Publications by authors named "Massimo Castorina"

19Publications

Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.

Authors:
Maurizio Taddei Serena Ferrini Luca Giannotti Massimo Corsi Fabrizio Manetti Giuseppe Giannini Loredana Vesci Ferdinando M Milazzo Domenico Alloatti Mario B Guglielmi Massimo Castorina Maria L Cervoni Marcella Barbarino Rosanna Foderà Valeria Carollo Claudio Pisano Silvia Armaroli Walter Cabri

J Med Chem 2014 Mar 17;57(6):2258-74. Epub 2014 Mar 17.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena , Via A. Moro 2, I-53100 Siena, Italy.

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March 2014

Camptothecins in tumor homing via an RGD sequence mimetic.

Authors:
Domenico Alloatti Giuseppe Giannini Loredana Vesci Massimo Castorina Claudio Pisano Elena Badaloni Walter Cabri

Bioorg Med Chem Lett 2012 Oct 26;22(20):6509-12. Epub 2012 Jul 26.

Corporate R&D, sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy.

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October 2012

Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors.

Authors:
Alberto Bargiotti Loana Musso Sabrina Dallavalle Lucio Merlini Grazia Gallo Andrea Ciacci Giuseppe Giannini Walter Cabri Sergio Penco Loredana Vesci Massimo Castorina Ferdinando Maria Milazzo Maria Luisa Cervoni Marcella Barbarino Claudio Pisano Chiara Giommarelli Valentina Zuco Michelandrea De Cesare Franco Zunino

Eur J Med Chem 2012 Jul 28;53:64-75. Epub 2012 Mar 28.

Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, Via Celoria 2, 20133 Milano, Italy.

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July 2012

Novel 3,4-isoxazolediamides as potent inhibitors of chaperone heat shock protein 90.

Authors:
Riccardo Baruchello Daniele Simoni Giuseppina Grisolia Giuseppina Barbato Paolo Marchetti Riccardo Rondanin Stefania Mangiola Giuseppe Giannini Tiziana Brunetti Domenico Alloatti Grazia Gallo Andrea Ciacci Loredana Vesci Massimo Castorina Ferdinando M Milazzo Maria L Cervoni Mario B Guglielmi Marcella Barbarino Rosanna Foderà Claudio Pisano Walter Cabri

J Med Chem 2011 Dec 23;54(24):8592-604. Epub 2011 Nov 23.

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Ferrara, I-44121 Ferrara, Italy.

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December 2011

Conjugates of a novel 7-substituted camptothecin with RGD-peptides as α(v)β₃ integrin ligands: An approach to tumor-targeted therapy.

Authors:
Alma Dal Pozzo Emiliano Esposito Minghong Ni Laura Muzi Claudio Pisano Federica Bucci Loredana Vesci Massimo Castorina Sergio Penco

Bioconjug Chem 2010 Nov 15;21(11):1956-67. Epub 2010 Oct 15.

Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Milano, Italy.

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November 2010

Synthesis and in vitro antitumor activity of new 4,5-dihydropyrazole derivatives.

Authors:
Cenzo Congiu Valentina Onnis Loredana Vesci Massimo Castorina Claudio Pisano

Bioorg Med Chem 2010 Sep 9;18(17):6238-48. Epub 2010 Aug 9.

Dipartimento di Tossicologia, Sezione di Chimica Farmaceutica, Università degli Studi di Cagliari, via Ospedale 72, Cagliari I-09124, Italy.

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September 2010

Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.

Authors:
Loana Musso Sabrina Dallavalle Lucio Merlini Adriana Bava Gianluca Nasini Sergio Penco Giuseppe Giannini Chiara Giommarelli Andrea De Cesare Valentina Zuco Loredana Vesci Claudio Pisano Massimo Castorina Ferdinando Milazzo Maria Luisa Cervoni Fabrizio Dal Piaz Nunziatina De Tommasi Franco Zunino

Bioorg Med Chem 2010 Aug 1;18(16):6031-43. Epub 2010 Jul 1.

Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, Via Celoria 2, 20133 Milano, Italy.

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August 2010

Novel tumor-targeted RGD peptide-camptothecin conjugates: synthesis and biological evaluation.

Authors:
Alma Dal Pozzo Ming-Hong Ni Emiliano Esposito Sabrina Dallavalle Loana Musso Alberto Bargiotti Claudio Pisano Loredana Vesci Federica Bucci Massimo Castorina Rosanna Foderà Giuseppe Giannini Concetta Aulicino Sergio Penco

Bioorg Med Chem 2010 Jan 12;18(1):64-72. Epub 2009 Nov 12.

Istituto di Ricerche Chimiche e Biochimiche G.Ronzoni, via G Colombo 81, 20133 Milano, Italy.

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January 2010

Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity.

Authors:
Daniele Simoni Romeo Romagnoli Riccardo Baruchello Riccardo Rondanin Giuseppina Grisolia Marco Eleopra Michele Rizzi Manlio Tolomeo Giuseppe Giannini Domenico Alloatti Massimo Castorina Marcella Marcellini Claudio Pisano

J Med Chem 2008 Oct 11;51(19):6211-5. Epub 2008 Sep 11.

Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy.

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October 2008

A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids.

Authors:
Daniela Arosio Laura Belvisi Lino Colombo Matteo Colombo Donatella Invernizzi Leonardo Manzoni Donatella Potenza Massimo Serra Massimo Castorina Claudio Pisano Carlo Scolastico

ChemMedChem 2008 Oct;3(10):1589-603

Istituto di Scienze e Tecnologie Molecolari, Consiglio Nazionale delle Ricerche, Via Fantoli 16/15, 20138 Milano, Italy.

