Massimo Gadina

Massimo Gadina

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Massimo Gadina

Publications by authors named "Massimo Gadina"

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Selective Janus kinase inhibitors come of age.

Nat Rev Rheumatol 2019 Feb;15(2):74-75

Translational Immunology Section, National Institutes of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41584-018-0155-9DOI Listing
February 2019

Janus kinases to jakinibs: from basic insights to clinical practice.

Rheumatology (Oxford) 2019 Feb;58(Supplement_1):i4-i16

Molecular Immunology and Inflammation Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/rheumatology/key432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657570PMC
February 2019

JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians.

Immunol Rev 2018 11;286(1):148-159

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

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http://dx.doi.org/10.1111/imr.12705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178832PMC
November 2018

Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs.

J Leukoc Biol 2018 09 12;104(3):499-514. Epub 2018 Jul 12.

National Institute of Arthritis, Musculoskeletal and Skin Diseases, Molecular Immunology and Inflammation Branch, National Institutes of Health, Bethesda, Maryland, USA.

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http://doi.wiley.com/10.1002/JLB.5RI0218-084R
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http://dx.doi.org/10.1002/JLB.5RI0218-084RDOI Listing
September 2018

Small molecules to the rescue: Inhibition of cytokine signaling in immune-mediated diseases.

J Autoimmun 2017 Dec 1;85:20-31. Epub 2017 Jul 1.

Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis Musculoskeletal and Skin Diseases, USA.

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http://dx.doi.org/10.1016/j.jaut.2017.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705536PMC
December 2017

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.

Nat Rev Drug Discov 2017 Dec 6;16(12):843-862. Epub 2017 Nov 6.

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nrd.2017.201DOI Listing
December 2017

Erratum to: JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects.

Drugs 2017 07;77(11):1261

Molecular Immunology and Inflammation Branch, National Institute of Arthritis Musculoskeletal and Skin diseases, National Institutes of Health, Bethesda, USA.

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http://link.springer.com/10.1007/s40265-017-0772-7
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http://dx.doi.org/10.1007/s40265-017-0772-7DOI Listing
July 2017

Erratum to: JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects.

Drugs 2017 05;77(8):939

Molecular Immunology and Inflammation Branch, National Institute of Arthritis Musculoskeletal and Skin diseases, National Institutes of Health, Bethesda, USA.

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http://dx.doi.org/10.1007/s40265-017-0736-yDOI Listing
May 2017

JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects.

Drugs 2017 04;77(5):521-546

Molecular Immunology and Inflammation Branch, National Institute of Arthritis Musculoskeletal and Skin diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1007/s40265-017-0701-9DOI Listing
April 2017

HiJAKing Innate Lymphoid Cells?

Front Immunol 2017 13;8:438. Epub 2017 Apr 13.

Translational Immunology Section, Office of Science Technology (OST), NIAMS, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.3389/fimmu.2017.00438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390009PMC
April 2017

Generation and differentiation of induced pluripotent stem cells reveal ankylosing spondylitis risk gene expression in bone progenitors.

Clin Rheumatol 2017 Jan 18;36(1):143-154. Epub 2016 Nov 18.

Pediatric Translational Research Branch, NIAMS, NIH, Bldg. 10/CRC, Rm 1-5132, 10 Center Drive MSC 1102, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s10067-016-3469-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216109PMC
January 2017

Targeting cytokine signaling in autoimmunity: back to the future and beyond.

Curr Opin Immunol 2016 12 4;43:89-97. Epub 2016 Nov 4.

Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.10.001DOI Listing
December 2016

Decernotinib: A Next-Generation Jakinib.

Arthritis Rheumatol 2016 Jan;68(1):31-4

National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1002/art.39463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026186PMC
January 2016

Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases.

Nat Rev Rheumatol 2016 Jan 3;12(1):25-36. Epub 2015 Dec 3.

Molecular Immunology &Inflammation Branch, and Translational Immunology Section, National Institute of Arthritis &Musculoskeletal and Skin Diseases, NIH, Building 10, 9000 Rockville Pike, Bethesda, Maryland 20892-1616, USA.

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http://dx.doi.org/10.1038/nrrheum.2015.167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688091PMC
January 2016

The JAK-STAT pathway: impact on human disease and therapeutic intervention.

Annu Rev Med 2015 ;66:311-28

Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892; email:

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http://dx.doi.org/10.1146/annurev-med-051113-024537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634336PMC
September 2015

Super-enhancers delineate disease-associated regulatory nodes in T cells.

Nature 2015 Apr 16;520(7548):558-62. Epub 2015 Feb 16.

Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature14154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409450PMC
April 2015

Advances in kinase inhibition: treating rheumatic diseases and beyond.

Authors:
Massimo Gadina

Curr Opin Rheumatol 2014 Mar;26(2):237-43

Office of Science and Technology, National Institute of Arthritis Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1097/BOR.0000000000000023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106228PMC
March 2014

Jakpot! New small molecules in autoimmune and inflammatory diseases.

Exp Dermatol 2014 Jan;23(1):7-11

Department of Dermatology, University Medical Center, Eberhard Karls University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1111/exd.12265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877164PMC
January 2014

Janus kinases: an ideal target for the treatment of autoimmune diseases.

Authors:
Massimo Gadina

J Investig Dermatol Symp Proc 2013 Dec;16(1):S70-2

Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/jidsymp.2013.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181323PMC
December 2013

The arrival of JAK inhibitors: advancing the treatment of immune and hematologic disorders.

BioDrugs 2013 Oct;27(5):431-8

Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis Musculoskeletal and Skin Diseases National Institutes of Health, Bethesda, MD, 20895, USA.

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http://dx.doi.org/10.1007/s40259-013-0040-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778139PMC
October 2013

Cytokine signaling: birth of a pathway.

