virus (HBV) covalently-closed-circular DNA (cccDNA) in mice transduced with a recombinant AAV-HBV vector.

Antiviral Res 2017 Sep 11;145:14-19. Epub 2017 Jul 11.

INSERM, U1052, Cancer Research Center of Lyon (CRCL), Université de Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.antiviral.2017.07.006DOI Listing
September 2017

PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation.

Hepatology 2017 08 19;66(2):398-415. Epub 2017 Jun 19.

Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.29133DOI Listing
August 2017

Genome-wide identification of direct HBx genomic targets.

BMC Genomics 2017 02 17;18(1):184. Epub 2017 Feb 17.

Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, Rome, 00161, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-017-3561-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316204PMC
February 2017

Intrahepatic innate immune response pathways are downregulated in untreated chronic hepatitis B.

J Hepatol 2017 05 30;66(5):897-909. Epub 2016 Dec 30.

INSERM U1052-Cancer Research Center of Lyon (CRCL), 69008 Lyon, France; Department of Hepatology, Croix Rousse Hospital, Hospices Civils de Lyon, France; University of Lyon, UMR_S1052, CRCL, 69008 Lyon, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2016.12.024DOI Listing
May 2017

HBV cure: why, how, when?

Curr Opin Virol 2016 06 19;18:135-43. Epub 2016 Jul 19.

Cancer Research Center of Lyon (CRCL), Lyon 69008, France; INSERM, U1052, Lyon 69003, France; Hospices Civils de Lyon (HCL), 69002 Lyon, France; University of Lyon, UMR_S1052, UCBL, 69008 Lyon, France; Institut Universitaire de France (IUF), 75005 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coviro.2016.06.003DOI Listing
June 2016

The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells.

Sci Rep 2016 06 20;6:28025. Epub 2016 Jun 20.

Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep28025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913258PMC
June 2016

Current treatments for chronic hepatitis B virus infections.

Curr Opin Virol 2016 06 15;18:109-16. Epub 2016 Jun 15.

Cancer Research Center of Lyon (CRCL), Lyon 69008, France; INSERM, U1052, Lyon 69003, France; Hospices Civils de Lyon (HCL), 69002 Lyon, France; DMISM and CLNS IIT Sapienza, Sapienza University Rome, 00161 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coviro.2016.06.004DOI Listing
June 2016

Aiming for cure in HBV and HDV infection.

J Hepatol 2016 10 3;65(4):835-848. Epub 2016 Jun 3.

Cancer Research Center of Lyon (CRCL) - INSERM U1052, Lyon, France; IIT Centre for Life Nanoscience (CLNS), Rome, Italy; Dept of Internal Medicine (DMISM), Sapienza University, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2016.05.043DOI Listing
October 2016

Mechanisms of HBV-induced hepatocellular carcinoma.

J Hepatol 2016 Apr;64(1 Suppl):S84-S101

Inserm, UMR-1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Institut Universitaire d'Hematologie, Paris, France; Université Paris Descartes, Labex Immuno-Oncology, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; Université Paris 13, Sorbonne Paris Cité, Unité de Formation et de Recherche Santé, Médecine, Biologie Humaine, Bobigny, France; Université Paris Diderot, Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2016.02.021DOI Listing
April 2016

Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes.

Gut 2016 Apr 16;65(4):672-82. Epub 2015 Jun 16.

INSERM U1052, Cancer Research Center of Lyon (CRCL), Lyon, France University of Lyon, UCBL, UMR_S1052, Lyon, France Hospices Civils de Lyon (HCL), Lyon, France Institut Universitaire de France (IUF), Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2014-309011DOI Listing
April 2016

TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.

FEBS Lett 2014 Aug 28;588(16):2590-9. Epub 2014 Jun 28.

Center for Life Nanosciences (CNLS) - IIT/Sapienza, Rome, Italy; Laboratory of Gene Expression, Department of Internal Medicine (DMISM), Sapienza University of Rome, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2014.06.047DOI Listing
August 2014

Molecular mechanisms of HBV-associated hepatocarcinogenesis.

Semin Liver Dis 2013 May 8;33(2):147-56. Epub 2013 Jun 8.

Department of Internal Medicine, DMISM and Sapienza Life Nanoscience Laboratory, Sapienza University, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0033-1345721DOI Listing
May 2013

Mechanism of action of ribavirin in anti-HCV regimens: new insights for an age-old question?

Gut 2014 Jan 9;63(1):3-4. Epub 2013 May 9.

Team 15, INSERM U1052, CNRS UMR 5286, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL), LabEx DEVweCAN, , Lyon, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2013-304528DOI Listing
January 2014

The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1.

Mol Carcinog 2013 Jul 2;52(7):526-34. Epub 2012 Mar 2.

Department of Experimental Medicine, Sapienza University, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mc.21887DOI Listing
July 2013

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection.

J Hepatol 2011 Nov 2;55(5):996-1003. Epub 2011 Mar 2.

Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Trogerstrasse, 30, 81675 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2011.02.015DOI Listing
November 2011

ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters.

OMICS 2011 May 19;15(5):305-12. Epub 2011 Feb 19.

Translational Oncogenomics Unit, Regina Elena Cancer Institute, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/omi.2010.0084DOI Listing
May 2011

Control of hepatitis B virus replication by innate response of HepaRG cells.

Hepatology 2010 Jan;51(1):63-72

INSERM (Institut National de la Santé et de la Recherche Médicale), U871, Lyon, France.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/hep.23230
Publisher Site
http://dx.doi.org/10.1002/hep.23230DOI Listing
January 2010

p73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes.