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October 2008

Synthesis of benzo[1,2-d;3,4-d']diimidazole and 1H-pyrazolo[4,3-b]pyridine as putative A2A receptor antagonists.

Authors:
Giovanni Piersanti Luca Giorgi Francesca Bartoccini Giorgio Tarzia Patrizia Minetti Grazia Gallo Fabrizio Giorgi Massimo Castorina Orlando Ghirardi Paolo Carminati

Org Biomol Chem 2007 Aug;5(16):2567-71

Institute of Medicinal Chemistry, University of Urbino "Carlo Bo", Piazza del Rinascimento 6, 61029 Urbino PU, Italy.

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August 2007

Novel combretastatin analogues endowed with antitumor activity.

Authors:
Daniele Simoni Romeo Romagnoli Riccardo Baruchello Riccardo Rondanin Michele Rizzi Maria Giovanna Pavani Domenico Alloatti Giuseppe Giannini Marcella Marcellini Teresa Riccioni Massimo Castorina Mario B Guglielmi Federica Bucci Paolo Carminati Claudio Pisano

J Med Chem 2006 Jun;49(11):3143-52

Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Via Fossato di Mortara 17/19, 44100 Ferrara, Italy.

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June 2006

Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study of their conformational and biological behavior.

Authors:
Alma Dal Pozzo Minghong Ni Laura Muzi Roberto de Castiglione Rosanna Mondelli Stefania Mazzini Sergio Penco Claudio Pisano Massimo Castorina Giuseppe Giannini

J Med Chem 2006 Mar;49(5):1808-17

Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Via G. Colombo 81, 20133 Milano, Italy.

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March 2006

Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders.

Authors:
Giovanni Casiraghi Gloria Rassu Luciana Auzzas Paola Burreddu Enrico Gaetani Lucia Battistini Franca Zanardi Claudio Curti Giuseppe Nicastro Laura Belvisi Ilaria Motto Massimo Castorina Giuseppe Giannini Claudio Pisano

J Med Chem 2005 Dec;48(24):7675-87

Dipartimento Farmaceutico, Università di Parma, Parco Area delle Scienze 27A, I-43100 Parma, Italy.

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December 2005

2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.

Authors:
Patrizia Minetti Maria Ornella Tinti Paolo Carminati Massimo Castorina Maria Assunta Di Cesare Stefano Di Serio Grazia Gallo Orlando Ghirardi Fabrizio Giorgi Luca Giorgi Giovanni Piersanti Francesca Bartoccini Giorgio Tarzia

J Med Chem 2005 Nov;48(22):6887-96

Istituto di Chimica Farmaceutica, Università degli Studi di Urbino Carlo Bo, Piazza del Rinascimento 6, 61029 Urbino (PU), Italy.

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November 2005

Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids.

Authors:
Laura Belvisi Anna Bernardi Matteo Colombo Leonardo Manzoni Donatella Potenza Carlo Scolastico Giuseppe Giannini Marcella Marcellini Teresa Riccioni Massimo Castorina Pietro LoGiudice Claudio Pisano

Bioorg Med Chem 2006 Jan 7;14(1):169-80. Epub 2005 Oct 7.

Dipartimento di Chimica Organica e Industriale and Centro Interdisciplinare Studi bio-molecolari e applicazioni Industriali, (CISI), Università degli Studi di Milano, via G. Venezian 21, I-20133 Milan, Italy.

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January 2006

Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.

Authors:
Giuseppe Campiani Stefania Butini Caterina Fattorusso Bruno Catalanotti Sandra Gemma Vito Nacci Elena Morelli Alfredo Cagnotto Ilario Mereghetti Tiziana Mennini Miriana Carli Patrizia Minetti M Assunta Di Cesare Domenico Mastroianni Nazzareno Scafetta Bruno Galletti M Antonietta Stasi Massimo Castorina Licia Pacifici Mario Vertechy Stefano Di Serio Orlando Ghirardi Ornella Tinti Paolo Carminati

J Med Chem 2004 Jan;47(1):143-57

Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro and European Research Centre for Drug Discovery and Development, Universitá degli Studi di Siena, 53100 Siena, Italy.

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January 2004

Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine.

Authors:
Claudio Pisano Graziella Pratesi Diletta Laccabue Franco Zunino Pietro Lo Giudice Augusta Bellucci Licia Pacifici Barbara Camerini Loredana Vesci Massimo Castorina Sandra Cicuzza Giovanni Tredici Paola Marmiroli Gabriella Nicolini Stefania Galbiati Menotti Calvani Paolo Carminati Guido Cavaletti

Clin Cancer Res 2003 Nov;9(15):5756-67

Research and Development, Sigma-Tau S.p.A. Industrie Farmaceutiche Riunite, Rome, Italy.

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November 2003

Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.

Authors:
Giuseppe Campiani Stefania Butini Sandra Gemma Vito Nacci Caterina Fattorusso Bruno Catalanotti Gianluca Giorgi Alfredo Cagnotto Mara Goegan Tiziana Mennini Patrizia Minetti M Assunta Di Cesare Domenico Mastroianni Nazzareno Scafetta Bruno Galletti M Antonietta Stasi Massimo Castorina Licia Pacifici Orlando Ghirardi Ornella Tinti Paolo Carminati

J Med Chem 2002 Jan;45(2):344-59

Dipartimento Farmaco Chimico Tecnologico, Universitá degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy.

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January 2002