J Immunol 2011 Dec;187(11):5475-8

National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutesof Health, Bethesda, MD 20892, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1102913
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http://dx.doi.org/10.4049/jimmunol.1102913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226779PMC
December 2011

Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).

J Immunol 2011 Apr 7;186(7):4234-43. Epub 2011 Mar 7.

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.1003668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108067PMC
April 2011

Accurate and simple measurement of the pro-inflammatory cytokine IL-1β using a whole blood stimulation assay.

J Vis Exp 2011 Mar 1(49). Epub 2011 Mar 1.

Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases.

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http://www.jove.com/index/Details.stp?ID=2662
Publisher Site
http://dx.doi.org/10.3791/2662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197325PMC
March 2011

Immune modulation: Turncoat regulatory T cells.

Nat Med 2009 Dec;15(12):1365

Translational Immunology Section, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/nm1209-1365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994186PMC
December 2009

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

J Biol Chem 2009 Apr 2;284(14):9587-95. Epub 2009 Feb 2.

Division of Infection and Immunity, Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, Queen's University Belfast, University Road, Belfast BT7 1NN, Northern Ireland.

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http://dx.doi.org/10.1074/jbc.M807216200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666611PMC
April 2009

IL-33: a sheep in wolf's clothing?

Sci STKE 2007 Jun 12;2007(390):pe31. Epub 2007 Jun 12.

Division of Infection and Immunity, Centre for Cancer Research and Cell Biology, Queen's University Belfast, UK.

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http://dx.doi.org/10.1126/stke.3902007pe31DOI Listing
June 2007

Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase.

J Virol 2007 Apr 24;81(7):3428-36. Epub 2007 Jan 24.

Molecular Immunity, Infection and Immunity Group, Centre for Cancer Research and Cell Biology, Queens University Belfast, Whitla Medical Building, 97 Lisburn Rd., Belfast BT9 7BL, Northern Ireland.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.02303-06
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http://dx.doi.org/10.1128/JVI.02303-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866062PMC
April 2007

The newest interleukins: recent additions to the ever-growing cytokine family.

Vitam Horm 2006 ;74:207-28

Division of Infection and Immunity, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom.

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http://dx.doi.org/10.1016/S0083-6729(06)74008-0DOI Listing
December 2006

Immunodeficiency is a tough nut to CRAC: the importance of calcium flux in T cell activation.

Mol Interv 2006 Oct;6(5):253-6

Division of Infection and Immunity, Center for Cancer Research and Cell Biology, Queen's University Belfast.

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http://dx.doi.org/10.1124/mi.6.5.6DOI Listing
October 2006

Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway.

J Biol Chem 2006 Jul 15;281(29):19985-94. Epub 2006 May 15.

Division of Infection and Immunity, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast BT9 7BL, UK.

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http://dx.doi.org/10.1074/jbc.M601629200DOI Listing
July 2006

G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK.

J Immunol 2005 Sep;175(5):2994-9

Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.175.5.2994DOI Listing
September 2005

CXCL12 signaling is independent of Jak2 and Jak3.

J Biol Chem 2005 Apr 20;280(17):17408-14. Epub 2004 Dec 20.

Molecular Immunology and Inflammation Branch, NIAMS, Laboratory of Host Defenses, NIAID, and Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M414219200DOI Listing
April 2005

Ubiquitination for activation: new directions in the NF-kappaB roadmap.

Mol Interv 2004 Jun;4(3):144-6

Department of Micrbiology and Immunology, Queen's University, Belfast BT9 7BL, Northern Ireland, UK.

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http://dx.doi.org/10.112/4.3.3DOI Listing
June 2004

Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory.

J Immunol 2004 May;172(10):6313-23

Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.172.10.6313DOI Listing
May 2004

Inhibiting cytokines of the interleukin-12 family: recent advances and novel challenges.

J Pharm Pharmacol 2004 Feb;56(2):145-60

Cytokine Biology and Genetics Programme, Biomolecular Sciences Research Group, School of Pharmacy, Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.

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http://dx.doi.org/10.1211/0022357022962DOI Listing
February 2004

New interleukins: are there any more?

Curr Opin Infect Dis 2003 Jun;16(3):211-7

Department of Microbiology and Immunology, School of Medicine, The Queen's University of Belfast, Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1097/01.qco.0000073769.11390.eaDOI Listing
June 2003

Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.

J Clin Immunol 2003 May;23(3):147-61

Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Building 10, Room 9N262, 10 Center Drive, MSC 1820, Bethesda, Maryland 20802-1820, USA.

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http://dx.doi.org/10.1023/a:1023381027062DOI Listing
May 2003

Cytokines and their role in lymphoid development, differentiation and homeostasis.

Curr Opin Allergy Clin Immunol 2002 Dec;2(6):495-506

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1097/01.all.0000044534.45448.bfDOI Listing
December 2002

STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation.

Proc Natl Acad Sci U S A 2002 Sep 4;99(19):12281-6. Epub 2002 Sep 4.

Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.182618999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129436PMC
September 2002

Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection.

Science 2002 Sep;297(5589):2063-6

Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA.

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http://dx.doi.org/10.1126/science.1074900DOI Listing
September 2002

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation.

Nat Immunol 2002 Aug 1;3(8):741-8. Epub 2002 Jul 1.

Molecular Inflammation Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1820, USA.

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http://dx.doi.org/10.1038/ni817DOI Listing
August 2002

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.

Cell 2002 Apr;109 Suppl:S121-31

Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20852, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)00701-8DOI Listing
April 2002

Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity.

Proc Natl Acad Sci U S A 2002 Mar 26;99(5):2625-9. Epub 2002 Feb 26.

Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.052712999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122398PMC
March 2002