Cancer Res 2009 Nov 27;69(22):8563-71. Epub 2009 Oct 27.

Istituto di Tecnologie Biomediche CNR-Bari, Universita' degli Studi di Bari, Bari, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-09-0259DOI Listing
November 2009

The p53 family protein p73 provides new insights into cancer chemosensitivity and targeting.

Clin Cancer Res 2009 Nov 27;15(21):6495-502. Epub 2009 Oct 27.

Department of Clinical Sciences, University of Parma, Parma, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-09-1229DOI Listing
November 2009

Control of cccDNA function in hepatitis B virus infection.

J Hepatol 2009 Sep 10;51(3):581-92. Epub 2009 Jun 10.

Department of Internal Medicine, Sapienza University of Rome, Policlinico Umberto I, 0061 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2009.05.022DOI Listing
September 2009

hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage.

Mol Cell Biol 2009 Apr 2;29(8):1989-98. Epub 2009 Feb 2.

Laboratory of Gene Expression, Fondazione A Cesalpino, Viale del Policlinico 155, 00161 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00552-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663319PMC
April 2009

Molecular and functional analysis of occult hepatitis B virus isolates from patients with hepatocellular carcinoma.

Hepatology 2007 Feb;45(2):277-85

Unit of Clinical and Molecular Hepatology, Department of Internal Medicine, University of Messina, Messina, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.21529DOI Listing
February 2007

Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones.

Gastroenterology 2006 Mar;130(3):823-37

Laboratory of Gene Expression, Fondazione A. Cesalpino, University of Rome La Sapienza, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2006.01.001DOI Listing
March 2006

MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis.

Blood 2006 Jun 7;107(11):4549-53. Epub 2006 Feb 7.

Department of Clinical Sciences, Section of Hemato-Oncology, University of Parma, Via Gramsci 14, 43100 Parma, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2005-07-2829DOI Listing
June 2006

Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter and directing the factor on viral genes.

J Biol Chem 2006 Mar 3;281(11):7110-7. Epub 2006 Jan 3.

Department of Biology and Dermatology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M512366200DOI Listing
March 2006

A role of p73 in mitotic exit.

J Biol Chem 2005 Aug 28;280(34):30354-60. Epub 2005 Jun 28.

Laboratory of Gene Expression, Fondazione Andrea Cesalpino, 00161 Rome Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M500635200DOI Listing
August 2005

The p73 gene is an anti-tumoral target of the RARbeta/gamma-selective retinoid tazarotene.

J Invest Dermatol 2004 Dec;123(6):1162-8

Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.0022-202X.2004.23498.xDOI Listing
December 2004

Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells.

Blood 2004 Jul 18;104(2):519-25. Epub 2004 Mar 18.

Dipartimento di Scienze Cliniche, Via Gramsci 14, 43100 Parma, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2003-08-2743DOI Listing
July 2004

Regulation of the p300 HAT domain via a novel activation loop.

Nat Struct Mol Biol 2004 Apr 7;11(4):308-15. Epub 2004 Mar 7.

Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nsmb740
Publisher Site
http://dx.doi.org/10.1038/nsmb740DOI Listing
April 2004

Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target.

Oncogene 2003 Nov;22(54):8738-48

Istituto di Tecnologie Biomediche, Sezione di Bari di Bioinformatica e Genomica CNR, Via Amendola, 165/A Bari 70126, Italy.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/1206967
Publisher Site
http://dx.doi.org/10.1038/sj.onc.1206967DOI Listing
November 2003

p73 is regulated by phosphorylation at the G2/M transition.

J Biol Chem 2003 Dec 13;278(49):49196-202. Epub 2003 Aug 13.

Laboratory of Gene Expression, Fondazione Andrea Cesalpino, University of Rome "La Sapienza," 00161 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M304921200DOI Listing
December 2003

HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53.

Oncogene 2003 May;22(19):2910-9

Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1206539DOI Listing
May 2003

Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

Nat Cell Biol 2003 Jun;5(6):552-8

Laboratory of Gene Expression, Fondazione Andrea Cesalpino, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ncb998
Publisher Site
http://dx.doi.org/10.1038/ncb998DOI Listing
June 2003

Endothelial activation by angiotensin II through NFkappaB and p38 pathways: Involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin.

J Cell Physiol 2003 Jun;195(3):402-10

Laboratory of Gene Expression, Fondazione Andrea Cesalpino, Universita' degli Studi di Roma La Sapienza, Viale del Policlinico 155, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.10191DOI Listing
June 2003

Viral determinants and host immune responses in the pathogenesis of HBV infection.

J Med Virol 2002 Jul;67(3):454-7

Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jmv.10096
Publisher Site
http://dx.doi.org/10.1002/jmv.10096DOI Listing
July 2002

DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest.

Oncogene 2002 May;21(23):3796-803

Laboratory of Gene Expression, Fondazione Andrea Cesalpino, University of Rome La Sapienza, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1205465DOI Listing
May 2002

Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage.

Biochem J 2002 Jun;364(Pt 2):441-7

Biochemistry Laboratory, IDI-IRCCS, c/o Department of Experimental Medicine & Biochemical Sciences, University of Rome Tor Vergata, Via Tor Vergata 135, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20011713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222589PMC
June 2002

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

J Biol Chem 2002 May 13;277(21):18817-26. Epub 2002 Mar 13.

Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome 00158, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M201405200DOI Listing
May 2002

Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.

Eur J Immunol 2002 02;32(2):447-56

Department of Cellular and Developmental Biology, University of Rome La Sapienza, Via del Sardi 70, I-00185 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/1521-4141(200202)32:2<447::AID-IMMU447>3.0.CO;2-5DOI Listing
February 2002